Abstract: The present invention relates to a metered drop bottle for dispensing microliter amounts of a liquid in the form of a drop comprising: (a) a bottle with a flexible portion on the walls to decrease the internal volume by a fixed volume; (b) a plunger with a fixed stroke for depressing the flexible portion of the walls of the bottle; and (c) a nozzle tip having an internal and/or outer diameter no more than 1.2 mm.

Abstract: The invention relates to a bottle for packaging a liquid with dropper delivery comprising a reservoir with an elastically deformable wall that can be reversed by letting air into the receptacle, surmounted by a dispensing head for the liquid comprising a drop-counting end-piece protruding to the outside of the bottle and an anti-bacterial filtering membrane, made partially hydrophilic and partially hydrophobic, which is interposed across the path of the liquid and of the air, at the base of the said end-piece. The dispensing head comprises an insert with a recessed body which contains a porous pad regulating the flow of liquid placed downstream of the reservoir and upstream of a chamber delimited downstream of the said membrane. At the base of this insert on the inner side of the bottle, longitudinal arches supporting a central pellet make star-shaped passageways radially guiding the air that enters the bottle after having passed through the porous pad.

Abstract: A device for dispensing liquid including a liquid reservoir which can be deformed so as to dispense liquid by pressing on the reservoir,a liquid-dispensing end piece fitted on the reservoir, a channel for the passage of liquid, a channel for the passage of air from the outside to the inside of the reservoir, the channel for the passage of air being closed off by a member made of an air-permeable polymeric material, this material being non-porous, the member being called the air-permeable member.

Abstract: An emergency eyewash station and dispensing structure therefore is disclosed. The emergency eyewash station includes a main body configured and arranged to hold and dispense eyewash fluid therefrom, an actuator arm assembly movable from a closed position to an open position, and a dispensing structure having an eyepiece sealed by a membrane. The eyepiece is in fluid connection with the eyewash fluid contained in the main body. The dispensing structure is removably coupled to the actuator arm assembly such that when the actuator arm assembly is moved from the closed position to the open position, the membrane is unsealed and the eyewash fluid dispenses from the eyepiece.

Abstract: Apparatuses, systems, and methods for applying reduced pressure to a tissue site on a foot are provided. An apparatus may include an insole and a tissue contacting surface covering at least a portion of the insole. At least one portion of the tissue contacting surface is removable to form a void. The apparatus may also include a reduced-pressure interface for receiving reduced pressure from a reduced-pressure source, and at least one flow channel fluidly coupled to the reduced-pressure interface and the void.

Abstract: A dispensing tip apparatus for an eye drop dispenser to administer topical ophthalmic solutions is described. The apparatus integrates an ophthalmic solution-dispensing tip with an optical gauging assembly. The tip provides continuous visual feedback about it orientation and relationship to the eye. The dispensing tip when attached to any standard topical ophthalmic solution dispensing bottle or reservoir enables the user to view a target, visually align the dispenser tip, and administer an eye drop with precision. There is also a visual feedback by which the dispenser tip is prevented from gaining too close proximity and contacting the eye, thus preventing contamination of the medication and its dispenser. The visual feedback can also contain textual or graphic information that serves as a promotional advertisement. The is assembly can be attached to the neck of an eye drop bottle or attached to the tip of an eye drop bottle.

Abstract: Precision lid retracting eyedropper device with a hollow, rigid housing having an upper aperture that allows a push button topped piston to enter the housing where the piston can impinge on a resilient tubular member that is part of a pump assembly. The housing also includes a solution storing chamber that feeds solution to the pump assembly. A solution exit tube attached to the outgoing portion of the pump assembly emanates from the bottom part of the housing and can be directed towards the user's eye. Integral downwardly facing resilient legs are placed just above and below the user's orbital ridge so that when the legs are squeezed and released, the user's eye lids are forced open allowing the user to dispense a precise amount of solution into his or her eye.

Abstract: The present invention provides a device to facilitate the self-administration of eye drops. The device includes a body portion adapted for placement on the user's face, generally over the eye in which the drops are to be applied. The body portion preferably includes an integral handle which may be held between the thumb and forefinger of the user. Many embodiments may also incorporate a nose bridge to assist in locating the device in the correct position.

Abstract: An attachment for use with a unit dose eye drop dispenser comprises a tapered receptacle and a lateral positioning arm. The tapered receptacle is “squeezable” so that a reservoir of the unit dose dispenser can be placed within the receptacle and the walls of the receptacle squeezed to dispense a droplet. The positioning arm is shaped to be placed over the patient's nosebridge to properly position the receptacle over the eye for optimum placement of an eye drop.

Abstract: A method of delivering safe, suitable, and repeatable dosages to a subject for topical, oral, nasal, or pulmonary use and a device for droplet ejection includes a fluid delivery system capable of delivering a defined volume of the fluid in the form of droplets having properties that afford adequate and repeatable high percentage deposition upon application. The method and device include a housing, a reservoir disposed within the housing for receiving a volume of fluid, an ejector mechanism configured to eject a stream of droplets having an average ejected droplet diameter greater than 15 microns, the stream of droplets having low entrained airflow such that the stream of droplets deposit on the eye of the subject during use.

Abstract: The present invention provices a counter comprising: a first member disposed in at least a partial helical turn about a longitudinal axis of an entity whose movements and/or contents are to be counted, said first member having an indicium or indicia indicative of a count; a second member extending generally in the direction of said longitudinal axis, said second member being operatively disposed in overlapping relationship under and over one or more portions of said at least partial helical turn of said first member; and means to effect relative movement between said first and second members, said movement comprising a relative incremental rotation about said longitudinal axis.

Abstract: Systems and methods for treating ocular disorders are disclosed. One system has an implant and a delivery device. The implant has inlet and outlet portions, a lumen extending therebetween and communicating with inlet and outlet ports. The implant is sized so that in use aqueous humor flows from an anterior chamber of an eye through the implant and into a uveal scleral outflow path of the eye. The delivery device is configured to advance the implant from within the anterior chamber, with the outlet portion leading the inlet portion, to a location where the outlet and inlet ports respectively communicate with the uveal scleral outflow path and the anterior chamber. One method involves advancing an implant from within the anterior chamber, and draining fluid from therein such that fluid flows into an implant inlet port and out through an implant outlet port and into the uveal scleral outflow path.

Abstract: An eye drops container including a container body filled with a drug solution along with a pressurized gas and including a valve mechanism discharging a fixed amount of drug solution; a nozzle member coupled with a stem for open operation of the valve mechanism and including a drug solution drop nozzle; an operating member including an operating piece and attached to the container body; a guide member contained in the operating member and guiding the nozzle member in the axial direction; and a ball contained in the guide member. The nozzle member includes an outer flange for suspending a skirt on the lower surface thereof; the guide member includes a ring-like bottom groove into which the forward end of the skirt enters; and the ball falls into the bottom groove in an upright state to block the open operation of the valve mechanism, and falls onto the outer flange in an inverted state to permit the open operation of the valve mechanism.

Abstract: One applicator for use with ointment includes a housing defining a holding chamber. The holding chamber has a single entrance distinct from a single exit and is flexible such that deformation of the housing reduces capacity of the holding chamber and forces contents of the holding chamber to pass through the exit. A one-way valve is at the entrance for allowing the ointment to enter the holding chamber through the entrance and restricting the ointment from exiting the holding chamber through the entrance. A tip extends from the housing adjacent the exit. The tip has a proximal end meeting the housing and a pliant distal end spaced apart from the housing. The tip distal end is flared from the tip proximal end and has a generally planar leading surface. A channel in the tip extends from the exit to the leading surface, and is flared at the leading surface.

Abstract: The present invention provides an ophthalmic fluid delivery device adapted to deliver an ophthalmic fluid in the form of a mist to an ocular region of a patient. The ophthalmic fluid delivery device comprises a nozzle defining an aperture through which the ophthalmic fluid can flow and at least one shutter positioned proximate to the aperture of the nozzle. The shutter is mounted for movement with respect to the aperture of the nozzle between an open position permitting flow of the ophthalmic fluid through the aperture of the nozzle and a closed position at least partially covering the aperture. A shutter actuator is positioned proximate to the shutter. The shutter actuator is mounted for movement with respect to the nozzle, and the shutter actuator is coupled to the shutter such that the movement of the shutter actuator moves the shutter between the open position and the closed position.

Abstract: The invention relates to a device for administering a liquid drop by drop. This administering device comprises a packaging filled with the liquid, an outflow channel with an administering opening, and means connected to the outflow channel for opening the packaging, wherein the opening means and the packaging are movable relative to each other. The device can have means for receiving the packaging, which receiving means can be adapted to fix the packaging, wherein the opening means are then movable relative to the receiving means. The opening means can conversely also be fixed relative to the receiving means, wherein the packaging is then movable in the receiving means. The opening means can be formed by a sharp outer end of the outflow channel.

Abstract: A method for establishing the refraction of an eye (9) by means of a refractometer (3) is provided, in which the current visual axis (S) of the eye (9) is established before establishing the refraction, the refractometer (3) is aligned with respect to the visual axis (S) of the eye (9) and the refraction is established after the alignment. The visual axis (S) of the eye (9) is established on the basis of the position of a Purkinje image of at least one light source (41, 50) used to illuminate the eye and a relationship between the position of the Purkinje image and the visual axis (S).

Abstract: The present invention is directed to a pulsatile ophthalmic peri-corneal drug delivery device. The device includes an annular body and a mechanism for releasing multiple separate and distinct doses of a therapeutic composition over an extended period of time.

Abstract: An method and a device for implant into the eye of a patient configured in size to frictionally engage within a cup-like depression naturally occurring in the optic nerve of the eye. The implant has a reservoir for calculated disbursement of medicine to tissue surrounding it and in one mode is refillable and in another mode is formed of biodegradable material which is absorbed by the patient after use ceases.

Abstract: In one embodiment consistent with the present invention a method of treating mammalian meibomian glands involves clearing the glands by applying a regulated heat to an eyelid containing the meibomian glands to a temperature adequate to melt obstructions in the meibomian glands to put the obstructions in a fluid or suspension (melted) state and maintaining the heat for a time period adequate to melt the obstructions. The glands can then be mechanically treated to express fluid from the glands, wherein the treating is carried out either during the time period or after the time period but while the obstruction remains in a fluid state. Subsequent pharmacological treatment of the glands by use a pharmacological agent (topical or systemic) can then be used to assist in maintaining proper flow of lipids from the glands. This abstract is not to be considered limiting, since other embodiments may deviate from the features described in this abstract.

Abstract: A medical device for the treatment and prevention of eye and respiratory tract conditions is provided. The medical device may include a pack with a pump, a filter, and a vaporizer chamber for storing fluid and selectively supplying fluid vapor to ambient air. The medical device may further include a glasses unit comprising a pair of frames and a diffuser. The medical device may further include a tube having a first end configured for connection to the pack and a second end configured for connection to the diffuser. The glasses unit may be separated from the pack when the medical device is in use. Various methods for the treatment and prevention of eye and respiratory tract conditions and a method for modifying a pair of conventional glasses for treatment are also disclosed.

Abstract: This invention discloses apparatus and methods of providing a pump for dispensing a liquid into the eye and in some embodiments, a pump coupled to a blink detecting mechanism to time administration of a liquid into the eye.

Abstract: This invention discloses methods and apparatus for providing a variable optic insert into an ophthalmic lens. An energy source is capable of powering the variable optic insert included within the ophthalmic lens. In some embodiments, an ophthalmic lens is cast molded from a silicone hydrogel.

Abstract: The present application discloses a pharmaceutical delivery system for delivering a desired amount of liquid in the form of droplets. The pharmaceutical delivery system comprises a container having resilient compressible walls of uniform thickness, an elongated neck, and a valveless dropper tip. The pharmaceutical delivery system dispenses liquid through an outlet orifice in the valveless dropper tip in a drop by drop manner, producing droplets of substantially uniform volume independent of the amount of pressure applied on the container.

Abstract: A tip is provided for a liquid dropper which facilitates formation of a mini drop, a mini drop being a drop smaller than a standard typical drop. A conduit is provided extending from a reservoir of liquid to a tip. The tip provides a location for release of the mini drop. The tip includes a rim surrounding a port with the rim having a particularly thin wall and with the port being particularly narrow. The dimensions of the rim and port facilitate formation of the mini drop. The material forming the tip is flexible and resilient so that should the tip come into contact with sensitive structures, such as an eye of a patient, a potential for injury is minimized. Dispensers featuring the unique tip are disclosed in multiple different embodiments for attachment to a bottle of liquid to be dispensed, or to fit over an existing outlet.

Abstract: Precision lid retracting eyedropper device with a hollow, rigid housing having an upper aperture that allows a push button topped piston to enter the housing where the piston can impinge on a resilient tubular member that is part of a pump assembly. The housing also includes a solution storing chamber that feeds solution to the pump assembly. A solution exit tube attached to the outgoing portion of the pump assembly emanates from the bottom part of the housing and can be directed towards the user's eye. Integral downwardly facing resilient legs are placed just above and below the user's orbital ridge so that when the legs are squeezed and released, the user's eye lids are forced open allowing the user to dispense a precise amount of solution into his or her eye. A precision eye drop solution container having the ability to retain and dispense a precise single portion of eye drop solution each time the user depresses an actuator device located on and within the housing of the container.

Abstract: A dispensing tip apparatus for an eye drop dispenser to administer topical ophthalmic solutions is described. The apparatus integrates an ophthalmic solution-dispensing tip with an optical gauging assembly. The tip provides continuous visual feedback about it orientation and relationship to the eye. The dispensing tip when attached to any standard topical ophthalmic solution dispensing bottle or reservoir enables the user to view a target, visually align the dispenser tip, and administer an eye drop with precision. There is also a visual feedback by which the dispenser tip is prevented from gaining too close proximity and contacting the eye, thus preventing contamination of the medication and its dispenser. The visual feedback can also contain textual or graphic information that serves as a promotional advertisement. The is assembly can be attached to the neck of an eye drop bottle or attached to the tip of an eye drop bottle.

Abstract: The feed connector (270) capable of interacting with a device for delivering active principles comprising a reservoir delimited by at least two lateral walls of substantially cylindrical shape and extending opposite one another, is characterized in that it includes means (202, 203, 204, 205) for dispensing active principles into the reservoir that are arranged such that said reservoir is filled substantially uniformly between the two lateral walls.

Abstract: The present invention relates to a device for the delivery of predetermined doses of liquid medicament to a patient, which medicament is intended to be inhaled by the patient or intended to be injected into the body of the patient. The device is adapted to be in a medicament delivery state and in a medicament non-delivery state. When the device is in a medicament delivery state, said device is adapted to drive a piston into a cartridge containing the liquid medicament to be delivered, with a force that is above or equal to a predetermined minimum force value and below a predetermined maximum force value. The minimum force value is the lowest force value needed to deliver the predetermined dose and the maximum force value is the first force value at which it exists a risk of damaging the cartridge or the components of the device. Further, more of the spring force is brought to an efficient output torque ensuring that a predetermined volume of medicament is expelled from a cartridge.

Abstract: A drop dispenser has a substantially conical sleeve member with a narrow upper end and a wide lower end. Centrally located at the apex of the upper end of the sleeve member is an aperture which has an inner diameter and is circumscribed by a raised ridge. The aperture and the ridge form a nozzle. The interior space of the substantially conical sleeve member forms a substantially conical chamber between the narrow upper end and wide lower end of the sleeve member. The nozzle is in liquid communication with the chamber through the aperture. The drop dispenser may have external threads at the lower end of the sleeve member for engaging a cap having a protuberance centrally located at its internal top end for hermetically engaging the aperture of the nozzle when the cap fully engages the sleeve member.

Abstract: The present invention relates to medication applied to the eye, and in particular to an apparatus for applying such medication. An arrangement as described herein enables precise quantities of medication to be administered without the apparatus contacting the eye ball. The application comprises a shield portion (12) for application over a user's eye, comprising an opening (20, 22) for receiving a support into which medication can be dispensed. The opening is configured to guide and release the medication from the support into the user's eye.

Abstract: A discharge device for pharmaceutical media has a reservoir for storing the medium, with a discharge opening for delivering the medium to the environment, the discharge opening in a use position being positioned in front of an eye of the user and a feed mechanism for feeding the medium from the reservoir to the discharge opening. A control system with a control unit and a sensor device is also provided. The control system is constructed for detecting an opening state of the eye of the user and/or a viewing direction of the eye of the user and for influencing the delivery of the medium as a function of the detected opening state and/or detected viewing direction.

Abstract: The present invention relates to a device for delivery of medicament comprising a main housing; a container arranged in said housing and arranged to be connected to a medicament delivery member, wherein said container includes at least two chambers and at least one longitudinally movable plunger and wherein at least one chamber contains a medicament agent; a pre-treating arrangement acting on said container; drive force means acting on a longitudinally movable plunger rod capable of exerting a force on said container; and activating delivery means acting a said drive force means for delivering medicament via said medicament delivery member characterised in that said pre-treating arrangement comprises clickable means for manually and delay intermittently mixing said medicament agent and for manually priming said container

Abstract: The present invention relates to a metered drop bottle for dispensing microliter amounts of a liquid in the form of a drop comprising: (a) a bottle with a flexible portion on the walls to decrease the internal volume by a fixed volume; (b) a plunger with a fixed stroke for depressing the flexible portion of the walls of the bottle; and (c) a nozzle tip having an internal and/or outer diameter no more than 1.2 mm.

Abstract: A liquid delivery container comprises a bag 2 which is disposed in a container body 1 to contain a liquid and can expand and shrink or deform freely, a delivery port 3 communicating with the bag 2 and having an outlet hole 31 for discharging the liquid contained in the bag 2, a squeeze portion 6 which is disposed between the delivery port 3 and the bag 2 and is capable of deforming to discharge the liquid through the delivery port when pressed and is restorable, and the check valve 5 disposed on the upstream of the squeeze portion 6 in the discharging direction and regulating the flow of the liquid contained in the bag 2 in one way toward the squeeze portion. When the squeeze portion 6 is pressed, the liquid is discharged through the delivery port 3, and when the pressure is removed, the squeeze portion 6 restores the original shape and at the same time sucks up the liquid from the bag 2.

Abstract: To overcome shortcomings of the prior art, the subject invention is provided which includes various dropper bottle designs and dropper bottle assemblies including accessories for dropper bottles. With certain aspects of the subject invention, improvements in the administration of eye drops is provided by adding accessories or modifications to conventional dropper bottles, so that doses and/or single drops may be administered in a repeatable and reliable manner. More specifically, certain embodiments use devices (10, 300) to restrict the amount the dropper bottle (12) is deformed in administering a dose; other embodiments rely on mechanical reduction of interior volume (without deformation of the dropper bottle (12)) to administer a dose, such as with a displaceable piston (500, 602); and, yet, a further embodiment provides a valving arrangement (402, 404) to limit a dose.

Abstract: A subpalpebral lavage catheter device for a mammal comprising a subpalpebral catheter having a first and a second end wherein the first end is located under the skin of the mammal and the second end further comprises an injection port, a hollow pouch, wherein the pouch has an opening adapted to receive the injection port of the catheter, a means for closing the opening of said pouch, and a plurality of loops attached to a side of the pouch, spaced apart and of a length wherein the loops are adapted to be braided into hair of the mammal.

Abstract: The present invention relates to a device to be used with a medical administration device, which administration device comprises administration drive means for administrating a prescribed dose of medicament; mechanical dose setting means for setting a prescribed dose of medicament to be administered, including a mechanical indicating member (76) fixedly connected to said administration drive means (84) for indicating the prescribed set dose, wherein said device comprises mechanical dose information means for registering the prescribed dose of medicament to be administered including a mechanical information member adjustable to display that said prescribed dose to be administered is correct, and inter-connected to said mechanical indicating member such that when the prescribed dose is set, this is indicated positively by indications on said mechanical information member.

Abstract: A metered dispenser includes a housing including a reciprocal piston drive stem including an inlet opening at a first end thereof, a floating piston at a second end, and a passage between the first and second ends. An inlet valve is provided adjacent the first end for permitting entry of liquid product into the passage. A biased cocking mechanism is reciprocally disposed substantially within the housing. A biased loading mechanism is movable in a second generally opposite direction by the cocking mechanism, and is engageable with the piston drive stem to move the drive stem in the second direction. When the cocking mechanism is moved from an initial rest position toward the second direction, a series of operations allow the loading mechanism to project the drive stem in the first direction to dispense a metered dose of liquid product through a discharge orifice provided adjacent the second end.

Abstract: An ophthalmic dropper for distributing medicinal fluid to an eye is provided. The dropper comprises a fluid carrying container having a hollow body extending along a longitudinal axis, and an opening defined in the hollow body. A nozzle is coupled to the opening of the container for receiving fluid from the container. The nozzle defines an outlet port for distributing fluid from the nozzle. The outlet port of the nozzle is positioned to deliver fluid along an axis that is substantially perpendicular to the longitudinal axis of the container.

Abstract: A device for dispensing ophthalmic solutions to a user's eyes comprising a container for holding ophthalmic solutions, transfer tubing attached to the container for dispensing and applying said solution and a clip attached to the container for attaching said applicator to eyeglasses. The transfer tubing is the clip by being formed into the shape of a clip for attaching said eye solution applicator to eyeglasses.

Abstract: An optically controlled microfluidic chip is provided for administering a fluid to a neuronal site. The chip is made of at least one unit or pixel, each of which constitutively emits fluid in the dark, and reduces emission of fluid in response to light. The individual pixels are capable of being individually controlled, thereby translating a spatial pattern of incident light into a spatial pattern of neuronal stimulation. Each pixel contains a housing, an aperture in the housing, and a reservoir containing fluid that is connected to the aperture. The aperture is designed to allow continuous emission of fluid from the reservoir through the aperture when the pixel is in the dark. Each pixel also includes an optical control, which reduces the emission of fluid from the reservoir through the aperture in response to light.

Abstract: A drop metering device for use in combination with an eye dropper or other liquid dispenser comprises a rigid receptacle having an open chamber for removably receiving a squeeze bottle of the dropper. The plunger is mounted to reciprocate radially inwardly with respect to the rigid receptacle so that, when the squeeze bottle is in place, a controlled deflection can be induced in the squeeze bottle. The plunger may be mounted on a lever arm with a ring adjustment mechanism which provides a variable stop surface between the lever arm and the receptacle. Alternatively, the plunger may be mounted in a radially oriented slide bearing with a threadably mounted stop member for adjusting the length of travel.

Abstract: An eyedropper including a container and a cap which can be screwed onto the container unit wherein a tubular fluid instilling portion is provided at a tip of the container. An outer circumferential region of the tubular fluid instilling portion is provided with a step portion where the outer diameter of the container is smaller and whose outer diameter is substantially not reduced or changed moving towards the tip. The cap is provided with a convex seal portion, which, in the mounted condition, is in close contact with the tip and the step portion.

Abstract: A liquid dispensing apparatus includes a liquid storage space having an opening for dispensing liquid, and a movable wall operable to reduce the liquid storage space. The apparatus also includes an intermediate storage space having variable volume, the intermediate storage space including a liquid inlet in fluid communication with the liquid storage space for receiving liquid therefrom. A specific amount of the liquid is transferred from the liquid storage space to the intermediate storage space in a single operation. A nozzle is in fluid communication with the intermediate storage space, the nozzle having an outlet for dispensing the liquid from the intermediate storage space to an intended surface.

Abstract: A bottomed conical hollow 6b is formed in a tip end of the container body A formed of a thermoplastic material with a liquid filled and sealed therein simultaneously during the molding process, the hollow having an inside diameter enlarging toward the tip end, and a small-diameter instilling hole 6c is penetrated through the bottom of the hollow 6b for controlling, at a set quantity, the liquid pushed out of the container body A.

Abstract: An ophthalmic dispenser and method of filling and dispensing fluid stored therein. The dispenser includes a rigid housing defining a fluid-receiving chamber, a flexible bladder receivable within the fluid-receiving chamber, a pump coupled in fluid communication with the fluid-receiving chamber, and a nozzle having a valve defining an annular, axially-extending valve seat, an outlet aperture coupled in fluid communication between the valve seat and the pump, and a flexible valve cover extending about the valve seat and forming an annular, axially-extending interface therebetween.

Abstract: The present invention provides a dispensing device for applying fluid comprising a pressurized reservoir equipped with a dosing module having at least one dosing chamber which is able to communicate with the reservoir and with a nozzle provided for dispensing a dose of fluid, characterized in that the dosing chamber comprises a moving and/or deformable member which delimits at least a first and a second compartments of variable volume, each compartment having an inlet and an outlet associated with valve means, wherein valve means are controlled according to a first configuration in which the inlet of the first compartment and the outlet of the second compartment are open while the other inlet and outlet being closed, and according to a second configuration in which the inlet of the second compartment and the outlet of the first compartment are open while the other inlet and outlet being closed.

Abstract: A method and device for delivering an agent, such as an anti-vascular endothelial growth factor (VEGF) agent to ameliorate inflammation, at a site in the body that may be the eye, a joint, the brain, etc. The device located at the body site administers agent using an equilibrium diffusion process.

Abstract: An ophthalmic dispenser has a rigid housing defining a fluid-receiving chamber, a flexible bladder receivable within the fluid-receiving chamber, a pump coupled in fluid communication with the fluid-receiving chamber, and a nozzle having a valve defining an annular, axially-extending valve seat, an outlet aperture coupled in fluid communication between the valve seat and the pump, and a flexible valve cover extending about the valve seat and forming an annular, axially-extending interface therebetween.