Abstract: The present invention is to provide a gas mist pressure bathing system enabling to cause a gas mist to be absorbed into the skin and the mucous membrane of the living organism under an optimum condition of controlling the amounts of gas and liquid.

Abstract: Disclosed herein in exemplary embodiments are methods and compositions for repairing or treating a defected cornea in a patient in need. The methods and compositions including, for example, administering a dose of a composition to the patient, wherein the composition comprises may be administered to an intraocular area of the patient via a container having a spout for ophthalmic delivery. The methods and compositions promote progenitor cell migration and increase cellular proliferation in the cornea of the patient.

Abstract: A system for administering medication to an eye. The system includes a siphon tube in fluid communication with a medication reservoir, a dispensing nozzle connected to the siphon tube, and a shield coupled to the dispensing nozzle for movement relative thereto between an opened position and a closed position. The siphon tube defines a longitudinal axis extending along a substantially vertical direction when the siphon tube is in an upright position. The dispensing nozzle extends at an angle offset from the longitudinal axis when the shield is in the opened position. The nozzle and the angle are so dimensioned as to facilitate accessing the eye when the siphon tube is substantially in the upright position.

Abstract: The present invention relates to a transdermal device including porous microparticles capable of containing an active principle, in particular nicotine, and to the use thereof as a drug, in particular for tobacco cessation. The present invention further relates to a method for preparing a transdermal device including porous microparticles filled with an active principle.

Abstract: An apparatus for producing medical foam for wound care or hair stimulation has a foam generation unit including a fluid reservoir, a fluid delivery line and a foam generation tip. The apparatus also includes a compressed gas unit having at least one container of compressed gas, a source of electric power, and a gas regulator valve. A supply of wound care or hair stimulating solution is communicably connected to the foam generation tip such that when the apparatus is operated medical foam is produced by the foam generator tip.

Abstract: A surgical technique and device wherein an indwelling tube is placed in the eye of a patient having glaucoma. The tube diverts aqueous humor from the anterior chamber to the suprachoroidal space from which it is removed by blood flowing in the choroidal and uveal tissues. This decreases the intraocular pressure.

Abstract: A skin dressing comprising first and second electrodes, an electrical power supply not electrically connected to either or both of the first and second electrodes, and further comprising a physiologically or antimicrobially active precursor substance, the dressing being operable, when placed on a skin site to be treated, to connect the electrical power supply to both the first and second electrodes, thereby to trigger the electrochemical oxidation or reduction of the precursor substance on one of the electrodes to produce a physiologically or antimicrobially active oxidised or reduced compound which is capable of diffusing towards the skin site for the treatment thereof.

Abstract: The invention relates to transdermal therapeutic systems (TTS) comprising a backing, a reservoir layer containing at least one pharmaceutical active ingredient, and an adhesive. Said transdermal therapeutic systems are characterised in that they are able to continuously adhere to the surface of the skin over a long period of time. During said long period of time, a) there is at least one time interval during which the TTS adhering to the surface of the skin is intensively exposed to water, and b) the active ingredient is transdermally released. The invention also relates to a method for the continuous transdermal release of at least one pharmaceutical active ingredient over a long period of time.

Abstract: This invention provides for a method and a device for dispensing precise quantities of a predetermined volume of medicaments or other liquids onto the eye, via one or more discrete drop(s) generated by the device in a practical and innoxious way to users.

Abstract: The invention relates to a method for treating overactive bladders and a device for storing and administering non-occluded oxybutynin topical compositions.

Abstract: A skin treatment method which includes ionizing oxygen and then mixing the ionized oxygen with saline solution to produce an energized saline solution is disclosed. The method further includes applying the energized saline solution to the skin as a mist-like spray to treat the skin. The system used to carry out the method includes an oxygen concentrator for generating oxygen and an ionizer for imparting an electric charge to the oxygen to produce ionized oxygen. The system also includes a bag of saline solution as well as a peristaltic pump for pumping the saline solution from the bag to a spray nozzle mounted in a handheld wand. The concentrator further includes apparatus for pumping or delivering the oxygen and ultimately the ionized oxygen to the spray nozzle. The spray nozzle mixes and atomizes the ionized oxygen and saline solution to produce a spray-like mist of the same which is then applied to an individual's skin.

Abstract: In various embodiments of the invention, the components can include a hemostatic vacuum cup which can utilize ancillary or self-contained vacuum generation, and a therapeutic agent which is supplied prior, simultaneously or subsequent to the application of a vacuum with the ultimate aim of slowing or arresting the flow of blood in a bodily tissue or organ. The invention relates to a hemostatic vacuum cup which can utilize ancillary or self-contained vacuum generation. The cup produces a hemostatic effect by the physical application of the device upon a traumatized tissue site and through the delivery of an agent, such as one that assists in hemostasis, antinociception, coagulation, sterilization, or other effective wound healing agents including antibiotics, antiseptics and antioxidants. The cup can be adapted to deliver the therapeutic agent, by methods integral to the vacuum cup. The therapeutic agent can be delivered in the form of a sponge, cellulose or other filter material.

Abstract: The present invention relates to an ophthalmic device designed to ease the use of eye drop dispensers. It is one ophthalmic device but can be thought of as consisting of two parts: the nose bridge (11), which rests on the user's nose and the body (19), which connects to the eye drop dispenser. The body is flat and comes off of the nose bridge at an angle, allowing the eye drop dispenser to point toward the eye. The body attaches to the eye drop dispenser by Velcro (18), adhesive tape, strap, or any other measure to adhere two things together. This allows the ophthalmic device to work with any type of eye drop dispenser. Together, the nose bridge and the body, allow the user to securely and easily administer an eye drop to the medial part of their eye.

Abstract: An ophthalmic dispenser and method of filling and dispensing fluid stored therein. The dispenser includes a rigid housing defining a fluid-receiving chamber, a flexible bladder receivable within the fluid-receiving chamber, a pump coupled in fluid communication with the fluid-receiving chamber, and a nozzle having a valve defining an annular, axially-extending valve seat, an outlet aperture coupled in fluid communication between the valve seat and the pump, and a flexible valve cover extending about the valve seat and forming an annular, axially-extending interface therebetween.

Abstract: A hand-held applicator (10) for self-administration of a semi-solid medicament comprises an applicator head (14) with one or more elongate dispensing nozzles (40) and an applicator body (12) for housing a medicament reservoir, such as a cartridge (20). The applicator has a pump assembly and an actuator (30) for pumping the medicament from the one or more of the dispensing nozzles. The applicator head and applicator body are fixed relative to each other in use such that movement of the nozzle or nozzles away from the scalp or other body area during actuation may be avoided. The applicator may further include an application face for spreading medicament over a body area thereby enabling dual functionality as a scalp and body applicator. A dispensing system in the form of a dispensing head and cartridge therefor is also described and characterised by venting features for improving priming of the dispenser. Such priming means are suitable for use in the applicators of the application.

Abstract: A medical spraying device and method for irrigating a wound, in particular lavage system, having a liquid reservoir for a medical irrigation liquid or a connection for such a liquid reservoir, and a compressed gas reservoir. The compressed gas reservoir is connected or connectable via a pressure line to the liquid reservoir, such that the irrigation liquid can be pushed by the gas pressure of the compressed gas reservoir acting on the irrigation liquid through a nozzle in order to produce a spray cone. A pressure reduction valve is arranged in the pressure line and limits the gas pressure acting in the liquid reservoir on the irrigation liquid. The device and method produce a spray cone of a medical irrigation liquid in which a gas pressure is limited using a pressure reduction valve, wherein the gas pressure limited by the pressure reduction valve is conveyed through a pressure line to a liquid reservoir of the medical irrigation liquid.

Abstract: The present disclosure relates to a dermal drug delivery platform comprising: a primary wound dressing comprising three-dimensional polymer protuberances that extend upward from the dressing surface to engage the wound. The protuberances comprise at least one biocompatible and/or biodegradable polymer and medicinal nanoparticles. In one embodiment, the medicinal nanoparticles may be metallic and provide surface-area-enhanced galvanic action to drive medicinal ions into the wound bed. Various methods of making the disclosed dermal drug delivery platform, as well as three-dimensional methods of treating a wound using the platform are also disclosed.

Abstract: A medical spraying device and method, for irrigating a wound, having a liquid reservoir for a medical irrigation liquid or a connection for such a liquid reservoir and an arrangement for applying pressure to the medical irrigation liquid, such that the irrigation liquid is pushable through a nozzle by the pressure acting on the irrigation liquid in order to produce a spray cone. The nozzle has a plurality of openings, which are arranged at an angle to one another in such a way that the irrigation liquid jets exiting from the openings, at a such flow rate and angle, meet in an atomisation space and/or a discharge opening of the nozzle; thus, a spray cone is produced from the atomised irrigation liquid.

Abstract: A method of treating Herpes Labialis includes assembling a patch having hydrocolloid particles added to a layer of adhesive to so configure the patch to have a limited absorption of moisture into the patch combined with a permeability of moisture through and out of the patch. The method additionally includes providing the patch to the user and having the user apply the patch to the user's face in treating the Herpes Labialis, and configuring the patch to be less visible when applied to the user's face than a cream is visible when applied to the user's face.

Abstract: A medical spraying device and for irrigating a wound, in particular lavage system, have a liquid reservoir for a medical irrigation liquid or a connection for such a liquid reservoir and a compressed gas reservoir. The compressed gas reservoir is connected or connectable via a pressure line to the liquid reservoir, such that the irrigation liquid can be pushed by the gas pressure of the compressed gas reservoir acting on the irrigation liquid through a nozzle in order to produce a spray cone. At least one pressure relief valve is arranged in the wall of the pressure line and opens outwardly and closes the pressure line in accordance with the gas pressure from the compressed gas reservoir.

Abstract: The invention is to provide a gas mist pressure bath system, which is possible to control the amount of gas and liquid, pressure and others, and cause a gas mist to be absorbed through a skin and mucous membrane of a human living body under an optimum condition.

Abstract: The present invention is a herbal composition and method of preparing thereof. The herbal composition comprising extracts of Carthami Flos (CF), Dipsaci Radix (DR), Notoginseng Rhizoma (NR) and Rhei Rhizoma (RR). The present invention also relates to an oil-in-water or water-in-oil type nano-emulsion and method of preparing thereof. The nano-emulsion comprises an aqueous phase, an organic phase and a surfactant, wherein said aqueous phase comprises hydrophilic extract of herbal materials and said organic phase comprises hydrophobic extract of said herbal materials. The present invention also relates to a transdermal patch comprises said nano-emulsion. The herbal composition of the present invention is useful in treating traumatic injuries, in particular bone injuries. The present nano-emulsion and patch thereof can promote skin absorption of active ingredients in herb, thereby increasing the herb's bioavailability and efficacy in therapy.

Abstract: The invention is to provide a gas mist pressure bath system, which is possible to control the amount of gas and liquid, pressure and others, and cause a gas mist to be absorbed through a skin and mucous membrane of a human living body under an optimum condition.

Abstract: An eye drop device and a method of applying eye drops to the eye are disclosed herein. An exemplary embodiment of the device contains a main housing having an interior and exterior with a top opening sized to surround the eye and a bottom opening sized to accept the tip of an eye drop vial. The device also preferably contains a cavity for accepting the battery and an LED positioned within the interior of the main housing. A switch may be used to energize the LED. The method includes the steps of attaching an eye drop vial to the main housing, positioning the device over the eye, energizing the LED, and applying the eye drops.

Abstract: Provided is a method of activating osteogenic or chondrogenic activity at a site in a subject in need thereof. Also provided is a method of treating a bone or cartilage defect in a subject. Additionally, the use of a reduced pressure apparatus for treating a bone or cartilage defect adjacent to dura mater, periosteum, or endosteum is provided. Further provided is a composition for treating a bone or cartilage defect. Also, the use of a reduced pressure apparatus and a biocompatible scaffold for the manufacture of a composition for treating a bone or cartilage defect adjacent to dura mater, periosteum or endosteum is provided.

Abstract: The invention relates to a self-destructing transdermal therapeutic system (TTS), preferably in the form of a transdermal patch, that includes an active ingredient, an agent rendering the active ingredient useless, and a perforation mechanism. The perforation mechanism allows a mobile phase to reach the agent that is capable of rendering the active ingredient useless after removing the TTS after use. The agent then comes into contact with the active ingredient and destroys the active ingredient in the presence of the mobile phase.

Abstract: Wound dressings and wound inserts comprising substantially dry reactive agents, methods of forming wound inserts comprising dry reactive agents, and wound-treatment methods.

Abstract: A device for delivery of a measured or predetermined dose of an active agent to a dermal or mucosal surface comprising: a) a deformable chamber comprising at least one dome-shaped member defining a reservoir for an active agent; and b) a porated disc.

Abstract: A method, and apparatus for the controlled acceleration, and/or retardation of the body's inflammatory response generally comprises a foam pad for insertion substantially into a wound site, a heating, a cooling pad for application over the wound site, a wound drape or sealing enclosure of the foam pad, the heating, and cooling pad at wound site. The foam pad is placed in fluid communication with a vacuum source for promotion of the controlled acceleration or retardation of the body's inflammatory response. The heating, and cooling provision controls the local metabolic function as part of the inflammatory response.

Abstract: A vacuum bandage is provided for use with a wound having a wound surface. The bandage is connectable to a vacuum source and includes a wound dressing member having a wound contacting surface, a top surface, and a port configured for communication with the vacuum source. The wound dressing member further includes holes in the wound contacting surface configured for communication with the wound surface of the wound and a passageway between the port and each hole. The vacuum bandage further includes a pack adjacent to the top surface of the member. The pack may include an aperture positioned about the port.

Abstract: According to the invention a transdermal therapeutic system for administering fentanyl or an analogue thereof through the skin is provided that has a pressure-sensitive adhesive matrix layer containing a mixture of two polyisobutylenes with specific storage moduli.

Abstract: Particular aspects of the invention provide methods for decreasing the amount of fluid present in the subretinal space of the eye by administering interferon gamma to the basolateral side of the retinal pigment epithelium. Adverse ocular conditions associated with the accumulation of fluid in the subretinal space can be treated by administering an amount of interferon gamma to the basolateral side of the retinal pigment epithelium effective to remove excess fluid from the subretinal space.

Abstract: A hemostatic tablet preferably including potassium ferrate and a cation ion exchange resin pressure formed into a tablet for delivery to a bleeding wound. The tablet improves the rate of adhesion to a bleeding wound surface, and allows a significantly greater and more uniform pressure to be exerted by manual compression of the tablet on the wound site, as compared to that of a thin layer of scattered hemostatic powder. After the seal is formed from the interaction of blood or exudates with the immediate contacting surface of the tablet, the bulk of the unused tablet easily delaminates from the seal making clean up facile. If the unused portion of the tablet is not removed from the wound site, a reservoir of hemostatic dressing stops further bleeding and to provide antimicrobial protection and healing. The tablet may be applied to any surface orientation and take any shape and thickness possible.

Abstract: An article for therapy and treatment of at least one eye. The article includes a backing for application to the at least one eye. The backing includes at least one receiver positioned to align with the at least one eye. The article also includes at least one pod that is detachably secured within the at least one receiver. The at least one pod includes material for delivering therapy and treatment to the at least one eye.

Abstract: Methods, dressings, and systems for promoting epithelialization of a wound or other tissue are presented. The methods, dressings, and systems help form simulated rete pegs. In one instance, an epithelialization dressing is disclosed that may include a dressing body having a plurality of projections. A plurality of apertures is formed on a portion of the dressing body. The dressing helps manage fluids on the wound and the projections form cavities into which epithelial tissue migrates to from epithelial columns that function like rete pegs. Other dressings, methods, and systems are disclosed.

Abstract: The invention relates to a transdermal therapeutic system, comprising a back layer that is impermeable to an active ingredient, a polymer matrix containing the active ingredient, and a protective layer that can be pulled off, wherein 5-aminolevulinic acid hydrochloride is used as the active ingredient and the basic polymer of the polymer matrix is an adhesive polyacrylate. Said transdermal therapeutic system is suitable for diagnosing and treating preliminary stages of skin cancer, such as actinic keratosis, and oncological skin diseases.

Abstract: This disclosure relates generally to methods and devices for use in treating eye conditions. In some embodiments, a site-specific therapeutic agent is mixed with a releasing agent with a dual syringe apparatus in order to achieve homogeneity. Once mixed, the site-specific therapeutic agent and releasing agent can be either dispensed directly within an area of the eye or within an implant. The implant can be at least partially filled with the site-specific therapeutic agent and releasing agent either prior to or after implantation into the eye. Some ratios of site-specific therapeutic agents to releasing agents are disclosed which provide various releasing profiles of the site-specific therapeutic agent within the eye.

Abstract: An applicator for topically applying a semi-solid medicament comprises an applicator head having an applicator face for spreading medicament across the skin; a sealable aperture on the applicator face; and a drive mechanism for forcing medicament out through the aperture. The applicator head includes a cartridge port at the rear of the applicator face for receiving a dispensing end of a cartridge charged with medicament. The drive mechanism comprises a dial knob rotatable around a longitudinal axis of the applicator for advancing a piston along a drive member towards the applicator head to force medicament from the cartridge and thereby dispense a predetermined dose of medicament onto the applicator face.

Abstract: The present invention relates to a fluid applicator apparatus and methods of using the apparatus. In particular, the present invention relates to an apparatus for storing and dispensing solutions (e.g., fluid solutions of any kind) (e.g., liquid medicaments and/or sterilization solutions) to a surface of a subject.

Abstract: A film-shaped therapeutic system comprising at least two layers connected with each other, for transmucosal administration of active substances. The system has a layer which is mucoadhesive in an aqueous environment and a mono-layered or multi-layered backing layer. At least one of these layers contains an active substance. The mucoadhesive layer is capable of swelling in an aqueous media, but is insoluble or only poorly soluble in an aqueous media. A process for treating a patient by medicinal therapy or prophylaxis by the film-shaped therapeutic system is also provided.

Abstract: The invention relates to an absorbent article for application to human or animal skin surfaces in the region of wounds, consisting of an outer covering (2) which is permeable for liquid substances, and of an inner layer (1) which is surrounded by the covering (2) and which consists essentially of a mixture of an amount of strongly osmotically active substances with an amount of osmotically comparatively weak or osmotically inactive substances, such as cellulose. The inner layer (1) is filled with osmotically active substances in such a way that it is possible to exert on a wound, with the wound fluids contained therein, an osmotic pressure via which the wound fluid can be removed from the organism to be treated, and thus it is possible to assist both in the surfaced wound region and in the depth of the tissue a normal interstitial hydration of tissue by directing endogenous fluids in their direction of flow to the patient's skin surface into the absorbent article, and keeping them there.

Abstract: Disclosed is a transdermal delivery system of multiple adhesive layers having a drug-free adhesive layer as an intermediate layer to control drug delivery rate. The transdermal delivery system enhances transdermal delivery rate in the early stage after application on skin and provides sustained control of the drug delivery rate in the intermediate and later stages. Thus, the drug delivery rate effective for treatment can be controlled in a sustained manner.

Abstract: Methods and devices for treatment of damaged tissue are disclosed, including treatment of wounds by employing non-electrically powered, reduced pressure therapy devices. The devices are capable of generating a substantially constant reduced pressure with low tolerance for pressure fluctuations. Also disclosed herein are reduced pressure therapy systems that comprise an alarm system to detect the depleted state of the suction device and provide an alert to the patient and/or practitioner.

Abstract: An adhesive composite dressing useful for applying an active ingredient to a treated skin site, as well as methods of manufacture and use of such dressings. In one embodiment, an adhesive composite dressing comprising an anchor member, a target member, and a folding member, where the anchor member comprises a first skin-contact adhesive, the target member comprises an opening adapted to enable skin treatment, the folding member comprises a drug reservoir, and where the folding member is attached to the anchor portion through a hinge defined by a line of attachment that is not contiguous with an edge of the anchor member.

Abstract: A method of topically applying natural plant product for dissipation of human adipose tissue, comprising: (a) topically applying an inner portion of a natural plant product to an epidermal layer exterior to adipose tissue to be dissipated of a user's body for a period of time, upon which a percentage of the adipose tissue softens and dissolves, thus, reducing the adipose tissue of the user's body; (b) removing the topically applied inner portion of the natural plant product from the epidermal layer for another period of time; (c) repeating steps (a) and (b); and weight reduction apparatus comprising a topical applicator having a receiving container adapted to removably receive a natural plant product and having an opening or a porous wall adapted to facilitate pulp, juices, and/or extracts of the natural plant product to contact a user's epidermal layer exterior to the adipose tissue to be dissipated.

Abstract: The present invention relates to a titratable dosage transdermal delivery system for systemic delivery of a therapeutic agent or drug. The system comprises a plurality of patch units that are connected along one or more borders. The plurality of patch units are divisible into units along the one or more borders having one or more lines of separation. Each patch unit is surrounded by a border. The therapeutic patch has at least a backing layer and a therapeutic agent comprising layer. The dosage of therapeutic agent delivered to a patient is proportional to the number of patch unit applied per treatment. The system enables systemic administration of a titratable dosage of therapeutic agent, adjustable by the patient under the direction of a physician, through the skin or mucosa. Moreover, the invention relates to a method of making the titratable dosage transdermal delivery system.

Abstract: A disposable sterile breakable vial includes a handle section and a vial section which are completely separable in response to a manually applied separation force. The vial section includes a sterile void dimensioned to contain a unit dose of a sterile therapeutic topical agent. An elongated member comprises a proximal portion supported by the handle section and a distal portion provided with a sterile applicator element, such as a brush. At least the applicator element is completely enclosed within the vial section with the applicator element immersed within the therapeutic topical agent. A hermetic seal between the handle and vial sections maintains sterility of at least the vial section prior to handle and vial section separation. Complete separation of the handle section and the vial section exposes the elongated member and the applicator element for topical application of the therapeutic agent saturating the applicator element.

Abstract: An irrigator system for delivering a volume of fluid from a fluid source to an abscess or wound. The irrigator system includes a fluid source connector for removably connecting to the fluid source, a fluid receiver for receiving the fluid from the fluid source, a fluid delivery nozzle for delivering the fluid to the abscess or wound, and a shield removably positioned around the fluid delivery nozzle to protect the fluid delivery nozzle.

Abstract: This invention includes the implementation of several unconventional droplet manipulations on a superhydrophobic-patterned surface microfluidic platform, which may be applied to automated biological analyses and point-of-care diagnostic applications.

Abstract: Transdermal drug delivery systems comprising a drug-containing layer, a backing layer, and an occlusive overlay layer extending beyond the perimeter of the backing layer by 3 to 6 mm in all directions are described. The systems achieve increased drug delivery over an extended time period.