Abstract: A biocompatible wound dressing comprised of a pad for insertion substantially into a wound site and wound drape for sealing enclosure of the foam pad at the wound site. The pad, comprised of a foam or other like material having relatively few open cells in contact with the areas upon which cell growth is to be encouraged so as to avoid unwanted adhesions, but having sufficiently numerous open cells so that drainage and negative pressure therapy may continue unimpaired, is placed in fluid communication with a vacuum source for promotion of fluid drainage, as known in the art. The pad is further comprised of an ultra-low density fused-fibrous ceramic, or a bioabsorbable branched polymer, or cell growth enhancing matrix or scaffolding.

Abstract: A bandage includes a generally planar substrate having a first surface and a second surface opposed from the first surface. A first matrix extends outwardly from the first surface. The first matrix has a first plurality of reservoirs. A second matrix extends outwardly from the first surface. The second matrix has a second plurality of reservoirs. The second matrix is separated from the first matrix by a drain channel. A method of treating a wound using the bandage is also disclosed.

Abstract: Methods and devices for treatment of damaged tissue are disclosed, including treatment of wounds by employing non-electrically powered, reduced pressure therapy devices. The devices are capable of generating a substantially constant reduced pressure with low tolerance for pressure fluctuations. Also disclosed herein are reduced pressure therapy systems that comprise an alarm system to detect the depleted state of the suction device and provide an alert to the patient and/or practitioner.

Abstract: Apparatus to treat an eye comprises an annular retention structure to couple to an anterior surface of the eye. The retention structure is coupled to a suction line to couple the retention structure to the eye with suction. A coupling sensor is coupled to the retention structure or the suction line to determine coupling of the retention structure to the eye. A fluid collecting container can be coupled to the retention structure to receive and collect liquid or viscous material from the retention structure. A fluid stop comprising a porous structure can be coupled to an outlet of the fluid collecting container to inhibit passage of the liquid or viscous material when the container has received an amount of the liquid or viscous material. The coupling sensor can be coupled upstream of the porous structure to provide a rapid measurement of the coupling of the retention structure to the eye.

Abstract: A garment used to provide hydration and elasticity to the skin of the abdomen area is disclosed. The garment comprises a detachable front panel configured to encase and secure to the abdomen area. The front panel comprises an inner layer and an outer layer each having an interior side and an exterior side. The exterior side of the inner layer is contiguous to the interior side of the outer layer. The inner layer comprises a gelatinous material comprising proteins. In one embodiment, the interior side of the inner layer comprises a self-adhesive edge which secures the front panel to the abdomen area. In another embodiment, the garment comprises a back strap which secures the front panel to the abdomen area at a first and second region.

Abstract: Compositions for the transdermal delivery of amphetamine in a flexible, finite form are described. The compositions comprise a polymer matrix that includes amphetamine or a pharmaceutically acceptable salt or prodrug thereof and a backing layer comprising a polyurethane film layer and a polyester film layer, with a polyurethane adhesive disposed therebetween. Related methods also are described.

Abstract: Systems and methods of stimulating or activating fluids for use in wound treatment systems.

Abstract: The invention provides systems and methods for controlled dispensing of topical analgesics contained in a metered dispensing system. The systems and method are useful for treating signs and symptoms of osteoarthritis. The method includes depressing a hand pump to dispense a dose of a topical pain reliever in a viscous solution from the hand pump, wherein the hand pump is configured to dispense the dose within a tolerance specified by a corresponding label approved by a government regulatory agency; and spreading the topical solution on skin.

Abstract: A method and device for dispensing a liquid from a tip includes a support structure, a cartridge, and a drive unit. The support structure is adapted for supporting a collapsible container having a connector end and a closed end. The support structure includes a liquid passage adapted for fluid communication with the collapsible container for selectively discharging the liquid. The cartridge includes an actuator selectively movable from a first position to the second position via the operatively connected drive unit. At least a portion of the actuator moves toward the connector end when moving from the first position to the second position. The actuator is adapted for gradually compressing the collapsible container from the closed end toward the connector end in order to discharge liquid droplets.

Abstract: A method of employing a bag-in-box container system in a dispensing machine includes placing a box in a first orientation, inserting a bag in the box, and closing the box with a portion of a dispensing end of the bag protruding through an opening in a first wall of the box. The first wall is a top surface of the box in the first orientation. The method further includes securing the portion of the dispensing end outside of the box and inverting the box to a second orientation, such that the first wall is a bottom surface of the box in the second orientation. The method also includes inserting the dispensing end of the bag into a holder of a dispensing machine.

Abstract: An apparatus and method for aspirating, irrigating and/or cleansing wounds is provided. The apparatus and method include one or more of the following: simultaneous aspiration and irrigation of the wound, supplying of thermal energy to fluid circulated through the wound; supplying physiologically active agents to the wound; a biodegradable scaffold in contact with the wound bed; and application of stress or flow stress to the wound bed.

Abstract: A lotion distribution device is configured to apply lotion to a back area that is unreachable by human hands. The lotion distribution device includes an applicator twisted and tied to form a left loop and a right loop. The applicator has a porous property that enables the applicator to store the lotion. The human hands can hold the left loop and the right loop to apply the applicator and thus the lotion to the back area.

Abstract: An adjustable shape abscess irrigation device includes a first tube that is slidably associated with a second tube. The irrigation device includes a retainer that defines a variable shape diameter. The diameter of the retainer is selectively adjustable by the relative positioning of the first tube and the second tube such that, once placed relative to an abscess, the shape of the device can be manipulated to allow desired drainage of irrigation and abscess fluids beyond the confines of the abscess. Upon adequate drainage of the abscess, the cross-section shape of the retainer can be reduced to facilitate more comfortable and less detrimental removal of the device from the patient. Preferably, the irrigation device is formed via one or multi-shot injection molding and is formed of more than material.

Abstract: A hand-held applicator is defined for applying a viscous product, such as a pharmaceutical product to the skin. The applicator includes a substrate with a flat face defining multiple dosing areas of the product. The product can be dispensed from a tube in a first area for a first recommended dosage and in combination in a first area and a second area for a second recommended dosage. Once the desired dosage is dispensed, the applicator is used to apply to product to an affected area of the skin.

Abstract: An improved wound care system is set forth. The system includes a wound care device having a first end and a second end. A fastener, adapted to extend to a desired length to selectively attach the device at an anchor, wherein the anchor is provided on a second end of the device is also provided. The fastener is sufficiently sized and formed of a suitable material to prevent the device from moving when secured to the anchor. In an embodiment, medicine is provided in a desired treatment area of the device. The medicine can be inserted via a medicinal delivery device by inserting the medicinal delivery device up to a stop on the medicinal delivery device into the wound care device.

Abstract: Skin cholesterol is measured by applying an adhesive tape onto a selected area of the skin to adhere the tape to the selected skin area and stripping the tape off the selected skin area to obtain a sample representative of the outer stratum corneum layer of the skin, the sample adhering to the tape so as to have exposed skin constituents. The sample is assayed using a detector reagent that specifically binds to cholesterol and in addition has an indicator component that allows quantitation of the amount of cholesterol present in the exposed skin constituents.

Abstract: A handheld applicator designed to transfer a liquid drop of ophthalmic medicament into a human eye. The basic structure comprises a finger grip section and a drop retainer section, preferably connected to the grip section with an extension. The device is made from an elastomeric material that will allow for the safe transfer of a liquid drop into the eye. A drop dispensed from a container is placed onto the drop retainer section of the device where the surface tension provides drop adhesion. The user may administer the drop, without having to tilt the head, while maintaining an eyeglass assisted view into a mirror. Application of the drop occurs from the peripheral line of vision. When contact is made to the eye, surface tension is relieved and the drop safely transfers into the eye. The same applicator may have a drop retainer section with a different structure on each side.

Abstract: The present invention provides a device for wound treatment, comprising a chamber that includes an inner surface and defines a treatment space, the chamber being made of a flexible, impermeable material. The device further includes a plurality of structures configured to exert mechanical stress on a wound, the plurality of structures intruding from the inner surface of the chamber into the treatment space. The device further includes a tube having a first end connected to the chamber, the tube being in fluid communication with the treatment space so as to enable at least one selected from the group of applying negative pressure to the treatment space and applying a therapeutic agent.

Abstract: The present invention relates to a method of treating the scalp, the method comprising the following steps: •applying a composition to the scalp, the composition including at least one active ingredient selected from: •anti-dandruff agents; •anti-seborrheic agents; •soothing or anti-irritant agents; •exfoliating agents; and •anti-hairloss agents; and •moisturizing agents; and •performing a massage of the scalp by means of a motor-driven massage device (10, 20) that includes spikes (21) that are driven by an oscillating movement.

Abstract: A micro toothed cap device with a cavity can penetrate through a hair weave to exfoliate and stimulate the scalp. The device can be used to apply medicated products directly into the hard-to-reach areas under a hair weave to easily access the scalp. The device is small enough to penetrate to the undergrowth under the plaits, cornrows and wefts, allowing the scalp to be exfoliated, cleansed and treated properly without shifting the weft out of place.

Abstract: A system for delivering moisturizing liquid to the lips of a subject includes an applicator for applying the moisturizing liquid to the lips supported by a support structure so that at least a part of applicator is deployed so as to engage a recess between the lips of subject without obstructing contact between the subject's upper and lower lips. The proximity of the applicator to the lips allows the use of simple contact-based implementations of the applicator. At the same time, disruption of speech and other normal oral movement is minimized by avoiding any obstruction to contact between the lips.

Abstract: An applicator having a hydrophilic foam that is suitable for use with antiseptic solutions may be a hydrophilic polyurethane foam that does not reduce the amount of active ingredient in the solution as it passes through the foam so that it can be applied to the skin. The foam may be used to deliver antiseptics solutions such as octenidine salts, chlorhexidine salts, or any cationic molecule to the skin. The foam may be attached to an applicator containing an antiseptic solution, or it may be used in conjunction with an unattached antiseptic solution reservoir. The foam also allows the solution to wick into the foam and fully saturate the foam without dripping or channeling.

Abstract: An applicator having a hydrophobic foam that is suitable for use with antiseptic solutions may be a hydrophobic polyurethane foam that does not reduce the amount of active ingredient in the solution as it passes through the foam so that it can be applied to the skin. The foam may be used to deliver antiseptics solutions such as octenidine salts, chlorhexidine salts, or any cationic molecule to the skin. The solution may include alcohol solution. The foam may be attached to an applicator containing an antiseptic solution, or it may be used in conjunction with an unattached antiseptic solution reservoir. The foam also allows the solution to wick into the foam and fully saturate the foam without dripping or channeling.

Abstract: An abdominal wound dressing and methods of use are described that enable the application of negative pressure to the wound site in a healing manner while also limiting the formation of adhesions that would prevent the removal of the dressing. The dressing comprises a layer of porous foam material enclosed by sheets of elastomeric material punctuated by a number of appropriately placed holes. Multiple layers of porous foam may also be used. A suction tube connector is provided on an upper surface of a layer of foam for connection to a negative pressure source. At least one layer of foam is enclosed in elastomeric material and is placed in direct contact with the tissue within the open wound. Fluids are drawn by negative pressure through the holes positioned in the elastomeric envelope and through the foam.

Abstract: Embodiments described herein generally relate to improved devices, systems, kits, products and methods related to topical medicament application of measured dosages. The kits and devices can single use and/or disposable for example.

Abstract: Methods for promoting angiogenesis comprising administering platelet-rich plasma to a site and stimulating the site with an electromagnetic field. Platelets include platelet-rich plasma and compositions can further include stem cells such as adipose stromal cells and cells derived from bone marrow aspirate. Methods also comprise isolating platelets from a patient's blood, forming a composition including the platelets, delivering the composition to a site in need of treatment, and electrically stimulating the site.

Abstract: A method for self-dosing and self-administering a pharmaceutical or a cosmetic composition is provided. The method utilizes a three-dimensional dispensing device configured for receiving the composition. The dispensing device includes a bottom element having an inner surface and an outer surface and two side elements integrated with the bottom element, each side element being set at an angle to the bottom element.

Abstract: An eyelid margin wipe comprising chemical means for adjusting the temperature of the wipe relative to the ambient temperature. The wipe is particularly useful for treatment of disorders of the eyelid or eyelid margin such as meibomian gland dysfunction.

Abstract: Dispensing units and methods for using dispensing units to apply eye drops to an eye of a user are disclosed. A dispensing unit may include a dispensing barrel having a dispensing orifice and one or more concentric rings. A particular dispensing unit has one concentric ring that is disposed around the circumference of the dispensing barrel and is configured to permit a user to properly visually align the dispensing barrel above an eye of the user. An alternate dispensing unit has first and second rings disposed around a circumference of the dispensing barrel that are configured to permit a user to properly visually align the dispensing barrel above an eye of the user by one or more of color mixing or polarization techniques.

Abstract: The invention relates to a hair removal device (1) having a hair removal unit (30) and a skin cooling unit (10), wherein the skin cooling unit (10) has a skin contact surface (11), and the skin cooling unit (10) is equipped to apply an application substance (80) onto the skin by way of the skin contact surface (11) during use of the hair removal device. In addition to the cooling of the skin by means of contact cooling, a further cooling effect may also be achieved in such a hair removal device in that an application substance is applied, which contributes to the cooling of the skin, for example, by means of evaporation. The hair removal device may comprise a removable attachment, which also comprises at least the skin.

Abstract: The present invention is a disposable garment, such as a glove, a sock, or a shoe, for treating foot or hand inflammation or disease. In a preferred embodiment, the garment comprises a flexible outer cover that is nonporous and an inner layer closely adhered to the inside of the outer cover. The outer cover may preferably have a flexible closure at the level of the ankle or wrist, arranged such that liquids will be retained therein. The inner layer serves as a reservoir for a selected therapeutic product, and preferably comprises a bladder. Preferably, the bladder has a perforation, and may be disposed within the inner layer in a position allowing a user to apply pressure to bladder with his foot or hand. A therapeutic product in liquid form is stored within the reservoir, and is released upon application of pressure by the user's foot or hand.

Abstract: Disclosed are a patch, system, and method for delivery of a permeant composition into a subject via at least one formed pathway through a biological membrane of the subject. The patch comprises a matrix, at least one hydrophilic permeant disposed within the matrix, wherein at least a portion of the permeant can dissolve in biological moisture received from the subject, and at least one permeability enhancer disposed within the matrix. Also disclosed are systems and methods for delivery of a permeant composition into a subject via at least one formed pathway through a skin layer of the subject.

Abstract: An agent delivery apparatus for administering a pharmacological agent formulation to a sub-mucosal compartment of a body organ, comprising injector means having an internal formulation chamber that is adapted to receive and contain the pharmacological agent formulation therein and an elongated agent delivery member having a first end that is in communication with the internal formulation chamber and a second ejection end, the injector means including force generating means that is adapted to generate sufficient force to expel the pharmacological agent formulation from the injector means and into and through the agent delivery member, and out of the ejection end of the elongated agent delivery member. In one embodiment of the invention, the delivery member comprises a needleless delivery member.

Abstract: Cellulite is treated by severing septae, which interconnects the skin with the underlying muscle. The septae may be severed in connection with a liposuction procedure or independent of a liposuction procedure.

Abstract: The invention provides a system and method for delivering antibiotic powder to a surgical wound that reduces the likelihood of contamination. A pre-packaged, sterile antibiotic powder delivery system comprises a container; a measured dosage of an antibiotic powder disposed within the container; and a sieve top attached to the top of the container, wherein the container and sieve top are sealed as a unit in a sterile packaging. To use the delivery system in the sterile surgery or operating room environment, the delivery system is removed from the sterile packaging. The delivery system is shaken over the surgical wound for a reasonable amount of time to cover the entire wound, avoid surgeon fatigue at the end of surgery, and avoid prolonging the total time the wound is open.

Abstract: The invention relates to a method for treating overactive bladders and a device for storing and administering non-occluded oxybutynin topical compositions.

Abstract: This invention relates to matrix patches for the topical (i.e., transdermal) delivery of piroxicam and methods for the treatment of acute and chronic pain and inflammation therewith, particularly pain and inflammation caused by sports injuries or other muscle aches or injuries requiring the application of analgesic and/or anti-inflammation medication, in this instance, piroxicam.

Abstract: The present invention pertains to use of sodium diacetate (NaHAc2) as an antimicrobial agent against bacteria growing in biofilms. The aspects of the invention include a wound care product comprising sodium diacetate, a kit comprising a wound care product, and a method of treating an infected wound.

Abstract: A Life-Saving Innovation which utilizes Mind controls/Voice activated Satellite Technology to cure HIV disease of the Soul. Body Scans before and after the process demonstrated that Souls/Agents were cured of HIV The Souls should be a Visible Image. The Satellite—Transforms the Soul into an Invisible Image; performs a series of three Aromatizations; mobilizes materials such as water and a specialized washing solution for the procedure; rinses the Soul with water for two minutes; washes the Soul for three minutes; rinses the Soul for three minutes; performs a series of three Materializations; transforms the Soul into a Visible Image; drys the Soul with heated air at a low velocity for further disinfection. The invention is ten minutes in duration and is usually curative in two treatments; once per consecutive day. Can be performed anywhere in the world. This invention is a “Must-Have.

Abstract: A method for treating poison ivy and similar poison plant induced rashes utilizes a sealed pouch containing a mixture of anti-inflammatory, analgesic, and anti-oxidant property ingredients. The pouch is placed in a container filled with boiling water. The ingredients in the pouch permeate through the water. A metal applicator has a spoon-shaped section with a curved lower surface and a handle. The spoon-shaped section is inserted into the boiled herbal water mixture. The bottom surface of the curved lower surface of the spoon-shaped section is then momentarily placed on the pustule or red bump of the poison ivy. The applicator is then lifted up away from the area. Usually two or three touches with the applicator on the effected area will completely remove the itching and the itching and pustule will be entirely eliminated within twenty-four to forty-eight hours.

Abstract: A smoke capture adapter comprising: a first adapter part having a first generally ring-shaped portion with a first cylindrical inner surface for securely engaging a laser apparatus having a beam propagation axis, the first generally ring-shaped portion being oriented such that the beam propagation axis passes through a region bound the first generally ring-shaped portion and a tubular outlet extending from said first generally ring-shaped portion for communicating with a vacuum tube; a second adapter part rotatably connected to the first adapter part and arranged to rotate generally about the beam propagation axis having a second generally ring-shaped portion adjacent the first generally ring-shaped portion, the first and second generally ring-shaped portions defining a generally toroidal cavity and an inlet in fluid communication with the cavity; the tubular outlet and inlet in fluid communication through the cavity; whereby the position of the inlet relative to the first adapter part may be adjusted by rota

Abstract: A portable system for subatmospheric pressure therapy in connection with healing a surgical wound, includes a wound dressing dimensioned for positioning relative to a wound bed of a subject, a portable subatmospheric pressure mechanism dimensioned to be carried or worn by the subject and a container for collecting exudates from the wound bed removed under the subatmospheric pressure supplied by the subatmospheric pressure mechanism. The portable subatmospheric pressure mechanism includes a housing, a subatmospheric pressure source disposed within the housing and in fluid communication with the wound dressing to supply subatmospheric pressure to the wound dressing and a power source mounted to or within the housing for supplying power to actuate the subatmospheric pressure source.

Abstract: The present invention provides methods and devices for delivering an active agent into the eye of a subject. In one aspect, for example, the present invention provides an ocular drug delivery device including a housing configured to couple to the eye of the subject and a corneal seal coupled to the housing and positioned in the housing to encircle the cornea during use to form a corneal region, where the housing extends outward from the corneal seal to form a scleral region, and where the scleral region being positioned over the eye's sclera during use. The device further includes an active agent reservoir coupled to the housing and positioned to release active agent into the scleral region and a pressure regulator coupled to the housing that is operable to introduce negative pressure between the housing and the eye. Thus the corneal seal is operable to fluidically isolate the corneal region from the scleral region in response to the negative pressure.

Abstract: A container-closure system includes a container configured to hold a therapeutic liquid and having a dispensing tip configured to dispense a dose of the therapeutic liquid. A vented cap is configured to fit over at least a portion of the container including the dispensing tip and having one or more vents that allow air to pass into and out of a cavity defined between the vented cap and the dispensing tip. A second cap is configured to fit over at least a portion of the vented cap. A tamper evident seal is coupled to the second cap and one or both of the container and the vented cap.

Abstract: Disclosed is a container capable of dispensing a liquid contained in the container by drops while keeping the liquid in an uncontaminated state. Also disclosed is a method of dispensing a liquid by drops using the container, and a method of removing a stoma pouch flange using the container. The liquid storing container comprises a storage portion with a sealed periphery and a nozzle portion connected with the storage portion for dispensing a liquid contained in the storage portion by drops to the outside. The container has an enclosed inner space. Liquid is dispensed by drops by peeling apart a sealed nozzle tip portion that is oriented toward the tip of the nozzle portion to form a drop dispensing opening.

Abstract: Embodiments of the present invention provide a temporary tattoo, appliqué or decal and a method of using the tattoo on a patient to identify on that patient a selected operative site, wherein said operation is identified by name on said decal and wherein the accuracy of site selection may be endorsed by the patient and the responsible operator directly on the selected site in such a manner that the endorsement indicia remain legible after the decal is eradicated.

Abstract: A method of decreasing intraocular pressure (IOP) in an eye of a patient in need thereof includes implanting a first lacrimal implant through an upper punctum and into an upper lacrimal canaliculus of the eye of the patient. The method may further comprise implanting a second lacrimal implant through a lower punctum and into a lower lacrimal canaliculus of the eye of the patient, and releasing, on a sustained basis a therapeutically effective amount of an intraocular pressure-reducing therapeutic agent.

Abstract: The present invention includes methods and devices for delivering an active agent into the eye of a subject. One such device may include an anode assembly having an anode housing and an anode configured to electrically couple to a power source, the anode assembly being configured to contact and remain against a surface of the eye. The device may also include a cathode assembly having a cathode housing and a cathode configured to electrically couple to the power source, the cathode assembly being configured to contact and remain against the surface of the eye. Additionally, the device may include at least one active agent reservoir functionally associated with at least one of the anode assembly and the cathode assembly.

Abstract: A method for treating muscle cramping (e.g., acute nocturnal) includes the steps of placing a transdermal delivery agent on skin above an affected muscle that is in spasm. The transdermal delivery agent includes a composition that includes a therapeutic amount of magnesium. Placement of the transdermal delivery agent on the skin results in transdermal delivery of the magnesium directly to the affected muscle that is in spasm, thereby providing therapeutic relief while limiting the delivery of the magnesium to the entire circulatory system (systemic effect).

Abstract: An eye watering/treating hands free system 12 for use with a computer system 10 or any other type of system and which selectively emits an eye watering/treating substance 80 in the direction of the eyes 35, 37 of a user 30 in order to treat eyes 35, 37 for dryness and/or discomfort.