Abstract: A device, a system, or a method is described for treating a disease or a condition of one or more joints of articulating bone in a mammalian subject. The device provides one or more medicaments to one or more joints of the mammalian subject. A device is described that includes one or more substrates configured to contact one or more body contours in proximity to one or more joints of articulating bone of a mammalian subject; one or more sensors configured to monitor movement of the one or more body contours; and one or more applicators supported by the one or more substrates and configured to respond to the movement of the one or more body contours by injecting one or more medicaments to the one or more joint tissues of the mammalian subject.

Abstract: A control apparatus for an ophthalmic surgical system for phacoemulsification of an eye lens has an optical system for generating an object region wherein at least part of the eye lens and part of a needle of a phacoemulsification handpiece are arranged. The handpiece is provided with an aspiration line; an image evaluation unit is suitable for evaluating the generated image in such a way that an evaluation variable, dependent on an occlusion of the aspiration line, is determined, which is a kinematic measurement variable and/or a geometric measurement variable and/or an optical measurement variable of a particle, produced by emulsification, of the eye lens to be treated. A control unit, dependent on the evaluation variable supplied thereto, determines a control variable to control an absolute value of a parameter of the ophthalmic surgical system.

Abstract: The invention is generally directed toward a novel fluid cartridge for medical infusion devices. The disclosed invention describes a medicament cartridge having an internal vent structure and hydrophobic venting material to permit the equilibration of pressure between an infusion device's reservoir chamber and the external environment, without the need for a costly, difficult to maintain vent located in the housing of the infusion device.

Abstract: A medical syringe pump has a first processor (21) responsible for controlling infusion and a second processor (22) that functions as a watchdog to monitor operation of the first processor. A data communication connector (27) is located in the pump battery compartment (25) so that the batteries (24) have to be removed before external access can be made using an external connector (4). Removing the batteries (24) disables the infusion function of the first processor and ensures that the pump is prevented from infusing medication. When the external connector (4) is connected the first processor (21) can reprogram the second processor (22) or information about historical operation of the pump can be downloaded.

Abstract: A medical remote controller device is disclosed. The device includes a display and at least one input switch dedicated to bolus delivery wherein a bolus delivery is programmed when the input switch receives an input and wherein the number of inputs received by the input switch determines the amount of bolus to be delivered.

Abstract: There is provided an auto-injector for a syringe that is suitable for use in the injected delivery of drug to a patient. The auto-injector comprises a cassette unit arranged for receipt of a syringe provided with a needle cover and removable cap. The auto-injector also comprises a drive unit arranged for docking receipt of the cassette unit at a docking position and a drive arrangement. The drive unit is provided with a timer that starts a time count on removal of the removable cap and needle cover from the cassette unit.

Abstract: Some embodiments of an infusion pump system may be configured to provide a desired level of resistance to liquid ingress to the pump casing while contemporaneously providing air transmissibility for equalization of air pressure differentials between the interior and exterior of the pump casing. Further, some embodiments can detect when moisture inside a casing of the infusion pump system is greater than or equal to a threshold level and can initiate one or more patient safety countermeasures.

Abstract: Some embodiments of an infusion pump system may be configured to detect when at least one component of the pump system is exposed to a moisture level above a threshold level. In particular embodiments, the infusion pump system can be equipped with a moisture level detection system that can sense when a moisture level above the threshold level has occurred to the pump device, which thereby enables the infusion pump system to initiate one or more patient safety countermeasures.

Abstract: An apparatus and method for detecting an occlusion in a downstream fluid line of a medical pump in relation to increased pressure in the downstream fluid line between the beginning and the end of each interval of a series of intervals of operation of the pump even if one or more intervals between the first and last intervals does not reflect such an increase in pressure in the downstream fluid line.

Abstract: A fluid control system for delivery of a liquid includes a pneumatic drive that incorporates a linear actuator to effect known volume changes in a gas reservoir. The gas reservoir is in fluid communication with a gas-side reservoir that is separated from a fluid-side reservoir by a flexible membrane. Movement of the linear actuator effects positive or negative volume differences on the gas in the gas-side reservoir, resulting in a decrease or increase in pressure of the gas that is transmitted to the fluid-side reservoir to draw fluid, primarily liquid, in from a source or deliver liquid out to a sink. In another aspect, a mechanism is provided for the detection and elimination of air bubbles in the fluid path.

Abstract: A fluid control system for delivery of a liquid includes a pneumatic drive that incorporates a linear actuator to effect known volume changes in a gas reservoir. The gas reservoir is in fluid communication with a gas-side reservoir that is separated from a fluid-side reservoir by a flexible membrane. Movement of the linear actuator effects positive or negative volume differences on the gas in the gas-side reservoir, resulting in a decrease or increase in pressure of the gas that is transmitted to the fluid-side reservoir to draw fluid, primarily liquid, in from a source or deliver liquid out to a sink. In another aspect, a mechanism is provided for the detection and elimination of air bubbles in the fluid path.

Abstract: A wearable infusion pump assembly. The wearable infusion pump assembly includes a reservoir for receiving an infusible fluid and a fluid delivery system configured to deliver the infusible fluid from the reservoir to an external infusion set. The fluid delivery system includes a controller, a pump assembly for extracting a quantity of infusible fluid from the reservoir and providing the quantity of infusible fluid to the external infusion set, the pump assembly comprising a pump plunger, the pump plunger having distance of travel, the distance of travel having a starting position and an ending position, at least one optical sensor assembly for sensing the starting position and ending position of the pump plunger distance of travel and sending sensor output to the controller, and a first valve assembly configured to selectively isolate the pump assembly from the reservoir, wherein the controller receives the sensor output and determines the total displacement of the pump plunger.

Abstract: A device, a system, or a method is described for treating a disease or a condition of one or more joints of articulating bone in a mammalian subject. The device provides one or more medicaments to one or more joints of the mammalian subject. A device is described that includes one or more substrates configured to contact one or more body contours in proximity to one or more joints of articulating bone of a mammalian subject; one or more sensors configured to monitor movement of the one or more body contours; and one or more applicators supported by the one or more substrates and configured to respond to the movement of the one or more body contours by injecting one or more medicaments to the one or more joint tissues of the mammalian subject.

Abstract: A device, a system, or a method is described for treating a disease or condition of one or more joints of articulating bone in a mammalian subject. A device is described which includes one or more substrates configured to contact one or more body contours at one or more joints of articulating bone of a mammalian subject; and an applicator supported by the one or more substrates and configured to inject one or more medicaments to one or more joint tissues of the mammalian subject.

Abstract: An infusion pump including a drive mechanism; an assembly operable with the drive mechanism, the assembly configured to deliver a flowable material to a patient; a mountable housing holding the drive mechanism and configured at its front side to receive the assembly and at its backside to mount in either a first orientation or a second orientation to an external support, wherein the housing supports the drive mechanism and the assembly in each of the orientations; a controller operably connected to the housing; and a display operably connected to the controller and supported by the front side of the housing, the display configured to be rotatably responsive so that information displayed by the display is oriented right-side-up regardless of whether the assembly is in the first orientation or the second orientation.

Abstract: Control of conduction through a heart is described. A lead with a proximal end and a distal end is provided. The distal end of the lead is inserted into a target area. An agent is delivered through the lead to the target area. Delivery of the agent is monitored via a closed loop feedback system.

Abstract: A system includes at least one pressurizing mechanism, a fluid path adapted to be placed in operative connection with the pressurizing mechanism to deliver an injectate to a patient, wherein the injectate includes cells, a control system operably associated with the at least one pressurizing mechanism; and at least one parameter generation system in operative connection with the control system. The parameter generation system includes an input system to receive data of a type of cells to be injected and is adapted to generate at least one parameter for the injection procedure at least in part on the basis of the data of the type of cells. The at least one parameter for the injection procedure may, for example, be a variable associated with the injectate, a variable associated with an injection protocol or a variable associated with at least one component of the fluid path.

Abstract: An injector automatic limiting of the operating pressure of the injector as determined by the selection of a flow rate; a syringe cradle having a warming capability; a purge/retract trigger for control of the injection procedure having intuitive direction (i.e., forward for injecting, reverse for filing), non-contact control transmission through the housing of an injector for an improved seal integrity, a speed lock, and/or the ability to change the concentration and/or flow rate of media or other fluid during an injection procedure; a switch to determine when the drive ram is in a “home” position; a “soft” on/off power switch separate from the injector; and a structure to prevent rotation of the drive ram about its axis of symmetry. Additionally, the injector system includes software for the control of various components.

Abstract: A control unit for an equipment arrangement is provided. The control unit includes an imaging modality, a measurement device for measuring a control variable and a controllable injection device for a regulatory substance influencing the control variable, wherein the injection rate of the injection device may be varied during a data acquisition such that a proposed value for the control variable is reached.

Abstract: Embodiments relate to systems, methods and devices for delivering a drug or other therapy to a patient with an ambulatory infusion pump configured to provide a series of tolerance-building steps leading up to a plateau delivery rate. The plateau delivery rate is maintained until the prescribed amount of drug or therapy fluid is delivered to the patient. Embodiments of the invention include providing the patient or other user with a mechanism to decrease, or step down, the therapy delivery rate if a tolerance was not achieved at a lower rate, and providing notifications prior to a step up in a dosage delivery rate.

Abstract: The invention relates to a pump unit, replaceably attachable to a reusable backend of an injection arrangement for delivering a liquid medicament, the pump unit comprising a medicament inlet, a medicament outlet and a pump for delivering the liquid medicament from the inlet to the outlet, wherein a medicament container is arranged in the pump unit, wherein a fluid communication between the medicament container and the pump is establishable when the pump unit is attached to the reusable backend.

Abstract: A compact medical pump includes a linear peristaltic pumping mechanism driven by a motor located within a periphery of a belt of the pumping mechanism. The motor drives a gear set that drives a driving pulley which engages the belt having the rollers. A battery for the pump is positioned adjacent to the gear set. The pump includes a controller and user interface for operating the pumping mechanism as a function of pumping parameters input via the user interface. The controller may sense motor current and determine fluid path characteristics based on the sensed current.

Abstract: The pharmaceutical injection device comprises a syringe mounting portion configured to mount thereon a syringe containing a drug, the syringe including at a front end side thereof an injection needle mounting portion on which an injection needle is mounted and a gasket at a rear end side thereof, a plunger operable to press the gasket in the syringe mounted on the syringe mounting portion toward the injection needle mounting portion, a motor operable to drive the plunger, an encoder operable to detect a rotation amount of the motor, and a controller connected to the encoder and operable to control a driving of the motor. The controller is operable to obtain a motor rotation amount that corresponds to a deformation amount of the gasket deformed by the plunger, and control a rotation of the motor at a time of injection of the drug in accordance with the motor rotation amount.

Abstract: A status of a battery operated infuser may be detected by measuring a controlled input parameter. The measurement may be used to determine a magnitude of the input parameter and a parameter of the control. For example, control of power input to a motor may be by pulse density modulation. An integral of current over time may sever as a measure of current magnitude and pulse density. The result of the integral may be used to determine the status of the injector. The status may include normal functions for example start of pumping and/or malfunctions such as occlusion or drive disengagement.

Abstract: There is provided a method of reducing or preventing catheter reflux during infusion of a therapeutic agent into a brain of a subject comprising administering the therapeutic agent to a target area of the brain by intermittent infusion at a predetermined interval. There is provided a method of treating a CNS disorder comprising administering a therapeutic agent to a target area of a brain of a subject by intermittent infusion at a predetermined interval. There is also provided a system for reducing or preventing catheter reflux during infusion of a therapeutic agent into a target area of a brain of a subject comprising an infusion device, at least one chronically implanted intracranial catheter, a monitoring device configured to monitor the target area of the brain after each infusion, and a determination unit configured to determine whether a predetermined interval is acceptable.

Abstract: A medical device fluid sensing system is provided. The system includes a transmitter array positioned in association with a fluid maintaining device, such as a reservoir in a cassette. Electrical circuitry is connected to the transmitter array and configured to cause the transmitter array to transmit light energy at a predetermined wavelength and producing a desired absorption coefficient based on expected conditions within the fluid maintaining device. The system also includes a receiver array configured to receive light energy transmitted through the fluid maintaining device and originating from the transmitter array, and a controller configured to determine fluid level in the fluid maintaining device based on conditions sensed by the receiver array. In one embodiment, three transmitters and three matching sensors are provided in a surgical cassette, and when optical energy having predetermined characteristics is provided to the transmitter array, the presence or absence of fluid is determined.

Abstract: A portable infusion apparatus and method are provided for controlling the delivery of medicinal fluid to a patient. A fluid delivery system receives control input to control a setting of a variable fluid flow resistor. The variable fluid flow resistor resists passage of fluid through a fluid pathway between a fluid source and a recipient. The fluid delivery system; produces a control signal indicative of the setting of the variable fluid flow resistor; derives a fluid flow rate value from the control signal; and applies pressure to the fluid source to deliver the fluid from the fluid source to the recipient through the variable fluid flow resistor at a rate as specified by the derived fluid flow rate value.

Abstract: Devices of this invention include replaceable cartridges for delivery of doses of fluids. Cartridges having a fluid supply reservoir comprising an expandable element are designed to be connected with non-disposable actuating module supplied with a sensor, a mechanism to apply a force to the fluid, thereby forcing a predetermined dose out of the reservoir, and a processor providing control outputs from a sensor system according to preprogrammed instructions. Methods of this invention include delivery of microdoses of fluids using devices of this invention.

Abstract: In accordance with another embodiment, a controller in a fluid delivery system initiates drawing fluid into a chamber of a diaphragm pump. During a delivery phase of pumping the fluid in the chamber to a target recipient, the controller applies pressure to the chamber. At multiple different times during the delivery phase, the controller temporarily discontinues application of the pressure to the chamber to calculate how much of the fluid in the chamber has been pumped to the target recipient.

Abstract: A system and method of varying the flow rate of fluid from a medical pump through tubing includes determining an inner diameter of the tubing and fluid flow velocity of fluid in the tubing with a controller based on acoustic signals received by a capacitive micromachined ultrasonic transducer sensor system and then determining and adjusting a fluid flow rate of fluid in the tubing with the controller. In addition, the same sensor system also detects air bubbles in the fluid in the tubing.

Abstract: A system and method for preventing an undesirable reverse rotation of an infusion pump assembly. The infusion pump motor includes a roller assembly, a coil, a rotor, a rotor position sensor, and a controller. The rotor is in communication with the coil, and the rotor is rotationally coupled to a roller assembly. If the pump is in not pumping, then the system monitors for reverse rotation of the pump, and if reverse rotation of the pump is detected, energizes the coil in a manner that holds the rotor in place. The system may also activate an indicator if reverse rotation is detected.

Abstract: In various embodiments, a device for delivering pressurized irrigation may include a squeeze plate and a pressure sensor module. The squeeze plate may move relative to the pressure sensor module to apply pressure to a flexible container (e.g., a bag of irrigation fluid) between the squeeze plate and the pressure sensor module. The pressure sensor module may include a pressure sensor to measure a force exerted on the pressure sensor module by the flexible container as pressure is applied to the flexible container from the squeeze plate. In some embodiments, the pressure sensor module may include a bag contact plate and the pressure sensor may measure a force exerted on the bag contact plate by the flexible container located between the bag contact plate and the squeeze plate. In some embodiments, the pressure sensor may sense a pressure associated with the flexible container without an intervening bag contact plate.

Abstract: A nursing device for feeding infants with a cleft lip and/or cleft palate includes upper and lower portions. The upper portion includes a bottle with an opening in its top for containing a liquid, a nipple and a screw cap for maintaining the nipple in sealing engagement with the opening. A submersible pump is disposed in the bottom of the bottle and connected to an opening in the nipple by a tube. A lower portion of the device includes a motor and a magnetic coupling for activating the pump. A microprocessor control timer regulates the timing and flow of a feeding cycle with a display for help in regulating the feeding cycle.

Abstract: Detection of fluid conditions in an administration set. A light source is positioned to transmit an infrared light through administration set tubing and any fluid therein. A light sensor senses the infrared light transmitted through the tubing and generates an output signal. A frequency of the output signal is a function of an intensity of the light transmitted through the tubing. A processor receives and determines the frequency of the output signal, and compares the determined frequency to threshold frequency values to determine whether fluid is in the tubing. The processor also monitors the generated output signal to determine if the frequency of the output signal changes over time, and determines whether fluid is flowing in the tubing as a function of the determined change in frequency.

Abstract: Disclosed is a medical device to treat diabetes. The medical device includes a bolus calculator to determine an insulin bolus based on, at least in part, a glycemic index value associated with an intake to be consumed by a user, the bolus calculator further adapted to determine the insulin bolus using one or more inputs selected from the group consisting of a carbohydrate load of the intake, a current glucose level of the user, a residual insulin of the user, a carbohydrate to insulin ration, an insulin sensitivity of the user and a target glucose level of the user. The bolus calculator is housed in one or more of, for example, an insulin dispensing pump, a handheld remote control unit for the insulin dispensing pump and/or a handheld glucose monitor.

Abstract: An infusion pump assembly is disclosed. The infusion pump assembly includes a locking tab and a pump barrel inside a pump barrel housing, where the pump barrel accommodates a reservoir assembly. The reservoir assembly includes a reservoir and a plunger rod. The infusion pump assembly also includes a locking disc at a terminus of the pump barrel. The locking disc includes a clearance hole for the plunger rod. The locking disc also includes at least one locking tab notch in close proximity with the locking tab. The locking tab is in moveable engagement with the locking tab notch, and the reservoir moves the locking tab from a locked position to an unlocked position when the plunger rod is inserted through clearance hole. The locking disc rotates upon torque being applied to the reservoir assembly, the locking disc rotating from a non-loaded position to a loaded position with respect to the plunger rod and a drive screw.

Abstract: This document discusses, among other things, an apparatus comprising a pump configured to deliver a fluid, an input and a controller. The controller is configured to receive via the input information related to physical activity of a user and to automatically calculate a change in insulin therapy based on an amount of carbohydrates metabolized by the physical activity.

Abstract: A programmable implantable insulin pump is disclosed. The pump includes an implantable pump and a hermetically sealed module. The module provides for varying flow rates of fluid being dispensed from the pump or may provide for a constant flow rate of such fluid. In the case of varying flow rate capabilities, the module preferably includes one or more sensors to determine information relating to the pressure of the fluid, electronics for analyzing the pressure information and determining the flow rate of the fluid, and a mechanism for physically altering the flow rate. First and second resistor capillaries are included in the implantable pump to provide a large range of flow rate capabilities between basal operation and bolus operation. Methods of dispensing a medicament to a patient utilizing such a system are also disclosed, as are variations of the pump system.

Abstract: Exemplary systems for small volume collection for a breastpump system are provided. The systems allow breast milk to flow directly from the breastshield to the collection container without leaving the control volume. A valve is present outside of the milk flow path that does not contact breast milk prior to the milk reaching a collection vessel.

Abstract: A patient care system is configured for infusing fluid to a patient. The system includes a plurality of fluid infusion pumps, each of which is connected to a respective fluid supply for pumping the contents of a fluid supply to a patient via fluid supply lines. The system includes a pressure sensor downstream of the fluid infusion pumps for determining if a particular fluid is connected to a designated infusion pump.

Abstract: In order to improve the energy efficiency of an injection device 100, a current is caused to be applied to a motor 113 of the injection device 100, which is related to a signal from a force sensor 115. The signal represents a force that is applied by the motor 113 to a plunger 122 of a cartridge 121.

Abstract: A drug infusion pump is provided. The drug infusion pump includes a main body including a drive motor and a processor, and a cartridge module including a pump module and a drug cartridge and detachably provided in the main body. When the cartridge module is fitted in the main body, the pump module and the drug cartridge are accommodated in the main body and the pump module is coupled to the drive motor. The drug infusion pump is configured such that the pump module is coupled with the drive motor when the cartridge module is fitted in the main body. Accordingly, the cartridge may be easily separated and replaced so as to address a problem of a patient's inconvenience in using the drug infusion pump.

Abstract: A method for delivering a target volume of fluid to a destination is provided. The method includes delivering a first volume of fluid to the destination in increments each having approximately a first incremental volume, the first volume of fluid being less than the target volume and delivering a second volume of fluid to the destination in increments each having approximately a second incremental volume, the second incremental volume being less than the first incremental volume, such that the sum of the first volume and the second volume is approximately equal to the target volume.

Abstract: Systems and methods for sensing bubbles during fluid infusion are disclosed. An infusion device comprises a pathway, at least one pump adjacent the pathway, first and second bubble sensors positioned adjacent the pathway, and a processor. The pathway is adapted to receive tubing. The pump alters the pathway to pump fluid through the tubing when the tubing is received in the pathway. The second bubble sensor is spaced from the first bubble sensor. The first and second bubble sensors are configured to detect a bubble in the fluid being pumped through the tubing. The processor is programmed to determine that the first bubble sensor detects a bubble, determine whether the second bubble sensor detects a bubble, and to generate an alarm condition only when the first bubble sensor and the second bubble sensor detect the same bubble.

Abstract: Novel fluid delivery systems are disclosed to improve the delivery of bio-compatible fluids to a patient. The systems can include a housing having a bladder pressurized by a pressurization unit so that fluid flow rate can be controlled, changed and/or monitored. The systems can also include a scale and/or a flow control unit.

Abstract: A pharmaceutical injection device comprises a main body case (2); a pharmaceutical syringe mounting component (3) that is provided inside the main body case (2) and onto which a pharmaceutical syringe (4) is mounted; a piston (5) provided movably with respect to the pharmaceutical syringe (4) mounted onto the pharmaceutical syringe mounting component (3); a drive mechanism (6) for driving the piston (5); a memory (46) that stores a preset pharmaceutical injection schedule; and a controller (7) that resets a current pharmaceutical dose by comparing a planned cumulative pharmaceutical dose, which is a planned cumulative amount of pharmaceutical injected up to the last time on the basis of the pharmaceutical injection schedule stored in the memory, and an actual cumulative pharmaceutical dose, which is a cumulative amount of pharmaceutical actually injected up to the last time.

Abstract: An infusion pump system is disclosed. The system includes a syringe having a plunger within the syringe barrel, the syringe having an exit end, at least one temperature determination device adjacent to the syringe, at least one device to determine the distance the plunger has moved with respect to the syringe barrel, and a pump processor in communication with the at least one temperature determination device and the at least one optical sensor, wherein when the controller determines a change in temperature and a corresponding plunger movement, the controller increases or decreases a preprogrammed basal rate of the infusion pump by a predetermined amount for a predetermined time.

Abstract: A volume of an analyte-enriched fluid can be withdrawn out of a user's subcutaneous compartment using a patch unit that includes a reversible pumping mechanism. The volume can be withdrawn out of the body and into the patch unit through a cannula inserted into the subcutaneous compartment so that an analyte concentration in the volume can be measured using a sensing element within the patch unit. After analyte concentration analysis, at least the volume can be delivered back into the subcutaneous compartment by operating the pumping mechanism in a forward direction. biologically compatible fluid can optionally be pumped into the subcutaneous compartment from a reservoir in the patch unit and then allowed to partially or completely equilibrate with the analyte concentration in the interstitial fluid of the subcutaneous compartment via a permeable or semi-permeable cannula surface before being drawn back into the patch unit for analysis. Related systems, apparatus, methods, and/or articles are also described.

Abstract: Different embodiment programmable pumps including multiple reservoirs are disclosed, as are methods of utilizing same. The pumps generally include at least two reservoirs and means for dispensing active substances housed in each at varying flow rates.

Abstract: A number of parameters related to the operation of a fluid delivery device are determined based on a pressure within the device sensed using a pressure sensor. In one example, the volume of therapeutic fluid added to or removed from a reservoir of a fluid delivery device is determined based on a sensed pressure of the reservoir. In another example, the volume of therapeutic fluid added to or removed from the reservoir is determined based on a sensed pressure of a refill port assembly of the device. In another example, an initial temperature of the reservoir as a therapeutic fluid is removed from the reservoir is estimated based on a sensed pressure within the device. In another example, a temperature of a therapeutic fluid added to the reservoir is estimated based on a sensed pressure within the device.