Abstract: A drug delivery device is provided comprising a container, a first product and a second product. The device is configured to mix the first product and the second product with each other within the container for forming a drug mixture. The device is further configured for dispensing the drug mixture. The device comprises a mixing member. The device is switchable from a first state, in which the first product and the second product are separated, into a second state, in which the first product and the second product are mixed. The mixing member is configured to exert a force onto the container in order to move the container to mix the first product and the second product with each other. Furthermore, a method for maintaining a predetermined property of a drug mixture to be dispensed from a drug delivery device is provided.

Abstract: A system and method provide for enhanced reliability and safety of programming and/or operating a medical device, such as an infusion pump, with a remote control device, such as a mobile phone (e.g., a smartphone). A safety processor acts as an intermediary device between the smartphone and medical device to review transmissions from the smartphone prior to the transmissions being delivered to the medical device. The safety processor can determine whether the smartphone is compatible with the medical device by checking the type and version of the smartphone as well as the versions of the operating software and/or firmware resident on the phone. The safety processor can also check whether the operating command entered into the smartphone is within acceptable parameters.

Abstract: An infusion pump comprises at least three operating layers. A first layer includes epicyclic gear means comprising a rotatable central gear, a stationary outer ring gear, and movable planet gears arranged between the central gear and the ring gear in movable engagement with the central and ring gears. A second layer includes roller bearing means comprising a stationary outer ring and a movable inner roller arrangement in movable arrangement with the outer ring and coupled with the epicyclic gear means to provide a rotational bearing for the central and planet gears. A third layer includes rotary peristaltic pump means comprising stationary flexible tubing which includes a bent portion having an essentially part-cycle form and a rotor having engagement elements to squeeze the bent portion during rotation for a pump action, wherein the rotor is coupled with the central gear to transfer torque from the central gear to the rotor.

Abstract: A fluid purging system has a spring-energized relief valve having an inlet port that is coupled to a fluid chamber to receive incoming fluid, and an outlet port through which incoming fluid is relieved. The outlet port is fluidly coupled to a pressurized chamber. The fluid purging system also includes an electro-mechanical pressure switch, and an electrically operated solenoid valve which functions as a pressure exhaust valve. The pressure switch and the solenoid valve are in fluid communication with the pressurized chamber.

Abstract: Devices, systems, and methods for reconditioning an intravascular device for reuse are provided. The method includes reading first security data from a memory of the intravascular device; determining if the intravascular device is authentic; generating second security data, when the intravascular device is authentic; and writing the second security data to the memory of the intravascular device. Devices, systems, and methods for authenticating an intravascular device for use are also provided.

Abstract: A micropump has a tube unit including a tube and a plurality of fingers, and a control unit including a cam. The tube unit is coupled to the control unit. The control unit encases the tube unit.

Abstract: A needleless injection system is provided to deliver therapeutic fluids to an internal treatment site in a patient, where the system is pressurized and is capable of compensating for differences in injection media viscosity and mechanical system characteristics. In one aspect, a needleless therapeutic fluid injection system is provided that includes modular, interchangeable components. In particular, the system includes a console that generally includes the electronic and/or hydraulic control components for the system, an injection chamber, and a shaft or catheter tube.

Abstract: A patient care system is configured for infusing fluid to a patient. The system includes a plurality of fluid infusion pumps, each of which is connected to a respective fluid supply for pumping the contents of a fluid supply to a patient via fluid supply lines. The system includes a pressure sensor downstream of the fluid infusion pumps for determining if a particular fluid is connected to a designated infusion pump.

Abstract: The systems, methods and apparatuses described herein provide a computing environment that manages private key storage. An apparatus according to the present disclosure may comprise a first non-volatile storage for storing a private root key for signing digital certificates, an input device for receiving manual input from an operator, a communication interface consisting of a one-way transmitter for transmitting information from the apparatus, and a processor. The processor may be configured to retrieve the private root key from the first non-volatile storage, receive information for a new digital certificate through the input device, generate the new digital certificate according to the received information, sign the new digital certificate using the private root key and transmit the new digital certificate from the apparatus using the transmitter.

Abstract: Systems and methods for automatically monitoring and controlling pressure in a body part are disclosed. The systems include an implantable tube with one open end of the tube implanted in the body part, an implantable valve coupled with the tube having at least one open state and a closed state, an implantable sensor for measuring pressure, and an implantable control device coupled with the sensor and the valve. The control device switches the valve between the at least one open state and the closed state, based on pressure information received from the sensor. When the valve is in the at least one open state, the tube drains fluids from the body part due to a difference of pressure between the open ends of the tube. Methods for using the systems to administer drugs and monitor and control fluid pressures in various biological systems are also disclosed.

Abstract: Apparatus are provided for motor control systems and related medical devices. In one embodiment, a control system includes a motor having a rotor, a modulation module coupled to the motor, and a control module coupled to the motor and the modulation module. The modulation module generates a modulated voltage that is applied to the motor, and the control module adjusts a duty cycle of the modulated voltage to achieve a commanded rotation of the rotor and detects a degradation condition based on the duty cycle.

Abstract: A method and apparatus for delivering intravenous drugs to a patient provides for remote loading and programming of IV pumps that may be shipped in a loaded and programmed configuration to a remote site for use with the patient. A special carrier may be provided for pneumatic delivery of the preloaded pump. Password enabled customizing of pump features according to specific user's need may be provided to prevent undesired changing of the pump parameters at the remote site.

Abstract: Apparatus are provided for motor control systems and related medical devices. In one embodiment, a control system includes a motor having a rotor, a sensor to obtain a measured displacement that is influenced by rotation of the rotor, and a control module coupled to the sensor. The control module adjusts a duty cycle for a modulated voltage applied to the motor in response to a difference between an expected displacement and the measured displacement. The expected displacement is influenced by or otherwise corresponds to a commanded rotation of the rotor.

Abstract: A medical treatment system, such as peritoneal dialysis system, may include control and other features to enhance patient comfort and ease of use. For example, a peritoneal dialysis system may include patient line state detector for detecting whether a patient line is primed before it is to be connected to the patient. The patient line state detector can also the ability to detect whether a patient line has been properly mounted for priming. Both patient line presence/absence and fill state can be determined using an optical system, e.g., one that employs a single optical sensor.

Abstract: Methods of treating a psychotic disorder include applying at least one stimulus to a stimulation site within a patient with an implanted stimulator in accordance with one or more stimulation parameters configured to treat the psychotic disorder. Systems for treating a psychotic disorder include a stimulator configured to apply at least one stimulus to a stimulation site within a patient in accordance with one or more stimulation parameters configured to treat the psychotic disorder.

Abstract: A method for ventilator suction management. The method includes accessing data associated with a patient, wherein the patient is associated with a ventilator; analyzing the data; and determining that suction is needed on the patient based on the analyzed data.

Abstract: A medicament delivery device (1) comprises a housing (2) for holding a medicament cartridge (9), a piston rod (22, 24) and a drive (11, 20). The medicament cartridge (9) has a medicament outlet and a bung (13) moveable axially along the medicament cartridge for dispensing a medicament, the piston rod has a plunger (24) for moving the bung and a lead member (22) telescopically coupled to the plunger (24) that may be driven by the drive (11, 20) to extend or retract the piston rod (22, 24). Additionally, the device comprises a linkage (40) coupled between the plunger (24) and an anchorage (44) and a drive member (20) telescopically coupled to the lead member (22). The drive (11) is operative to rotate the drive member (20) to telescopically move the lead member relative to the drive member whereby the plunger is moved relative to the lead member by way of the linkage (40).

Abstract: Apparatus are provided for motor control systems and related medical devices. In one embodiment, a control system includes a motor having a rotor, a modulation module coupled to the motor, and a control module coupled to the modulation module. The modulation module generates a modulated voltage that is applied to the motor and rotates the rotor to deliver fluid via a fluid path. The control module adjusts a duty cycle of the modulated voltage to achieve a commanded rotation of the rotor and detects an occlusion condition in the fluid path based on the duty cycle.

Abstract: There are cases where a fluid transport apparatus cannot accurately discharge a set discharge amount of fluid, due to individual differences in components of the fluid transport apparatus, such as the diameter of an opening of an elastic tube. Therefore, in a fluid transport apparatus including a fluid transport cartridge and a fluid transport driving unit that are separable from each other, the fluid transport driving unit comprises a driving section that causes a drive mechanism to operate to transport fluid filling a transport path of an attached fluid transport cartridge to a discharge opening of the transport path; a receiving section that receives a characteristic value measured in advance for each of a plurality of the fluid transport cartridges; and a control section that controls the driving section based on the characteristic values received by the receiving sections.

Abstract: Embodiments provide apparatus and methods for delivering solid form medications such as pellets to various locations in the body. One embodiment provides an apparatus for in vivo delivery of medication pellets comprising a first chamber including an opening; a second chamber substantially surrounding the first chamber, a carriage disposed in the first chamber, a mechanism for transferring the medication pellets from the first chamber to the second chamber and a pusher plate. The carriage can hold and dispense a plurality of medication pellets. Each pellet contains a selected dose of drug to treat a medical condition. A catheter is positioned in the second chamber. The catheter has a lumen sized for the pellet, a proximal end inside the chamber and a distal end extending through chamber opening to deliver the pellet to a delivery site. The pusher plate engages and advances the pellet though the catheter to the delivery site.

Abstract: The present Invention relates to an injection device capable of emitting a flashing light signal indicating the time elapsed since last ejection and/or the size of the last ejected dosage and/or a return signal indicating the operable state of the device and/or a time out signal indicating when the pen can be removed after ejecting of a dosage. The injection device comprises an electronic control circuit comprising: a sensor unit arranged to detect the occurrence of an ejection of a drug from the injection device; a timer for determining an approximate time elapsed since last ejection; a signal emitting device being able to emit a signal, the signal emitting device being controllable by the electric control circuit, so as to emit a time signal that varies with the time elapsed since last ejection.

Abstract: The present invention relates to a device and a method for monitoring a patient access, particularly for monitoring the venous vascular access in extracorporeal blood treatment where blood is withdrawn from the patient via a flexible arterial line which has an arterial needle or cannula, and provided to the patient via a flexible venous line which has a venous needle or cannula. The needle or cannula of the present invention is so designed that, due to the liquid flowing through the needle or cannula, air is drawn in if the needle or cannula is out of the vascular access, whereby sound is generated. A vascular access which is not in proper order is detected with great certainty and reliability by monitoring the surrounding environment for the occurrence of sound, particularly for the occurrence of the solid-borne sound which propagates along the flexible venous line of the extracorporeal blood circuit.

Abstract: A system and method of managing therapy provided to patients in an institution. The system monitors all aspects of the medication delivery to a patient, as well as other information related to the patient, such as values of vital signs, laboratory results and patient factors such as history, diagnosis, allergies and the like. The system includes one or more databases of information, including institutionally developed rules, guidelines and protocol representing the best medical practices of the institution. The system provides alerts and/or recommendations based on the application of the rules to the information being monitored, and alerts care givers accordingly, providing for dynamic adjustment of the patient's therapy. The system also monitors the status of the alerts, and if no action is taken in a selected period of time, may escalate the priority of the alert and/or halt the delivery of medication to the patient until the alert is resolved.

Abstract: A vehicle is provided that includes a vehicle navigation system, a dialysis machine, and an interface providing an electrical communication between the dialysis machine and the vehicle navigation system. The dialysis machine is configured to perform a dialysis treatment on a patient while the vehicle is operating. The vehicle can be a car, a train, a plane, or another vehicle.

Abstract: A patch-sized fluid delivery device may include a reusable portion and a disposable portion. The disposable portion may include components that come into contact with the fluid, while the reusable portion may include only components that do not come into contact with the fluid. Redundant systems, such as redundant controllers, power sources, motor actuators, and alarms, may be provided. Alternatively or additionally, certain components can be multi-functional, such a microphones and loudspeakers that may be used for both acoustic volume sensing and for other functions and a coil that may be used as both an inductive coupler for a battery recharger and an antenna for a wireless transceiver. Various types of network interfaces may be provided in order to allow for remote control and monitoring of the device.

Abstract: A wearable insulin dispensing device has features and operation characteristics supporting and easing compliance by the users of the device. For example, the device may provide capabilities of rendering a very specific and well-tuned dosage which may be altered according to the specific development of the individual user.

Abstract: Embodiments disclosed herein propose a precision spray pumping system including a positive displacement pump in fluid communication with at least one spray nozzle. The positive displacement pump includes a displaceable member, and displacement of the displaceable member corresponds to a pumping cycle of the positive displacement pump. A controller is in communication with the positive displacement pump. The controller is operable to apply an actuation parameter to direct a displacement of the displaceable member and is also operable to receive an indication of an actual position of the displaceable member. The controller is further operable to compare a predetermined actuation parameter associated with an expected displacement of the displaceable member to a measured actuation parameter associated with the actual position of the displaceable member.

Abstract: A lubrication device for lubricating a joint of a human or mammal patient, which is entirely implantable in a patient's body, comprises a reservoir for storing a lubricating fluid and a fluid connection for introducing the lubricating fluid into the joint when the device is implanted in the patient's body. Further, the fluid connection comprises a fluid connection device connecting the reservoir with the joint such that a lubricating fluid flow is established from the reservoir into the joint. The fluid connection comprises either an infusion needle adapted to be intermittently placed into the joint for injecting the lubricating fluid, or a tube adapted to be permanently placed into the joint for continuously injecting the lubricating fluid.

Abstract: A method of infusing a fluid includes receiving values of one or more infusion parameters for an infusion of a fluid. Based on the received infusion parameter values, an occlusion pressure threshold for the infusion of the fluid is automatically calculated. During the infusion, a fluid pressure value is sensed. An indication is provided responsive to whether a value of the sensed fluid pressure is greater than the occlusion pressure threshold.

Abstract: An apparatus for debridement of devitalized tissue in skin lesions, that includes a plurality of height- and angle-adjustable inlet tubes and at least one outlet tube and a member that forms an occlusive seal around a skin lesion. The plurality of inlet tubes is adapted for directing a continuous stream of enzymatic solution to the surface and into the entire volume of the wound bed of the lesion and the at least one outlet is adapted for removing the enzymatic solution, fluids draining from the lesion and tissue debris from the occluded skin lesion.

Abstract: Disclosed is a dispensing system. The dispensing system includes a dispensing unit to dispense therapeutic fluid, and a validation mechanism to enable operation of the dispensing unit based, at least in part, on a determination of whether operation of the dispensing device is authorized.

Abstract: An autonomous vehicle is provided that includes an autonomous vehicle control system, a dialysis machine, and an interface providing an electrical communication between the dialysis machine and the autonomous vehicle control system. The dialysis machine is configured to perform a dialysis treatment on a patient while the autonomous vehicle is under the control of the autonomous vehicle control system. A vehicle is also provided that includes a navigation system, a dialysis machine, and an interface between the navigation system and the dialysis machine. The vehicle can be a car, a train, a plane, or another vehicle.

Abstract: An autonomous vehicle is provided that includes an autonomous vehicle control system, a dialysis machine, and an interface providing an electrical communication between the dialysis machine and the autonomous vehicle control system. The dialysis machine is configured to perform a dialysis treatment on a patient while the autonomous vehicle is under the control of the autonomous vehicle control system. A vehicle is also provided that includes a navigation system, a dialysis machine, and an interface between the navigation system and the dialysis machine. The vehicle can be a car, a train, a plane, or another vehicle.

Abstract: A vehicle is provided that includes a vehicle navigation system, a dialysis machine, and an interface providing an electrical communication between the dialysis machine and the vehicle navigation system. The dialysis machine is configured to perform a dialysis treatment on a patient while the vehicle is operating. The vehicle can be a car, a train, a plane, or another vehicle.

Abstract: A holographic occlusion detection system has a holographic label placed onto a sensing portion of a pressure sensor connected to infusion tubing. The sensor at the sensing portion can have a relatively thin wall section and may be wider and flatter than a normal cross section of the tubing. The label is then illuminated by a polychromatic light source, and the light reflected off the holographic label is then received by a photodetector. Pressure changes within the tubing cause a change in orientation of the holographic label, thereby resulting in a shift in the peak wavelength of the light sensed by the photodetector. This wavelength shift can then be calibrated to the swelling of the sensing portion so that pressure within the line can be calculated. In another variation, monochromatic light is reflected off a holographic label, and pressure changes are detected by measuring the amplitude of the reflected light.

Abstract: The invention provides various devices for delivering Glucagon-Like Peptide-1 (7-36), in various infusion patterns and rates, to optimally stimulate carbohydrate metabolism, to inhibit gastropancreatic secretion and gastric motility, and to treat various disease conditions (including diabete) as described in the instant specification. The devices and methods of the invention provide various ways to deliver doses (escalating, constant, on demand, etc.) of GLP-1 in response to different patient need.

Abstract: A pump operations module having a base function includes only base function programming in the module itself but is configured to receive advanced delivery programs in a buffer for execution autonomously. An advanced interface module (AIM) is used to prepare advanced delivery programs and upload them to one or more delivery modules as well as monitor the performance of those modules. However, the advanced interface module does not control the execution of those advanced delivery programs by the pump operations modules. The AIM includes a touch screen and access to drug libraries. The AIM will generate graphical slide controls on the touch screen with the minimum and maximum values on the touch screen for the user to create an advanced delivery program for upload, to greatly lessen the risk of errors. Support for PK applications is provided.

Abstract: An intravenous (“IV”) liquid delivery system includes: an IV pump tubing set; a shuttle pump or membrane pump actuator operable with the IV pump tubing set; upstream and downstream valve actuators operable with the IV pump tubing set; the IV pump tubing set including an air removal device; an air detector configured to sense air in the IV pump tubing set; a control unit configured and arranged to (i) open the upstream valve actuator and close the downstream valve actuator to allow the pump actuator to draw liquid into a pump actuation portion of the IV pump tubing set, and (ii) close the upstream valve actuator and open the downstream valve actuator to allow the pump actuator to push liquid out of the pump actuation portion, the system configured to attempt to remove the air via the air removal device while operating the upstream and downstream valve actuators according to (i) and (ii).

Abstract: An autonomous vehicle is provided that includes an autonomous vehicle control system, a dialysis machine, and an interface providing an electrical communication between the dialysis machine and the autonomous vehicle control system. The dialysis machine is configured to perform a dialysis treatment on a patient while the autonomous vehicle is under the control of the autonomous vehicle control system. A vehicle is also provided that includes a navigation system, a dialysis machine, and an interface between the navigation system and the dialysis machine. The vehicle can be a car, a train, a plane, or another vehicle.

Abstract: Presently disclosed is a hydraulic pump device and its use thereof, especially in a fluid delivery system. In one embodiment, the fluid delivery system is an inexpensive, single-use device for slow dosing medicament applications. The fluid delivery system may employ a spring-compressed bellows crank or other combination of simple mechanisms operating according to the well-known peristaltic principle to force a volume of ultrapure bio-inert hydraulic fluid through an aperture, thereby expanding one chamber of a two chamber hydraulic cylinder. The second, fluid storage chamber, containing the medicament, is emptied through a conventional orifice in response to the expansion of the pump chamber. The medicament may then flow through any suitable infusion set into a patient removeably attached thereto.

Abstract: The present invention relates to a fluid-controlling device (10) for incorporation into a microchip (100). The fluid-controlling device (10) of the present invention includes: a glass substrate (1b) having a hollow part (3) provided therein, the hollow part (3) having a first opening (3?) extending to a top surface of the glass substrate (1b) and a second opening (4) extending to a bottom surface of the glass substrate (1b); and a glass sheet (2) being 1 to 50 ?m in thickness and sealing the first opening (3?), the glass sheet (2) changing a volume of the hollow part (3) when a position of the glass sheet (2) is displaced by and according to a pressing force applied toward the hollow part (3). With use of the present invention, it is possible to provide a versatile microchip system being usable under a high pressure and being usable with an organic solvent.

Abstract: Systems for use with a medical device for reducing medication errors are provided. In one aspect, a system includes a medical device that is configurable with operating limit parameters for providing medication to a patient, and a limiting system. The limiting system includes a memory that includes patient-specific information for the patient and a database includes acceptable operating parameters for providing the medication to the patient using the medical device, and a processor. The processor is configured to compare the acceptable operating parameters with the patient-specific information, and provide a modification of the operating limit parameters for providing the medication to the patient based on the comparison of the acceptable operating parameters with the patient-specific information. Methods and machine-readable media are also provided.

Abstract: There is proposed a lubricant system having a plurality of motor-driven pumps operating in parallel as main oil pumps, wherein even if at least one of the main oil pumps stops, the other normally operating main oil pumps do not stop due to overload of a motor. A lubricant system 7 comprises a hydraulic pressure piping 9, a plurality of lubricant pumps 10 arranged in parallel, a plurality of AC motors 11 driving each of the lubricant pumps 10, an error detector 24 detecting a presence or absence of an error in an operating state of each of the AC motors 11, a pressure loss addition unit 25 configured to increase pressure loss in the hydraulic pressure piping 9, and a controller 26 causing the pressure loss addition unit 25 to increase pressure loss when the error detector 24 detects an error in at least one of the AC motors 11.

Abstract: A disease management system, methods, and devices are shown and described. In one embodiment, the system includes an infusion pump and a remote controller with the ability to be paired to each other. A method to verify a wireless connection between an infusion pump and a remote controller is shown and described herein. In a further embodiment, a method to verify a wireless connection between an infusion pump and a remote controller is provided. In addition, a method of operating a diabetes management system is provided in which the system includes an infusion pump and at least a remote controller.

Abstract: Described herein are systems and methods for determining the location, composition and concentration of a hydrocarbon containing plume in environmental seawater. These systems and methods disclosed use multiple complex admittance measurements from seawater in order to identify the contents, concentration, and location of the hydrocarbon containing plume. In preferred variations system includes a sensor array that substantially simultaneously records plume location, depth, and composition.

Abstract: A power injector (40) includes a movable ram (74) operable to interface with and move a plunger (90a/b) of a syringe (86a/b). The power injector (40) may be operable to automatically determine a proper home position for a particular type of the syringe (86a/b) to be used in a fluid injection sequence. The power injector (40) may also include a ram homing logic (182) operable to automatically move the ram (74) to the home position after the injection sequence. Such automatic homing of the ram (74) may, for example, be initiated by an end of the injection sequence in preparation for another injection sequence, by opening of a faceplate (102a/b), by a user input, or by any combination thereof.

Abstract: A system and method for use in surgical procedures. The system includes an endoscope, an imaging device coupled to the endoscope, an imaging processor coupled to the imaging device, and at least one management system coupled to the imaging processor, in which a function of the management system is automatically adjusted upon receipt of a communication from the imaging processor.

Abstract: A system and method determine when fluid is not flowing properly from a secondary infusion source during a secondary infusion. The system includes an upstream pressure sensor and a processor programmed to receive signals from the sensor and analyze the signals to determine if secondary fluid flow is proper. The processor samples the output signals from the upstream pressure sensor and analyzes the sampled signals to determine if a pressure rise in the infusion line has occurred when the secondary infusion is initiated. If a pressure rise, indicating that fluid from the secondary container has begun flowing into the infusion line, has not been detected, the processor is programmed to provide a signal indicating that attention should be given to the infusion set up.

Abstract: A medication delivery apparatus for use with a medication container includes a housing, a fluid conduit at least partially extending within the housing and configured to deliver medication within the medication container to a patient, a medication port extending from the housing and configured to be coupled to a fluid outlet of the medication container, the medication port being fluidically coupled to the fluid conduit, and at least one sensor disposed within the housing to generate information characterizing administration of the medication for processing by a remote data collection system. The housing can have a size and shape that enables it to be supported by a first hand of a user while the user administers the medication from the medication container via the medication port using a second hand of the user. Related apparatus, systems, and techniques are also described.

Abstract: A fluid medicament delivery device includes a patient attachment unit and a separate indicator unit. The patient attachment unit includes a housing and a fluid channel located therein, wherein at least a portion of the fluid channel includes a flexible member substantially coterminous with the housing. The separate indicator unit is adapted to be detachably coupled to the housing of the patient attachment unit and includes a first sensing element for contacting the flexible member when the indicator unit is coupled to the housing to sense a flexure of the flexible member.