Abstract: The present invention provides an infusion-patch comprising; a cannula; a base; at least one adhesive region in said base suitable for skin attachment; at least one skin-access area within said base; and at least one conduit in fluid connection with said at least one skin access area, wherein said at least one conduit in fluid connection with said at least one skin access area facilitates the transfer of an anesthetic substance within at least a first anesthetic-reservoir which may be removably attached and in fluid connection with said at least one contact area, promoting delivery of said anesthetic substance to said at least one skin-access areas, and wherein said anesthetic substance delivered to said skin-access areas may be at least partially replenished without removing said infusion-patch.

Abstract: Devices, systems, and methods for reconditioning an intravascular device for reuse are provided. The method includes reading first security data from a memory of the intravascular device; determining if the intravascular device is authentic; generating second security data, when the intravascular device is authentic; and writing the second security data to the memory of the intravascular device. Devices, systems, and methods for authenticating an intravascular device for use are also provided.

Abstract: The present invention relates to a radiopharmaceutical distribution device. Thus, the present invention provides the radiopharmaceutical distribution device comprising: a vial for storing an object selected from radiopharmaceuticals or radioactive isotopes; an object supply unit which checks radioactivity by extracting the object stored inside the vial as much as a set amount so as to temporarily store or discharge the same, and which measures radioactivity of the residual object of the discharged object; a saline solution supply unit which is selectively communicated with the object supply unit so as to discharge a saline solution that is to be mixed with the extracted object; and an injection part for storing the object having a specific radioactivity and discharged from the object supply unit and the saline solution of a set volume discharged from the saline solution supply unit in a mixed state.

Abstract: A flow sensor is provided to enable volumetric dose data to be acquired automatically by sampling flow rates of insulin measured by a flow sensor exposed to a flow manifold though which the insulin flows. The flow sensor preferably connects to a standard insulin pen on one end, and to a standard pen needle on the other end. Particular geometries and algorithms are utilized to accommodate the unique requirements of insulin flow determination during an injection event.

Abstract: Drive mechanism for a drug delivery device is disclosed. The drive mechanism includes an elongated housing extending in an axial direction. It includes a piston rod that operably engages with a piston of a cartridge to displace the piston in an axial distal direction. It includes a first dose indicating member that is rotatably supported on a longitudinal axis. It includes a second dose indicating member axially adjacent to the first dose indicating member and rotatably supported on the longitudinal axis. It includes a dose setting sleeve extending in an axial direction, rotatably engaged with the first dose indicating member and axially extending through the first dose indicating member to rotatably engage with the second dose indicating member.

Abstract: Illustrative embodiments of positive displacement pumps utilizing pressure compensating calibration, as well as related systems and methods, are disclosed. In one illustrative embodiment, a method of operating a positive displacement pump includes sensing, with a pressure sensor disposed at a fluid outlet of the positive displacement pump, a back pressure at the fluid outlet, transmitting a pressure signal associated with the sensed back pressure from the pressure sensor to a controller of the positive displacement pump, and identifying, on the controller, a volume of fluid pumped by the positive displacement pump using the pressure signal.

Abstract: An infusion pump includes: a main body; a tube attachment section inside the main body; a liquid feed driving unit inside the main body; an access cover mounted on the main body and for covering the infusion tube when the infusion tube is attached to the tube attachment section when closed; and a bubble detection unit for detecting a bubble inside the infusion tube when the infusion tube is attached to the tube attachment section. The bubble detection unit includes a first member at the access cover and a second member at the main body.

Abstract: In a method for adjusting a fluid control apparatus, in a pressing step, a piezoelectric pump is placed on a stage with a cover plate facing upward, the stage is moved up, and a center portion of a principal surface of the cover plate on a side opposite to a diaphragm is pressed with a pressing pin. As a result, the cover plate and the base plate are shaped so as to warp convexly toward the diaphragm side, and a portion joined to a flexible plate is pulled, such that the flexible plate is caused to warp convexly toward the diaphragm side. Thus, residual tensile stress occurs in a movable portion of the flexible plate. Therefore, due to the residual tensile stress, the tensile stress of the movable portion of the flexible plate is increased.

Abstract: An automatic injection apparatus uses non-continuous fluid-flow of drugs to identify an intended injection site and includes a drive mechanism, a sensor and a controller for establishing fluid flow and pressure and preventing fluid flow until the pressure drops below a predetermined threshold. The pressure threshold is determined based on an internal pressure generated during an injection and more fluid will not flow until it drops below a predetermined pressure. An injection is performed to establish an initial pressure threshold and then to stop the fluid flow into a patient until the pressure drops below a predetermined pressure which allows fluid flow to resume, thus identifying a fluid filled tissue space. The initial pressure threshold is used as a control parameter to a microprocessor below which controls the rate of injection. Fluid flows below certain pressures are also used to identify a specific location within the body during injections.

Abstract: Method and apparatus for providing a data stream generator that generates a data stream associated with a monitored analyte level, and a radio frequency logic portion operatively coupled to the data stream generator, the radio frequency logic portion configured to generate a radio frequency data stream based on the data stream generated from the data stream generator, the radio frequency logic portion further including one or more finite state machines and a plurality of discrete digital logic circuits, the one or more finite state machines configured to control the plurality of digital logic circuits to generate the radio frequency data stream for wireless communication are provided. Systems and kits incorporating the same are also provided.

Abstract: Infusion channel identifiers are generated and used that identify infusion channels transporting medication from an infusion pump to a patient. The infusion pump includes a user interface device, a controller, and at least one infusion device. At a first user interface of the user interface device, data associated with an infusion channel is received. Based on the data, the controller generates an infusion channel identifier identifying the infusion channel. On the first user interface, the infusion channel identifier is displayed. At a second user interface of the user interface device, the infusion channel identifier, a beginning time of a desired provision of the medication to the patient, and a time duration of the desired provision is received. The controller actuates the infusion device and the infusion channel at the beginning time for the time duration. The infusion device delivers, via the infusion channel, the medication to the patient.

Abstract: A method includes receiving data regarding a catheter being used with the infusion device. The catheter has a lumen operably coupled to a reservoir of the infusion device and is configured to deliver fluid from the infusion device to a target location of a patient. The method further includes infusing fluid from the reservoir into the lumen of the catheter at a first rate and monitoring pressure via a pressure sensor in communication with the lumen of the catheter. Monitoring the pressure includes acquiring pressure data from the pressure sensor at a first frequency. The method also includes (i) determining whether the monitored pressure exceeds a first threshold, wherein the first threshold is based on the data regarding the catheter; and (ii) decreasing the rate at which the fluid is delivered from the reservoir into the catheter if the monitored pressure is determined to exceed the threshold.

Abstract: Safe and effective exercise poses a specific set of challenges for subjects diagnosed with diabetes. These challenges include the coordination of exercise with blood glucose monitoring and insulin administration. Failure to coordinate these factors effectively can lead to various pathologies related to aberrant blood glucose levels. Presented herein are methods, systems, algorithms, computer program products, and computer-executable code for exercise guidance and instruction specific to diabetes relief and management. The approaches as disclosed herein can help ameliorate, slow, or reduce a likelihood of developing a diabetic condition.

Abstract: Access devices may receive signals over a network and calculate a frequency spectrum of the received signals. An analyzer system may collect the frequency spectrum data from multiple access devices, and based on the collected data, detect, identify, and locate sources of anomalies in a communication network.

Abstract: A selective aortic balloon device includes a catheter comprising an open distal end configured to be inserted into a body cavity or vessel, and a plurality of adjustable port regions with inflatable balloons between adjacent adjustable port regions. Each adjustable port region is configured to move between a closed position and an open position to selectively allow fluid flow to enter the catheter through the open distal end and to exit the catheter through one or more of the plurality of adjustable port regions depending on an inflation pattern of the inflatable balloons.

Abstract: A drug delivery system is provided. The drug delivery apparatus including at least one sensor configured to detect at least one of a drug delivery parameter and patient data and a portable communication device communicatively coupled to the drug delivery apparatus. The portable communication device includes an input device configured to receive data from the drug delivery apparatus, wherein the data includes at least one of a drug delivery parameter and patient data and an output device coupled to the input device and configured to display the received data.

Abstract: The disclosure is directed to a pressure sensor of an implantable medical device. The pressure sensor may utilize detect fluid pressure based on a changing capacitance between two capacitive elements. The pressure sensor may define at least a portion of a fluid enclosure of the IMD. In one example, the pressure sensor has a self-aligning housing shape that occludes an opening in the pump bulkhead of the IMD. An operative surface of the pressure and the portion of the fluid enclosure may be formed of a corrosion resistant and/or biocompatible material. A first capacitive element of the pressure sensor may be a metal alloy diaphragm that deflects in response to external fluid pressure. A second capacitive element of the pressure sensor may be a metal coating on a rigid insulator sealed from the fluid by the diaphragm and a housing of the sensor.

Abstract: One aspect of the present disclosure includes a closed-loop therapy delivery system for regulating an endogenous level of a first neuromodulatory agent in a subject. The therapy delivery system includes a sensing component, a delivery component, and a controller. The sensing component is configured to detect an extracellular level of the first neuromodulatory agent. The delivery component is configured to deliver an amount of a second neuromodulatory agent to an intraparenchymal target site of the subject. The controller is configured to coordinate operation of the sensing component and the delivery component.

Abstract: Techniques are disclosed for permitting a person to keylessly start a vehicle using a machine-sensible item such as his/her mobile device without requiring the person to possess a smart key.

Abstract: Method and apparatus for providing a data stream generator that generates a data stream associated with a monitored analyte level, and a radio frequency logic portion operatively coupled to the data stream generator, the radio frequency logic portion configured to generate a radio frequency data stream based on the data stream generated from the data stream generator, the radio frequency logic portion further including one or more finite state machines and a plurality of discrete digital logic circuits, the one or more finite state machines configured to control the plurality of digital logic circuits to generate the radio frequency data stream for wireless communication are provided. Systems and kits incorporating the same are also provided.

Abstract: A controller for a programmable medical pump comprises a memory including a plurality of preloaded infusion therapies, each preloaded infusion therapy including a plurality of program parameters. The controller also includes a device receiving a selection of one of the preloaded infusion therapies, profile data corresponding to a specific patient, and values for the program parameters. The controller further includes a processor configured to determine which of the plurality of program parameters to associate with the selected preloaded infusion therapy, determine limits for the associated program parameters based upon the selected preloaded infusion therapy and the profile data, determine if the received values of program parameters exceed the determined limits, and responsive to determining that the values of the program parameters are within the determined limits, cause the selected preloaded infusion therapy to be administered via the medical pump using the received values for the program parameters.

Abstract: Described is drug infusion device and lineset for delivering medication. The novel pump and lineset described herein eliminate the ability of the pump and lineset from being primed when the cartridge reservoir is in fluid communication with the drug-delivering cannula, through which medication is delivered, is inserted into the skin of a patient. The system and method of the invention include a lineset having a plurality of electrical leads for allowing electrical communication between the infusion pump and the infusion set and for allowing the pump to determine whether the lineset is connected to the infusion set when a priming operation is initiated.

Abstract: An implantable medical device for implantation in a mammal joint having at least two contacting surfaces is provided. The medical device comprises; an artificial contacting surface adapted to replace at least the surface of at least one of the mammal's joint contacting surfaces, wherein the artificial contacting surface is adapted to be lubricated, when implanted in said joint. Furthermore the medical device comprises at least one inlet adapted to receive a lubricating fluid from a reservoir, at least one channel at least partly integrated in the artificial contacting surface in connection with the at least one inlet for distributing the lubricating fluid to the surface of the artificial contacting surface. The medical device could be adapted to be operable by an operation device to receive the distributed lubricated fluid from a reservoir.

Abstract: This invention relates to an ingestible drug delivery device configured for wireless communication with other ingestible drug delivery devices.

Abstract: A conductivity sensor is described in which electrodes are held in a desired position within a housing of the sensor by a number of slots accurately positioned within the housing. In one embodiment the slots are integrally formed within the housing. Once the electrodes have been inserted into the slots a thermoset resin is poured into the housing and cured. A through bore is then drilled through the housing, the electrodes and the cured resin to form a flow conduit through the sensor. A dual frequency excitation technique is also described that allows a measurement to be obtained of a polarization resistance of the electrodes. In one embodiment this measurement is stored and used to correct subsequent conductivity measurements.

Abstract: A system for detecting and removing a gas bubble from a vascular infusion line, comprising a disposable cassette adapted for disposition intermediate the fluid line, the disposable cassette comprising a body comprising an inlet port, a chamber, an outlet port, and a purge port, a first passageway connecting the inlet port to the chamber, the first passageway comprising a first bubble detection section where a gas bubble may be detected within the first passageway, a second passageway connecting the chamber with the outlet port, and a first pinch valve disposed along the second passageway intermediate the chamber and the outlet port, and a third passageway connecting the chamber with the purge port, the third passageway comprising a second bubble detection section where a gas bubble may be detected within the third passageway, and a second pinch valve disposed along the third passageway intermediate the chamber and the bubble detection section.

Abstract: Disclosed are methods, systems, devices and articles, including method for adaptive wireless communication transmissions between units of an ambulatory portable medical device. The method includes obtaining data relating to wireless transmissions between the units of the medical device, and setting one or more attributes of wireless transmission of one or more messages between the units of the medical device based, at least in part, on the obtained data.

Abstract: An infusion pump system includes an infusion channel, and a display associated with the infusion channel. The display is for rendering a scannable barcode.

Abstract: A drug delivery device is provided comprising a container, a first product and a second product. The device is configured to mix the first product and the second product with each other within the container for forming a drug mixture. The device is further configured for dispensing the drug mixture. The device comprises a mixing member. The device is switchable from a first state, in which the first product and the second product are separated, into a second state, in which the first product and the second product are mixed. The mixing member is configured to exert a force onto the container in order to move the container to mix the first product and the second product with each other. Furthermore, a method for maintaining a predetermined property of a drug mixture to be dispensed from a drug delivery device is provided.

Abstract: A system and method provide for enhanced reliability and safety of programming and/or operating a medical device, such as an infusion pump, with a remote control device, such as a mobile phone (e.g., a smartphone). A safety processor acts as an intermediary device between the smartphone and medical device to review transmissions from the smartphone prior to the transmissions being delivered to the medical device. The safety processor can determine whether the smartphone is compatible with the medical device by checking the type and version of the smartphone as well as the versions of the operating software and/or firmware resident on the phone. The safety processor can also check whether the operating command entered into the smartphone is within acceptable parameters.

Abstract: A fluid purging system has a spring-energized relief valve having an inlet port that is coupled to a fluid chamber to receive incoming fluid, and an outlet port through which incoming fluid is relieved. The outlet port is fluidly coupled to a pressurized chamber. The fluid purging system also includes an electro-mechanical pressure switch, and an electrically operated solenoid valve which functions as a pressure exhaust valve. The pressure switch and the solenoid valve are in fluid communication with the pressurized chamber.

Abstract: An infusion pump comprises at least three operating layers. A first layer includes epicyclic gear means comprising a rotatable central gear, a stationary outer ring gear, and movable planet gears arranged between the central gear and the ring gear in movable engagement with the central and ring gears. A second layer includes roller bearing means comprising a stationary outer ring and a movable inner roller arrangement in movable arrangement with the outer ring and coupled with the epicyclic gear means to provide a rotational bearing for the central and planet gears. A third layer includes rotary peristaltic pump means comprising stationary flexible tubing which includes a bent portion having an essentially part-cycle form and a rotor having engagement elements to squeeze the bent portion during rotation for a pump action, wherein the rotor is coupled with the central gear to transfer torque from the central gear to the rotor.

Abstract: Devices, systems, and methods for reconditioning an intravascular device for reuse are provided. The method includes reading first security data from a memory of the intravascular device; determining if the intravascular device is authentic; generating second security data, when the intravascular device is authentic; and writing the second security data to the memory of the intravascular device. Devices, systems, and methods for authenticating an intravascular device for use are also provided.

Abstract: A micropump has a tube unit including a tube and a plurality of fingers, and a control unit including a cam. The tube unit is coupled to the control unit. The control unit encases the tube unit.

Abstract: A needleless injection system is provided to deliver therapeutic fluids to an internal treatment site in a patient, where the system is pressurized and is capable of compensating for differences in injection media viscosity and mechanical system characteristics. In one aspect, a needleless therapeutic fluid injection system is provided that includes modular, interchangeable components. In particular, the system includes a console that generally includes the electronic and/or hydraulic control components for the system, an injection chamber, and a shaft or catheter tube.

Abstract: A patient care system is configured for infusing fluid to a patient. The system includes a plurality of fluid infusion pumps, each of which is connected to a respective fluid supply for pumping the contents of a fluid supply to a patient via fluid supply lines. The system includes a pressure sensor downstream of the fluid infusion pumps for determining if a particular fluid is connected to a designated infusion pump.

Abstract: The systems, methods and apparatuses described herein provide a computing environment that manages private key storage. An apparatus according to the present disclosure may comprise a first non-volatile storage for storing a private root key for signing digital certificates, an input device for receiving manual input from an operator, a communication interface consisting of a one-way transmitter for transmitting information from the apparatus, and a processor. The processor may be configured to retrieve the private root key from the first non-volatile storage, receive information for a new digital certificate through the input device, generate the new digital certificate according to the received information, sign the new digital certificate using the private root key and transmit the new digital certificate from the apparatus using the transmitter.

Abstract: Systems and methods for automatically monitoring and controlling pressure in a body part are disclosed. The systems include an implantable tube with one open end of the tube implanted in the body part, an implantable valve coupled with the tube having at least one open state and a closed state, an implantable sensor for measuring pressure, and an implantable control device coupled with the sensor and the valve. The control device switches the valve between the at least one open state and the closed state, based on pressure information received from the sensor. When the valve is in the at least one open state, the tube drains fluids from the body part due to a difference of pressure between the open ends of the tube. Methods for using the systems to administer drugs and monitor and control fluid pressures in various biological systems are also disclosed.

Abstract: Apparatus are provided for motor control systems and related medical devices. In one embodiment, a control system includes a motor having a rotor, a modulation module coupled to the motor, and a control module coupled to the motor and the modulation module. The modulation module generates a modulated voltage that is applied to the motor, and the control module adjusts a duty cycle of the modulated voltage to achieve a commanded rotation of the rotor and detects a degradation condition based on the duty cycle.

Abstract: Apparatus are provided for motor control systems and related medical devices. In one embodiment, a control system includes a motor having a rotor, a sensor to obtain a measured displacement that is influenced by rotation of the rotor, and a control module coupled to the sensor. The control module adjusts a duty cycle for a modulated voltage applied to the motor in response to a difference between an expected displacement and the measured displacement. The expected displacement is influenced by or otherwise corresponds to a commanded rotation of the rotor.

Abstract: A method and apparatus for delivering intravenous drugs to a patient provides for remote loading and programming of IV pumps that may be shipped in a loaded and programmed configuration to a remote site for use with the patient. A special carrier may be provided for pneumatic delivery of the preloaded pump. Password enabled customizing of pump features according to specific user's need may be provided to prevent undesired changing of the pump parameters at the remote site.

Abstract: A medical treatment system, such as peritoneal dialysis system, may include control and other features to enhance patient comfort and ease of use. For example, a peritoneal dialysis system may include patient line state detector for detecting whether a patient line is primed before it is to be connected to the patient. The patient line state detector can also the ability to detect whether a patient line has been properly mounted for priming. Both patient line presence/absence and fill state can be determined using an optical system, e.g., one that employs a single optical sensor.

Abstract: A method for ventilator suction management. The method includes accessing data associated with a patient, wherein the patient is associated with a ventilator; analyzing the data; and determining that suction is needed on the patient based on the analyzed data.

Abstract: Methods of treating a psychotic disorder include applying at least one stimulus to a stimulation site within a patient with an implanted stimulator in accordance with one or more stimulation parameters configured to treat the psychotic disorder. Systems for treating a psychotic disorder include a stimulator configured to apply at least one stimulus to a stimulation site within a patient in accordance with one or more stimulation parameters configured to treat the psychotic disorder.

Abstract: A medicament delivery device (1) comprises a housing (2) for holding a medicament cartridge (9), a piston rod (22, 24) and a drive (11, 20). The medicament cartridge (9) has a medicament outlet and a bung (13) moveable axially along the medicament cartridge for dispensing a medicament, the piston rod has a plunger (24) for moving the bung and a lead member (22) telescopically coupled to the plunger (24) that may be driven by the drive (11, 20) to extend or retract the piston rod (22, 24). Additionally, the device comprises a linkage (40) coupled between the plunger (24) and an anchorage (44) and a drive member (20) telescopically coupled to the lead member (22). The drive (11) is operative to rotate the drive member (20) to telescopically move the lead member relative to the drive member whereby the plunger is moved relative to the lead member by way of the linkage (40).

Abstract: Apparatus are provided for motor control systems and related medical devices. In one embodiment, a control system includes a motor having a rotor, a modulation module coupled to the motor, and a control module coupled to the modulation module. The modulation module generates a modulated voltage that is applied to the motor and rotates the rotor to deliver fluid via a fluid path. The control module adjusts a duty cycle of the modulated voltage to achieve a commanded rotation of the rotor and detects an occlusion condition in the fluid path based on the duty cycle.

Abstract: Embodiments provide apparatus and methods for delivering solid form medications such as pellets to various locations in the body. One embodiment provides an apparatus for in vivo delivery of medication pellets comprising a first chamber including an opening; a second chamber substantially surrounding the first chamber, a carriage disposed in the first chamber, a mechanism for transferring the medication pellets from the first chamber to the second chamber and a pusher plate. The carriage can hold and dispense a plurality of medication pellets. Each pellet contains a selected dose of drug to treat a medical condition. A catheter is positioned in the second chamber. The catheter has a lumen sized for the pellet, a proximal end inside the chamber and a distal end extending through chamber opening to deliver the pellet to a delivery site. The pusher plate engages and advances the pellet though the catheter to the delivery site.

Abstract: There are cases where a fluid transport apparatus cannot accurately discharge a set discharge amount of fluid, due to individual differences in components of the fluid transport apparatus, such as the diameter of an opening of an elastic tube. Therefore, in a fluid transport apparatus including a fluid transport cartridge and a fluid transport driving unit that are separable from each other, the fluid transport driving unit comprises a driving section that causes a drive mechanism to operate to transport fluid filling a transport path of an attached fluid transport cartridge to a discharge opening of the transport path; a receiving section that receives a characteristic value measured in advance for each of a plurality of the fluid transport cartridges; and a control section that controls the driving section based on the characteristic values received by the receiving sections.

Abstract: The present Invention relates to an injection device capable of emitting a flashing light signal indicating the time elapsed since last ejection and/or the size of the last ejected dosage and/or a return signal indicating the operable state of the device and/or a time out signal indicating when the pen can be removed after ejecting of a dosage. The injection device comprises an electronic control circuit comprising: a sensor unit arranged to detect the occurrence of an ejection of a drug from the injection device; a timer for determining an approximate time elapsed since last ejection; a signal emitting device being able to emit a signal, the signal emitting device being controllable by the electric control circuit, so as to emit a time signal that varies with the time elapsed since last ejection.

Abstract: The present invention relates to a device and a method for monitoring a patient access, particularly for monitoring the venous vascular access in extracorporeal blood treatment where blood is withdrawn from the patient via a flexible arterial line which has an arterial needle or cannula, and provided to the patient via a flexible venous line which has a venous needle or cannula. The needle or cannula of the present invention is so designed that, due to the liquid flowing through the needle or cannula, air is drawn in if the needle or cannula is out of the vascular access, whereby sound is generated. A vascular access which is not in proper order is detected with great certainty and reliability by monitoring the surrounding environment for the occurrence of sound, particularly for the occurrence of the solid-borne sound which propagates along the flexible venous line of the extracorporeal blood circuit.