Abstract: Fluid delivery devices and methods are described, where the device may comprise a piezoelectric actuator operatively coupled to an ampoule with fluid, under a preloading force. The ampoule may comprise a thin-walled thermoplastic package which includes one or more apertures positioned on the wall of the ampoule. The piezoelectric actuator may be configured to clamp at least partially around the circumference of the ampoule and apply oscillations to its wall. The oscillations, typically in ultrasonic frequency, produce cycles of acoustic pressure in the fluid, leading to ejection of the fluid droplets or streams from the apertures.

Abstract: A unit dose capsule for use with a sonic generator includes a deformable membrane adapted to releasably engage the distal end of the elongate horn, a nozzle including at least one delivery opening; a nozzle including at least one delivery opening; and a reservoir containing a liquid composition disposed therebetween. When the unit dose capsule is engaged to the distal end of the elongate horn, the nozzle is disposed in an outwardly facing orientation, and the reservoir is in liquid communication with the at least one nozzle. The unit dose capsule can be included in a kit with a handheld misting device comprising a housing having a dispensing window arranged and configured to contain a sonic generator and a power source.

Abstract: Systems and methods are provided for generating and applying biomimicry tear film layers to a cornea surface. An example method includes forming a multiple layered tear film that are optically transparent, ultra-thin, and smoothly conforming to cornea surface. The multiple layered tear film can include a biomimicry adhesive layer, a biomimicry aqueous layer, and a biomimicry lipid layer. An atomizer/nebulizer/micronizer can be used to generate and applying the biomimicry tear film layers.

Abstract: A bronchoscope adapter is configured for one hand operation by providing a slide lock that is captured within a housing and a retaining nut that can be operated with a single finger or thumb. Rotation of the retaining nut is eased by isolating rotational force from a compression block with a spacer ring.

Abstract: A manually actuated pump, such as a bolus delivery circuit of an insulin pump, combines a direct drive piston system with a lost motion valve system, to deliver reliably a full bolus dose, while precluding partial dosing or inadvertent overdosing conditions. The pump may also include a signaling device to indicate when a full bolus dose is delivered.

Abstract: Device for packaging and dispensing drops of a substance for ophthalmic use, generally fluid, semi-fluid or in suspension, emulsion or oily solution, comprising a dispensing accessory (7) with a first valve (5) made of an elastomer material that allows the substance to pass through when the dispensing accessory (7) is stressed, without allowing outside air to pass through in the opposite direction when the dispensing accessory (7) is relaxed, characterized in that the first valve (5) is covered by a layer of Parylene.

Abstract: Disclosed herein in exemplary embodiments are methods and compositions for repairing or treating a defected cornea in a patient in need. The methods and compositions including, for example, administering a dose of a composition to the patient, wherein the composition comprises may be administered to an intraocular area of the patient via a container having a spout for ophthalmic delivery. The methods and compositions promote progenitor cell migration and increase cellular proliferation in the cornea of the patient.

Abstract: A surgical tissue therapy device includes a sealant layer and a collection chamber. The sealant layer functions so as to create a sealed enclosure or space between it and the surface of a patient by forming, preferably, an airtight seal around a surgical area of skin trauma. The closed incision tissue therapy device also comprises a collection chamber, which may comprise an elongate tubular chamber with a plurality of longitudinally spaced openings. The collection chamber may be configured to be in fluid communication with the sealant layer and the area of skin trauma and functions as to distribute the negative pressure applied to a surgically closed area of skin trauma. Preferably, the pressure under the sealant layer is reduced by expanding the volume of the enclosure space and thereby decreasing the density of air molecules under the sealant layer.

Abstract: An injection device has a dispensing chamber housing, a plunger, and a temperature control device. The dispensing chamber housing has a first part and a second part. The first part is thermally coupled to a needle. The second part is thermally coupled to the first part. The second part has an inner surface and an outer surface. The inner surface partially defines a dispensing chamber for holding a quantity of a substance. The plunger is engaged with an inner surface of the dispensing chamber housing, is capable of sliding in the dispensing chamber housing, and is fluidly sealed to the inner surface of the dispensing chamber housing. The temperature control device at least partially surrounds the dispensing chamber housing and is capable of altering a temperature of the substance in the dispensing chamber. The second part has a greater thermal coefficient than the first part.

Abstract: A method and apparatus for measuring a volume of a wound are described, the method comprising the steps of: applying a dressing over a wound, the volume of which is to be measured, the dressing including at least a sealing drape over the wound so as to create a sealed wound cavity; creating a vacuum in said wound cavity by vacuum pump means so as to produce a predetermined vacuum in the wound cavity; measuring a volume of air extracted from said wound cavity in producing said predetermined vacuum; and, calculating a volume of said wound.

Abstract: The current invention discloses a fluid dispenser especially suitable for ophthalmic treatments and delivering of ophthalmic agents such as eye drops. The fluid dispenser incorporates a tube made from compliant materials as the key dosing component. A first point and a second point on the tube may be acted upon by folding the tube or by external elements, making the segment between the first point and the second point a squeezing section that houses a dosing chamber. The squeezing section may be pressed by an anvil or other structures, pressurizing the fluid contained in the dosing chamber so that once the tube is released on one point, the fluid in the dosing chamber is discharged. With each dosing process, a single dose of the fluid is discharged. In addition, the fluid dispenser is capable of delivering a series of doses of the fluid by repeating the dosing process.

Abstract: Irrigation systems having splash shields attachable to bottles or syringes, also including abscess irrigation systems.

Abstract: A method of delivering safe, suitable, and repeatable dosages to a subject for topical, oral, nasal, or pulmonary use and a device for droplet ejection includes a fluid delivery system capable of delivering a defined volume of the fluid in the form of droplets having properties that afford adequate and repeatable high percentage deposition upon application. The method and device include a housing, a reservoir disposed within the housing for receiving a volume of fluid, an ejector mechanism configured to eject a stream of droplets having an average ejected droplet diameter greater than 15 microns, the stream of droplets having low entrained airflow such that the stream of droplets deposit on the eye of the subject during use.

Abstract: A smoke capture adapter comprising: a first adapter part having a first generally ring-shaped portion with a first cylindrical inner surface for securely engaging a laser apparatus having a beam propagation axis, the first generally ring-shaped portion being oriented such that the beam propagation axis passes through a region bound the first generally ring-shaped portion and a tubular outlet extending from said first generally ring-shaped portion for communicating with a vacuum tube; a second adapter part rotatably connected to the first adapter part and arranged to rotate generally about the beam propagation axis having a second generally ring-shaped portion adjacent the first generally ring-shaped portion, the first and second generally ring-shaped portions defining a generally toroidal cavity and an inlet in fluid communication with the cavity; the tubular outlet and inlet in fluid communication through the cavity; whereby the position of the inlet relative to the first adapter part may be adjusted by rota

Abstract: A container-closure system includes a container configured to hold a therapeutic liquid and having a dispensing tip configured to dispense a dose of the therapeutic liquid. A vented cap is configured to fit over at least a portion of the container including the dispensing tip and having one or more vents that allow air to pass into and out of a cavity defined between the vented cap and the dispensing tip. A second cap is configured to fit over at least a portion of the vented cap. A tamper evident seal is coupled to the second cap and one or both of the container and the vented cap.

Abstract: A lotion application compartment (10) includes an apparatus for topical application of a fluid to a human or animal body. The apparatus includes a spray nozzle (20) and a support (80) for the body. The apparatus further comprises of one or more of the following: a structure for moving the support, so as to change the distance between the body and the spray nozzle (20); a structure for varying the spray pattern, spray pressure, spray frequency and/or spray duty cycle of the nozzle (20); a structure for varying the rotational speed of the support (80); and a structure for raising the body's skin temperature directly by radiation. A lotion application compartment (10) consisting of apparatus for topical application of a fluid to a human or animal body, the apparatus comprising a spray nozzle (20) and a support (80) for the body.

Abstract: A surgical tissue therapy device includes a sealant layer and a collection chamber. The sealant layer functions so as to create a sealed enclosure or space between it and the surface of a patient by forming, preferably, an airtight seal around a surgical area of skin trauma. The closed incision tissue therapy device also comprises a collection chamber, which may comprise an elongate tubular chamber with a plurality of longitudinally spaced openings. The collection chamber may be configured to be in fluid communication with the sealant layer and the area of skin trauma and functions as to distribute the negative pressure applied to a surgically closed area of skin trauma. Preferably, the pressure under the sealant layer is reduced by expanding the volume of the enclosure space and thereby decreasing the density of air molecules under the sealant layer.

Abstract: Apparatus (130) for use in wound therapy of mammals is described, the apparatus (130) comprising: a dressing covering the wound, the dressing being substantially sealed to prevent ingress of ambient atmospheric air to the wound; aspiration means (132) operably connected to a space between the dressing and the wound by an aspiration conduit (142) sealed to the point of entry between wound and dressing against ingress of ambient atmosphere, said conduit (142) being for aspiration of said wound and for removal of fluid from said space between said wound and said dressing; a waste container (148) for receiving aspirated fluid to be discarded operably connected to said aspiration conduit; and heating means (144) for heating said fluid in order to increase the vapor pressure thereof and to cause evaporation to reduce the volume of the fluid in the waste container (148). In a preferred embodiment of the present invention the waste fluid is also provided with a sparge gas.

Abstract: A portable system for subatmospheric pressure therapy in connection with healing a surgical wound is provided. The system includes a wound dressing dimensioned for positioning relative to a wound bed of a subject, and a collection canister in fluid communication with the wound dressing. The canister includes a base defining a fluid receiving cavity and having a fluid inlet port and a vacuum port. The fluid inlet port is configured for fluid communication with a wound dressing, The system further includes a cover selectively engageable to the base, e.g., in a snap-fit manner. The cover is configured to receive a control unit and has a vent assembly for exhausting the control unit. A seal member is interposed relative to the base and the cover to establish and maintain a substantial sealed relationship between the two components when assembled.

Abstract: An ophthalmic drug delivery device containing a primary medicament reservoir and a replaceable medicated module containing a second medicament where the device has a selector to allow dispense of primary medicament or a combination of the primary and secondary medicaments such that a single activation of the ophthalmic drug delivery will deliver both medicaments to the user.

Abstract: An aspiration flow control device includes a housing having at least one vacuum port, at least one aspiration port, and an ejection port. The at least one vacuum port is adapted to be connected to a vacuum source, and the aspiration port is adapted to be connected to an aspiration line for receiving fluids from a surgical site. The device further includes a rotating structure having at least three vanes, which structure is configured to rotate within the housing. The at least three vanes divide an enclosed volume within the housing into at least three rotating fluid collection chambers. During rotation of the rotating structure, at least one fluid collection chamber is in communication with at least one vacuum port and the aspiration port through which fluid is received, and at least one other fluid collection chamber is simultaneously in communication with the ejection port through which fluid is expelled.

Abstract: Described herein is an automated fluid drain control apparatus and method which comprises a first collection chamber which is connected to a drain that has been inserted into the subarachnoid area in lumbar region of the body. The volume of fluid into the first collection chamber is controlled as a function of time by being constantly measured such that too much fluid will not be drained from the body.

Abstract: The present invention is directed to a pulsatile ophthalmic peri-corneal drug delivery device. The device includes an annular body and a mechanism for releasing multiple separate and distinct doses of a therapeutic composition over an extended period of time.

Abstract: Disclosed herein are devices, systems and methods for using such devices and systems for treating incisions and wounds. In an aspect, disclosed is a device having a generally planar tension relief module and a flexible sealant structure sized to cover the tension relief module, the flexible sealant structure comprising a lower adhesive surface. The tension relief module includes a conduit structure having a plurality of support structures on an upper surface of the conduit structure and at least one opening extending through the conduit structure from a lower surface to the upper surface. At least a portion of the conduit structure is adapted to be aligned with a longitudinal axis of the incision. The tension relief module also includes opposing adhesive structures coupled to the conduit structure. The lower adhesive surface of the flexible sealant structure and the upper surface of the conduit structure form a flow pathway.

Abstract: A surgical tissue therapy device includes a sealant layer and a collection chamber. The sealant layer functions so as to create a sealed enclosure or space between it and the surface of a patient by forming, preferably, an airtight seal around a surgical area of skin trauma. The closed incision tissue therapy device also comprises a collection chamber, which may comprise an elongate tubular chamber with a plurality of longitudinally spaced openings. The collection chamber may be configured to be in fluid communication with the sealant layer and the area of skin trauma and functions as to distribute the negative pressure applied to a surgically closed area of skin trauma. Preferably, the pressure under the sealant layer is reduced by expanding the volume of the enclosure space and thereby decreasing the density of air molecules under the sealant layer.

Abstract: A pressure bandage includes a banding porting, at least one infiltration and at least one fixing member. The banding portion includes at least one recession formed in one side of the banding portion, at least one tube having first and second ends, and at least one check valve mounted in the second end of the tube. The first end of the tube is connected to the recession. The infiltration is coupled on the inner surface of the recession of the banding portion. The fixing member fixes the banding portion to a treatment part.

Abstract: A surgical tissue therapy device includes a sealant layer and a collection chamber. The sealant layer functions so as to create a sealed enclosure, or space between it and the surface of a patient, by forming an airtight seal around a surgical area of skin trauma. The closed incision tissue therapy device also comprises a collection chamber, which may comprise an elongate tubular chamber with a plurality of longitudinally spaced openings. The collection chamber may be configured to be in fluid communication with the sealant layer and the area of skin trauma and functions as to distribute the negative pressure applied to a surgically closed area of skin trauma. Preferably, the pressure under the sealant layer is reduced by expanding the volume of the enclosure space and thereby decreasing the density of air molecules under the sealant layer. The collection material may comprise a material and/or a configuration that permits length changes based upon the length of the corresponding surgical wound or incision.

Abstract: Disclosed are devices, systems and methods for treating an incision. The device includes a generally planar tension relief module, comprising a central structure in fluid communication with the incision, wherein at least a portion of the central structure is adapted to be aligned with a longitudinal axis of the incision; and opposing adhesive structures coupled to the central structure and a flexible sealant structure comprising a lower adhesive surface and sized to seal over the tension relief module forming a sealed flow pathway. The opposing adhesive structures are adapted to be stretched from a relaxed configuration to a first tensile configuration and to return towards the relaxed configuration from the first tensile configuration into a second tensile configuration and impart a contracting force in a direction that is towards the opposing adhesive structure.

Abstract: A surgical tissue therapy device includes a sealant layer and a collection chamber. The sealant layer functions so as to create a sealed enclosure, or space between it and the surface of a patient, by forming an airtight seal around a surgical area of skin trauma. The closed incision tissue therapy device also comprises a collection chamber, which may comprise an elongate tubular chamber with a plurality of longitudinally spaced openings. The collection chamber may be configured to be in fluid communication with the sealant layer and the area of skin trauma and functions as to distribute the negative pressure applied to a surgically closed area of skin trauma. Preferably, the pressure under the sealant layer is reduced by expanding the volume of the enclosure space and thereby decreasing the density of air molecules under the sealant layer. The collection material may comprise a material and/or a configuration that permits length changes based upon the length of the corresponding surgical wound or incision.

Abstract: An apparatus (1) for cleansing wounds (5) in which irrigant fluid from a reservoir connected to a conformable wound dressing (2) and wound exudate from the dressing are moved by a device (18) (which may be a single pump or two pumps) for moving fluid through a flow path (6, 7, 9, 10) which passes through the dressing with a means for providing simultaneous aspiration and irrigation of the wound, and means for supplying thermal energy to the fluid in the wound. The former provides a desired balance of fluid at a controlled nominal flow rate that removes materials deleterious to wound healing, while distributing materials that are beneficial in promoting wound healing over the wound bed. The latter maintains a temperature at the wound bed under the wound dressing at a level that promotes wound healing.

Abstract: A gravity-fed, emergency eyewash station includes a flow regulator in the feed line between the solution bag and the dispensing nozzle to maintain a constant flow rate throughout the entire activation time frame. The flow regulator uses a float valve to variably open and close an orifice that feeds the dispensing nozzle. Solution enters the flow regulator from an orifice at the top and leaves from an opening at the bottom. Solution flowing into and out of the regulator quickly reaches an equilibrium state, resulting in a constant flow rate for the entire activation time frame.

Abstract: Apparatus for the provision of topical negative pressure therapy to a user is described, the apparatus comprising a device and a waste canister connected thereto, the waste 5 canister being operably connected for receiving wound exudate to a wound dressing by an aspiration conduit which is releasably connected to the dressing, wherein the waste canister has a blank connector portion thereon for sealably receiving a disconnected dressing end of the aspiration conduit.

Abstract: The invention relates to a handheld apparatus and a method for eye wash for first aid, where there is a need for immediate washing of the eye, caused by foreign objects or chemicals in and/or around the eye(s). The apparatus comprises two rocker arms, where each of the rocker arms (2) on one side of a hinge (3) has a jaw (4) for placing on the eyelids, and a wing (5) on the opposite side of the hinge, thereat by manual compression of the wings, and the thereby caused rotation of the rocker arms around the hinge, to force the jaws and thus the eyelids apart. The apparatus comprises a connecting part for connection to a liquid container of aerosol type (13) with a pressure valve (14). The rocker arms are connected to a pressure device configured by compression of the wings to press the pressure valve into the liquid container and thereby cause the release of liquid from the liquid container, thus the onset of release of liquid is simultaneous with the compression of the jaws forcing the eyelids apart.

Abstract: The invention relates to a bottle for packaging a liquid with dropper delivery comprising a reservoir with an elastically deformable wall that can be reversed by letting air into the receptacle, surmounted by a dispensing head for the liquid comprising a drop-counting end-piece protruding to the outside of the bottle and an anti-bacterial filtering membrane, made partially hydrophilic and partially hydrophobic, which is interposed across the path of the liquid and of the air, at the base of the said end-piece. The dispensing head comprises an insert with a recessed body which contains a porous pad regulating the flow of liquid placed downstream of the reservoir and upstream of a chamber delimited downstream of the said membrane. At the base of this insert on the inner side of the bottle, longitudinal arches supporting a central pellet make star-shaped passageways radially guiding the air that enters the bottle after having passed through the porous pad.

Abstract: A wound dressing for use in negative wound pressure therapy includes a cover layer for positioning over a wound to define a reservoir over the wound in which a reduced pressure may be maintained. At least one vacuum port is affixed to the cover layer and includes a conduit receiving portion configured to receive a fluid conduit to provide fluid communication between the fluid conduit and the reservoir. The at least one vacuum port is configured to receive the fluid conduit from a plurality of directions relative to the cover layer.

Abstract: A surgical tissue therapy device includes a sealant layer and a collection chamber. The sealant layer functions so as to create a sealed enclosure or space between it and the surface of a patient by forming, preferably, an airtight seal around a surgical area of skin trauma. The closed incision tissue therapy device also comprises a collection chamber, which may comprise an elongate tubular chamber with a plurality of longitudinally spaced openings. The collection chamber may be configured to be in fluid communication with the sealant layer and the area of skin trauma and functions as to distribute the negative pressure applied to a surgically closed area of skin trauma. Preferably, the pressure under the sealant layer is reduced by expanding the volume of the enclosure space and thereby decreasing the density of air molecules under the sealant layer.

Abstract: A treatment device and associated methods are disclosed, the treatment device comprising: a fluid dispenser comprising: a sealable reservoir for storing a fluid to be dispensed; a transfer body for carrying a predetermined volume of said fluid from said reservoir to a dispensing point outside of said reservoir; and a sliding seal for maintaining said reservoir in a sealed state while a portion of said transfer body carrying said predetermined volume of fluid and said predetermined volume of fluid are moved from a position inside of said reservoir to said dispensing point outside of said reservoir; and an applicator for applying a predetermined volume of fluid present at said dispensing point to a part of the human or animal body, wherein said applicator comprises means for dispersing said predetermined volume of fluid in a jet of gas directed towards said part of the human or animal body.

Abstract: A device for applying an ophthalmologic medicament to a patient's eye is disclosed. The device comprises spectacles defined by a frame and at least one lens; at least one container adapted for accommodating the ophthalmologic medicament; the container is incorporated into the frame; dosing mechanism adapted to control doses of the medicament; and at least one nozzle in a fluid interconnection with the medicament container; the nozzle is secured mechanically to the frame; the nozzle is adapted for providing a medicament mist flow. The nozzle is placed in front of a peripheral portion of a patient's eye slot and adapted to provide the mist flow in front of the patient's eye.

Abstract: The present invention provides a device to facilitate the self-administration of eye drops. The device includes a body portion adapted for placement on the user's face, generally over the eye in which the drops are to be applied. The body portion preferably includes an integral handle which may be held between the thumb and forefinger of the user. Many embodiments may also incorporate a nose bridge to assist in locating the device in the correct position.

Abstract: A wound dressing member is provided for use in a vacuum bandage connected to a vacuum source and for use with a wound having a wound surface. The member may include a top surface and a bottom surface adapted to be in contact with and generally conform to the wound surface. The member may further include a plurality of discrete holes formed in the bottom surface and at least one discrete opening formed in the top surface. A port of the member may be provided to communicate with the vacuum source, each discrete hole, and the at least one discrete opening.

Abstract: A system for subatmospheric pressure therapy in connection with the healing of a surgical wound is disclosed. The system may be portable or semi-portable, thereby providing the subject with the ability to be partially or completely ambulatory through the course of the treatment. The system includes a wound dressing dimensioned for positioning relative to a wound bed of a subject and a portable subatmospheric pressure mechanism dimensioned to be carried or worn by the subject. The subatmospheric pressure mechanism includes a housing, a vacuum source at least partially disposed within the housing and in fluid communication with the fluid conduit, a filter in fluid communication with the vacuum source, and a collection canister for collecting exudates from the wound bed removed under subatmospheric pressure. An elevation member is mounted with respect to the housing.

Abstract: A portable system for subatmospheric pressure therapy in connection with healing a surgical wound is provided. The system includes a wound dressing dimensioned for positioning relative to a wound bed of a subject, and a collection canister in fluid communication with the wound dressing. The canister includes a base defining a fluid receiving cavity and having a fluid inlet port and a vacuum port. The fluid inlet port is configured for fluid communication with a wound dressing. The system further includes a cover selectively engageable to the base, e.g., in a snap-fit manner. The cover is configured to receive a control unit and has a vent assembly for exhausting the control unit. A seal member is interposed relative to the base and the cover to establish and maintain a substantial sealed relationship between the two components when assembled.

Abstract: Splash shield systems for use with wide mouth irrigation squeeze bottles and other irrigation fluid sources.

Abstract: The delivery systems of the present disclosure are configurable to administer either single-dose or multiple-doses of one or more substances to a user, for example to the eye, nose, mouth, ear or rectum of the user. The precise and repeatable dosing features of the presently disclosed delivery systems overcome many of the disadvantages associated with known methods for dispensing substances to, for example, the eye of a user. The delivery systems administer precise doses of a substance to a precise location from unit dosage forms that may be single-dose or multiple-dose unit dosage forms, which may be externally or internally pierced.

Abstract: Precision lid retracting eyedropper device with a hollow, rigid housing having an upper aperture that allows a push button topped piston to enter the housing where the piston can impinge on a resilient tubular member that is part of a pump assembly. The housing also includes a solution storing chamber that feeds solution to the pump assembly. A solution exit tube attached to the outgoing portion of the pump assembly emanates from the bottom part of the housing and can be directed towards the user's eye. Integral downwardly facing resilient legs are placed just above and below the user's orbital ridge so that when the legs are squeezed and released, the user's eye lids are forced open allowing the user to dispense a precise amount of solution into his or her eye. A precision eye drop solution container having the ability to retain and dispense a precise single portion of eye drop solution each time the user depresses an actuator device located on and within the housing of the container.

Abstract: An ophthalmic fluid atomizer including a body having a proximal end and a distal end and a container connected to the body, wherein the container contains an ophthalmic fluid disposed therein. The atomizer further including a discharge plate disposed at the distal end and a wick extending from the container to the discharge plate and transmitting the ophthalmic fluid from the container to the discharge plate via capillary action. Transmission of the ophthalmic fluid across the discharge plate generates a plume of ophthalmic fluid along a direction directly toward the eye, wherein the plume of ophthalmic fluid travels unassisted from the discharge plate to the eye and at the eye has a momentum subliminal to at least one of an ocular blink reflex and a lacrimation reflex of the eye.

Abstract: An eye drops container including a container body filled with a drug solution along with a pressurized gas and including a valve mechanism discharging a fixed amount of drug solution; a nozzle member coupled with a stem for open operation of the valve mechanism and including a drug solution drop nozzle; an operating member including an operating piece and attached to the container body; a guide member contained in the operating member and guiding the nozzle member in the axial direction; and a ball contained in the guide member. The nozzle member includes an outer flange for suspending a skirt on the lower surface thereof; the guide member includes a ring-like bottom groove into which the forward end of the skirt enters; and the ball falls into the bottom groove in an upright state to block the open operation of the valve mechanism, and falls onto the outer flange in an inverted state to permit the open operation of the valve mechanism.

Abstract: In a container (3) for a plurality of single doses of a fluid active substance, in which the single doses are separately packaged in a gas-tight manner and can be released separately, the container (3) comprises a substantially flat carrier film, which carries a plurality of gas-tight cavities (33) including discharge channels (32) oriented to the periphery of the carrier film and opening at a distance from the periphery of the carrier film. Incisions (30) departing from the periphery and ending transversely to the discharge channels (32) at a distance from the same are provided, which discharge channels (32) are releasable by tearing and separating transversely to the axis of the discharge channels (32) upon bending and pulling on the tabs formed by the incisions (30).

Abstract: A system and method for generating an oxygen enriched aqueous solution for therapeutic application includes a diffuser comprising a first diffusing member having a surface incorporating surface disturbances, and a second diffusing member positioned relative to the first diffusing member to form a channel through which an aqueous solution and oxygen gas may flow. A reservoir containing the aqueous solution is connected to a pump that draws the aqueous solution from the reservoir and inputs the aqueous solution into the diffuser. The aqueous solution is moved through the channel relative to the surface disturbances to create cavitation in the aqueous solution to diffuse the oxygen gas into the aqueous solution to produce an oxygen enriched aqueous solution.

Abstract: The invention provides a suction-cleansing device that is capable of forming a swirling stream at a position close to skin and has both a cleansing and a massaging effect by adequately maintaining a state of minute air bubbles in the stream of water, comprising a vessel body having a hollow portion converging from the rear part side thereof toward the front part side thereof, an air/liquid jetting port secured at the front end portion of the vessel body, a liquid-introducing pipe 4 connected to the circumferential wall at the rear part side of the vessel body in the tangential direction, and an air/liquid jet-guiding portion that is disposed at the outer circumferential portion of the air/liquid jetting port and is widened to open from the air/liquid jetting port toward the jetting direction.