Closure Moved By Relative Movement Between Closure And Separate Protruding Member Patents (Class 604/91)
  • Patent number: 10080848
    Abstract: The present invention provides a drug delivery device (1) comprising a dose delivery mechanism and a blocking structure (80, 180) for preventing inadvertent activation of the dose delivery mechanism. The blocking structure (80,180) enables and disables the dose delivery mechanism dependent on the position of a needle holder (30, 130) relative to a drug cartridge holder (20, 120).
    Type: Grant
    Filed: November 12, 2014
    Date of Patent: September 25, 2018
    Assignee: Novo Nordisk A/S
    Inventors: Christian Hoejris Nielsen, Kristoffer Aagaard Eriksen
  • Patent number: 9855385
    Abstract: Various syringe systems are disclosed. One illustrative syringe system may include a syringe body having a hollow lumen and a distal end. The syringe body may be configured to house a plurality of fluids therein. A first plunger may be positioned in the hollow lumen of the syringe body, forming a first seal with an inner wall of the syringe body, and forming a first compartment between the first plunger and the distal end of the syringe. A second plunger may be positioned proximal to the first plunger in the hollow lumen of the syringe body, forming a second seal with the inner wall of the syringe body, and forming a second compartment between the first plunger and the second plunger. A plurality of recesses may be disposed about the inner wall of the syringe body near the distal end of the syringe body.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: January 2, 2018
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Kevin P. Cowan, Edward J. Rhinehart, Barry L Tucker
  • Patent number: 9332975
    Abstract: An occlusion device for vascular surgery, suitable for clogging treatments of vascular entry sites and for endovascular interventions such as embolizations of blood vessels, treatment of arteriovenous malformations or small aneurysms, arterial dissections and the like, by releasing in an operation region a quick setting surgical glue or haemostatic fluid, through an outlet mouth of a duct. The device prevents the surgical glue from contacting within the duct a patient's biological fluids, in particular blood, which would close the duct. In the case of clogging treatments of vascular entry sites, a backflow preventing device may be provided, preferably provided by a coupling device between the duct and an introducer sheath by which an outlet mouth is kept in contact to keep in a one-way fluid tight contact against the outer surface of the introducer sheath until an injection pressure P2 is applied to cause release of the surgical glue.
    Type: Grant
    Filed: August 13, 2009
    Date of Patent: May 10, 2016
    Inventor: Andrea Del Corso
  • Patent number: 8992469
    Abstract: An apparatus comprises a plunger able to fit in a cartridge or syringe. The plunger includes an outer portion and a deflection portion. The outer portion is able to engage the body of the cartridge or syringe. The outer portion is operable to apply a first radial force to the cartridge or syringe. The deflection portion is positioned within the outer portion and is movable between a locked position and an unlocked position. The deflection portion in the unlocked position causes the outer portion to apply a second radial force to the cartridge or syringe.
    Type: Grant
    Filed: December 5, 2013
    Date of Patent: March 31, 2015
    Assignee: Glucago LLC
    Inventors: Rush L. Bartlett, II, Peter M. Greco, Jr., Barry J. Davignon
  • Publication number: 20150057608
    Abstract: Delivery devices and components thereof are disclosed. In an embodiment, a delivery device may include a barrel holding a liquid for delivery. The delivery device may also include a finger flange assembly coupled to the barrel. The finger flange assembly may include a first flange and a second flange each extending laterally from opposite sides of the finger flange assembly, wherein the first flange and the second flange each curve toward the barrel. The delivery device may also include a plunger coupled to the barrel and passing through the finger flange assembly. The plunger may also include a disc-shaped head.
    Type: Application
    Filed: March 28, 2013
    Publication date: February 26, 2015
    Inventors: Carl F. Hitscherich, JR., Soham Bhatt, Nam Chen, Chase Fetzer
  • Publication number: 20150045773
    Abstract: A steroid delivery system including a mixing syringe having a first chamber and a second chamber and at least one hypodermic needle is provided. The first chamber of the mixing syringe contains a pre-measured volume of a local anesthetic and the second chamber contains a pre-measured volume of a corticosteroid. An improved mixing syringe and a method for treating pain using the steroid delivery system of the present invention is also provided herein. The improved syringe achieves mixing without the introduction or elimination of air and without puncturing or rupturing of a membrane, diaphragm or other material. The kit concept improves the speed of the procedure, sterility, accuracy of dosing, and immediate availability of disparate items to implement the procedure in a variety of medical practice settings.
    Type: Application
    Filed: October 23, 2014
    Publication date: February 12, 2015
    Inventor: Michael P. Connair
  • Publication number: 20150025454
    Abstract: Mixing syringes including a valve mechanism are configured and configurable to enable one or more substances to be prefilled into the syringe. The valve mechanism may be an aspect of a distal seal assembly. Actuation of the valve mechanism permits opening of a fluid passage for the mixing of one or more substances, and the resulting mixed substance can be delivered by the syringe, for example, for administration of a pharmaceutical to a subject.
    Type: Application
    Filed: July 16, 2014
    Publication date: January 22, 2015
    Inventors: Lance W. Wetzel, Gautam N. Shetty, Lou Castagna
  • Publication number: 20150025455
    Abstract: Mixing syringes including a valve mechanism are configured and configurable to enable one or more substances to be prefilled into the syringe. The valve mechanism may be an aspect of a distal seal assembly. Actuation of the valve mechanism permits opening of a fluid passage for the mixing of one or more substances, and the resulting mixed substance can be delivered by the syringe, for example, for administration of a pharmaceutical to a subject. The repetitive mixing of substances contained in a distal and proximal chamber is also provided, where the plunger rod is configured to releasably engage a locking mechanism to actuate the valve, and can axially displace the distal seal assembly while the fluid passage is open.
    Type: Application
    Filed: July 16, 2014
    Publication date: January 22, 2015
    Inventors: Gautam N. Shetty, Lou Castagna
  • Publication number: 20150025456
    Abstract: Sequential delivery syringes including a valve mechanism are configured and configurable to enable one or more substances to be prefilled into the syringe. The valve mechanism may be an aspect of a distal seal assembly. Actuation of the valve mechanism permits opening of a fluid passage for the mixing of one or more substances, and the resulting mixed substance can be delivered by the syringe, for example, for administration of a pharmaceutical to a subject. The sequential delivery of substances contained in a distal and proximal chamber is also provided, where a second substance from the distal chamber is delivered followed by the delivery of a first substance from the distal chamber after the first substance from the proximal chamber is transferred into the distal chamber involving the actuation of the valve mechanism.
    Type: Application
    Filed: July 16, 2014
    Publication date: January 22, 2015
    Inventors: Gautam N. Shetty, Lance W. Wetzel, Lou Castagna
  • Publication number: 20140371670
    Abstract: A medicament delivery device for a reconstituted medicament, comprising a proximal housing part (12; 12?; 12??), a distal housing part (10; 10?; 10??), a medicament delivery drive unit and actuation means, wherein the medicament delivery drive unit is mounted in said distal housing part and wherein the actuation means further include an activation member (74; 101; 201) which is displaceable between an inactive position wherein the actuator is prevented from engaging the medicament delivery drive unit and an active position wherein the actuator is able to engage the medicament delivery drive, whereby the actuator is capable of interacting with said medicament delivery drive unit to perform a delivery of the reconstituted medicament only in the active position of the activation member and in the second position of the medicament delivery drive unit.
    Type: Application
    Filed: January 31, 2012
    Publication date: December 18, 2014
    Applicant: SHL GROUP AB
    Inventors: Anders Holmqvist, Stefan Lööf
  • Patent number: 8910832
    Abstract: Device for the preservation of substances to be kept separate until their application includes a container (2), which is provided with an at least partially deformable body (6), and a delivery mouth (4), on which there is provided a delivery element for delivering the mixture. A watertight chamber (5) is arranged between the delivery mouth and the body of the container and is provided with a connection mouth (12) for the connection to the body (6), which is closed by cap means (20). A component of the substance to be delivered is contained in the watertight chamber (5), whereas another component is contained in the body (6). The communication between the two components is established by removing said cap, by interference between the walls of the cap and the walls of the body.
    Type: Grant
    Filed: January 25, 2013
    Date of Patent: December 16, 2014
    Assignee: Inge S.p.A.
    Inventor: Alessio Nobbio
  • Patent number: 8834449
    Abstract: A movable mixing disc is inserted into a regular syringe. The mixing disc has a small hole covered by a fine screen, allowing only saline solution to get behind the disc. When the plunger of the syringe is pressed, the saline solution emerges from the mixing disc hole as a high velocity jet, stirring up the settled particles. As the ejection continues, the mixing disc is pushed forward by the plunger in order to eliminate any unused volume.
    Type: Grant
    Filed: February 28, 2012
    Date of Patent: September 16, 2014
    Assignee: Ikomed Technologies, Inc.
    Inventors: Lindsay S. Machan, Daniel Gelbart
  • Patent number: 8728054
    Abstract: A syringe-carpule assembly comprising first and second carpules, a housing holding the first and second carpules in an end-to-end relationship, an outer hollow plunger rod supported by and slidable relative to the housing, and an inner hollow rod having first and second openings and being slidably arranged inside the outer hollow plunger rod. The inner hollow rod is slidable between first and second positions. The inner hollow rod in the first position has the first opening disposed within the first carpule and the second opening disposed within the second carpule. This allows liquid solvent in the second carpule to flow into the first carpule, which comprises an evacuated chamber containing solid matter that dissolves in the presence of that solvent to form a mixture. The second carpule is then removed and the mixture in the first carpule is injected into the patient.
    Type: Grant
    Filed: October 28, 2009
    Date of Patent: May 20, 2014
    Assignee: Synchrojet LLC
    Inventor: Steven Schulhof
  • Patent number: 8721627
    Abstract: A disinfecting and pre-opening device is disclosed for use with a female needleless connector. The disinfecting and pre-opening device includes a housing comprising a chamber having a distal opening and configured to fit over the female needleless connector, and an elongated finger attached to the housing and disposed within the chamber such that the elongated finger opens the fluid path through the female needleless connector when the distal opening of the disinfecting and pre-opening device is placed proximally adjacent to the septum and the disinfecting and pre-opening device is advanced in the distal direction.
    Type: Grant
    Filed: July 22, 2010
    Date of Patent: May 13, 2014
    Assignee: CareFusion 303, Inc.
    Inventor: Robert S. Alpert
  • Patent number: 8657780
    Abstract: An application device for applying a dispensable material is disclosed having a closed state and an open state, the application device comprising an elastic part made of an elastic material and having a through channel being configured for engaging a cavity of a receptacle, further comprising a holder supporting a dispensing means fluidly connected with the through channel. A pinch seal is used for sealing the through channel when being in the closed state. Long-term storage is made possible, since leakage of the pinch seal is prevented by a cap effecting the pinch seal which is partially fitted into a collar.
    Type: Grant
    Filed: January 15, 2010
    Date of Patent: February 25, 2014
    Assignee: Schott Schweiz AG
    Inventor: John Paul Palmer-Felgate
  • Patent number: 8613720
    Abstract: The present invention is directed to an automatic reconstitution drug delivery device. The inventive device effects simple and automatic reconstitution of a dry drug. To effect reconstitution, a user displaces a release button which causes first and second chambers of a drug cartridge to communicate, resulting in automatic mixing of a diluent and dry drug to effect reconstitution of the dry drug. The user then simply sets the dose volume using a dose-setting mechanism, and administers the injection in a manner typical of self-injection drug delivery devices. Whole or partial automatic priming can be also achieved by the device.
    Type: Grant
    Filed: December 8, 2011
    Date of Patent: December 24, 2013
    Assignee: Becton Dickinson and Company
    Inventors: Antonio Bendek, John Laiosa
  • Patent number: 8506527
    Abstract: A method of supplying a flush/lock solution to a catheter assembly is disclosed which includes the steps of securing a distal end of a syringe assembly to the catheter assembly, advancing a plunger rod of the syringe assembly within a body of the syringe assembly until the plunger bottoms out on a distal wall of the body to eject a first fluid from a first fluid reservoir of the body from the fluid outlet of the syringe assembly, and after the plunger bottoms out on the distal wall of the body, advancing the plunger rod further within the body to advance a piercing member to pierce the plunger to eject a second fluid from a second fluid reservoir defined by the plunger from the fluid outlet.
    Type: Grant
    Filed: March 20, 2012
    Date of Patent: August 13, 2013
    Assignee: Covidien LP
    Inventor: James L. Carlyon
  • Patent number: 8454559
    Abstract: Hypodermic syringe having a barrel which with an inner wall thereof defines a reservoir, a closing-off device near the first end of the barrel, and a plunger that is movably placed in the second end of the barrel, wherein the closing-off device comprises a circumferential wall that sealingly abuts the inner wall of the barrel, at the side facing away from the nozzle is provided with a recess extending along a centre line of the closing-off device and over the full width thereof, which recess merges into the through-opening, with in the recess two diametrically opposite flexible locking members, extending in the longitudinal direction of the recess and towards the inner wall, which locking members engage into diametrically placed locking grooves in the inner wall, and at the side facing away from the nozzle, at a circumferential part of the closing-off device situated outside of the recess, is provided with two diametrically opposite and radially outwardly extending blocking members, that engage in diametrical
    Type: Grant
    Filed: June 19, 2009
    Date of Patent: June 4, 2013
    Assignee: Addino B.V.
    Inventors: Richardus Gerardus Theodora Fierkens, Richardus Henricus Johannes Fierkens, Arnoldus Theodorus Maria Telkamp, Dirk Vogelaar
  • Patent number: 8419722
    Abstract: An apparatus for percutaneous delivery of a sealant comprising: at least two fluid reservoirs, an introducer needle having a distal tip that is in fluid communication with at least one reservoir, a fluid delivery tube that is in fluid communication with a second reservoir, wherein the fluid delivery tube has a tip and wherein the fluid delivery tube is configured so that the tip of the fluid delivery tube does not extend past the distal tip of the introducer needle during use.
    Type: Grant
    Filed: January 5, 2007
    Date of Patent: April 16, 2013
    Assignee: Spinal Restoration, Inc.
    Inventors: Mark Richards, Brian D. Burkinshaw, Kevin Pauza, James B. Rogan, John Wheeler
  • Patent number: 8403882
    Abstract: Disclosed is an applicator device (10) for applying a multi-component fluid, especially a multi-component tissue glue, comprising a plurality of substantially cylindrical supply containers (12) for respectively one component of the fluid to be applied, each supply container (12) having a front end (16) with an outlet opening (18), a rear end (22) opposite to the front end (16), and a slidably displaceable piston (24) arranged within the supply container (12) and having a piston rod (26) extending out of the rear end (22) for operating the piston (24). Moreover, the applicator device includes a manifold (72) having terminal ends (50,58) with a first port for fluid connection with the front ends (16) of the supply containers (12), the manifold (72) further having internal channels (62) extending from the first ports of the terminal ends (50,58) to an outlet site.
    Type: Grant
    Filed: November 22, 2005
    Date of Patent: March 26, 2013
    Assignee: Omrix Biopharmaceuticals, S.A.
    Inventor: Edit Goldberg
  • Patent number: 8403923
    Abstract: A method and kit for treating a disc that is leaking nucleus pulposus through at least one defect in the annulus fibrosus. The method includes injecting a fibrin sealant into the disc to reduce at least a portion of the at least one defect, wherein the fibrin sealant injected into the disc comprises fibrinogen and an activating compound, wherein at least a portion of the fibrin forms after injection, with the proviso that a corticosteroid is absent from the fibrin sealant injected into the disc.
    Type: Grant
    Filed: August 17, 2005
    Date of Patent: March 26, 2013
    Assignee: Spinal Restoration, Inc.
    Inventors: Steven I. Whitlock, Brian D. Burkinshaw, Kevin Pauza
  • Patent number: 8398585
    Abstract: The invention relates to a single-use injector and to a two-chamber system, wherein at least one first chamber is part of a cylinder-piston unit that can be received in the single-use injector, and wherein the second chamber is part of a container having at least one opening, and closed at least intermittently by means of a stopper and place in a container adapter releasably supported on the single-use injector. To this end, the stopper and the container adapter can be permanently latched to each other. When the container is inserted, the container adapter closes off the opening and displaces the stopper. When the container is inserted into the container adapter, the adapter connects the interior of the cylinder-piston unit to the interior of the container. By means of the present invention, a single-use injector and a two-chamber system having a reduced number of components is developed.
    Type: Grant
    Filed: April 11, 2011
    Date of Patent: March 19, 2013
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventor: Rudolf Matusch
  • Patent number: 8382704
    Abstract: A system for delivering a cell-slurry to a patient may include a fluid, cells that are non-dissolvable or immiscible in the fluid, thereby forming the cell-slurry, a syringe adapted to contain the cell-slurry and a supernate of the cell-slurry, the syringe defining a first end having an outlet through which the cell-slurry is delivered to the patient, a fluidizing system associated with the syringe and adapted to effect dilation of the cell-slurry with a portion of the supernate, to form a dilated cell-slurry, the dilated cell-slurry being transferred from the fluidizing system to the syringe, while maintaining at least a portion of the supernate, the cell-slurry and supernate being transferred from the fluidizing system to the syringe, a pressurizing mechanism adapted to create a pressure to cause the dilated cell-slurry contained within the syringe to flow for delivery to the patient and a control unit in communication with and adapted to control the fluidizing system, the pressurizing mechanism and movemen
    Type: Grant
    Filed: December 20, 2007
    Date of Patent: February 26, 2013
    Assignee: Medrad, Inc.
    Inventors: Arthur E. Uber, III, David M. Griffiths, David M. Reilly, Alan D. Hirschman, Kevin P. Cowan, Mark Trocki
  • Patent number: 8357147
    Abstract: A method of repairing a defect in an annulus fibrosus of an intervertebral disc, without excising the entire nucleus pulposus of the disc. The method includes inserting an introducer needle through the annulus fibrosus by puncturing the annulus fibrosus with the introducer needle, injecting an in situ curable, bio-compatible polymerizable or polymeric material composition into the disc through the introducer needle directly or indirectly so that the in situ curable composition contacts a defect in the annulus fibrosus; and curing said material in situ.
    Type: Grant
    Filed: February 16, 2007
    Date of Patent: January 22, 2013
    Assignee: Spinal Restoration, Inc.
    Inventors: Brian D. Burkinshaw, John L. Wheeler, James B. Rogan, Steven I. Whitlock
  • Patent number: 8317743
    Abstract: A method for mixing and injection and an apparatus for performing the method includes the use of a needle and a needle base, a syringe attachment element and a mixing chamber engagement assembly including a needle chamber surrounding the needle and a first liquid conduit portion, sealed from the needle chamber. A mixing chamber engagement portion includes a second liquid conduit portion communicating with the first liquid conduit portion and a mixing chamber. When the syringe attachment element and the needle base are in a first relative engagement orientation liquid can flow between an interior of the syringe and the first liquid conduit portion and upon axially displacing the needle base and syringe attachment element to a second relative engagement orientation, liquid can flow between an interior of the syringe and the needle.
    Type: Grant
    Filed: July 15, 2008
    Date of Patent: November 27, 2012
    Assignee: Medimop Medical Projects Ltd.
    Inventor: Igor Denenburg
  • Patent number: 8262608
    Abstract: One aspect of the invention relates to an applicator system, and methods of use thereof, that can be used to house separately one or more liquids and one or more solids (e.g., components of a polymerizable hydrogel). In certain embodiments, the applicator systems are further designed to facilitate the mixing of the solids and liquids inside the applicator. In addition, in certain embodiments, the applicator systems are also designed to facilitate the application of the mixture to a surface.
    Type: Grant
    Filed: January 25, 2008
    Date of Patent: September 11, 2012
    Assignee: HyperBranch Medical Technology, Inc.
    Inventors: Jeffrey G. Clark, Keith R. D'Alessio
  • Patent number: 8252228
    Abstract: A kit is described including at least one container including a predetermined quantity of sterilized biodegradable carriers in a powder form having a treatment agent disposed therein. The kit further includes a delivery device for delivering the predetermined quantity of sterilized biodegradable carriers with the treatment agent disposed therein to a treatment site. In other embodiments, methods are described for producing the sterilized treatment agent loaded biodegradable carriers and delivering the sterilized carriers to a treatment site.
    Type: Grant
    Filed: October 13, 2008
    Date of Patent: August 28, 2012
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Abigail Freeman, Thierry Glauser, Paul M. Consigny
  • Patent number: 8226627
    Abstract: A reconstitution assembly includes: a flexible bag containing a diluent; a drug vial containing a drug; a reconstitution device further comprising: a first sleeve connected to the first container; a second sleeve connected to the second container, the second sleeve being associated with the first sleeve and movable axially with respect thereto from an inactivated position to an activated position; a piercing member positioned in the sleeves, the piercing member providing a fluid pathway between the bag and vial when the sleeves are in the activated position.
    Type: Grant
    Filed: August 12, 2008
    Date of Patent: July 24, 2012
    Assignee: Baxter International Inc.
    Inventors: Thomas A. Fowles, Robert J. Weinburg
  • Publication number: 20120184900
    Abstract: A pen injection device designed for use with dual or multi-chamber cartridges 14, is provided with an extended length plunger 24 having a non-drive portion 24? on its forward end and the usual screw-threaded drive portion 24? on its rearward end. This arrangement allows the plunger to be pushed forwardly whilst the dosing drive mechanism is disengaged to effect a reconstitution movement of the rearward bung 18? in the cartridge. Thereafter the threaded portion on the plunger 24? engages the drive mechanism to allow metered dosing.
    Type: Application
    Filed: March 29, 2012
    Publication date: July 19, 2012
    Applicant: OWEN MUMFORD LIMITED
    Inventors: Jeremy MARSHALL, Steven Mark Guy ROLFE
  • Patent number: 8092420
    Abstract: The present invention is directed to an automatic reconstitution drug delivery device. The inventive device effects simple and automatic reconstitution of a dry drug. To effect reconstitution, a user displaces a release button which causes first and second chambers of a drug cartridge to communicate, resulting in automatic mixing of a diluent and dry drug to effect reconstitution of the dry drug. The user then simply sets the dose volume using a dose-setting mechanism, and administers the injection in a manner typical of self-injection drug delivery devices. Whole or partial automatic priming can be also achieved by the device.
    Type: Grant
    Filed: November 22, 2005
    Date of Patent: January 10, 2012
    Assignee: Becton, Dickinson and Company
    Inventors: Antonio Bendek, John Laiosa
  • Patent number: 7980243
    Abstract: A cartridge for propellant-free administration of a liquid pharmaceutical composition by inhalation includes: an elongate displacing device including an upper end and a lower end, the lower end for at least partial insertion into a container; a cartridge chamber disposed at the lower end of the displacing device and operable store a pharmaceutical formulation, the cartridge chamber including at least one pierceably sealed opening; and a cannula guide extending from the upper end of the displacing device to the cartridge chamber, wherein insertion of a cannula through the guide pierces the sealed opening and releases the pharmaceutical formulation into a liquid solvent in the container to form the liquid pharmaceutical composition.
    Type: Grant
    Filed: June 7, 2007
    Date of Patent: July 19, 2011
    Assignee: Boehringer Ingelheim Pharma GmbH & Co., KG
    Inventor: Dieter Hochrainer
  • Patent number: 7963939
    Abstract: An injection device such as a syringe, which has a helical flow path for a solution in which the solvent and solute have been introduced. The helical flow path is formed by a helically configured member which has general overall configuration of a helical coil spring. Individual coils may be formed to have a groove located along the length of the helix. When compressed, the novel member effectively takes on a cylindrical outer configuration. Because the groove is covered and sealed by the surface of the next turn of the helix when compressed, an enclosed helical flow path is formed in the compressed member. The invention may be an injection device using the novel flow path forming member or alternatively, the flow path forming member itself.
    Type: Grant
    Filed: April 24, 2009
    Date of Patent: June 21, 2011
    Inventor: Thomas Chun
  • Patent number: 7963938
    Abstract: A device for producing medical foam, for example, a sclerosing agent, a diagnostic agent, a therapeutic agent, etc. The device comprises an active ingredient chamber and a gas chamber. Both chambers are respectively closed by a piston and connected to a foam generator. Both pistons are interconnected, especially by a connecting element, and can be displaced together, in order to supply the active ingredient and the gas to the foam producer.
    Type: Grant
    Filed: November 13, 2003
    Date of Patent: June 21, 2011
    Assignee: Chemische Fabrik Kreussler & Co.
    Inventors: Jan-Christoph Wollmann, Dorothee Schliephake
  • Patent number: 7879002
    Abstract: Mixing devices used with a syringe or syringe system and related systems for mixing dissimilar components contained therein. The devices and systems include a hollow elongate handle having a proximal end, a distal delivery end, and a delivery passageway therethrough. A mixing member is disposed at or near the proximal end of the hollow elongate handle, which mixing member and a portion of the handle are axially slidable within a syringe barrel during use. The user may push and pull the distal end of the handle, causing corresponding axial movement of the mixing member within the syringe barrel. The devices and systems may be used to homogenously mix difficult to mix two part compositions, as well as single part compositions which include components that may tend to separate over time (e.g., a fluoride varnish composition).
    Type: Grant
    Filed: October 27, 2008
    Date of Patent: February 1, 2011
    Assignee: Ultradent Products, Inc.
    Inventor: Neil T. Jessop
  • Patent number: 7861893
    Abstract: A number of surgical devices for the mixing and dispensement of a dual component surgical adhesive onto tissue are described. The surgical devices can provide adhesive storage chambers for the adhesive components within the surgical device and can have removable cartridges that draw and mix and apply the adhesive onto tissue. The removable cartridges can be easily replaced when clogged with set adhesive. Alternately, an adhesive dispensing device can comprise an adhesive dispensing gun containing the dual components of the adhesive and a plurality of rotatable orifices that can dispense the adhesive. One orifice can be selected and aligned with the adhesive dispensing gun to mix and apply the adhesive onto tissue. A fresh orifice can be rotated into alignment with the gun should a prior orifice become blocked.
    Type: Grant
    Filed: November 10, 2006
    Date of Patent: January 4, 2011
    Assignee: Ethicon Endo-Surgery, Inc.
    Inventors: James W. Voegele, Jessica M. Liberatore
  • Patent number: 7828765
    Abstract: The invention relates to a method and device for treating or preventing or suppressing a disease or condition in a non-human animal. The method comprises the steps of providing a single delivery device containing two components for sequential delivery from the delivery device. A first component is delivered from the single delivery device into a teat canal of a non-human animal and subsequently the second component is delivered from the single delivery device into the teat canal. The components are delivered without substantial mixing of the components.
    Type: Grant
    Filed: February 2, 2005
    Date of Patent: November 9, 2010
    Assignee: Bimeda Research & Development Ltd
    Inventors: Stephen Hallahan, Nicholas McHardy, Brendan Smith, Louis Van Vessem
  • Patent number: 7793655
    Abstract: A cartridge for propellant-free administration of a liquid pharmaceutical composition by inhalation includes: an elongate displacing device including an upper end and a lower end, the lower end for at least partial insertion into a container; a cartridge chamber disposed at the lower end of the displacing device and operable store a pharmaceutical formulation, the cartridge chamber including at least one pierceably sealed opening; and a cannula guide extending from the upper end of the displacing device to the cartridge chamber, wherein insertion of a cannula through the guide pierces the sealed opening and releases the pharmaceutical formulation into a liquid solvent in the container to form the liquid pharmaceutical composition.
    Type: Grant
    Filed: July 11, 2005
    Date of Patent: September 14, 2010
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventor: Dieter Hochrainer
  • Publication number: 20100114067
    Abstract: Mixing systems for storing and mixing multiple components of various medical compositions are provided. Generally, the instant mixing systems comprise a barrel, a plunger slidably disposed inside a barrel, and a pushing rod slidably disposed inside the plunger. The instant mixing system may further comprise multiple chambers for storing individual components or mixtures of components, with at least one chamber disposed in the barrel and at least one chamber disposed inside the plunger.
    Type: Application
    Filed: October 31, 2008
    Publication date: May 6, 2010
    Applicant: Warsaw Orthopedic, Inc.
    Inventors: Hai H. Trieu, Sean M. Haddock
  • Patent number: 7699804
    Abstract: A fluid ejection system (20) comprising a cartridge (24), an ejector (32, 300) and, optionally, a fill station (28) for filling the cartridge with a fluid, such as a vaccine. In some embodiments (52), the cartridge includes a transfer passageway (96) for receiving fluid from the fill station. In other embodiments (200, 400), the cartridge includes a vented fluid reservoir (208, 408) offset from an ejection chamber (224, 420). In yet other embodiments (500, 600), the cartridge includes a vented fluid reservoir chamber (512, 636) inline with the ejection chamber (508, 644). In still other embodiments (700, 1000, 1100), the cartridge includes first and second chambers (728, 736, 1036, 1048, 1136, 1148) initially fluidly sealed from on another by a valve, e.g., either a traveling valve (704, 800, 900, 1200, 1300) or a temporarily stationary valve (1004, 1104).
    Type: Grant
    Filed: January 30, 2004
    Date of Patent: April 20, 2010
    Assignee: Creare Inc.
    Inventors: James J. Barry, Mark C. Bagley, Peter L. Burghardt, Steven J. Fulton
  • Patent number: 7591808
    Abstract: Vaginal or rectal applicators for the delivery of a small volume of pharmaceutical preparation, i.e. less than 1 mL are disclosed herein. The delivery of a small volume of a pharmaceutical preparation allows for the transvaginal delivery of the preparation to the region of the upper vaginal vault or rectum for the treatment of diseases and disorders of the female urogenital system, cervix, uterus, ovaries, fallopian tubes and peritoneal cavity and the lower abdomen. The vaginal or rectal applicators contain four main parts, an applicator barrel, a plunger, a plunger tip, and an applicator cap. The applicator functions similar to a syringe. The applicator is filled with a pharmaceutical preparation with the plunger in the back position. The cap is attached to seal the pharmaceutical preparation in the applicator. To use the applicator, the cap is removed, the applicator is positioned, and the plunger is depressed.
    Type: Grant
    Filed: January 16, 2004
    Date of Patent: September 22, 2009
    Assignee: FemmePharma Holding Company, Inc.
    Inventors: Gerianne Tringali DiPiano, John Andrew Ziemniak, Joel Martin Bartholomew
  • Publication number: 20090112157
    Abstract: Mixing devices used with a syringe or syringe system and related systems for mixing dissimilar components contained therein. The devices and systems include a hollow elongate handle having a proximal end, a distal delivery end, and a delivery passageway therethrough. A mixing member is disposed at or near the proximal end of the hollow elongate handle, which mixing member and a portion of the handle are axially slidable within a syringe barrel during use. The user may push and pull the distal end of the handle, causing corresponding axial movement of the mixing member within the syringe barrel. The devices and systems may be used to homogenously mix difficult to mix two part compositions, as well as single part compositions which include components that may tend to separate over time (e.g., a fluoride varnish composition).
    Type: Application
    Filed: October 27, 2008
    Publication date: April 30, 2009
    Applicant: ULTRADENT PRODUCTS, INC.
    Inventor: Neil T. Jessop
  • Patent number: 7404820
    Abstract: Medical devices for filtering fluids flowing through a lumen and a method of forming medical devices. The devices can be used in vascular channels, urinary tracts, biliary ducts and the like, and filter emboli and other debris generated at a treatment site.
    Type: Grant
    Filed: April 4, 2005
    Date of Patent: July 29, 2008
    Assignee: ev3 Inc.
    Inventors: Rudy Mazzocchi, Timothy Claude, James Segermark
  • Patent number: 7311692
    Abstract: A dual-chamber type prefilled syringe comprises a cylindrical body within which a front plug member, a middle plug member and an end plug member are hermetically fitted to form a first chamber and a second chamber. The cylindrical body has an inner surface formed with a bypass. When the middle plug member moves to a position where the bypass is formed, the first chamber is communicated with the second chamber for the first time via the bypass. In this beginning state of liquid transfer (S), an inner volume (VS) of the cylindrical body between a leading end of the cylindrical body and a rear end of the front plug member is set to be at least 60% of a volume (VC) of a second component. When liquid component within the second chamber flows into the first chamber, it is possible to prevent part of the liquid component from passing through the first chamber to reach a portion for attaching an injection needle at a leading end of the cylindrical body.
    Type: Grant
    Filed: February 18, 2004
    Date of Patent: December 25, 2007
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Masahiko Kato, Yasaburo Akagi
  • Patent number: 6858137
    Abstract: A closure element for sterile closure of connections, in particular connections of filter modules for dialysis, hemofiltration or ultrafiltration is described. A closure element with a simple design that provides a reliable seal is formed by having the closure element include a wall with an automatically closing slit-shaped indentation which when closed creates a germ-proof seal. The sealing element is used for sterile closure of connections of medical items, as well as for the medical items themselves.
    Type: Grant
    Filed: January 18, 2002
    Date of Patent: February 22, 2005
    Assignee: Fresenius Medical Care Deutschland GmbH
    Inventors: Uwe Hahmann, Christian Sauerwald, Klaus Heilmann, Gerhard Breith, Steffen Fritzsche
  • Patent number: 6692468
    Abstract: A dual-chamber syringe has a plunger within an inner delivery chamber in fluid communication with an ejection port. The deliver chamber is formed within a tubular element axially slidable within a tubular guide. The tubular guide and the syringe outer barrel form an outer reservoir chamber. The outer reservoir chamber is sealed from the delivery chamber while the tubular element is in a first position within the guide. Upon withdrawal of the plunger, frictional contact imparted by the plunger seal causes the tubular element to slide away from sealing engagement with the barrel into a second position within the guide. In the second position of the tubular element, a fluid passageway is opened from the reservoir to the delivery chamber allowing fluid to be drawn into the delivery chamber. A porous seal between the plunger rod and barrel allows air into the reservoir during transfer of fluid to the delivery chamber.
    Type: Grant
    Filed: May 1, 2000
    Date of Patent: February 17, 2004
    Inventor: Ottfried Waldenburg
  • Patent number: 6602223
    Abstract: A pre-filled syringe having an elastic-sliding valve to produce a hermetic closure inside a pre-filled syringe which keeps the liquid content to be injected totally isolated, in order to prohibit the liquid from coming in contact with the needle or the external air.
    Type: Grant
    Filed: August 24, 2001
    Date of Patent: August 5, 2003
    Inventors: Jaime Luis Szapiro, Saul Moreno, Leonardo Szames
  • Patent number: 6599264
    Abstract: A method and a needleless injection system for administering a medication. In order to simplify as far as possible the handling necessary for loading the injector with medication and thereby eliminate risks caused by a complex handling the method and system according to the invention provide loading of medication into a needleless injector device by means of a syringe prefilled with a medication, this loading step preferably including connecting the syringe to the injector device by means of a suitable coupling member or adapter and operating the syringe for transferring medication prefilled therein into the injector device. After this transfer the syringe and/or the coupling member or adapter are detached from the injector device, which is then ready to be operated for ejecting the loaded dosage of said medication from the injector device and thereby pass the selected dosage through the skin of an injection receiver.
    Type: Grant
    Filed: January 26, 2000
    Date of Patent: July 29, 2003
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Werner Erni, Martin List
  • Patent number: 6551298
    Abstract: A controlled medicament security enclosure system that houses liquid filled reservoirs which consists of a portable enclosure (20) formed with a top half (22) and a bottom half (24) that permanently snap together to form a secure inseparable repository for the reservoirs. Inside the enclosure is at least one glass vial (36) for storing the liquid medicament with each vial having a sliding piston stopper (42) within that seals the inside of the vial and slides to maintain the liquid air free regardless of the volume. An adapter socket (48) is removably attached to the stopper and includes a hollow needle that pierces the stopper and permits a flowpath for the liquid. A flexible outlet tube (62) along with connectors on each end transmit the medicament to a mechanical drug delivery system that has a peristaltic pump and a control module.
    Type: Grant
    Filed: November 21, 2000
    Date of Patent: April 22, 2003
    Inventors: Jack Y. Zhang, Frank Zhishi Xia, Mary Ziping Luo
  • Publication number: 20030036725
    Abstract: This reconstitution and injection system delivers a drug in solution under pressure, and injects powdered or lyophilized drugs that require reconstitution, rehydration or dilution. In one embodiment, the system includes a syringe having a barrel, a plunger, a handle, a pump and a channel communicating the barrel with an injection needle. The pump pushes a liquid from the barrel through the injection needle via the channel upon fluid communication between the barrel and the injection needle for delivery of the liquid. In another embodiment, the system includes a first port receiving a syringe, a second port receiving a drug vial, a channel providing communication between the first and second ports, and a controller permitting or inhibiting fluid communication between the first and second ports. In yet another embodiment, the system includes an actuator and a housing having a channel providing fluid communication between a reservoir and the injection needle.
    Type: Application
    Filed: September 20, 2001
    Publication date: February 20, 2003
    Inventors: Gilad Lavi, Gjl Yigal, Jonathan Bar-Or
  • Publication number: 20020104791
    Abstract: A closure element for sterile closure of connections, in particular connections of filter modules for dialysis, hemofiltration or ultrafiltration is described. A closure element with a simple design that provides a reliable seal is formed by having the closure element include a wall with an automatically closing slit-shaped indentation which when closed creates a germ-proof seal. The sealing element is used for sterile closure of connections of medical items, as well as for the medical items themselves.
    Type: Application
    Filed: January 18, 2002
    Publication date: August 8, 2002
    Inventors: Uwe Hahmann, Christian Sauerwald, Klaus Heilmann, Gerhard Breith, Steffen Fritzsche