Solid Ejected From Body Inserted Conduit Patents (Class 604/60)
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Patent number: 7329242Abstract: An implant retention trocar includes a cannula for puncturing the skin of an animal and an obturator for delivering the implant beneath the skin of the animal. The implant retention trocar has a cannula distal tip design which causes a minimum of trauma and tearing of tissue during implant insertion. A spring element received within the cannula prevents an implant which is to be inserted into an animal from falling out of the cannula during the implant insertion process. The spring element includes a longitudinal leg which is folded with a zigzag-shaped bend. When the spring element is inserted into the cannula, the zigzag-shaped bend of the longitudinal leg retains the implant within the cannula.Type: GrantFiled: July 8, 2002Date of Patent: February 12, 2008Assignee: Alza CorporationInventor: John R. Peery
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Publication number: 20070249992Abstract: A subcutaneous implantation instrument with dissecting tool and method of construction are described. An incising shaft longitudinally defines a substantially non-circular bore continuously formed to communicatively receive an implantable object and further includes a beveled cutting blade formed on a distal end. A dissecting tool includes a needle tip forming a pair of longitudinal cutting edges progressively defined outwardly from the needle tip planar to the beveled cutting blade and removably affixable to the distal end of the incising shaft through a proximal coupling. A delivery mechanism longitudinally defines a substantially non-circular bore formed to deploy the implantable object into the incising shaft. One goal is to reduce the subcutaneous sensor insertion of implantable objects and devices, such as sensors, having non-conforming shapes to be the functional equivalent of an injection.Type: ApplicationFiled: July 10, 2006Publication date: October 25, 2007Inventor: Gust H. Bardy
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Patent number: 7217252Abstract: A device for delivering a medicated product into a bodily cavity includes a barrel member having a dispensing end, a proximal end, which is positioned opposite the dispensing end, and a bore, which extends through the barrel member. The bore is sized and shaped so as to receive a medicated product therein and includes an opening formed in the dispensing end of the barrel member. The opening is sized and shaped so as to permit a medicated product received in the bore to be dispensed therethrough. The applicator is also provided with a plunger member movably extending through the bore of the barrel member for dispending a medicated product from the bore through the opening. The barrel member includes at least one substantially flexible section located between the dispending end and the proximal end such that the barrel member is bendable about the flexible section.Type: GrantFiled: March 23, 2004Date of Patent: May 15, 2007Assignee: McNeil-PPC, Inc.Inventor: Paul B. Swick
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Patent number: 7198612Abstract: An applicator for delivering pharmaceutical products or the like to a bodily cavity includes a barrel member having a distal end which is equipped with an opening. The applicator also includes a plurality of petals extending outwardly from the distal end in a generally axial direction. The petals cooperate with the opening so as to form a receptacle for releasably receiving a pharmaceutical product in the distal end of the barrel member. Each of the petals has a truncated flexible tip sized and shaped so as to engage a substantially central portion of the pharmaceutical product such that a large section of the pharmaceutical product extends outwardly beyond the petals so as to facilitate the release of the pharmaceutical product from the receptacle. The device also includes a plunger member for releasing the pharmaceutical product from the receptacle. In accordance with the present invention, the device can be packaged in a package together with the pharmaceutical product received in the receptacle.Type: GrantFiled: February 12, 2003Date of Patent: April 3, 2007Assignee: McNeil-PPC, Inc.Inventor: Paul B. Swick
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Patent number: 7192436Abstract: A system and method for delivering a pledget of hemostasis promoting material to a blood vessel puncture to facilitate hemostasis, having an introducer sheath having an inner diameter and an outer diameter, a control tip coupled to the introducer sheath, and a self-expandable member disposed around a portion of the control tip to control blood flow at the blood vessel puncture.Type: GrantFiled: May 28, 2004Date of Patent: March 20, 2007Assignee: Sub-Q, Inc.Inventors: Eduardo Chi Sing, Luis Urquidi, Mark Ashby, Andrew Cragg, Tom Furey, Robert Bowes, Vincent Tangherlini
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Patent number: 7182747Abstract: A solid drug solution perforator (SSP) system and an associated drug reservoir are provided for delivering therapeutic, prophylactic and/or cosmetic compounds, for nutrient delivery and for drug targeting. For drug delivery, the SSP system includes an active drug ingredient and a matrix of perforator material that biodegrades or dissolves quickly upon contact with a patient's body. The SSP system provides a skin barrier perforator and a controller for prompt initiation and cut-off of drug delivery. In a preferred method of transdermal drug delivery, an SSP system containing a selected drug penetrates into an epidermis or dermis, and the drug is promptly released from the (dissolving) SSP system perforator. An additional drug is optionally delivered from a patch reservoir through skin pores created by insertion of the perforator. Formulation and fabrication procedures for the SSP and associated reservoir are also provided. An SSP system can be fabricated with variety of shapes and dimensions.Type: GrantFiled: November 21, 2005Date of Patent: February 27, 2007Assignee: TheraJect, Inc.Inventor: Sung-Yun Kwon
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Patent number: 7175629Abstract: An extractable device is used to insert a medicinal filling into a vertebral body. The device comprises a filling member and a pasty medicine. The filling member is made of a flexible and permeable wall and is provided with a holding portion and an injection port via which the pasty medicine is injected into the holding portion after the filling member is inserted into the vertebral body. The holding portion is provided with an opening which is releasably lashed by one end of one or more threads so as to make the opening leakproof. Upon completion of solidification of the pasty medicine in the holding portion of the filling member, other end of the thread is pulled to unlash the opening of the holding portion, thereby enabling the filling member to be extracted from the vertebral body so as to leave only the medicine in the vertebral body.Type: GrantFiled: September 27, 2004Date of Patent: February 13, 2007Assignee: Crosstrees Medical, Inc.Inventors: Kwan Ku Lin, Philip S. Yuan
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Patent number: 7175627Abstract: An extractable device is used to insert a medicinal filling into an animal tissue. The device comprises a filling member and a pasty medicine. The filling member is made of a flexible and permeable wall and is provided with a holding portion and an injection port via which the pasty medicine is injected into the holding portion after the filling member is inserted into the animal tissue. The holding portion is provided with an opening which is releasably lashed by one end of one or more threads so as to make the opening leakproof. Upon completion of solidification of the pasty medicine in the holding portion of the filling member, other end of the thread is pulled to unlash the opening of the holding portion, thereby enabling the filling member to be extracted from the animal tissue so as to leave only the medicine in the animal tissue.Type: GrantFiled: September 2, 2003Date of Patent: February 13, 2007Assignee: Crosstrees Medical, Inc.Inventors: Kwan Ku Lin, Philip S. Yuan
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Patent number: 7175628Abstract: An extractable device is used to insert a medicinal filling into an animal tissue. The device comprises a filling member and a pasty medicine. The filling member is made of a flexible and hermetic wall and is provided with a holding portion and an injection port via which the pasty medicine is injected into the holding portion after the filling member is inserted into the animal tissue. The holding portion is provided with an opening which is releasably lashed by one end of one or more threads so as to make the opening leakproof. Upon completion of solidification of the pasty medicine in the holding portion of the filling member, other end of the thread is pulled to unlash the opening of the holding portion, thereby enabling the filling member to be extracted from the animal tissue so as to leave only the medicine in the animal tissue.Type: GrantFiled: September 2, 2003Date of Patent: February 13, 2007Assignee: Crosstrees Medical, Inc.Inventors: Kwan Ku Lin, Philip S. Yuan
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Patent number: 7172573Abstract: A device (100) for depositing a non-flowable object or a non-flowable medicament in a body cavity includes an elongate body (12) which includes an elongate barrel (14) with a passage (18), configured to receive a non-flowable object or medicament, extending through the body (12). The passage (18) has an outlet (22) at a free end of the barrel (14), a portion of the passage (18) being curved. The device (10) also includes an ejector or plunger (30) which can be displaced along the passage (18) to push a non-flowable object or medicament received in the passage (18) out of the passage (18) through the outlet (22) thereof.Type: GrantFiled: April 26, 2000Date of Patent: February 6, 2007Inventor: Peter James Brian Lamb
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Patent number: 7141036Abstract: A method of applying a medicinal substance onto an area within a patient's body cavity includes providing an applicator formed by six integral sections. A proximal section is formed with an entry passage. An axial intermediate passage of the applicator extends from the entry passage through a flange section and a passage section. A slot section has a slot delivery passage communicating with the axial intermediate passage, and at least one axially-elongated slot therethrough. A solid section extends from the slot section, and a dome section extends to an end of the applicator. The method further includes locating the slot delivery passage adjacent the area within the cavity, forming a substance mass externally of the cavity, moving the mass into the slot delivery passage, and moving at least a portion of the substance onto the area.Type: GrantFiled: June 4, 2002Date of Patent: November 28, 2006Assignee: Syringe, LLCInventors: Irwin R. Berman, Richard D. Gillespie, Gervasio Salgado
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Patent number: 7125394Abstract: A device 560, for administering multiple single doses of a medicated cream, includes a cartridge 562 having a barrel 564 for containing the cream, a plunger 608 for moving the cream from within the cartridge, and a stem 610 for moving the plunger within the cartridge. A carrier 612 is formed with a cartridge-receiving nest 712 for receiving the barrel 564. A plurality of spaced, transaxial grooves 726, 728, 730 and 732 are formed in the carrier 612 for receiving a flange 572 of the cartridge 562 during the dispensing of multiple, successive, single doses of the cream. The carrier 612 is formed with a pair of resilient ears 750 and 752 and a passage 738 for removably retaining the stem 610 with the carrier while allowing axial movement of the stem.Type: GrantFiled: May 29, 2003Date of Patent: October 24, 2006Assignee: Syringe, LLCInventors: Irwin R. Berman, Richard D. Gillespie, Gervasio Salgado
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Patent number: 7118550Abstract: A dispenser for delivering a suppository within a body cavity. The dispenser has two main components: a barrel and a plunger. The barrel includes a head, a foot, and a body having a length and extending between the head and the foot. The barrel further defines an axial passage disposed along substantially the entire length of the body beginning at the foot and ending proximate the head, and includes a side aperture providing external access through the body of the barrel to the axial passage at the head of the barrel. The plunger includes a nose, a tail, and a frame extending between the nose and the tail. The plunger is sized to travel within the axial passage of the barrel between a relaxed position and a compressed position, in which a suppository is ejected from the side aperture, upon actuation.Type: GrantFiled: July 10, 2003Date of Patent: October 10, 2006Assignee: B. Braun MedicalInventor: Benjamin N. Loomis
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Patent number: 7104968Abstract: An applicator for delivering pharmaceutical products or the like to a bodily cavity includes a barrel member having a distal end which is equipped with an opening. The applicator also includes a plurality of petals extending outwardly from the distal end in a generally axial direction. The petals cooperate with the opening so as to form a receptacle for releasably receiving a pharmaceutical product in the distal end of the barrel member. Each of the petals has a truncated flexible tip sized and shaped so as to engage a substantially central portion of the pharmaceutical product such that a large section of the pharmaceutical product extends outwardly beyond the petals so as to facilitate the release of the pharmaceutical product from the receptacle. The device also includes a plunger member for releasing the pharmaceutical product from the receptacle. In accordance with the present invention, the device can be packaged in a package together with the pharmaceutical product received in the receptacle.Type: GrantFiled: June 14, 2002Date of Patent: September 12, 2006Assignee: McNeil-PPC, Inc.Inventor: Paul B. Swick
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Patent number: 7083607Abstract: The invention relates to an injection device containing a hollow needle (1), a cutting needle that can be inserted into the hollow needle and that has a cutting tip projecting from the front end of the hollow needle, a catheter (9) that replaces said cutting needle and that can be inserted approximately up to its front end into the hollow needle (9), said catheter having a receiving chamber (30) for a substance in the form of a capsule on its distal end, in addition to a mandrin (29) that can be inserted into the catheter (9) and which can be placed in a position defining a receiving chamber (30) filled with capsules (22) on the distal end of said catheter, wherein the capsules (22) contained in the receiving chamber (30) of the inserted catheter (9) are released without exerting any pressure in the target area of the body (23) once the injection device has been arranged in a target area of a body (23) by relatively pulling back both the catheter (9) and the hollow needle (1) in relation to the mandrin (29) aType: GrantFiled: July 12, 2002Date of Patent: August 1, 2006Assignee: Bavarian Nordic A/SInventors: Matthias Löhr, Walter Günzburg
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Patent number: 7077821Abstract: A system for placing an implant in the body includes an elongated member having at least one inner lumen extending from a proximal end portion of the member to an opening in a distal end portion of the member. At least one compressible implant is in the inner lumen of the member. The implant optionally includes anchor members projecting from its outer surface to limit migration of the implant in the body. Structure is provided to push the implant through the opening in the distal end portion of the member. The implant is placed between layers of body tissue to bulk the tissue. In one of the disclosed methods, the system is used to treat gastroesophageal reflux disease (GERD) by placing the implant between layers of body tissue at or near the gastroesophageal junction.Type: GrantFiled: May 22, 2003Date of Patent: July 18, 2006Assignee: Boston Scientific Scimed, Inc.Inventor: Russell Durgin
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Patent number: 7063681Abstract: An implant retention trocar includes a cannula for puncturing the skin of an animal and an obturator for delivering the implant beneath the skin of the animal. The implant retention trocar has a cannula distal tip design which causes a minimum of trama and tearing of tissue during implant insertion. A spring element received within the cannula prevents an implant which is to be inserted into an animal from falling out of the cannula during the implant insertion process. The spring element includes a longitudinal leg which is folded with a zig-zag shaped bend. When the spring element is inserted into the cannula the zig-zag shaped bend of the longitudinal leg retains the implant within the cannula.Type: GrantFiled: April 23, 1999Date of Patent: June 20, 2006Assignee: Alza CorporationInventor: John R. Peery
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Patent number: 7048710Abstract: A system for facilitating hemostasis of a puncture site in a blood vessel injects an absorbable sponge pledget in a hydrated state at an exterior of the blood vessel puncture to facilitate hemostasis. The system includes a tract dilator for locating the puncture, an introducer, and a plunger. The introducer includes a staging chamber for receiving the absorbent sponge pledget and a delivery chamber having a diameter smaller than a diameter of the staging chamber into which a hydrated pledget passes. The pledget is hydrated and compressed within the introducer and then ejected with the plunger to the delivery site to facilitate hemostasis of the blood vessel puncture. The system delivers the absorbable sponge pledget over a guidewire to ensure the proper positioning of the pledget over the puncture. The implanted absorbable sponge once delivered expands rapidly to fill the target site and is absorbed by the body over time.Type: GrantFiled: July 11, 2000Date of Patent: May 23, 2006Assignee: Sub-Q, Inc.Inventors: Andrew H. Cragg, Rodney Brenneman, Mark Ashby
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Patent number: 7037323Abstract: A system for delivering hemostasis promoting material of the present invention allows the hemostasis promoting material to be delivered to a blood vessel puncture site by fluid pressure. The system allows the hemostasis promoting material to be delivered through an introducer sheath which is already in place within a tissue tract. This system includes a control tip which is insertable through the introducer sheath to locate and occlude the blood vessel puncture site and a hydration chamber for receiving and delivering the hemostasis promoting material to the blood vessel puncture site. The system accurately locates the blood vessel wall at a puncture site and for properly placing a hemostasis plug over the puncture site.Type: GrantFiled: December 9, 2003Date of Patent: May 2, 2006Assignee: Sub-Q, Inc.Inventors: Eduardo Chi Sing, Luis Urquidi, Mark Ashby, Andrew Cragg
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Patent number: 6964648Abstract: A disposable device for inserting one or more implants, the device including a tublar cannula (10) having a tip (11), the cannula also serving as a container for the implants, a plunger (20) and a handle (30) having a first end (31) directed towards the cannula, and a second end (32) directed away from the cannula. The plunger and handle are attached or attachable to each other in fixed manner, and the cannula is arranged to be movable in the longitudinal direction, so that the plunger is placed within. The cannula can, after inserting the implant or implants, be drawn on top of the plunger (20) so far that tip (11) becomes covered by handle (30) or by a piece connected to handle (30), and/or cannula (10) is, when drawn to its extreme position, towards second end (32) of handle (30), arranged to be irretrievably locked in relation to plunger (20).Type: GrantFiled: March 7, 2001Date of Patent: November 15, 2005Assignee: Schering OyInventors: Christine Talling, Esa Hallinen
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Patent number: 6964658Abstract: A system for facilitating hemostasis of a puncture site in a blood vessel delivers an absorbable sponge pledget in a hydrated state to a position at an exterior of the blood vessel puncture to facilitate hemostasis. The system includes a staging chamber, a delivery cannula, and a pusher. The staging chamber is used for hydrating a pledget of absorbable sponge, compressing the pledget, and delivering the pledget to the delivery cannula. The staging chamber may include a valve for facilitating hydration and staging of the pledget. The delivery cannula and pusher are used to accurately place the sponge pledget outside the blood vessel. An easy loader connector may be used to facilitate loading the dry pledget into the staging chamber.Type: GrantFiled: February 14, 2003Date of Patent: November 15, 2005Assignee: Sub-Q, Inc.Inventors: Mark Ashby, Luis R. Urquidi, Eric Lee
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Patent number: 6962574Abstract: A biological therapeutic delivery device is provided. In one preferred embodiment, the invention includes a device for effectuating localized tissue injury comprised of a resorbable body having at least one therapeutic agent and a retention device to anchor the agent within a tissue, the therapeutic agent being released into the tissue as the body resorbs. In an additional preferred embodiment, the invention includes a device for effectuating localized tissue injury comprised of a resorbable body having a cavity containing a therapeutic agent and a series of projections extending from the body to anchor the body in a tissue, the therapeutic agent being released into the tissue as the body resorbs.Type: GrantFiled: June 13, 2003Date of Patent: November 8, 2005Assignee: Biomet Manufacturing Corp.Inventors: Niles L. Noblitt, Richard Craig Blaschke
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Patent number: 6960183Abstract: A veterinary pill/capsule delivery device comprised of a dispensing head for holding a pill or capsule, the dispensing head being attached to the end of a syringe component for ejecting the pill or capsule out from the dispensing head into the animal's mouth while at the same time injecting a quantity of water into the mouth. The syringe component includes a push-rod that protrudes into dispensing head for ejecting the pill/capsule therefrom, plus water release holes near the dispensing head for simultaneously jetting water out of the syringe component into the animal's mouth, thereby compelling the animal to swallow the pill.Type: GrantFiled: December 2, 2003Date of Patent: November 1, 2005Inventor: Jon R. Nicolette
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Patent number: 6949107Abstract: A method of locating a vessel lumen to enable placement of a vascular hole closure device comprising the steps of providing a syringe containing a fluid therein, connecting the syringe to an elongated instrument, exerting a force on the syringe plunger as it is inserted through the tissue towards the vessel wall, and detecting movement of the syringe to eject the fluid to determine entry of the elongated instrument into the vessel lumen.Type: GrantFiled: June 27, 2003Date of Patent: September 27, 2005Assignee: Rex Medical, LPInventors: James F. McGuckin, Jr., Peter W. J. Hinchliffe, Richard T. Briganti, Walter H. Peters
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Patent number: 6949117Abstract: Implants and associated delivery systems for promoting angiogenesis in ischemic tissue are provided. The implants may be delivered percutaneously, thoracically or surgically and are particularly well suited for implantation into the myocardium of the heart. The implants are configured to have a first configuration having a low profile and an expanded, second configuration having a large profile. The implants are delivered to the ischemic tissue location in the first configuration, implanted then expanded to the second configuration. The expanded implants maintain a stress on the surrounding tissue, irritating and slightly injuring the tissue to provoke an injury response that results in angiogenesis. The flow of blood from the surrounding tissue into the implant and pooling of the blood in and around the implant leads to thrombosis and fibrin growth. This healing process leads to angiogenesis in the tissue surrounding the implant.Type: GrantFiled: January 29, 2004Date of Patent: September 27, 2005Assignee: C. R. Bard, Inc.Inventors: Richard A. Gambale, Stephen J. Forcucci, Michael F. Weiser, Richard T. Choh, Sean Forde
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Patent number: 6945952Abstract: A solid drug solution perforator (SSP) system and an associated drug reservoir are provided for delivering therapeutic, prophylactic and/or cosmetic compounds, for nutrient delivery and for drug targeting. For drug delivery, the SSP system includes an active drug ingredient and a matrix of perforator material that biodegrades or dissolves quickly upon contact with a patient's body. The SSP system provides a skin barrier perforator and a controller for prompt initiation and cut-off drug delivery. In a preferred method of transdermal drug delivery, an SSP system containing a selected drug penetrates into an epidermis or dermis, and the drug is promptly released from the (dissolving) SSP system perforator. An additional drug is optionally delivered from a patch reservoir through skin pores created by insertion of the perforator. Formulation and fabrication procedures for the SSP and associated reservoir are also provided. An SSP system can be fabricated with variety of shapes and dimensions.Type: GrantFiled: June 25, 2002Date of Patent: September 20, 2005Assignee: TheraJect, Inc.Inventor: Sung-Yun Kwon
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Patent number: 6939318Abstract: In one embodiment of the present invention a system for maneuvering an implant to a target site and deploying the implant at the target site is provided. This system includes an inner housing and an outer housing where the inner housing is slidable within the outer housing. The outer housing may have a working channel with a first end and a second end and a piercing jaw moveably coupled to the first end. The inner housing may have a working passage with a distal end and a proximal end, the distal end having a piercing jaw moveably coupled to it.Type: GrantFiled: December 5, 2001Date of Patent: September 6, 2005Assignee: Boston Scientific SciMed, Inc.Inventor: Eric B. Stenzel
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Patent number: 6840899Abstract: A surgical instrument includes an elongated cannula having a forward expulsion end and a rearward breach end, arranged to include a bio-compatible material; a drive member arranged to urge the bio-compatible material in a reciprocating motion having two alternating phases; and a directional brake disposed to contact the bio-compatible material. The directional brake has a preferred braking direction for resisting motion of the bio-compatible material. The preferred braking direction of the directional brake is oriented to resist retreat of said material during the retreating phase and to allow advance of said material during the advancing phase, thus producing a net advance of the material to expel it from the expulsion end. The directional brake is disposed nearer to the expulsion end than the breach end of the instrument, to prevent undesired axial compression of the bio-compatible material during ejection.Type: GrantFiled: August 29, 2002Date of Patent: January 11, 2005Assignee: Kinamed, Inc.Inventors: Margaret C. Koga, Mark Edward Apgar, William R. Pratt
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Patent number: 6835187Abstract: The technical field of the invention is that of needleless syringes used for injecting active principles in powder form for therapeutic purposes. The invention concerns a needleless syringe (1) comprising successively a gas generator (2), a gas expanding chamber (3), means for retaining active particles and an ejection tube (4). The invention is characterised in that the particle retaining means consists of an inner seal (14) having at least a cavity (15), the inner seal (14) serves both to contain the active principle and to generate a shock wave when it is ruptured.Type: GrantFiled: September 4, 2002Date of Patent: December 28, 2004Assignee: CrossjectInventors: Patrick Alexandre, Georges Baud, Philippe Gautier, Denis Roller
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Publication number: 20040243053Abstract: A hypodermic implant device, comprising a barrel; an upper piston segment engaged with an inner wall of the barrel; an axially aligned needle extendably distally out of the barrel for insertion into an object when the upper piston segment is moved distally within the body; a lower piston segment push rod in alignment with the needle, so that upon distal movement of the lower piston segment, the push rod moves distally through the needle expelling a releasable implant housed in the needle; and a means for retraction of the needle into a needle receptacle in the barrel.Type: ApplicationFiled: June 30, 2004Publication date: December 2, 2004Inventor: Stig O. Andersson
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Publication number: 20040215133Abstract: An apparatus and methods for delivering ocular implants or microimplants. The apparatus is ergonomically designed for ease of use, and a simple manual depression of an actuator produces proportional movement of a linkage causing the implant or microimplant to be ejected through a cannula disposed at the desired location in the eye. Small gauge cannulas are provided for self-sealing methods of delivery.Type: ApplicationFiled: May 24, 2004Publication date: October 28, 2004Applicant: ALLERGAN, INC.Inventors: David Weber, Ingrid Kane, Mike Rehal, Robert L. Lathrop, Kenny Aptekarev
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Patent number: 6802827Abstract: A hypodermic implant device, comprising a barrel; an upper piston segment engaged with an inner wall of the barrel; an axially aligned needle extendably distally out of the barrel for insertion into an object when the upper piston segment is moved distally within the body; a lower piston segment push rod in alignment with the needle, so that upon distal movement of the lower piston segment, the push rod moves distally through the needle expelling a releasable implant housed in the needle; and a means for retraction of the needle into a needle receptacle in the barrel.Type: GrantFiled: June 25, 2002Date of Patent: October 12, 2004Inventor: Stig O. Andersson
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Publication number: 20040087893Abstract: A solid drug solution perforator (SSP) system and an associated drug reservoir are provided for delivering therapeutic, prophylactic and/or cosmetic compounds, for nutrient delivery and for drug targeting. For drug delivery, the SSP system includes an active drug ingredient and a matrix of perforator material that biodegrades or dissolves quickly upon contact with a patient's body. The SSP system provides a skin barrier perforator and a controller for prompt initiation and cut-off drug delivery. In a preferred method of transdermal drug delivery, an SSP system containing a selected drug penetrates into an epidermis or dermis, and the drug is promptly released from the (dissolving) SSP system perforator. An additional drug is optionally delivered from a patch reservoir through skin pores created by insertion of the perforator. Formulation and fabrication procedures for the SSP and associated reservoir are also provided. An SSP system can be fabricated with variety of shapes and dimensions.Type: ApplicationFiled: June 25, 2002Publication date: May 6, 2004Inventor: Sung-Yun Kwon
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Publication number: 20040073151Abstract: A wound treatment apparatus is provided for treating tissue damage, which comprises a fluid impermeable wound cover sealed over a site for purposes of applying a reduced pressure to the site. The apparatus also includes a cover with protrusions on its surface for purposes of monitoring pressure at the site. An absorbable matrix may be placed in the site of a wound to encourage tissue growth into the matrix. Temperature of the site may be monitored using a layer of temperature sensitive material and temperature sensors connected to an alarm and recording device. A vacuum pump supplies suction within the wound cover over the treatment site. A portable version of the wound treatment apparatus is also provided. Finally, a method for treating wounds using reduced pressure is provided.Type: ApplicationFiled: August 28, 2003Publication date: April 15, 2004Inventor: Richard Scott Weston
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Patent number: 6712784Abstract: A drug delivery device includes an insert tube and an elongate plunger. The insert tube has a tubular wall that confines a passage and that has drug entrance and release ends. The drug release end has first and second radial parts, and is provided with a flexible grating that includes sets of first and second flexible strips. The first and second flexible strips extend from the first and second radial parts of the drug release end, respectively. The elongate plunger has a drug pushing end and an operating end, is slidably movable in the passage, and has a length sufficient to enable the drug pushing end to push a drug in the passage to move out of the passage and spread apart the first and second flexible strips for delivering the drug into a body cavity.Type: GrantFiled: February 20, 2002Date of Patent: March 30, 2004Inventor: Deborah Huang
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Patent number: 6706011Abstract: A drug delivery apparatus for dispensing predetermined volumes of drug, drug solution or other substances into an opening, such as a TMR channel in the human heart, or other laser treated area within the human body, the apparatus consisting of a bifurcated needle with a laser inlet for guiding a laser delivery means, such as an optical fiber or fiber bundle, to adjacent a surface of the human heart or other body structure for creating an opening, such as a TMR channel, or other laser treated area thereon. A drug inlet is for receiving the drug and transmitting the drug to the TMR channel or other laser treated area. Optionally, a piercing tip and/or suction device assists in positioning the apparatus adjacent the tissue to be treated. Drug is dispensed by manually or automatically actuating a piston or syringe element. A method of use is also disclosed.Type: GrantFiled: April 8, 1999Date of Patent: March 16, 2004Inventors: Douglas Murphy-Chutorian, Richard L. Mueller, Stuart D. Harman, Steve A. Daniel, Larry Witham, Bruce Richardson
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Patent number: 6692502Abstract: A process with special instruments to Arthroscopically reduce certain joint fractures in humans and animals. The instruments are shaped and sized so as to afford remote manipulation of bone fragments, while viewing the procedure with an arthroscope and a fluoroscope in a C Arm. The process utilizes a lateral approach. This process with the instruments allows a skilled surgeon to affect an anatomically correct joint surface and then bone graft any bone deficit, all through small incisions local to the joint.Type: GrantFiled: June 24, 1996Date of Patent: February 17, 2004Inventors: Janos Paul Ertl, Joseph John Spranza, III
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Patent number: 6669703Abstract: A vaginal suppository delivery device includes a pincer body having upper and lower clamp members that cooperate to confine a passage, a sleeve member, and a push rod. The clamp members have connecting and clamp end sections. The sleeve member is movable toward the connecting and clamp end sections of the clamp members so as to permit the clamp end sections to move away from and toward each other, thereby permitting a suppository to be disposed and clamped in a drug receiving groove in the passage. The push rod has an operating end that is operable so as to enable a drug pushing end to push the suppository to move out of the passage after the pincer body has been inserted into a vaginal cavity, thereby delivering the suppository into the vaginal cavity.Type: GrantFiled: February 20, 2002Date of Patent: December 30, 2003Inventor: Ming-Jeng Shue
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Patent number: 6648849Abstract: A system for injecting controlled release medicinal implants has a syringe-like injector body with a lumen and plunger. A needle is attached to the injector body and receives therein an injectable implant with an internal hollow. The implant is retained in the needle by friction, which is overcome by the plunger upon dispensing. As the plunger moves from the retracted position to the deployed position, it forces a medicament previously loaded into the injector body into the implant hollow and then pushes the implant out of the needle into the creature into which the needle has been inserted. The implant may contain a filler to absorb flowable medicaments to aid in their retention within the implant. As in known implants, the medicament is released gradually depending upon the dissolution rate of the implant body which is formed from a biodegradable material.Type: GrantFiled: June 27, 2001Date of Patent: November 18, 2003Assignee: Ethicon, Inc.Inventors: Kevor S. Tenhuisen, Joel Rosenblatt, John McAllen, III
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Publication number: 20030208153Abstract: In one embodiment of the present invention a system for maneuvering an implant to a target site and deploying the implant at the target site is provided. This system includes an inner housing and an outer housing where the inner housing is slidable within the outer housing. The outer housing may have a working channel with a first end and a second end and a piercing jaw moveably coupled to the first end. The inner housing may have a working passage with a distal end and a proximal end, the distal end having a piercing jaw moveably coupled to it.Type: ApplicationFiled: May 3, 2002Publication date: November 6, 2003Inventor: Eric B. Stenzel
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Publication number: 20030195527Abstract: The present invention relates to a system and method for the delivery of therapeutic agents, such as therapeutic drugs or genetic material, into the muscle or tissue that minimizes the loss of therapeutic agents due to contraction of the muscle. In one embodiment, an implant for delivering therapeutic agents into a muscle is provided, wherein the implant has at least one rod for insertion and delivery of therapeutic agents into the muscle and a patch that can be attached to the exterior surface of the muscle for preventing or minimizing therapeutic agent expelled due to the contraction of the muscle, such as the beating of a heart muscle.Type: ApplicationFiled: April 15, 2002Publication date: October 16, 2003Inventor: Michael N. Helmus
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Patent number: 6620162Abstract: An instrument for filling cavities in a body, such as a cavity within a reamed out spinal disc, with beads includes a cyclical agitator that functions to prompt the introduction of one bead at a time through the fill tube to prevent clogging and to promote compaction within the cavity.Type: GrantFiled: July 20, 2001Date of Patent: September 16, 2003Assignee: Spineology, Inc.Inventors: Stephen D. Kuslich, Francis Peterson, Joseph E. Gleason
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Patent number: 6616594Abstract: A cartridge is configured to be inserted into a medical instrument for treating patients with radioactive seeds. The cartridge includes a rotating internal barrel that is loaded with a plurality of seeds, where the internal barrel has a plurality of conduits for accepting the seeds. As the internal barrel rotates, a seed from one of the conduits is deposited into a shuttle, and then the shuttle is fully extended so as to provide the seed to the medical instrument. The shuttle is then retracted, and the barrel is rotated to the next conduit, so as to receive a seed from that next conduit. The cartridge includes a first shield and a second shield, each having slots where the slots of the first and second shields are aligned in a first verification or calibration mode, and where the slots are not aligned in a normal, seed depositing mode. The second shield also includes a plurality of numeric indicators that indicate a current number of seeds remaining in the cartridge.Type: GrantFiled: May 17, 2001Date of Patent: September 9, 2003Assignee: Integrated Implant Systems, L.L.C.Inventors: Diego Y. Fontayne, Daniel E. Ueda, Edward J. Kaplan, Steven S. Ravins, Ernest A. Elgin, III
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Publication number: 20030161824Abstract: The present invention provides a syringe and a hypodermic needle having both linear and arcuate segments for injecting bulking agents into soft tissue planes between an organ and surrounding sphincter muscle to treat undesired sphincter-related deficiencies such as stress urinary incontinence, anal incontinence and esophageal reflux. A penetration depth shield or guide may be added to the hypodermic needle to limit the penetration of the needle and aid in the proper positioning of the needle. In one embodiment, a method for injecting a bulking agent into the soft tissue plane between the urethra and surrounding sphincter muscle and/or proximal urethral submucosa by using a hypodermic needle having both linear and arcuate segments, a penetration depth shield and a syringe containing a bulking agent is provided. The bulking agent may comprise a plurality of discrete carbon coated substrate particles that are carried in a fluid and lubricative biocompatible medium.Type: ApplicationFiled: February 27, 2002Publication date: August 28, 2003Inventors: Raymond R. Rackley, Dean A. Klein, Kristina M. Wittchow
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Publication number: 20030158511Abstract: A vaginal suppository delivery device includes a pincer body having upper and lower clamp members that cooperate to confine a passage, a sleeve member, and a push rod. The clamp members have connecting and clamp end sections. The sleeve member is movable toward the connecting and clamp end sections of the clamp members so as to permit the clamp end sections to move away from and toward each other, thereby permitting a suppository to be disposed and clamped in a drug receiving groove in the passage. The push rod has an operating end that is operable so as to enable a drug pushing end to push the suppository to move out of the passage after the pincer body has been inserted into a vaginal cavity, thereby delivering the suppository into the vaginal cavity.Type: ApplicationFiled: February 20, 2002Publication date: August 21, 2003Inventor: Ming-Jeng Shue
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Patent number: 6599274Abstract: A cell delivery catheter having one of more apearutres is used to positon and deliver cells to an implant site in a patient.Type: GrantFiled: May 19, 2000Date of Patent: July 29, 2003Inventors: John Kucharczyk, George T. Gillies, William C. Broaddus, Helen L. Fillmore
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Patent number: 6589225Abstract: Methods, systems, and kits for subcutaneously implanting articles, such as drug inserts and reservoirs. The methods rely on percutaneously forming a tissue tract and radially dilating the tract to a diameter which permits introduction of the article. By fully expanding the lumenal diameter of the tissue tract prior to introduction of the article, damage to the article resulting from passage through a partially expanded tissue tract can be avoided. In the exemplary embodiment, a radially expandable sleeve is first percutaneously introduced to the subcutaneous target site. An assembly of a cannula and dilator is then passed through the sleeve, effecting radial expansion. The dilator is removed and the article is then introduced through a lumen of the cannula.Type: GrantFiled: March 30, 2001Date of Patent: July 8, 2003Assignee: Innerdyne, Inc.Inventors: Michael J. Orth, Mark C. Yang
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Publication number: 20030114799Abstract: An injection device for intramuscular or subcutaneous injection of solid or semi-solid medicaments is disclosed. The device includes main body member having a needle attached thereto. A protective sleeve covers the needle and retracts into the main body member when the device is pressed against the skin of a patient. A plunger with an attached rod maintains the medicament in the patient as the needle is withdrawn.Type: ApplicationFiled: September 26, 2002Publication date: June 19, 2003Inventor: Roland Cherif Cheikh
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Patent number: 6579256Abstract: An instrument for subretinal implantation comprising an elongate tube having a distal end and a proximal end, the tube having a lumen passing from the proximal end to the distal end, the distal end having a distal tip, wherein the lumen forms an opening in the tip, the instrument further including a plunger, the plunger being capable of sliding motion within and with respect to the tube, wherein the outer diameter of the distal end of the elongate tube is sufficiently small to be inserted through the pars plana area of an eye and the length of the distal end of the elongate tube is sufficient long to permit the opening in said tip to thereafter be inserted beneath the retina through an opening therein, wherein the plunger can express material within the lumen therefrom through the opening in the tip into the subretinal space of an eye into which the tip is inserted.Type: GrantFiled: October 4, 1999Date of Patent: June 17, 2003Assignee: Photogenesis, Inc.Inventor: Stephen E. Hughes
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Publication number: 20030104618Abstract: Surgical instruments, surgical techniques, grafts, cell and tissue isolation techniques, and a method for transplanting retinal cells, including photoreceptors, retinal pigment epithelium, and choroidea within their normal configuration, or all three tissues in a co-transplantation procedure are provided.Type: ApplicationFiled: December 17, 2002Publication date: June 5, 2003Applicant: Central Institute for the DeafInventor: Stephen E. Hughes