Abstract: A droplet delivery device includes a housing with a mouthpiece port or outlet from a nasal device for releasing fluid droplets, a fluid reservoir, and an ejector bracket having a membrane positioned between a mesh with a plurality of openings and a vibrating member that is coupled to an electronic transducer, such as an ultrasonic transducer. The transducer vibrates the vibrating member which causes the membrane to push fluid supplied by the reservoir through the mesh to generate droplets in an ejected stream released through the outlet.

Abstract: Liquid dispensers for bottles comprise a dispensing chamber having small portals at either end. Dropwise addition of flavoring or coloring liquids, such as vermouth or bitters, to alcoholic beverages using those liquid dispensers is also disclosed.

Abstract: The embodiments disclosed herein relate to ophthalmic compositions comprising calcineurin inhibitors or mTOR inhibitors, and more particularly to methods for treating an ocular disease and/or condition using the disclosed compositions. According to aspects illustrated herein, there is provided a pharmaceutical composition that includes a calcineurin inhibitor or an mTOR inhibitor; a first surfactant with an HLB index greater than about 10; and a second surfactant with an HLB index of greater than about 13, wherein an absolute difference between the HLB index of the first surfactant and the HLB index of the second surfactant is greater than about 3, and wherein the composition forms mixed micelles.

Abstract: The invention relates to a device for administering a liquid drop by drop, in particular an ophthalmic liquid. This administering device comprises a packaging filled with the liquid and an outflow channel for connecting to the packaging and comprising a perforation member at one end, which perforation member is received in a frame for mounting on the packaging. The invention further relates to an assembly of such an administering device and an outer packaging which comprises one or more receiving spaces for the administering device. The invention also relates to a method for manufacturing a frame for such an administering device. The invention also relates to a method for forming an administering device. The invention finally relates to a method for administering a liquid drop by drop.

Abstract: An eye rinsing device for rinsing at least one eye is embodied as an attachable attachment, which can be connected to a container, wherein the attachment can be placed onto the eye of a person. The eye rinsing device is provided with at least one rinsing opening, which is directed towards the eye by means of which the washing of an eye is carried out in an improved manner. The attachment encompasses a device having wing-like spreading elements which pull the upper eyelid and the lower eyelid apart so as to support the opening of the eye during the rinsing process.

Abstract: The present application discloses a new and novel system and apparatus for improving the accuracy with which a person may apply eye drops to their own eye. The apparatus holds a bottle of eye drops at a fixed and certain distance above the eye, beside the nose, and below the forehead brow such that the user may easily apply eye drops consistently to one particular portion of their own eye. The apparatus sits on the nasion of the nose using a nasal bridge device and also rests on two pillars that are placed on the user's forehead. Used in such a manner, the apparatus facilitates one-handed eye drop application, facilitates both non-visual alignment and oblique alignment, and reduces reflective blinking.

Abstract: Systems and methods for medication management are provided. Some embodiments provide for a portable medication management and monitoring system for eye drop instillation in ocular chronic conditions. At least one embodiment includes a device having one or more of the following elements: (a) a jacket that goes around an eye drop bottle; (b) tactile sensors to detect the user's fingers and generate data to activate the system; (c) motion sensors to detect the motion of the medication bottle when it is grabbed and moved by the user; (d) a wireless communication module to send and receive data to a computer and portable communication devices; and/or (e) a compartment for holding the electronic components.

Abstract: A device for dispensing liquid including a liquid reservoir which can be deformed so as to dispense liquid by pressing on the reservoir, a liquid-dispensing end piece fitted on the reservoir, a channel for the passage of liquid, a channel for the passage of air from the outside to the inside of the reservoir, the channel for the passage of air being closed off by a member made of an air-permeable polymeric material, this material being non-porous, the member being called the air-permeable member.

Abstract: An eye drop device and a method of applying eye drops to the eye are disclosed herein. An exemplary embodiment of the device contains a main housing having an interior and exterior with a top opening sized to surround the eye and a bottom opening sized to accept the tip of an eye drop vial. The device also preferably contains a cavity for accepting the battery and an LED positioned within the interior of the main housing. A switch may be used to energize the LED. The method includes the steps of attaching an eye drop vial to the main housing, positioning the device over the eye, energizing the LED, and applying the eye drops.

Abstract: Disclosed herein in exemplary embodiments are methods and compositions for repairing or treating a defected cornea in a patient in need. The methods and compositions including, for example, administering a dose of a composition to the patient, wherein the composition comprises may be administered to an intraocular area of the patient via a container having a spout for ophthalmic delivery. The methods and compositions promote progenitor cell migration and increase cellular proliferation in the cornea of the patient.

Abstract: A container for use in a system for spray coating a human subject includes a container body configured to hold a skin coating composition. The container further includes a first end portion having a male coupling valve, where the male coupling valve is configured to couple to a female fitting disposed in a spraying apparatus, where the male coupling valve is further configured to prevent flow of the skin composition from the container while the male coupling valve is not coupled to the female fitting. The container further includes a second end portion opposite the first end portion and having a vent, where the container is configured for inverted connection to the spraying apparatus such that when the male coupling valve is connected to the female fitting the male coupling valve is at a location below the vent, and where opening of the vent allows airflow into the container as the skin coating composition flows out of the container through the male coupling valve.

Abstract: The invention is a device and a method for delivering a dose of a pharmaceutical agent to the eye. The device and method provide a safe and effective way to instill a specified dose of the agent to the eye virtually independent of gravity and posture. The device includes a filter matrix in which the fluid capture and release properties can be modified. The filter matrix is attached to a flexible handle with an impermeable or semipermeable membrane there between.

Abstract: The present invention relates to a dispenser comprising: a container defining a reservoir, said container having a resilient sidewall, a closed end, and a dispensing tip opposite the closed end, said dispensing tip including a passageway in fluid communication with the reservoir, and said resilient side wall including at least one finger indent; and a lid comprising a tube configured to cover the dispensing tip and an outer wall configured to align with the resilient side wall when the tube covers the dispensing tip, the outer wall including at least one finger indent;wherein the lid is removably connectable to the container by a threaded connection between the tube and the dispensing tip.

Abstract: The present invention relates to a bottle for packaging a liquid to be distributed drop by drop comprising a reservoir the walls of which can be reversibly elastically deformed by letting air into the container, surmounted by a liquid dispensing head comprising a dropper nozzle protruding from the bottle and an anti-bacterial filter membrane, that is partially hydrophilic and partially hydrophobic, interposed across the path of the liquid and the air, at the base of the said nozzle. In the dispensing head, the proposal is to create the nozzle by itself out of a material containing a bactericidal agent that has the effect of preventing any bacterial growth on the surface of the said nozzle on the outside of the antibacterial membrane. A porous core is advantageously positioned inside the duct through which liquid is expelled and air is admitted.

Abstract: A portal through the sclera for delivery of an effective amount of therapeutic agent to the back of the eye.

Abstract: Systems and methods for medication management are provided. Some embodiments provide for a portable medication management and monitoring system for eye drop instillation in ocular chronic conditions. At least one embodiment includes a device having one or more of the following elements: (a) a jacket that goes around an eye drop bottle; (b) tactile sensors to detect the user's fingers and generate data to activate the system; (c) motion sensors to detect the motion of the medication bottle when it is grabbed and moved by the user; (d) a wireless communication module to send and receive data to a computer and portable communication devices; and/or (e) a compartment for holding the electronic components.

Abstract: The disclosure relates to medical databases, remote monitoring, diagnosis and treatment systems and methods. In one particular embodiment, a system for remote monitoring, diagnosis, or treatment of eye conditions, disorders and diseases is provided. This method generally includes administering a stream of droplets to the eye of a subject from an ejector device, and storing data related to the administration in a memory of the ejector device. The data may then be monitored and analyzed.

Abstract: An injection device has a dispensing chamber housing, a plunger, and a temperature control device. The dispensing chamber housing has a first part and a second part. The first part is thermally coupled to a needle. The second part is thermally coupled to the first part. The second part has an inner surface and an outer surface. The inner surface partially defines a dispensing chamber for holding a quantity of a substance. The plunger is engaged with an inner surface of the dispensing chamber housing, is capable of sliding in the dispensing chamber housing, and is fluidly sealed to the inner surface of the dispensing chamber housing. The temperature control device at least partially surrounds the dispensing chamber housing and is capable of altering a temperature of the substance in the dispensing chamber. The second part has a greater thermal coefficient than the first part.

Abstract: The present disclosure provides a portable drug dispenser which includes one or more chambers for holding a plurality of separately contained drug products, a dispensing mechanism for accurately dispensing one or more of the plurality of separately contained drugs upon activation of the dispensing mechanism in a specified dose (e.g. specified volume/number of drops) at specified times, and a processor configured to determine the time, and potentially other information such as, e.g. location, patient variables, user data input of each activation of the dispensing mechanism, and an ability to transmit the determined time of activation to a computer located remote to the dispenser, optionally stored on the device as well for read out by a clinician managing the patient.

Abstract: Drop dispenser for releasing a pharmaceutical liquid in drop form, with a housing, a liquid storage and a discharge opening, which penetrates a wall of the housing and to which an outlet valve is assigned, for extracting the liquid. The discharge opening is surrounded by a drop-formation area on the outside of the housing, wherein this drop-formation area, at least in an outer region with respect to an alignment of the drop dispenser with the discharge opening pointing vertically downwards, has a shape tapering downwards and towards the discharge opening. The drop dispenser allows the release of drops with a constant size and shortens drying time.

Abstract: An eyewash dispensing container to store and deliver an eyewash fluid that is particularly suitable for terminal sterilization. The container includes a base and a locking lid with a tamper indicator. The container is able to be opened quickly and deliver the eyewash fluid directly to an eye of a user.

Abstract: A dispensing container according to the invention includes a container body having a rod-like shape. The dispensing container is therefore compact and the user can hold the dispensing container as if the user holds a pen and use the thumb, the index finger, and any other finger to apply pressure to the dispensing container so as to dispense a drug solution. A heat insulating grip is attached to the outer circumferential surface of the container body, whereby heat originating from the body temperature of a finger of the user will not be transferred to the drug solution or volatilize it. No excessive dispensing that is not intended by the user will therefore occur. Since the container body is thin and hence unlikely crashed, the user can make adjustment of the pressure applied by the thumb, the index finger, and any other finger to readily extract a single droplet.

Abstract: A handheld applicator designed to transfer a liquid drop of ophthalmic medicament into a human eye. The basic structure comprises a finger grip section and a drop retainer section, preferably connected to the grip section with an extension. The device is made from an elastomeric material that will allow for the safe transfer of a liquid drop into the eye. A drop dispensed from a container is placed onto the drop retainer section of the device where the surface tension provides drop adhesion. The user may administer the drop, without having to tilt the head, while maintaining an eyeglass assisted view into a mirror. Application of the drop occurs from the peripheral line of vision. When contact is made to the eye, surface tension is relieved and the drop safely transfers into the eye. The same applicator may have a drop retainer section with a different structure on each side.

Abstract: A medical system comprising apparatus and methods for improved irrigation and lavage in wound management. The device attaches to at least one irrigation fluid source and is configured to administer the fluid indirectly to a wound or tissue.

Abstract: A liquid dispenser device including an air flow channel for passing air from the outside towards the inside of a liquid reservoir; a closure member for closing the air flow channel, the closure member being referred to as an “air diffuser member” and being made out of a non-porous polymer material that is permeable to air; and an isolator casing for isolating the diffuser member, the isolator casing being configured in such a manner that the diffuser member is not in contact with the liquid from the reservoir, the casing including an air flow element for passing air towards the inside of the reservoir.

Abstract: A smoke capture adapter comprising: a first adapter part having a first generally ring-shaped portion with a first cylindrical inner surface for securely engaging a laser apparatus having a beam propagation axis, the first generally ring-shaped portion being oriented such that the beam propagation axis passes through a region bound the first generally ring-shaped portion and a tubular outlet extending from said first generally ring-shaped portion for communicating with a vacuum tube; a second adapter part rotatably connected to the first adapter part and arranged to rotate generally about the beam propagation axis having a second generally ring-shaped portion adjacent the first generally ring-shaped portion, the first and second generally ring-shaped portions defining a generally toroidal cavity and an inlet in fluid communication with the cavity; the tubular outlet and inlet in fluid communication through the cavity; whereby the position of the inlet relative to the first adapter part may be adjusted by rota

Abstract: According to the present invention, there is provided a method of treating meibomian gland dysfunction in a mammal wherein an occlusion blocks at least a portion of the flow of naturally occurring secretion out of a gland channel orifice. The invention comprises selecting a device capable of delivering a jet of heated medium. The device is positioned such that when the jet is it is applied to the exterior surface of the eyelid, proximate to the gland channel orifice, a jet of heated medium is applied to the exterior surface of the eyelid proximate to the gland channel orifice at a pressure of from about 2 psi to about 30 psi. Application of the jet of heated medium is maintained for sufficient time to loosen, break up, fracture, soften or liquefy at least a portion of the occlusion such that at least a portion of the occlusion is removed. In an exemplary embodiment, the medium is water heated to a temperature of between about 42° C. and about 46° C.

Abstract: An eye watering/treating hands free system 12 for use with a computer system 10 or any other type of system and which selectively emits an eye watering/treating substance 80 in the direction of the eyes 35, 37 of a user 30 in order to treat eyes 35, 37 for dryness and/or discomfort.

Abstract: A lotion application compartment (10) includes an apparatus for topical application of a fluid to a human or animal body. The apparatus includes a spray nozzle (20) and a support (80) for the body. The apparatus further comprises of one or more of the following: a structure for moving the support, so as to change the distance between the body and the spray nozzle (20); a structure for varying the spray pattern, spray pressure, spray frequency and/or spray duty cycle of the nozzle (20); a structure for varying the rotational speed of the support (80); and a structure for raising the body's skin temperature directly by radiation. A lotion application compartment (10) consisting of apparatus for topical application of a fluid to a human or animal body, the apparatus comprising a spray nozzle (20) and a support (80) for the body.

Abstract: A discharge device for discharging pharmaceutical liquids, with a housing, a liquid reservoir with a receiving space for storing the pharmaceutical liquid, and a discharge opening which is provided on the housing and which connects the receiving space to an environment and serves to dispense the pharmaceutical liquid. A pretensioned spring mechanism is provided, by means of which liquid in the receiving space of the liquid reservoir is subjected to pressure and which, in the assembled state of the discharge device, is not accessible for input of energy.

Abstract: Devices, systems, and methods interface a cassette with an eye treatment system console to provide coupling between the console and an eye treatment probe. The console may receive the cassette using a driven axial translation linkage that inhibits rotation of the cassette. The cassette may facilitate accurately positioning of a pressure sensor relative to a the console by allowing sliding movement between the sensor and a cassette body. Multiple peristaltic drives may be mounted to the console so that their rotors rotate about a common axis. An integrated mount structure may support and/or position components of the console which will interface with cassette, and an axially compressible vacuum connector of the console seal to a tapered vacuum coupler of the cassette.

Abstract: An ejector device and method of delivering safe, suitable, and repeatable dosages to a subject for topical, oral, nasal, or pulmonary use is disclosed. The ejector device includes a housing, a reservoir disposed within the housing for receiving a volume of fluid, and an ejector mechanism in fluid communication with the reservoir and configured to eject a stream of droplets, the ejector mechanism comprising an ejector plate coupled to a generator plate and a piezoelectric actuator; the piezoelectric actuator being operable to oscillate the ejector plate, and thereby the generator plate, at a frequency and generate a directed stream of droplets.

Abstract: The present invention is directed to a pulsatile ophthalmic peri-corneal drug delivery device. The device includes an annular body and a mechanism for releasing multiple separate and distinct doses of a therapeutic composition over an extended period of time.

Abstract: An ejector device and method of delivering safe, suitable, and repeatable dosages to a subject for topical, oral, nasal, or pulmonary use is disclosed. The ejector device includes a housing, a reservoir disposed within the housing for receiving a volume of fluid, and an ejector mechanism in fluid communication with the reservoir and configured to eject a stream of droplets, the ejector mechanism comprising an ejector plate coupled to a generator plate and a piezoelectric actuator; the piezoelectric actuator being operable to oscillate the ejector plate, and thereby the generator plate, at a frequency and generate a directed stream of droplets.

Abstract: The invention relates to a device of ocular iontophoresis for delivering active substances, comprising a reservoir having an outer wall and a hollow body at least partly delimited by the outer wall, wherein the hollow body is capable of receiving an electrical conductive medium and active substances contained in the medium and has an outlet defining a surface, so-called “application surface”, intended to received a determine part of an eyeball surface, the application surface being at least partly limited by an outer line concave towards the optical axis of the eyeball, wherein the outer wall extends from the outer line with a global outwardly with respect to the said optical axis.

Abstract: An eyewash dispensing container to store and deliver an eyewash fluid that is particularly suitable for terminal sterilization. The container includes a base and a locking lid with a tamper indicator. The container is able to be opened quickly and deliver the eyewash fluid directly to an eye of a user.

Abstract: A cigarette lighter device comprising a cigarette lighter component having a top end, a bottom end, and a butane reservoir disposed inside; an eye drop dispenser removably attached to the bottom end of the cigarette lighter component, wherein the eye drop dispenser has a reservoir for storing an eye drop fluid; a connecting tube fluidly connecting the reservoir to an aperture tip disposed at a first end of the eye drop dispenser; wherein the eye drop fluid can be squeezed from the reservoir out of the eye drop dispenser; a removable cap attached to the first end of the eye drop dispenser for temporarily preventing eye drop fluid from unintentionally exiting the eye drop dispenser.

Abstract: Various embodiments of the present invention are directed to droppers that can be used at nighttime or in low-light conditions.

Abstract: The invention relates to a handheld apparatus and a method for eye wash for first aid, where there is a need for immediate washing of the eye, caused by foreign objects or chemicals in and/or around the eye(s). The apparatus comprises two rocker arms, where each of the rocker arms (2) on one side of a hinge (3) has a jaw (4) for placing on the eyelids, and a wing (5) on the opposite side of the hinge, thereat by manual compression of the wings, and the thereby caused rotation of the rocker arms around the hinge, to force the jaws and thus the eyelids apart. The apparatus comprises a connecting part for connection to a liquid container of aerosol type (13) with a pressure valve (14). The rocker arms are connected to a pressure device configured by compression of the wings to press the pressure valve into the liquid container and thereby cause the release of liquid from the liquid container, thus the onset of release of liquid is simultaneous with the compression of the jaws forcing the eyelids apart.

Abstract: A device for dispensing liquid including a liquid reservoir which can be deformed so as to dispense liquid by pressing on the reservoir,a liquid-dispensing end piece fitted on the reservoir, a channel for the passage of liquid, a channel for the passage of air from the outside to the inside of the reservoir, the channel for the passage of air being closed off by a member made of an air-permeable polymeric material, this material being non-porous, the member being called the air-permeable member.

Abstract: An emergency eyewash station and dispensing structure therefore is disclosed. The emergency eyewash station includes a main body configured and arranged to hold and dispense eyewash fluid therefrom, an actuator arm assembly movable from a closed position to an open position, and a dispensing structure having an eyepiece sealed by a membrane. The eyepiece is in fluid connection with the eyewash fluid contained in the main body. The dispensing structure is removably coupled to the actuator arm assembly such that when the actuator arm assembly is moved from the closed position to the open position, the membrane is unsealed and the eyewash fluid dispenses from the eyepiece.

Abstract: An apparatus for delivering at least one therapeutic agent to an ocular tissue of a subject includes at least one electrode, a medicament layer including the at least one therapeutic agent, an electrical signal source, and logic configured to control the electrical signal source. The at least one electrode has oppositely disposed, dome-shaped first and second major surfaces. The first major surface is curved such that the first major surface substantially conforms to a contour of the ocular tissue when placed in contact with the ocular tissue. The medicament layer is disposed on at least a portion of the second major surface. The electrical signal source provides a signal having certain characteristics and is electrically connected to the at least one electrode. The certain characteristics comprise at least one orienting frequency and at least one motivating frequency sufficient to motivate the at least one therapeutic agent into the ocular tissue.

Abstract: A dispensing tip apparatus for an eye drop dispenser to administer topical ophthalmic solutions is described. The apparatus integrates an ophthalmic solution-dispensing tip with an optical gauging assembly. The tip provides continuous visual feedback about it orientation and relationship to the eye. The dispensing tip when attached to any standard topical ophthalmic solution dispensing bottle or reservoir enables the user to view a target, visually align the dispenser tip, and administer an eye drop with precision. There is also a visual feedback by which the dispenser tip is prevented from gaining too close proximity and contacting the eye, thus preventing contamination of the medication and its dispenser. The visual feedback can also contain textual or graphic information that serves as a promotional advertisement. The is assembly can be attached to the neck of an eye drop bottle or attached to the tip of an eye drop bottle.

Abstract: An ophthalmic solution comprising a hydrogen peroxide source in an amount sufficient to result in between about 0.001% and about 0.01% by weight stabilized hydrogen peroxide in said formulation as a preservative, one or more ocularly-compatible hydrogen peroxide stabilizers, hydroxypropylmethylcellulose and sodium carboxymethylcellulose, as well as pharmaceutical compositions comprising such solutions, are provided.

Abstract: An assembly (1) for displaying and dispensing a pharmaceutical liquid contained in a single-use container (3), wherein said assembly (1) comprises: a dispenser comprising a frame (30) to hold said container (3) in a display position; and at least a single-use container (3) comprising a vessel (2) and a detachable closure element (6) which, once detached, defines an outlet to said vessel (2). The assembly (1) further comprises coupling means provided onto the container (3) and the detachable closure element (6) to mount the detachable closure element (6) onto the dispenser. The dispenser further comprises serving means to detach the closure element (6) from said vessel (3). These serving means are actuated by a lever and comprise a handle (33). The invention further relates to the said individual single-use containers as well as dispensers as described above.

Abstract: A hand-operable system for ejecting a fluid composition into an eye, the system comprises: (1) a container having a container opening and containing the fluid composition; (2) a double-acting pump mechanism securely disposed over the container opening; and (3) an actuator that is disposed over, and extends radially outward from, said pump mechanism, for actuating the pump mechanism by applying a force thereon, wherein said pump mechanism comprises a passage for said fluid composition, and said passage is positively sealed off when the application of said force is discontinued.

Abstract: A dispenser cap for an eye-drop container includes a cap holder, an eyelid-engaging member, and a cap enclosure pivotally extended from the cap holder alongside the eyelid-engaging member. The eyelid-engaging member has topside adapted for contacting with an eyelid of a user to maintain the eyelid in an opened position. The cap enclosure is outwardly folded away from the eyelid-engaging member for exposing the dispensing nozzle and is folded in to engage with the eyelid-engaging member to create a nozzle cavity for enclosing the dispensing nozzle. Therefore, the dispenser cap not only provides a sealing device for enclosing the dispensing nozzle of the eye-drop container but also forms an eyelid retractor for maintaining the eyelid of the user in an opened position and aligning the dispensing nozzle to the eye of the user.

Abstract: The present invention provides a device to facilitate the self-administration of eye drops. The device includes a body portion adapted for placement on the user's face, generally over the eye in which the drops are to be applied. The body portion preferably includes an integral handle which may be held between the thumb and forefinger of the user. Many embodiments may also incorporate a nose bridge to assist in locating the device in the correct position.

Abstract: A sterile pack (10) contains a sealed sterile container (2) container having a single-use seal (6) capable of being opened manually by a user. The container contains a cleansing solution (4) at a concentration suitable for immediate use in direct contact with the skin, periocular tissue or ocular surface of a human or animal. A removable label may be provided for placement in a patient record to provide traceability.

Abstract: A delivery device and method for the delivery of a substance to the eye or other bodily site of a user. The device delivers the substance to the eye in the form of a non-aerosol spray or mist. The delivery device is particularly suitable for the delivery of artificial tear compositions to the ocular surface.