Abstract: Described herein are syringe devices, systems and methods. In general, the syringe may include a first chamber and a cartridge movable within the first chamber. The cartridge may include a cartridge chamber and a valve in fluid communication with the cartridge chamber and the first chamber and having an open configuration and a closed configuration. The valve may allow movement of a liquid out of the cartridge chamber while in a open configuration. The cartridge may also include a second end, movable within the cartridge chamber, and a locking mechanism having a locked configuration and an unlocked configuration, the locking mechanism preventing movement of the second end within the cartridge chamber while in the locked configuration.

Abstract: The invention relates to a liquid applicator, for administering liquids, including vaccines, to animals. In particular, the applicator is useful for delivering liquids to mouths of animals.

Abstract: A transfer device for filing a fluid reservoir of a fluid infusion device with a fluid is provided. The transfer device comprises a first end to couple to a source of the fluid, and a second end to couple to a pressurizing device. The transfer device also comprises a body interconnecting the first end and the second end, and having an end to couple to the fluid reservoir. The body defining at least one fluid flow path between the source of the fluid, the pressurizing device and the fluid reservoir to enable the filling of the fluid reservoir with the fluid.

Abstract: A medical syringe apparatus includes a syringe unit, a hypodermic needle attached to the syringe unit and at least one interfacing member for mating a labeled medication container to the syringe unit. A filling needle is attached to the syringe unit for drawing fluid from a container. A movable needle sheath protects the hypodermic needle when not in use and may be moved out of the way when administering an injection. The medication label is visible. The container remains mated to the syringe when the syringe is in use. Risk of mislabeling the syringe may therefore be substantially reduced or eliminated and patient safety may accordingly be improved.

Abstract: A locking mechanism is provided for use with a reservoir and a reservoir holder so as to prevent unwanted tampering with the reservoir. The mechanism comprises a main body with an aperture that is coupled to the reservoir. A hinged flange is provided on the main body. The flange folds inwards at the pivot point provided by the hinge, toward the aperture of the main body, allowing the mechanism to pass over the ferrule of the reservoir. Once the mechanism is placed over the cartridge, the flange folds toward the reservoir at the pivot point, flexing away from the main body. The flange rests against the underside of the reservoir ferrule, thereby retaining the reservoir within the locking mechanism. The locking mechanism may be for use with either a disposable or a reusable delivery device.

Abstract: An automatic injection syringe assembly having an integrated and fillable medicine container that includes a medicine container within a housing and a conduit assembly. The medicine container includes a piston having an aperture at a distal end thereof for the passage of fluid therethrough. The conduit assembly includes a conduit member that is releasably connected to the housing and has an open proximal end and an open distal end. The open distal end of the conduit member is releasably engaged with the piston and in fluid communication with the piston aperture. The open proximal end and the open distal end of the conduit member are m fluid communication via a conduit within the conduit member.

Abstract: The present disclosure relates to fluid delivery devices for supplying a fluid, e.g., a flush medium, to a medical device, e.g., a vascular access device, inexpensively. The fluid delivery device includes a collapsible body defining a fluid reservoir and a connector for securing the fluid delivery device to the medical device. The collapsible body can include a bellows or pleated structure. In addition, structure including levers or plungers can be provided to collapse the body.

Abstract: A coded cartridge holder system is disclosed for use with a cartridge assembly (20) containing a fluid and a delivery device (10), where the system has keyed connectors (5, 5?, 6, 6?) to prevent accidental attachment of the wrong fluid delivery device (10). The system comprises a coupling (1) attachable to the dose setting portion (12) of the device (10) and keyed to the proximal end of the cartridge holder (14). The cartridge holder (14) may also contain medical coding (27, 28) to correspond to matching coding (27?, 28?) on the distal end of a cartridge assembly (20).

Abstract: A high pressure delivery device for delivering a medicament includes a first chamber for storing a supply of the medicament and a second chamber in fluid communication with the first chamber. A fluid connection path is in fluid communication with the second chamber for administering the medicament. A valving system is in fluid communication with the first chamber, the second chamber and the fluid connection path. The valving system allows a dose of the medicament to be injected from the first chamber into the second chamber while substantially preventing backflow of the dose into the first chamber and substantially preventing leakage through the fluid connection path. The valving system also allows the dose in the second chamber to be administered through the fluid connection path while substantially preventing the dose from flowing back into the first chamber.

Abstract: A device for administering an injectable substance, the device including a housing, a translation member moveable in a translation direction, a rotation member rotatably moveable about a rotation axis and coupled to the translation member to support the translation member counter to the translation direction, a rotary bearing including a bearing body bearing the rotation member rotatably about the rotation axis, the rotary bearing having support surfaces for supporting the rotation member axially on the bearing body, and a device for reducing play whereby at least two support surfaces are brought into contact with a pressing force, thereby reducing an axial play of the rotary bearing.

Abstract: A one way valve assembly flows a sterile flowable substance from a source to an outlet orifice and prevents any backflow of contaminants through the one way valve assembly when the flowable substance ceases to flow. The valve assembly includes an elastomeric membrane which aids in preventing any backflow of contaminants when dispensing of the flowable substance is stopped.

Abstract: The invention relates to a medicament container (2), comprising a bag (3) with an outlet (4), the bag (3) compressible by a compression means (6), the bag (3) having an inner surface arranged to stick when subjected to the compression means (6). The invention also refers to an arrangement (1) for administering a liquid medicament (M) comprising the medicament container (2) and a compression means (6) for locally compressing the bag (3).

Abstract: An apparatus for treatment of tissue within a body requiring thermotherapy includes a catheter to be inserted into a bodily conduit, an energy-emitting source disposed within the catheter, a compression balloon surrounding the energy-emitting source where the compression balloon has an inflated diameter that is greater than that of the bodily conduit in a relaxed state and an outside surface of the balloon is coated with one of gene modifiers and drug or medication, and means for activating the energy-emitting source to radiate energy to heat the drug-coated compression balloon and tissue to be treated whereby the heated drug-coated compression balloon effectively delivers the one of the gene modifiers and drug or medication to a target area of the diseased tissue. In addition, methods for using the above apparatus to treat diseased tissue are disclosed.

Abstract: A piston adapter, which can be easily removed even when it is mounted on a piston member of a rodless syringe and pressed in a cylinder member, is provided. In piston adapter 200, when manual operation member 230 is manually rotated relative to adapter rod 210, adapter shaft 220 is also rotated to turn the trailing end of flange engagement member 240 engaging with an engagement open/close mechanism near leading end of the flange engagement member, thereby piston adapter 200 can be easily put on and removed from the piston member of the rodless syringe its leading end by manually operating the trailing end of piston adapter 200.

Abstract: A hand-held remote for a medical fluid injector includes a syringe and a conduit which may be coupled to a pressure transducer on a control circuit of the injector. Movement of a plunger within a syringe body on the syringe creates a pressure which is sensed by the pressure transducer and the control circuit responds to the sensed pressure by causing fluid to be ejected from, or drawn into, a syringe mounted to the injector. The pressure developed by the remote provides tactile feedback to an operator for improved control over injections.

Abstract: A one way valve assembly flows a sterile flowable substance from a source to an outlet orifice and prevents any backflow of contaminants through the one way valve assembly when the flowable substance ceases to flow. The valve assembly includes an elastomeric membrane which aids in preventing any backflow of contaminants when dispensing of the flowable substance is stopped.

Abstract: A reusable continuously sealing one-way valve assembly and delivery system flows a sterile flowable substance from a source to an outlet orifice and prevents any backflow of contaminants through the continuously sealing one way valve assembly when the flowable substance ceases to flow. The valve assembly includes an elastomeric membrane which aids in preventing any backflow of contaminants when dispensing of the flowable substance is stopped. Multiple dosing of preservative-free flowable substance is provided.

Abstract: The present invention provides a pharmaceutical composition comprising a chemical compound or a herb extract or the combination having at least one of the activities of antiviral, antibacterial, antifungal, anti-inflammatory, anti-allergy, anti-cancer, promoting membrane healing or immunomodulating, for the treatment and prevention of a disease of a mammal. The present invention also provides a system for delivering the composition to the hard-to-reach sinuses of a mammal to reduce the load of the pathogen, to reduce the amount of inflammatory mediators, to heal pathological changes, and collectively to treat a disease of a mammal, such as allergic fungal rhinosinusitis. The invented method of treating a human disease reduces infectious and inflammatory agents without causing antibiotic resistance or adverse event.

Abstract: A reusable continuously sealing metered dosing one-way valve assembly and delivery system flows a premeasured amount of a sterile flowable substance from a source which is coupled to an actuator assembly to an outlet orifice and prevents any backflow of contaminants through the continuously sealing one way valve assembly when the flowable substance ceases to flow. The valve assembly includes an elastomeric membrane which aids in preventing any backflow of contaminants when dispensing of the flowable substance is stopped. Multiple dosing of preservative-free flowable substance is provided.

Abstract: A syringe plunger/jacket assembly may comprise a flexible jacket attached to a rigid plunger. The jacket may comprise at least two sealing rings (front and rear) that prevent fluid from leaking out of the rear of the barrel during injection of fluid from the syringe. The rear sealing ring may or may not contact or seal the interior surface of the syringe barrel in an unloaded state. In the loaded state, when force is applied in the direction of the forward discharge end of the syringe, pressure is created on the jacket. This condition causes the rear seal to expand and contact and/or seal the interior surface of the syringe barrel.

Abstract: A self-sealing male connector device for connection with a female Luer connector. The device has an elongated male body configured with lengthwise relatively rigid and flexible wall segments cooperating to allow the body to be radially compressed from an expanded configuration to a contracted configuration. A closure cap formed with a resealable aperture is disposed on the distal end of the male body so as to be responsive to the compression of the male body. The relatively flexible wall segments may be installed within notches in the male body or be formed integral with the relatively rigid wall segments.

Abstract: A one way valve assembly flows a sterile flowable substance from a source to an outlet orifice and prevents any backflow of contaminants through the one way valve assembly when the flowable substance ceases to flow. The valve assembly includes an elastomeric membrane which aids in preventing any backflow of contaminants when dispensing of the flowable substance is stopped.

Abstract: A one way valve assembly flows a sterile flowable substance from a source to an outlet orifice and prevents any backflow of contaminants through the one way valve assembly when the flowable substance ceases to flow. The valve assembly includes an elastomeric membrane which aids in preventing any backflow of contaminants when dispensing of the flowable substance is stopped.

Abstract: For safely inserting a catheter into a chest cavity of a child or corpulent patient to be retained therein and for preventing atmospheric air from proceeding into the chest cavity during a removal of a penetrating needle, discharge equipment for medical procedures is provided which equipment includes a connector cap and a storage bottle detachably connectable to each other, a connector to be connected to the catheter retained in the patient, a check valve including an outer periphery covered by a protective cover and being openable only toward a storage bottle side, and a coupling device to the storage bottle mounted on the connector cap. The storage bottle is a hollow container including an inlet port and a discharge port, a detachably connecting device for the connector cap mounted on the inlet port, and a check valve openable only toward an exterior of the storage bottle is mounted on the discharge port.

Abstract: Disclosed is a medical device used to prevent the cross-contamination of patients or injectors in which various components placed on the injector minimize or eliminate back splash contamination of the injector.

Abstract: A single use syringe and a plunger rod locking device for such a syringe are provided. The locking device and plunger rod include features that cause the plunger rod to be locked with respect to the syringe barrel upon completion of an injection stroke. A cutting member is provided at the distal end of the locking device. The cutting member will penetrate, and thereby disable the stopper affixed to the plunger rod in an attempt to retract the plunger rod following the injection stroke. The locking device includes barbs for engaging the syringe barrel.

Abstract: A single use syringe and a plunger rod assembly for such a syringe are provided. The syringe includes features that cause the plunger rod to be locked with respect to the syringe barrel upon completion of an injection stroke. The locking device may include barbs for engaging the syringe barrel and relatively long, proximally extending legs. The legs include barbs for engaging the syringe barrel and end portions for engaging the plunger rod. The plunger rod assembly includes a recess defined by converging surfaces, the recess being displaced from the longitudinal axis thereof. A locking element that fits a smaller syringe can thereby be used in a larger syringe as well.

Abstract: The present invention comprises a device for advancing a guide wire into a blood vessel of a patient, which comprises a housing from a distal end of which extends a needle hub support having a blood aspiration canal extending along its length; a syringe chamber located in the housing; a passageway extending between the blood aspiration canal and the syringe chamber for the passage therethrough of aspirated blood; a switch mounted for sliding movement along a surface of the housing and having attached thereto a cannula for movement therewith; the switch being formed with a through hole aligned with the cannula and the blood aspiration canal for the passage therethrough of a guide wire; the arrangement being such that movement of the switch towards the distal end of the housing will cause the cannula to block the passage of blood along the passageway between the blood aspiration canal and the syringe chamber.

Abstract: Disclosed is a single-use syringe comprising a needle housing, a bore-containing fluid-delivery needle and a volume-containing element. The needle housing has a top surface to which the volume-containing element is attached, a needle attachment side to which the bore-containing needle is attached, and a fluid delivery channel in communication between the top surface and the needle attachment side. The volume-containing element is fluid-tight but for communication with the fluid-delivery and a filling port. Embodiments are disclosed which include vapor-permeable portions which facilitate lyophilization of materials in situ.

Abstract: A fibrin glue applicator system (10) is provided for dispensing a first and a second protein solution which form a biological adhesive when intermixed on an application site. The fibrin glue applicator system (10) includes a coupler interface (16), a disposable loading unit (DLU) (14), and a housing (12) having a handle portion (20) which includes a trigger (22) operatively associated with a slide bar (36) for dispensing the solutions from the DLU (14). Each piercer (66) is fluid communication with one of the two cylinders (46) of the DLU (14) via a respective conduit (64) connected to a respective main conduit (60). A first one-way valve (68) is included within each conduit (64) to open, and close a path leading from the piercer (66) to the main conduit (60). A second one-way valve (70) is fixed within each main conduit (60) in proximity to each dispensing orifice to open, and close a path leading from each cylinder (46) to its corresponding dispensing orifice.

Abstract: The invention relates to a portable and non-implantable device to enable a patient to self-administer, on demand, successive doses of a liquid while ensuring that the period of time between two successive administrations cannot be less than a reference value. The device has a liquid reservoir formed in a piston which can be pushed in a chamber to expel the contents of the chamber via an injection outlet and which is returned in the opposite direction by a return. The liquid reservoir communicates with the inside of the chamber via a passage formed through the piston and is provided with a flow rate limiter so that the time required to fill the chamber corresponds to a reference value. The invention is suitable for medical applications.

Abstract: A dispensing cartridge is designed to dispense multiple doses of a flowable material from a collapsible container, i.e., from a container of the type which does not produce an internal vacuum as the flowable material is dispensed. The cartridge has a housing for protecting a delivery block enveloped by an elastic sheath. The delivery block receives the flowable material from the collapsible container through an input port and delivers it through an internal channel with branches to at least one output port. Sleeve valves are created at the output port or ports by the sheath. In a preferred embodiment an end of the sheath forms an outlet valve downstream of the sleeve valves.

Abstract: Device for mixing a pharmaceutical composition stored in a chamber (44) in said device with an agent to be added shortly before administration to form a preparation to be adminstered. The device should be capable of being shaken without leaking. It comprises a hollow body (2) having an outlet (4) sealed by a removable closure (12) and a plunger (6), which is slidable therein in sealing contact with the inner wall of the hollow body (2). The plunger (6), the hollow body (2) and the removable closure (12) define said chamber (44). An actuating means (22) is connected to the plunger (6) for displacing the same in the hollow body (2). A filling conduit (19) for said agent is connected to the chamber (44). A check valve (30) is associated with the conduit (19) and the chamber (44), which prevents flow from the chamber (44) but permits flow into said chamber through said conduit (19).

Abstract: A calcium-modified oxidized cellulose hemostat provides faster hemostasis than does either unmodified or sodium- or potassium-modified oxidized cellulose. The percentage by weight of calcium in the modified oxidized cellulose must be in a range between about 0.5 and about 4, in order to enhance hemostasis, while not interfering excessively with bioabsorbability. In a second embodiment, an oxidized cellulose hemostat is modified with both calcium and either sodium or potassium. The second embodiment may be used to deliver acid-sensitive materials.

Abstract: A re-usable nozzle for dispensing a flowable product from a resilient container has a removable one-way valve which facilitates cleaning and sterilisation of the nozzle. When the nozzle is used for dispensing a flowable pharmaceutical, the nozzle controls the amount of suck back of pharmaceutical into the nozzle on completion of dispensing. With a stand off of the valve float from the valve seat during dispensing of about one eighth of an inch (1) the suck back is sufficient to draw any drop of contaminated pharmaceutical at the tip of nozzle on completion of dispensing into the nozzle so as to reduce the risk of contamination of the environment and (2) the suck back is sufficiently small to minimize the risk of damage to any tissue with which the nozzle is intimately associated. Furthermore, with the distance from the valve seat to the nozzle tip being at least about three times the stand off, no contaminated pharmaceutical may enter the container so that the container may be re-used.

Abstract: A portable, closed circuit, disposable device for post operatory surgical suction which comprised a bellows-shaped body receptacle for suctioned fluids, a threaded neck located on the upper surface of said bellows-shaped body suitable to receive a threaded cap; said cap being provided with a suction tube system connected through said cap into the bellows-shaped body, and said system of tubes is provided with a check-valve, wherein said bellows-shaped body is provided with a cannula in its lower surface, having a nearly rectangular longitudinal section, having a lower end wall, wherein the side wall of said cannula is provided with at least one opening located in a position close to said lower end wall of said cannula; where an elastic tube, with a longer extension than said cannula, is introduced under pressure in said cannula in order to close the at least one opening of said cannula, and wherein a tube of rigid or semi-rigid material is introduced in said cannula, fixing the elastic tube between its interio

Abstract: A needleless device for introducing or withdrawing a fluid to/from the vascular system of a being. The device includes first and second housing sections movably connected with respect to each other and which define a hollow interior in which a pair of resilient valve elements are located. The first housing section includes a first luer fitting for connection to an input line. The second housing section includes a second luer fitting for connection to an output line. A tubular plunger is located within the device and is arranged, when the housing sections are in a first position, to be automatically extended through a first valve element if the input line is connected to the first luer fitting, so that a liquid can be forced from the input line through the device to the output line. When the housing sections are in the first position and the input line disconnected from the first luer fitting, the tubular plunger is retracted out of both valve elements so that the device is fully occluded.

Abstract: A dispensing apparatus comprising a container adapted to house a fluid to be dispensed in sealed relation; an exposing member borne by the container for exposing the fluid for dispensing from the container through an opening; and a mount borne by the container adjacent to the exposing member operable to secure a needle or the like, through which the fluid can be passed, in fluid transferring relation to the opening of the container.

Abstract: An improved injection port (1) for a single-use syringe is described. One embodiment of the injection port has a one-way valve system for making it more difficult to reuse the syringe (2). The one-way valve system has a flap or diaphragm valve (6) housed in a valve chamber (11) at the proximal end of port cylinder (45). When the valve (6) is seated against valve seat (51) on valve cap (5), refilling of the syringe is blocked. During injection, the valve (6) unseats and moves toward radial ribs (7), allowing flow of medicament into the proximal end of a needle (2). Another embodiment of the injection port (1) includes longitudinal grooves (8) on the interior surface of the chamber (12) at the distal end of cylinder (45). The grooves (8) vent pressure from a Luer syringe inserted in the distal end of the cylinder (45).

Abstract: A liquid container comprises a container body (2) having an opening (12) and a liquid-containing portion (2a), the container body containing liquid (W) therein; a cap (3) integrally formed with or fixedly connected to the opening after the liquid is charged in the container body, the cap having a base portion (3a) continuous to the opening, a thin-wall portion (3b) continuous to the base portion, a top portion (3c) continuous to the thin-wall portion, and at least one horn plate portion (13) continuous to the top portion, the horn portion radially outwardly extending beyond the diameter of the top portion; a cap opener (5) provided around the cap to be rotatable with respect to the cap, the cap opener having at least one craw plate (15) radially inwardly extending from inner wall of the cap opener to be in contact with the horn plate when the cap opener is rotated, an opening (5d) being made in the cap opener so as to exhaust the liquid (W) therethrough after the thin-wall portion is cut by twisting the cap o

Abstract: An improved flexible wall dispensing tube is disclosed. The tube has a plurality of circumferential ridges along its length and a spherical plunger ball mounted inside near its sealed end. The outside of the tube is squeezed from the rear to push forward the plunger ball which then uniformly pushes the tube contents ahead of it while significantly preventing leakage back past the ball. As the plunger ball is pushed, or softly clicked, past the inside vertex of each groove formed between ribs, a stepwise uniform amount of tube contents is pushed out of the tube.

Abstract: A vial holding syringe (84) includes a barrel (6) having a bore (12), a sealable needle end (8) and an open plunger end (10). A plunger (16) is mounted within the bore and includes an elongated hollow stem (18), having an interior (36) sized to hold a conventional vial (4), and a piston (20). The stem includes a hollow piercing member (46) having a piercing end (48), opposite the membrane (42) covering the vial ,and an outer end (50), adjacent a one-way valve (70) to permit passage of the medication (80) within the vial from the vial, through the hollow piercing member and through the one-way valve into a variable volume region (67) of the bore between the needle end of the barrel and the piston. An opening (14) at the needle end of the barrel is initially sealed by a cap (66). To use, the plunger is pulled part way from the bore to create a partial vacuum within the variable volume region. During this process, the diaphragm of the vial is driven onto the piercing end of the piercing member.

Abstract: A one way valve means for incorporation into a fluid administration set for enteral therapy which arrests retrograde movement of fluid into the set to avoid flow rate interruption or, in the event of extreme fluid back pressure, rupturing of the tubing in the set. The one way valve means is responsive to fluid back pressure and is incorporated in a male connector disposed on a distal end of the administration set tubing. As a result retrograde fluid movement caused by either irrigation or patient originated, fluid back pressure is immediately arrested before fluid enters the administration set.

Abstract: A bulb evacuator is provided for closed wound suction having a flexible compressible container with a pair of inlets having one way valves therein and a port to a suction source with a removable cap thereon at one end of the bulb evacuator. The opposite end of the bulb evacuator is provided with an integrally formed anti-reflux valve and a latching device surrounding the anti-reflux valve. A separate collection bag can be attached to the latching device so that when the bulb evacuator is filled with fluid from a closed wound, it can be compressed to force the fluid into the attached collection chamber and simultaneously creating a suction within the bulb evacuator to promote further withdrawal of fluids from the closed wound.

Abstract: The present invention involves a urethral fluid application device and system for insertion of fluids with backflow prevention. The device includes a tubular member having a feed port at one end and an outlet port at the opposite end, a unidirectional channel connecting the two ports and a one-way valve permitting flow only from the feed port to the outlet port. The device also includes a flange about the tubular member for contact with and attachment to the glans penis, as well as attachment means located on the flange. The system includes both the device and a supply container with a nozzle adapted to interconnect with the feed port of the device.

Abstract: A multiple fluid pulse dispenser comprising a plurality of interconnected fluid reservoirs defined by mating, oppositely directed concavities at least one of which mating concavity is formed from an invertable, preferrably permanently deformable blister. The reservoirs are in fluid communication with an outlet through which the contents of the reservoirs may be dispensed. A preferred embodiment permits fluid to flow through a reservoir after it has been discharged to allow random activation of the individual reservoirs.

Abstract: A spray dispenser of the squeeze bottle type, for use in the administration of nasal sprays, comprises a squeeze bottle in combination with a spray dispenser head assembly consisting of a cap, and associated spray nozzle which functions as a two-way check valve and a dip tube for conveying liquid from the bottle to the spray nozzle. The head may optionally be fitted with an overcap for protecting the spray head from contamination when not in use.

Abstract: A wound drainage device is provided which includes a manually operable suction pump having inlet and outlet ports, and a pliable fluid storage bag having a pair of plastic sheets in face-to-face contact and an inlet. The pump inlet port is adapted to be connected to a wound suction catheter for removing drainage fluid from the wound. The pump outlet port is connectable to storage bag inlet for discharging drainage fluid into the storage bag without disconnecting the suction catheter. The bag has an upper foldable portion between the main storage portion and the bag inlet to close fluid communication to the bag and can serve as an added protection against drainage fluid flowing back to the suction pump. The storage bag can be used to receive drainage fluid and thereby provide a relatively large storage capacity without requiring a relatively large suction pump.