Abstract: Disclosed herein are drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The devices are capable of controlled release of one or more drugs and may also include structures which allows for treatment of increased intraocular pressure by permitting aqueous humor to flow out of the anterior chamber of the eye through the device.

Abstract: The present invention is a resin container in which an inner wall surface of a container body includes a cyclic olefin copolymer, and a diameter upstream of an outlet of the container body ranges from 0.5 mm to 8.0 mm.

Abstract: Certain aspects of the present disclosure generally relate to ophthalmic surgery, and more particularly, to methods and apparatuses for controlling intraocular pressure (IOP) and administering ocular tamponades during or after ophthalmic surgery. An exemplary apparatus generally includes a proximal segment having a first inner diameter (ID), a first proximal end, and a first distal end. The apparatus further includes a distal segment having a second ID smaller than the first ID, a second proximal end, and a second distal end configured to be disposed inside a hub or a cannula transition of a valved cannula comprising the hub, a shaft, and the cannula transition between the hub and the shaft.

Abstract: Disclosed herein are pharmaceutical compositions in the form of a suspension for oral delivery. Some embodiments provide a pharmaceutical composition in the form of a suspension for oral delivery comprising an anti-cancer active pharmaceutical ingredient; water; a suspending agent; a buffering agent; and one or more of a wetting agent and a binder/filler. In some embodiments, the anti-cancer active pharmaceutical ingredient is selected from ibrutinib, nilotinib, dasatinib, sunitinib, sorafenib, erlotinib, and capecitabine.

Abstract: Disclosed in certain embodiments is an intracanalicular injectable applicator device includes a body forming a cavity and a cannula coupled to a first distal end of the body. The cannula forms a channel that is aligned with the cavity of the body. The cannula is configured to store an intracanalicular injectable in the channel. The intracanalicular injectable applicator device further includes a tip structure coupled to the body. The tip structure is disposed around at least a portion of the cannula. A distal end of the tip structure is configured to dilate a lacrimal punctum by inserting the distal end of the tip structure into the canaliculus via the lacrimal punctum. The intracanalicular injectable applicator device further includes an actuating structure configured to push the intracanalicular injectable through the channel and the distal end of the tip structure into a canaliculus via a lacrimal punctum.

Abstract: A lacrimal drug delivery device includes a reservoir configured to hold a drug. The reservoir is moveable between a relaxed state and an expanded state. A connector is fluidly coupled to the reservoir and a lumen is formed in the connector wherein the drug is configured to flow from the reservoir to an delivery site through the lumen. A hydrogel is within the lumen and configured to absorb the drug from the reservoir and deliver the drug from the lumen at the delivery site. The hydrogel includes a first section which absorbs the drug at a first rate of absorption. A delivery guide is detachably coupled to the reservoir to deliver the reservoir into a lacrimal sac of a patient.

Abstract: A device implantable into the eye that includes an elongate duct portion defining two lumens that extend parallel to one another from a distal end to a neck spaced longitudinally from the distal end, a second portion including two tubular segments that extend or flare outwardly from the neck opposite one another with at least one additional tubular segment that extends between the two tubular segments such that the tubular segments of the second portion form a tubular loop that surrounds an interior area. The tubular segments of the second portion that form the tubular loop define a common lumen with a plurality of outlets that are in fluid communication with the two lumens of the duct portion to permit fluid to flow through the device.

Abstract: A method is provided for treating a gland or duct of a patient. In a particular embodiment, an obstruction in a gland or duct and the orifice thereof can be alleviated; in another, a substance can be injected thereinto; in yet another, the gland can be aspirated. The method includes the step of inserting an elongated probe into a gland or duct via an orifice thereinto. In some embodiments the probe can have a longitudinal lumen therethrough, with at least one distal hole through the probe wall in fluid communication with the lumen. The lumen can be used in concert with a source of suction for removing debris from the gland or duct, and/or with a source of a fluid and pumping means, for injecting a substance into the gland or duct.

Abstract: Needle injectors and injector carriers for endothelial keratoplasty are provided. Needle injectors include first, second, and third portions each having a respective conduit therein. A first end of the second conduit is fluidly coupled to a second end of the first conduit, where the second conduit has a maximum diameter greater than a maximum diameter of the first conduit. A first end of the third conduit is configured to be fluidly coupled to a second end of the second conduit, where a second end of the third conduit is configured with a cutting surface for cutting and penetrating eye tissue. Injector carriers include a container, a cap configured to seal an opening of the container, and a coupling means configured to couple the needle injector to the cap and allow the needle injector to be disposed within the container.

Abstract: Methods, devices, and systems are presented for inserting an implant in the cornea of the eye, where the implant is a microshunt; a microshunt delivery device for delivering the microshunt into the cornea may comprise the microshunt, an actuator, and a suction stabilizer; a vacuum device may be inserted in the stabilizer such that the cornea may be sucked onto a concave bottom side of the stabilizer; the microshunt may then be inserted into a hole in the suction stabilizer with the actuator; the actuator may be turned to screw the microshunt into a hole in the cornea; and the actuator may be removed from the suction stabilizer, breaking the vacuum seal and leaving the microshunt inserted in the cornea.

Abstract: Provided herein are novel ready-to-use bortezomib formulations, methods of preparing, and methods of using the same.

Abstract: A flush syringe for use in maintaining intravenous catheters, wherein the flush syringe can more efficiently and effectively flush the catheters by providing a pulsating, pulsatile, and/or pulsative flow of fluid that can be produced using momentum of the fluid moving. A steady force applied to a plunger while flushing can provide the pulsating, pulsatile, and/or pulsative flow of the fluid to the catheters.

Abstract: Devices/techniques coupleable to patient sensors, ambient environment, and external sensory input. Devices/techniques receive/maintain information; correlate received/maintained information with measures associated with detecting/monitoring, predict, prevent/treat, and train/reward patient self-care, for dry eyes. Devices/techniques detect/monitor, predict, and prevent/treat dry eyes in real time; and train/reward patients to conduct self-care for dry eyes. The devices/techniques provide adjusted sensory inputs to prevent/treat dry eyes, or to train/reward patients to conduct self-care for dry eyes. The devices/techniques cooperate with other devices, including devices worn by nearby patients, to receive/maintain information about the ambient environment, or communicate with medical personnel. The devices/techniques adjust parameters they use, in response to received information that differs from predictions, to provide superior behavior, and communicate with other devices and medical personnel.

Abstract: A system for preparation of an implant and ab interno insertion of the implant into an eye including a handle having one or more actuators and an elongated shaft having an outer sheath and an elongate member positioned within a lumen of the tubular outer sheath. The system includes a recess sized for holding a patch of material fixed relative to the handle and a cutting member movable relative to the handle and to the recess. The cutting member cuts the patch of material into an implant as the cutting member moves towards a cutting configuration. The implant, once cut, is axially aligned with the lumen of the tubular outer sheath. The inner elongate member is movable relative to the tubular outer sheath to advance the implant into a deployment position in the lumen of the tubular outer sheath for delivery into the eye. Related devices and methods are provided.

Abstract: An ingress-egress apparatus for protection of a surgical work site during removal of a surgical implant therefrom includes an inverted frustum surface having a sidewall defining: a bottom open area at a base portion of the frustum surface sidewall, and an opposing top open area at a top portion of the frustum surface sidewall. The top open area has a larger area than the bottom open area. The apparatus includes an ingress port located at the base portion of the frustum surface sidewall and an egress port located at the base portion of the frustum surface sidewall. During surgical removal of the surgical implant using a surgical burr, the apparatus can be used to irrigate the work site, thereby cooling it and protecting it from damage, and further removing metal implant particles generated during burring.

Abstract: A patient interface system for positioning a patient's eye relative to a laser device for laser surgery is disclosed that includes a patient interface for coupling to the patient's eye, and a patient interface holder for arranging the patient interface on the laser device. The patient interface holder has a suction duct for connecting to a suction device, and the patient interface has a fluid-conducting device that couples to the patient interface holder, and when in the coupled state, together form a fluid path which fluidically couples the suction duct to the patient interface in order to hold a first positioning device of the patient interface against the patient's eye by a relative negative pressure generated by the suction device. A method is disclosed for coupling a patient interface to a patient interface holder, and a patient interface. A patient interface holder is also disclosed.

Abstract: A smoke evacuator for use with a surgical access device includes an evacuation ring having an inner peripheral surface defining one or more channels therein disposed in fluid communication with an operating cavity. A connection port is disposed thereon in fluid communication with the channel(s) and adapted to connect to a smoke evacuation system. The evacuation ring includes a profile having an inner flange that forms part of the inner peripheral surface of the evacuation ring and one or more lower flanges, the inner flange is configured to mechanically engage a rim of an access device and the lower flange(s) is adapted to mechanically engage a wound guard, wherein engagement of the inner flange of the evacuation ring atop the access device and engagement of the lower flange(s) with the wound guard secures the access device, the wound guard and the smoke evacuation ring within the operating cavity.

Abstract: A glaucoma treatment system includes a glaucoma drainage device having a flexible tube with distal and proximal ends, and an inserter with a filament that extends beyond the distal end of a rigid elongate member (e.g., rod or inserter tube). The filament is configured to detachably couple a distal portion of the drainage device tube to the elongate member of the inserter. The filament may extend through a wall of the distal portion of the drainage device tube. The filament and elongate member of the inserter can be configured for relative movement to detach the drainage device tube from the inserter. The elongate member can define an internal channel, and the filament can be configured for axial movement in this channel so that the filament may move toward the proximal end of the elongate member to detach the drainage device tube from the inserter. Other tools are described and claimed.

Abstract: The present invention recognizes that medical devices, such as but not limited to contact lenses, can be made having a coating made at least in part using printing technologies to provide drug storage and drug release structures. The coating preferably includes at least one drug reservoir layer and a least one barrier layer, and can include structures, such as but not limited to capillary structures that alone or in combination modulate the release of the drug from the coating. One aspect of the present invention is a medical device that incorporates a drug in at least one coating.

Abstract: Devices and methods to deliver microcurrent stimulation therapy to the human body, when connected to a micro-stimulation current-generating apparatus. The method of applying microcurrent stimulation therapy to key points around the eye for treatment of problems such as macular degeneration, retinitis pigmentosa, glaucoma, optic neuritis and other eye-related or nerve-related conditions, as well as other diseases, such as Bell's Palsy, requiring localized stimulation to the eyes and/or on other body parts.

Abstract: Apparatuses are described that provide for a mobile eye washing station. An example station includes a fluid storage cartridge that stores unused eye wash fluid and a nozzle assembly in fluid communication with the fluid storage cartridge. In operation, the nozzle assembly dispenses the unused eye wash fluid stored in the fluid storage cartridge via one or more nozzles of the nozzle assembly. The example station further includes a waste fluid collection basin that, in operation, collects eye wash fluid dispersed by the nozzle assembly. Due to contact with the fluid storage cartridge, the waste fluid collection basin compresses the fluid storage cartridge to drive fluid communication between the fluid storage cartridge and the nozzle assembly. The fluid storage cartridge is disposed vertically beneath the waste fluid collection basin.

Abstract: The present invention recognizes that medical devices, such as but not limited to contact lenses, can be made having a coating made at least in part using printing technologies to provide drug storage and drug release structures. The coating preferably includes at least one drug reservoir layer and a least one barrier layer, and can include structures, such as but not limited to capillary structures that alone or in combination modulate the release of the drug from the coating. One aspect of the present invention is a medical device that incorporates a drug in at least one coating.

Abstract: Described here are systems and methods for accessing Schlemm's canal and for delivering an ocular device or fluid composition therein. The ocular devices may maintain the patency of Schlemm's canal without substantially interfering with transmural fluid flow across the canal. The fluid composition may be a viscoelastic fluid that is delivered into the canal to facilitate drainage of aqueous humor by disrupting the canal and surrounding trabeculocanalicular tissues. Tools for disrupting these tissues and minimally invasive methods for treating medical conditions associated with elevated intraocular pressure, including glaucoma, are also described.

Abstract: A cable-holder system for physically supporting connections to a medical device used on a patient, the system including a first portion configured to be supported at the patient's head; a second portion moveably coupled to the first portion; and an electrical connector configured to electrically connect to the medical device, wherein the electrical connector is physically connected to the second portion.

Abstract: A method is provided for treating a gland or duct of a patient. In a particular embodiment, an obstruction in a gland or duct and the orifice thereof can be alleviated; in another, a substance can be injected thereinto; in yet another, the gland can be aspirated. The method includes the step of inserting an elongated probe into a gland or duct via an orifice thereinto. In some embodiments the probe can have a longitudinal lumen therethrough, with at least one distal hole through the probe wall in fluid communication with the lumen. The lumen can be used in concert with a source of suction for removing debris from the gland or duct, and/or with a source of a fluid and pumping means, for injecting a substance into the gland or duct.

Abstract: A dispenser for dispensing absorbent product having an outer cover having a first cover portion, a second cover portion and an interior region configured to hold the absorbent product and at least partially defined by one or more of the first and second cover portions, wherein the first cover portion is removably engaged to at least a portion of the second cover portion along a cover joint; and wherein the outer cover includes a hydrophobic section proximate the cover joint to direct any liquid on the cover near the cover joint away from the cover joint.

Abstract: The present invention recognizes that medical devices, such as but not limited to contact lenses, can be made having a coating made at least in part using printing technologies to provide drug storage and drug release structures. The coating preferably includes at least one drug reservoir layer and a least one barrier layer, and can include structures, such as but not limited to capillary structures that alone or in combination modulate the release of the drug from the coating. One aspect of the present invention is a medical device that incorporates a drug in at least one coating.

Abstract: A glaucoma drainage implant comprising a pressure relief valve via which aqueous humor can be drained. The pressure relief valve has a pressure relief flap which is movably connected with a base plate of the implant, which is to be embedded in a sclera, wherein the pressure relief flap has an actuation area by means of which the pressure relief flap can be mobilized non-invasively during a post-operative healing phase or thereafter. The actuation area is preferably designed as a thermomechanically active area.

Abstract: Embodiments of the present specification provide surgical methods and apparatuses to deploy at least one stent through an optic nerve sheath in order to maintain an opening/fenestration for intracranial fluid egress. The surgical method creates a fenestration, an opening, a slit, or a hole, through an optic nerve sheath of a human patient. The fenestration is created in a minimally invasive manner using an applicator, such as an endoscopic visualization apparatus, that includes a stent or shunt for deploying through the fenestration. The presently disclosed specification is indicated to treat papilledema and/or intracranial hypertension and to deliver therapeutic compositions through the optic nerve sheath.

Abstract: Methods of delivering agents to structures within the eye are provided.

Abstract: The present invention recognizes that medical devices, such as but not limited to contact lenses, can be made having a coating made at least in part using printing technologies to provide drug storage and drug release structures. The coating preferably includes at least one drug reservoir layer and a least one barrier layer, and can include structures, such as but not limited to capillary structures that alone or in combination modulate the release of the drug from the coating. One aspect of the present invention is a medical device that incorporates a drug in at least one coating. A second aspect of the present invention is a method of making a medical device that incorporates a drug in at least one coating. A third aspect of the present invention is a method of using a medical device of the present invention to treat, prevent from having, prevent from developing, control, reduce the severity, or reduce the progression of a disease, disorder or condition of a subject.

Abstract: The purpose of the present invention is to provide a myopia treatment device. A myopia treatment device of the present invention comprises a light transmission part selected from a group consisting of an eyesight correcting tool, an eye protection tool, a face protection tool, a sunshade, a display device, a window, a wall, a light source covering, and a coating material. The light transmission part of the device transmits violet light having a wavelength within a range of 360 nm to 400 nm inclusive and thus treats myopia. Or, the myopia treatment device comprises a light emission part selected from a group consisting of lighting equipment, a display device, and a light irradiation device. The light emission part of the device emits violet light having a wavelength within a range of 360 nm to 400 nm inclusive and thus treats myopia.

Abstract: A handheld applicator designed to transfer a liquid drop of ophthalmic medicament into a human eye. The basic structure comprises a finger grip section and a drop retainer section, preferably connected to the grip section with an extension. The device is made from an elastomeric material that will allow for the safe transfer of a liquid drop into the eye. A drop dispensed from a container is placed onto the drop retainer section of the device where the surface tension provides drop adhesion. The user may administer the drop, without having to tilt the head, while maintaining an eyeglass assisted view into a mirror. Application of the drop occurs from the peripheral line of vision. When contact is made to the eye, surface tension is relieved and the drop safely transfers into the eye. The same applicator may have a drop retainer section with a different structure on each side.

Abstract: An apparatus having an inserter device with a shaft disposed in an interior space and an intraocular implant adapted to self-retain to an inner wall of Schlemm's canal. The intraocular implant has a proximal portion sized and shaped to reside within an anterior chamber of the eye, the proximal portion having a proximal opening; a distal portion sized and shaped to reside within Schlemm's canal of the eye, the distal portion having a distal opening, and a passageway extending in a straight line from the proximal opening to the distal opening to conduct fluid from the anterior chamber to Schlemm's canal. The shaft of the inserter device is adapted to advance the intraocular implant out of the interior space and through an inner wall of Schlemm's canal.

Abstract: The present invention recognizes that medical devices, such as but not limited to contact lenses, can be made having a coating made at least in part using printing technologies to provide drug storage and drug release structures. The coating preferably includes at least one drug reservoir layer and a least one barrier layer, and can include structures, such as but not limited to capillary structures that alone or in combination modulate the release of the drug from the coating. One aspect of the present invention is a medical device that incorporates a drug in at least one coating. A second aspect of the present invention is a method of making a medical device that incorporates a drug in at least one coating. A third aspect of the present invention is a method of using a medical device of the present invention to treat, prevent from having, prevent from developing, control, reduce the severity, or reduce the progression of a disease, disorder or condition of a subject.

Abstract: A prosthesis comprising a water-dissolvable coating. A prosthesis for a lacrimal canaliculus comprising a swellable punctal plug with a proximal end and a distal end, with the plug comprising a water-dissolvable biocompatible coating on the distal and/or the proximal end. Materials and methods for making and using the same. A prosthesis for placement in or across natural or prosthetic lumens, ostia, ducts, sinus, or sphincters, the prosthesis comprising a coating. The prosthesis can further provide a depot for sustained drug delivery to tissue.

Abstract: A device for delivering a treatment medium to an eye includes a first body portion configured to be removably inserted and secured in an opening of the eye, and a second body portion supported by the first body portion. At least the second body portion includes a treatment medium, and a coating having an opening through which the treatment medium elutes out of the device.

Abstract: Amblyopia is a prevalent form of visual impairment that generally arises during infancy and early childhood when inputs to the visual cortex form the two eyes are poorly balanced. Disclosed herein are methods involving retinal inactivation of at least one retina to treat visual impairment in the form of amblyopia or other conditions.

Abstract: A controlled release container including a base. The base has a flexible diaphragm movable between a relaxed position and a depressed position. In the depressed position the flexible diaphragm reduces an interior volume of the container to dispense a dosage amount of material stored within the container. The dosage amount directly corresponds to an internal volume of the container displaced by moving the flexible diaphragm to the depressed position.

Abstract: An ocular implant delivery system is provided with a number of features. In some embodiments, the delivery system comprises a rotation mechanism configured to rotate and orient a cannula of the system, and an advancement mechanism configured to advance and retract an ocular implant through the delivery system and into an eye of a patient. In some embodiments, the cannula is sized and configured to be inserted into Schlemm's canal of the eye. The ocular implant is configured to maintain its orientation within the delivery system as the cannula is rotated. In some embodiments, the ocular implant automatically disengages the delivery system when it is advanced beyond a distal tip of the delivery system. Methods of implanting an ocular implant are also provided.

Abstract: The present invention recognizes that medical devices, such as but not limited to contact lenses, can be made having a coating made at least in part using printing technologies to provide drug storage and drug release structures. The coating preferably includes at least one drug reservoir layer and a least one barrier layer, and can include structures, such as but not limited to capillary structures that alone or in combination modulate the release of the drug from the coating. One aspect of the present invention is a medical device that incorporates a drug in at least one coating. A second aspect of the present invention is a method of making a medical device that incorporates a drug in at least one coating. A third aspect of the present invention is a method of using a medical device of the present invention to treat, prevent from having, prevent from developing, control, reduce the severity, or reduce the progression of a disease, disorder or condition of a subject.

Abstract: An apparatus having an inserter device with a shaft disposed in an interior space and an intraocular implant adapted to self-retain to an inner wall of Schlemm's canal. The intraocular implant has a proximal portion sized and shaped to reside within an anterior chamber of the eye, the proximal portion having a proximal opening; a distal portion sized and shaped to reside within Schlemm's canal of the eye, the distal portion having a distal opening, and a passageway extending in a straight line from the proximal opening to the distal opening to conduct fluid from the anterior chamber to Schlemm's canal. The shaft of the inserter device is adapted to advance the intraocular implant out of the interior space and through an inner wall of Schlemm's canal.

Abstract: A Personal Care Vaporizer Device for the Eye Area of the Face. A treatment chamber formed within the device will encircle the user's eyes and surrounding facial area when the device is positioned over the eye area of the face. A soft gel eyemask element provides maximum comfort for the wearer during treatment. The device introduces therapeutic mist or vapor into the treatment chamber. The mist/vapor is generated from an internal reservoir containing plain water or water mixed with other therapeutic additives. An onboard blower can control the flow rate of the mist/vapor into the treatment chamber. One or more onboard heating elements within the device provide direct heat to the treatment chamber wall(s), and/or to heat the mist/vapor prior to its being introduced into the treatment chamber. Onboard vibration generators apply soothing massaging motion to the user's face when activated.

Abstract: An apparatus is provided for draining aqueous humor from an eye for reducing intraocular pressure. The draining apparatus comprises a tube defining a passage for fluid flow between an inlet end and an outlet end. An outlet assembly contacts the conjunctival layer externally of the eyeball. The outlet assembly comprises a housing in fluid communication with the outlet end of the tube and having an aperture for allowing egress of aqueous humor onto the external ocular surface. A resistive component is disposed in the housing for providing resistance to a flow of aqueous humor. A pair of tabs project outwardly and are adapted to be disposed subconjunctivally for securing the draining apparatus relative to the eyeball.

Abstract: The present invention recognizes that medical devices, such as but not limited to contact lenses, can be made having a coating made at least in part using printing technologies to provide drug storage and drug release structures. The coating preferably includes at least one drug reservoir layer and a least one barrier layer, and can include structures, such as but not limited to capillary structures, which alone or in combination modulate the release of the drug from the coating. One aspect of the present invention is a medical device that incorporates a drug in at least one coating. A second aspect of the present invention is a method of making a medical device that incorporates a drug in at least one coating. A third aspect of the present invention is a method of using a medical device of the present invention to treat or prevent a disease, disorder or condition.

Abstract: The present invention relates to a process for preparing an ointment comprising subjecting a mixture of a fluorescent molecular rotor compound, mineral oil, and grinding media to ball milling agitation and combining this mixture with a hydrophobic vehicle for an ointment. The invention also relates to an ophthalmic formulation comprising a pharmaceutically acceptable carrier and a compound of the following structural Formula (I), or a pharmaceutically acceptable salt thereof: Values and preferred values of the variables in structural Formula (I) are described herein.

Abstract: An apparatus having an inserter device with a shaft disposed in an interior space and an intraocular implant adapted to self-retain to an inner wall of Schlemm's canal. The intraocular implant has a proximal portion sized and shaped to reside within an anterior chamber of the eye, the proximal portion having a proximal opening; a distal portion sized and shaped to reside within Schlemm's canal of the eye, the distal portion having a distal opening, and a passageway extending in a straight line from the proximal opening to the distal opening to conduct fluid from the anterior chamber to Schlemm's canal. The shaft of the inserter device is adapted to advance the intraocular implant out of the interior space and through an inner wall of Schlemm's canal.

Abstract: An adapter system can include a set of adapters operably adapted to a set of microsurgical tools. Each adapter in the set of adapters can be formed for a complimentary surgical tool in the set of surgical tools. Each adapter can have a setback feature designed to orient a corresponding tool tip at a common tip distance. An adapter receptacle can include a joint or joints having a rotary motion and/or translation mechanism and a setback stop feature.

Abstract: The present invention provides for a deformable, insertable device for relieving intraocular pressure comprising a body portion composed of a biocompatible porous material with pores throughout to permit drainage of fluid from the anterior chamber to the scleral tissue without collapse of the anterior chamber. The invention also includes a method for inserting the device into the eye and for using ultrasound intraoperatively to determine the position of surgical tools and devices within the sclera. The invention also includes a device excising sclera in an eye to create a chamber for insertion of the insertable device into the eye.

Abstract: Intraocular lens insertion apparatus includes a cylindrical body member configured to retain an intraocular lens, a fore-end opening provided for a tip of the body member, and a planate protrusion provided for a tip of the fore-end opening. Further, an end surface of the fore-end opening is an oblique surface which is oblique to a plane perpendicular to a central axis of the body member, and a fore-end area including a pair of lateral walls which are parallel to each other across the central axis is formed on a side of the tip of the fore-end opening.