Closure Or Barrier Between Compartments Moved To Permit Mixing Patents (Class 604/89)
  • Patent number: 10632261
    Abstract: A self-admixing disposable hypodermic needle (admixing needle) includes a reservoir containing an additive, such as a buffering agent, to facilitate homogeneous mixing of the additive with an injection fluid, such as Lidocaine, contained in a cartridge held within a mechanically conjoined syringe. The admixing needle establishes a fluid communication pathway for hypodermically delivering the injection mixture to a patient preceding a potentially painful dental or medical procedure. Prior to removal, a delivery needle cap is pushed toward the syringe to dispense the additive into the cartridge. The delivery needle is then placed within the patient's tissues and the syringe is operated to force the injection mixture from the cartridge. Mixing surfaces on the male body (reservoir plunger) and the female body (reservoir) and other mechanical features homogeneously combine the injection fluid with the additive as the injection mixture travels through the admixing needle during the hypodermic injection.
    Type: Grant
    Filed: August 21, 2019
    Date of Patent: April 28, 2020
    Assignee: Aurim, LLC
    Inventors: William E Pounds, Jason Streeter
  • Patent number: 10583257
    Abstract: A method and apparatus for use in controlling a dispensing rate of medication or other substance via a syringe, including, without limitation, into a patient, intravenous line port or heparin lock. A force (typically manual) is applied to an input plunger of a dashpot, which is directly coupled to a piston which, in turn, is coupled to an output plunger. The force applied to the input plunger is buffered and transmitted to the output plunger. The output plunger acts upon the plunger of a conventional syringe, thereby resulting in flow of medicine or any other substance from the syringe at a desired and controlled flow rate.
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: March 10, 2020
    Inventors: Gregory Folse, Tonia Dandry Aiken, James Beam Aiken, Tina Dandry Mayes
  • Patent number: 10543315
    Abstract: Described are multi-chambered vessels comprising a first chamber, a second chamber, and a seal comprising a first member and a second member, wherein the first and second members are engageable with one another to form a barrier separating the first and second chambers. The first and second members are disengageable from one another to open a channel between the first chamber and second chambers. The vessels allow communication between the first and second chambers at a desired time, for example in order to contact components contained within the chambers or in order to sequentially release components or doses of components from the vessel. Also provided is a kit comprising a seal of the invention. The kit allows a single-chambered vessel to be converted into a multi-chambered vessel capable of controlling communication between the chambers at the final stage of the filling process.
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: January 28, 2020
    Assignee: Cube Pharmaceuticals N. Kalofolias & Co. OE
    Inventor: Evagelos Kalofolias
  • Patent number: 10500343
    Abstract: This invention relates to a method of identifying an accurate dosage of medicine in a dosage chamber of a syringe including the steps of providing an accurate dosage of a detailed single dosage medicine for insertion into a dosage chamber of a syringe; identifying the accurate dosage of medicine in the dosage chamber by retaining a notifier of the accurate dosage; securing the notifier with the syringe wherein the accurate dosage of medicine in a dosage chamber of a syringe is shown by the details on the notifier when secured with the syringe and allowing usage of the syringe to dispense the accurate dosage.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: December 10, 2019
    Assignee: JAY-NIK PTY LTD (ACN 620 076 253)
    Inventor: George Poulos
  • Patent number: 10279121
    Abstract: A mixing device and a retractable syringe comprising same are provided. The mixing device comprises concentric outer and inner barrels that form an outer chamber, the inner barrel having an inner chamber. A mixing plunger is slidably located in the outer chamber. A seal located in the outer chamber is capable of axial movement, in response to depression of the mixing plunger, from a first position in sealing engagement with one or more apertures in the inner barrel to a second position intermediate the apertures and vents in the outer barrel. This allows depression of the mixing plunger to force a first substance from the outer chamber through the apertures to mix with a second substance in the inner chamber. The mixed substance in the inner barrel is then delivered by the syringe with subsequent needle retraction.
    Type: Grant
    Filed: October 22, 2015
    Date of Patent: May 7, 2019
    Assignee: UNL Holdings LLC
    Inventors: Ramin Mojdehbakhsh, Peter J. Dungar, Ashley W. Palmer, Robert E. Johannesson, Philip A. Weaver, Aaron M. Weir
  • Patent number: 10124116
    Abstract: An injection device with a feedback mechanism includes a housing for a medicament container having a stopper, a plunger rod for acting on the stopper, a button interactively connected to the plunger rod, an activation member having a flexible locking device releasably connected to the plunger rod, a drive force device, a locking member slidable between positions in which the locking member either completely or partially surrounds the flexible locking device, and a guide rod. Audible and tactile information that an injection has started is provided by the plunger rod's hitting the stopper.
    Type: Grant
    Filed: December 7, 2015
    Date of Patent: November 13, 2018
    Assignee: SHL GROUP AB
    Inventors: Sebastian Karlsson, Gunnar Elmen
  • Patent number: 10092704
    Abstract: The present invention relates to a medicament delivery device. The medicament delivery device may include an operation member configured to act on a medicament container for expelling a medicament. The device may configured to hold the operation member in a pre-tensioned state. The device may include an activation member configured to interact with the operation member to release it from the pre-tensioned state. The device may further comprise feedback. For example, the feedback may include generating an audible and/or tactile and/or visual signal indicating that the medicament has been completely expelled.
    Type: Grant
    Filed: November 17, 2015
    Date of Patent: October 9, 2018
    Assignee: SHL Group AB
    Inventor: Matthias Daniel
  • Patent number: 10030771
    Abstract: A gasket insertion method for inserting a gasket into an outer cylinder includes providing an outer cylinder having a base end opening section; providing a gasket having a recessed section that is open at a base end of the gasket and that includes a flat bottom surface; pushing the gasket into a sleeve configured to be inserted into the outer cylinder, by relatively moving an inserter in a tip end direction with respect to the sleeve while a flat tip end surface of a tip end section of the inserter abuts the bottom surface of the recessed section; inserting the sleeve into the outer cylinder through the base end opening section; and arranging the gasket inside the outer cylinder by relatively moving the sleeve in a base end direction with respect to the outer cylinder while maintaining relative axial positions of the outer cylinder, the gasket, and the inserter.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: July 24, 2018
    Inventors: Makoto Shimizu, Hajime Sasamoto
  • Patent number: 9962492
    Abstract: A syringe assembly having a barrel for containing one or more medicaments and a stopper disposed in the barrel defining and separating a first volume and a second volume within the syringe assembly. The stopper includes a permanent seal fluidly sealing the stopper to the barrel about the entire perimeter of the stopper intermediate the first volume and second volume, and a channel bypassing the permanent seal, the channel having a first opening in fluid communication with the second volume and a second opening selectively sealed from the first volume by a resilient seal. The resilient seal is moveable between a sealing configuration and an open configuration to selectively seal the channel from the first volume and is moveable from the sealing configuration to the open configuration upon fluid pressure in the first volume or second volume exceeding a first pressure threshold.
    Type: Grant
    Filed: February 22, 2013
    Date of Patent: May 8, 2018
    Inventors: Ian Anderson, Matt Ekman
  • Patent number: 9950113
    Abstract: Various embodiments of needle assemblies for use with a drug delivery device to deliver two or more medicaments are provided. Additionally, various embodiments of methods for delivering two or medicaments are provided. In one embodiment, a needle assembly comprises an injection needle, a proximal housing member, a distal housing member, and a medicament transfer element. The proximal housing member contains a first medicament and is configured to attach to a drug delivery device containing a second medicament. The distal housing member is movably engaged with the proximal housing member such that relative axial movement between the proximal and distal housing members causes the first medicament to be delivered. Upon activation of the drug delivery device (e.g.
    Type: Grant
    Filed: October 31, 2011
    Date of Patent: April 24, 2018
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Beate Franke, Zdenek Cerman
  • Patent number: 9937317
    Abstract: Modified medical syringe with a flow regulator for the administration of anaesthesia, which allows for anaesthesiologists to handle the needle, control continuous aspiration and administer the anaesthetic with a single hand, thereby preventing intravascular injections. It comprises a flexible tube, designed to be introduced inside the barrel, which supplies the anaesthetic; a cylindrical body located on the rod, equipped with a protuberance along a semicircle located on the proximal side of the body and a through-hole wherein one end of the flexible tube may be introduced; a cylindrical cap located inside the syringe barrel, equipped with a longitudinal groove along its cylindrical side, which is designed to house the aforementioned flexible tube; a preloaded spring around the rod located between the cap and the support disk; and a pressurization device connected to the flexible tube.
    Type: Grant
    Filed: June 14, 2016
    Date of Patent: April 10, 2018
    Assignee: IPSUMPRO, S.L.
    Inventors: Roberto Garcia Aguado, Jorge Ubeda Pascual
  • Patent number: 9751056
    Abstract: A movable mixing disc may be utilized in connection with a syringe. The mixing disc may comprise a hole which may be covered by a fine screen or coupled to a porous member, allowing only certain elements of a solution to pass through the mixing disc. Actuation of a plunger of the syringe may cause liquid to emerge from the mixing disc hole as a high velocity jet or other turbulent flow, stirring up any settled particles on a distal side of the mixing disc. As the ejection continues, the mixing disc may be pushed forward by the plunger in order to eliminate any unused volume. Also, the mixing disc may be moved forward by virtue of a pressure difference created by a pressure drop across the mixing disc, such as a pressure drop created as the plunger is displaced to induce fluid flow across the mixing disc.
    Type: Grant
    Filed: May 21, 2014
    Date of Patent: September 5, 2017
    Assignees: Merit Medical Systems, Inc., IKOMED Technologies, Inc.
    Inventors: Gregory R. McArthur, Lindsay S. Machan, Daniel Gelbart
  • Patent number: 9616181
    Abstract: An auto-injector with an interlock mechanism for defining an operation sequence of the auto-injector in a manner to allow a lateral trigger button to be operated only when a proximal end of the auto-injector is pressed against an injection site.
    Type: Grant
    Filed: September 1, 2015
    Date of Patent: April 11, 2017
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Thomas Mark Kemp, Douglas Jennings, Peter Scudamore, Matthew Ekman
  • Patent number: 9561329
    Abstract: Disclosed are a piston for a micro-volume syringe and a plunger. The micro-volume syringe has a syringe barrel with a space defined in it. The piston is slidable on and along a wall of the space. A leading member to be arranged on a side where the piston comes into contact with a solution filled in the space and a trailing member to be arranged on a side where a plunger rod is to be connected, the latter side being opposite to a solution side of the leading member, have been integrated with each other. The trailing member has a higher hardness than the leading member. With the micro-volume syringe in which a drug solution can be filled in a very small quantity, the piston makes it possible to perform smooth drawing and ejection of the drug solution without leakage. Even if the small piston connected to a tip of the plunger rod is operated in a direction that the piston is to be pulled out of the syringe, the plunger rod does not slip off from the piston accidentally.
    Type: Grant
    Filed: June 22, 2010
    Date of Patent: February 7, 2017
    Assignee: DAIKYO SEIKO, LTD.
    Inventor: Hideaki Kawamura
  • Patent number: 9468588
    Abstract: Apparatus for use in a drug mixing system including a vial adapter assembly including a main body element having a vial receiving portion and a needle puncturable port, the main body element including an axial hollow tubular portion which is in fluid flow engagement with a bore of a vial puncturing spike, the main body element further including a membrane support surface that supports a first membrane which is in fluid flow engagement with the vial puncturing spike via the bore and via a recess formed in an intermediate portion of the main body element, and a second membrane supported by a membrane support member and separated by a gap from the first membrane.
    Type: Grant
    Filed: February 16, 2010
    Date of Patent: October 18, 2016
    Assignee: Teva Medical Ltd.
    Inventor: Eli Shemesh
  • Patent number: 9463139
    Abstract: A container usable for lyophilization, storage, and reconstitution of medication having only two parts, one of which is a plug component having a flow path terminating in a side outlet port and a second of which is a barrel component. The barrel component has a spiral mixing channel near its distal end in which powder medication is stored and upon reconstitution, yields a gradient concentration. The inner wall of the barrel includes a longitudinal diluent groove. To connect the plug outlet port with the longitudinal diluent groove, the plug or barrel has a 360° distribution groove encircling the plug and connecting to the plug outlet port. Regardless of what rotational orientation the plug has to the barrel, the diluent will always reach the mixing channel.
    Type: Grant
    Filed: January 10, 2012
    Date of Patent: October 11, 2016
    Inventor: Byeong Seon Chang
  • Patent number: 9289562
    Abstract: Methods and apparatus are disclosed for disposing a valve within a barrel of a conventional syringe to provide, first, a mixing syringe embodiment and, second, a sequential delivery syringe embodiment. Generally, the valve divides the syringe barrel into a proximal and a distal chamber. When used for mixing, the valve is self-displaceable by expansion of decompressing matter disposed within the valve against exterior matter permitting proximal displacement of the valve independent of character of matter in the distal chamber. For sequential delivery, switching of the valve occurs after switch opening causing pressure is relieved, thereby reducing inadvertent uncontrolled flow when the valve opens. In addition, a combination mixing and flush syringe is disclosed whereby a mixing and a flush capability is provided within a conventional syringe.
    Type: Grant
    Filed: May 13, 2011
    Date of Patent: March 22, 2016
    Inventors: Gale H. Thorne, Jr., Gale H. Thorne
  • Patent number: 9205026
    Abstract: A medicament container having an opening that provides access to a cavity defined by the medicament container. A stopper is sealingly positioned within the opening of the medicament container and configured to be forced into the cavity to open the medicament container. The medicament container also includes a mating member configured to mate with a complementary receiver associated with a second container to connect the medicament container to a second container. The medicament container further includes a radial seal configured to engage and seal against an interior seal wall associated with a second container prior to the stopper being forced into the cavity defined by the medicament container. A system is also provided for establishing fluid communication between a first container and a second container. The system includes a first container (e.g., a medicament container) having a radial seal, a second container, and a port assembly.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: December 8, 2015
    Assignee: Hospira, Inc.
    Inventors: Yei F. Moy, Stanley F. Pytel, John S. Ziegler, Jesse C. Darley, Douglas S. Rodenkirch
  • Patent number: 9173999
    Abstract: An apparatus includes a housing, a medicament container, and a movable assembly. The movable assembly includes a first movable member and a second movable member. The second movable member is configured to move relative to the first movable member to move the movable assembly from a first configuration to a second configuration. A distal end portion of the second movable member is configured to move a plunger disposed within the medicament container in a distal direction when the movable assembly is moved to the second configuration. The movable assembly is configured to move between a first position and a second position to move the medicament container within the housing between a first container position and a second container position.
    Type: Grant
    Filed: January 25, 2012
    Date of Patent: November 3, 2015
    Assignee: kaleo, Inc.
    Inventors: Eric S. Edwards, Evan T. Edwards, Mark J. Licata, Paul F. Meyers, Frank E. Blondino
  • Patent number: 9101720
    Abstract: A prefilled syringe has a gasket composed of a gasket body and a plunger-mounting member mounted. The plunger-mounting member has a distal part, spiral ribs formed on an outer surface of the distal part, a flange part, and a plunger-mounting part formed on an inner surface of a hollow part. The gasket body has a spiral screwing part which screws the spiral ribs and an accommodation part for accommodating a portion where the spiral ribs are formed. A plunger has a mounting distal part. The plunger-mounting part has a spiral concave portion and an engaging rib disposed at a side distal from the spiral concave portion. The mounting distal part of the plunger has a spiral projected portion capable of screwing the spiral concave portion and an engaging portion which engages the engaging rib of the plunger-mounting member.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: August 11, 2015
    Inventors: Hitoshi Okihara, Hideo Watanabe
  • Patent number: 9095394
    Abstract: A delivery system includes a reservoir for storing pressurized fluid and a piston rod passing through the reservoir and having an end portion with a dimension larger than the piston rod. A sleeve is configured to engage the end portion of the piston rod such that when the piston rod is advanced, the end portion seals an opening in the sleeve. The sleeve and the end portion function as a piston for extracting fluid from a delivery chamber. When the piston rod is retracted, the sleeve engages a portion of the end portion to permit the reservoir to communicate with the delivery chamber through the opening. Methods of use are disclosed.
    Type: Grant
    Filed: April 26, 2012
    Date of Patent: August 4, 2015
    Assignee: KYPHON SARL
    Inventors: Bryan Click, Brian Donovan
  • Patent number: 9095425
    Abstract: An injector for inserting an intraocular lens into an eye, comprising a main body (10) and a plunger (50). A guide element (30) is connected to the distal end of the plunger to laterally guide the plunger during movement along a longitudinal axis (L). The distal end of the guide element has a structure for fastening a plunger needle to the guide element. A radial guide pin (40) is in aligned radial bores of the guide element and plunger and extends into a longitudinal slot (17) of the main body to prevent twisting and to secure the guide element to the plunger. A retaining element (24) interacts with a running surface on the perimeter of the plunger, the running surface having a variable radial distance from the longitudinal axis so as to cause an axial resistance force which depends on the axial position of the plunger.
    Type: Grant
    Filed: September 6, 2012
    Date of Patent: August 4, 2015
    Assignee: ASICO, LLC
    Inventor: Rolf Meyer
  • Patent number: 9089645
    Abstract: A drug delivery device having a fixed dose setting mechanism with a biasing element. The drug delivery device includes a first dose setting mechanism, where the first dose setting mechanism is operably coupled to a primary reservoir holding a first medicament. The device also includes a dose setter operably coupled to the first dose setting mechanism. The device further includes second dose setting mechanism, where the second dose setting mechanism is operably coupled to a secondary reservoir holding a second medicament. The second dose setting mechanism is mechanically linked to the first dose setting mechanism, and the second dose setting mechanism includes a biasing element. The dose setter is configured to set a variable dose of the first medicament and automatically set a fixed dose of the second medicament upon activation. In addition, the biasing element is configured to assist with dispense of the second medicament.
    Type: Grant
    Filed: November 28, 2011
    Date of Patent: July 28, 2015
    Inventors: David Martin Leak, Malcolm Stanley Boyd, Carmen Patricia Keating
  • Patent number: 9061107
    Abstract: In one aspect, a medical injector is provided herein having a body and an overcap releasably attached to the body configured to prevent mounting of a needle prior to mixing of components within the body. In a further aspect, a slidable collet may be provided useable to urge resilient members from an outward disrupted state inwardly to collectively define a needle mount. Advantageously, a medical injector is provided which ensures proper sequence in preparation of the device, particularly with respect to the step of allowing mounting of a medical needle to the device subsequent to preparation of the medicament to be administered.
    Type: Grant
    Filed: September 30, 2013
    Date of Patent: June 23, 2015
    Assignee: Becton, Dickinson and Comapany
    Inventors: Richard A. Cronenberg, Asif Fayyaz, Atul Patel, Matthew Dylan Sweeney, Lionel Vedrine
  • Publication number: 20150126969
    Abstract: A method for combining a first liquid component with a second lyo component in a drug mixing apparatus is provided. The method comprises displacing a seal that prevents the first liquid component within a first barrel from coming into contact with the second lyo/liquid component within a second barrel. The method also comprises using an activating mechanism to move the first liquid component from the first barrel through at least one communication channel to an area within the second barrel holding the second lyo component, allowing the first liquid component to mix with the second lyo component to form a medicament. Additionally the method comprises displacing a second seal that prevents a medicament from entering an outlet channel. The method also comprises using the activating mechanism to eject the mixed medicament from the drug mixing apparatus through the outlet channel.
    Type: Application
    Filed: November 3, 2014
    Publication date: May 7, 2015
    Inventor: Jianwei MO
  • Patent number: 9011377
    Abstract: The control device is used to control delivery of fluids from a multi-fluid delivery system during a medical injection procedure. The fluid delivery system includes an injector used to deliver injection fluids to a patient. The control device is operatively associated with the injector for controlling discrete flow rates of injection fluids delivered to the patient. The control device includes a housing, first and second actuators associated with the housing, and an electronic substrate disposed within the housing and having a conductive pattern. The first actuator is operatively associated with the conductive pattern. The conductive pattern includes a plurality of predetermined digital values corresponding to discrete flow rates of injection fluids to be delivered by the injector. The second actuator is operatively associated with the electronic substrate and initiates output signals to the injector corresponding to desired mixture ratios of the injection fluids to be delivered by the injector.
    Type: Grant
    Filed: November 5, 2008
    Date of Patent: April 21, 2015
    Assignee: Bayer Medical Care Inc.
    Inventors: Ralph H. Schriver, Thomas P. Joyce, Michael Riley, William D. Barlow
  • Patent number: 9005160
    Abstract: A medicament delivery device includes a distal housing part; a proximal housing part in which a multi-chamber medicament container is arranged, with the proximal housing part movable relative to the distal housing part for mixing substances in the container; a plunger rod arranged to act on a stopper in the container, where movement of the housing parts toward each other forces the stopper against the plunger rod for mixing the substances in the container; a drive force unit for forcing the plunger rod for subsequent delivery of medicament; an activation member slidable through the distal housing part and releasably connected to the drive force unit; and a guide shell one-way rotatable in the distal housing part with threads that cooperate with threads on the proximal housing part. The guide shell and plunger rod have guide members such that they are rotationally locked but slidable in relation to each other.
    Type: Grant
    Filed: October 15, 2010
    Date of Patent: April 14, 2015
    Assignee: SHL Group AB
    Inventors: Martin Karlsson, Nils Ronquist
  • Patent number: 8986245
    Abstract: Injection device for manual penetration and injection comprising a distal housing part (10); a proximal housing part (12) with a multi-chamber container (20); a plunger rod (40); a push button (70); an activation member (30); a drive force means(100) and a locking member (50), wherein the device further comprises a guide rod (60) arranged to generate an audible and tactile indication of the start of an injection.
    Type: Grant
    Filed: January 12, 2011
    Date of Patent: March 24, 2015
    Assignee: SHL Group AB
    Inventors: Sebastian Karlsson, Gunnar Elmén
  • Patent number: 8986313
    Abstract: A cartridge system for mixing and applying a mixing ware. The cartridges are arranged parallel and they are connected to a mixing space and an outlet opening. The cartridges each comprise a feed plunger for expelling starting components of the mixing ware from the cartridges through the openings, and each cartridge has at least one closure allocated to it that is shiftable in longitudinal direction of the cartridges, whereby the closures close the openings of the cartridges in a starting position, and the openings are open, at least in part, in an end position of the shiftable closures. In open position, the closure is shifted into a hollow space. The closures are cylindrical in shape and in their end position are capable of being lowered into cylindrical hollow spaces of the cartridges in order to uncover the openings.
    Type: Grant
    Filed: November 20, 2012
    Date of Patent: March 24, 2015
    Assignee: Heraeus Medical GmbH
    Inventors: Sebastian Vogt, Tim Schnieber
  • Patent number: 8968238
    Abstract: Mixing systems and methods include a mixing device comprising a primary tube having a proximal end, a distal end, an outer surface and an inner lumen and at least one secondary tube having a proximal end, a distal end, an outer surface and an inner lumen. The at least one secondary tube is substantially parallel to the primary tube. The distal end of the at least one secondary tube is fluidly connected to the primary tube at a junction located on the primary tube close to the distal end of the primary tube.
    Type: Grant
    Filed: December 3, 2010
    Date of Patent: March 3, 2015
    Assignee: Intravenous Solutions, Ltd.
    Inventors: Christopher Page, Stephen Probst, Thomas Corrado
  • Publication number: 20150018761
    Abstract: An automatic injection device including a housing, a chamber with a first compartment and a second compartment, and a seal structure between the compartments. The seal structure is initially in a sealing condition that seals the first compartment from the second compartment, where the seal includes a plug and an outer sealing member. The plug is slidably movable within the outer sealing member to convert the seal structure from the sealing condition to a mixing condition by opening a path between the first compartment and the second compartment. The automatic injection device also includes a needle assembly and an activation assembly. Activation of the activation assembly causes (1) pressurization of the first compartment, (2) the seal structure to convert from the sealing condition to the mixing condition, and (3) the first and second medicament components to be mixed and forced through the needle assembly.
    Type: Application
    Filed: July 11, 2013
    Publication date: January 15, 2015
    Inventors: Steven Griffiths, Robert L. Hill
  • Patent number: 8926558
    Abstract: A medicament delivery device comprising a housing (10; 110); a medicament container holder (12; 120) rotatably locked but slidable connected to said housing, the medicament holder comprising first mix engagement means (28; 126) on its outer surface, and second linear guide means; a multi-chamber medicament container (14; 130) arranged within the container holder, a plunger rod (60; 140) comprising first holding means (58; 146) on its outer circumferential surface; drive force means (64; 142) capable of pushing said plunger rod; characterized in that said device further comprises manual mixing means (44, 148) comprising a rotatable manual knob (62,186) protruding from the distal end of the housing and a mix member (48, 149) comprising flexible holding means (52; 160) releasibly engaged to the first holding means (58; 146) for holding the plunger rod and thereby the drive force means in a pre-tensioned state and second mix engagement means (46; 150) arranged to cooperate with the first mix engagement means (28;
    Type: Grant
    Filed: June 5, 2009
    Date of Patent: January 6, 2015
    Assignee: SHL Group AB
    Inventors: Jochen Ratjen, Anders Holmqvist, Martin Karlsson
  • Patent number: 8920367
    Abstract: An apparatus includes a medicament container assembly, a movable assembly, and a spring. The medicament container assembly includes a first plunger defining a first volume, and a second plunger defining a second volume. The movable assembly includes a first movable member and a second movable member. The second movable member can move the second plunger within the medicament container assembly. The first movable member can move the first plunger in a first direction within the medicament container assembly to expel a contents of at least the first volume via a needle. The spring is configured to urge the needle in a second direction. The release portion of the first movable member is configured to contact the second movable member after the first movable member moves the first plunger to enable the spring to move the needle in the second direction.
    Type: Grant
    Filed: December 15, 2011
    Date of Patent: December 30, 2014
    Assignee: kaleo, Inc.
    Inventors: Eric Shawn Edwards, Evan Thomas Edwards, Mark J. Licata, Paul F. Meyers
  • Publication number: 20140371670
    Abstract: A medicament delivery device for a reconstituted medicament, comprising a proximal housing part (12; 12?; 12??), a distal housing part (10; 10?; 10??), a medicament delivery drive unit and actuation means, wherein the medicament delivery drive unit is mounted in said distal housing part and wherein the actuation means further include an activation member (74; 101; 201) which is displaceable between an inactive position wherein the actuator is prevented from engaging the medicament delivery drive unit and an active position wherein the actuator is able to engage the medicament delivery drive, whereby the actuator is capable of interacting with said medicament delivery drive unit to perform a delivery of the reconstituted medicament only in the active position of the activation member and in the second position of the medicament delivery drive unit.
    Type: Application
    Filed: January 31, 2012
    Publication date: December 18, 2014
    Applicant: SHL GROUP AB
    Inventors: Anders Holmqvist, Stefan Lööf
  • Patent number: 8905975
    Abstract: The present invention relates to a container comprising: a body; a pusher movable with respect to the body between an initial position and an end-of-use position; a locker located on the pusher and forming an abutment so as to be able to abut against the body between the initial position and the end-of-use position, wherein, the abutment abuts against the body to limit distal movement of the pusher relative to the body to a pusher locking position located between the initial position and the end-of-use position; a locking arrangement capable of, temporarily, locking the locker on the pusher so as to define a locker locking position of the locker on the pusher, the locker locking position establishing the position of the abutment relative to the pusher so as to set the pusher locking position; and, an unlocking arrangement designed so that, with triggering, the locking arrangement is released so as to allow the locker to be displaced relative to the pusher and for the pusher to be moved past the pusher locking
    Type: Grant
    Filed: September 12, 2007
    Date of Patent: December 9, 2014
    Assignee: Becton Dickinson France S.A.S.
    Inventor: Frédéric Perot
  • Patent number: 8900206
    Abstract: Disclosed herein is a fluid infusion device of the type that delivers medication fluid to the body of a patient. The device includes or cooperates with a fluid reservoir, and the device has a sealing assembly to receive and form a fluid seal with the fluid reservoir. A retractable sealing element surrounding a hollow fluid delivery needle may be used to seal a port of the fluid reservoir. The port may include a pressure vent that is sealed by the retractable sealing element. In one variation, the reservoir includes a moving valve sleeve that holds a septum. The septum moves to allow the reservoir to vent, and to form a seal with the port when the needle pierces the septum. In another variation, the device includes a needleless sealing assembly. In yet other variations, the device uses a needled fluid reservoir.
    Type: Grant
    Filed: February 17, 2012
    Date of Patent: December 2, 2014
    Assignee: Medtronic MiniMed, Inc.
    Inventors: Edgardo C. Halili, Eric M. Lorenzen, Matthew William Yavorsky
  • Publication number: 20140350460
    Abstract: The invention is related to a dispense interface for a drug delivery device for delivering at least two drug agents, wherein the dispense interface is configured to be coupled to a cartridge holder of the drug delivery device, wherein the cartridge holder is configured to hold at least two cartridges, wherein the dispense interface comprises at least two inlet channels, each comprising a fluid inlet opening, wherein each fluid inlet opening is configured to receive fluid from a respective cartridge of the at least two cartridges when the dispense interface is axially coupled to the cartridge holder, an outlet channel comprising a fluid outlet opening, a valve structure configured to be selectively moved into any one of a plurality of positions, wherein in at least one position the valve structure selectively permits or prevents fluid flow from any of the at least two inlet channels to the outlet channel.
    Type: Application
    Filed: January 9, 2013
    Publication date: November 27, 2014
    Inventor: David Moore
  • Patent number: 8894608
    Abstract: A steroid delivery system including a mixing syringe having a first chamber and a second chamber and at least one hypodermic needle is provided. The first chamber of the mixing syringe contains a pre-measured volume of a local anesthetic and the second chamber contains a pre-measured volume of a corticosteroid. An improved mixing syringe and a method for treating pain using the steroid delivery system of the present invention is also provided herein. The improved syringe achieves mixing without the introduction or elimination of air and without puncturing or rupturing of a membrane, diaphragm or other material. The kit concept improves the speed of the procedure, sterility, accuracy of dosing, and immediate availability of disparate items to implement the procedure in a variety of medical practice settings.
    Type: Grant
    Filed: May 22, 2009
    Date of Patent: November 25, 2014
    Inventor: Michael P. Connair
  • Publication number: 20140316334
    Abstract: Device for medicament delivery with syringe-like usability having a restraining mechanism A device for medicament delivery with syringe-like usability comprising at least one grip, at least one medicament container holder, and at least one plunger rod being substantially rotationally fixed relatively to the grip. The medicament container holder (13) is movable towards the grip in a longitudinal direction of the device, and rotation of at least one rotatable part (40), which is rotatable relatively to the grip and substantially inhibits movement of the plunger rod (20) in a longitudinal direction for dose delivery when in at least one locking position until being rotated, is restrained by at least one restraining member (42) abutting or being connected to the rotatable part (40) and the grip (30) until the medicament container holder is moved towards the grip for interacting with the at least one restraining member.
    Type: Application
    Filed: May 7, 2012
    Publication date: October 23, 2014
    Applicant: SHL GROUP AB
    Inventors: Anders Holmqvist, Maria Hedin
  • Patent number: 8864719
    Abstract: A needle and receiver assembly for use with a syringe cartridge filled with medicine includes a cartridge receiver having a hollow interior, an open end sized for receiving at least part of the syringe cartridge, and a closed end opposite the open end. The assembly includes a needle mounted on the receiver having a fluid passage extending between a sharp delivery tip at a distal end of the needle and a sharp access tip at a proximal end of the needle opposite the delivery tip positioned inside the hollow interior of the receiver. The assembly includes a cutter movably mounted in the hollow interior of the receiver for movement relative to the receiver and the needle to cut the diaphragm of the cartridge when received in the hollow interior of the receiver.
    Type: Grant
    Filed: April 4, 2012
    Date of Patent: October 21, 2014
    Assignee: Covidien LP
    Inventors: David M. Selvitelli, Melvin A. Finke, Kathleen Tremblay
  • Publication number: 20140309586
    Abstract: Described herein are injection devices capable of automatically injecting substances into the soft tissue of a patient. The devices can inject low to high viscosity materials at predetermined, user selected injection rates, allowing the operator more control than a traditional syringe. The devices can allow mixing of more than one substance and/or reconstitution of a solid substance for injection. The injection devices described herein can allow the operator to easily inject one or more low to high viscosity liquid or gel soft-tissue augmentation fillers, one or more drugs, one or more other biocompatible materials, or combinations thereof.
    Type: Application
    Filed: June 26, 2014
    Publication date: October 16, 2014
    Inventors: Christopher S. Mudd, Ahmet Tezel
  • Patent number: 8852145
    Abstract: Inline liquid drug medical devices for use with a source of physiological fluid and a medicinal vessel for liquid drug reconstitution and administration purposes. The inline liquid drug medical devices include a housing having a longitudinal device axis, a rotary flow control member and a vial adapter for transposing the flow control member from an initial first flow control position for liquid drug reconstitution purposes to a second flow control position for liquid drug administration purposes. The inline liquid drug medical devices include a syringe port and a drug dispensing port co-axial with the device axis. The rotary flow control member is rotatable about an axis of rotation co-axial with the syringe port and the drug dispensing port.
    Type: Grant
    Filed: October 27, 2011
    Date of Patent: October 7, 2014
    Assignee: MEDIMOP Medical Projects, Ltd.
    Inventors: Igor Denenburg, Nimrod Lev, Moshe Gilboa
  • Publication number: 20140276385
    Abstract: A portable auto-injector is capable of moving from a compact state where the auto-injector is in a shape easier to transport than in an activation state wherein the auto-injector has been extended. A safety limits movement of the needle assembly and prevents premature needle sticks. The drug is stored in one or more dry and wet medicament states until need.
    Type: Application
    Filed: March 18, 2014
    Publication date: September 18, 2014
    Applicant: WINDGAP MEDICAL, INC.
    Inventors: Brent Alan Buchine, Christopher John Stepanian, Adam Standley
  • Patent number: 8813955
    Abstract: A container for medical products has at least one chamber. At least two lyophilized active substances and/or auxiliary substances are jointly present in the at least one chamber.
    Type: Grant
    Filed: June 18, 2009
    Date of Patent: August 26, 2014
    Assignee: Arzneimittel GmbH Apotheker Vetter & Co. Ravensburg
    Inventors: Frank Böttger, Benjamin Böbst, Patricia Koch
  • Patent number: 8814823
    Abstract: The invention relates to a method and a device for lyophilizing, reconstituting and administering a reconstituted substance. The device has an elongate housing having a dispensing-side front housing end and a housing end lying opposite it. A first chamber, containing a lyophilizate, is disposed in the housing in the region of the front housing end and is tightly sealed at an end facing the front housing end by a removable closure and is tightly sealed in the direction of the rear housing end by a plunger. A second chamber is provided or formed in the housing in the region of the rear housing end which is connected by at least one opening to the ambient atmosphere. This opening is closed by a membrane which is permeable to gas but not to bacteria.
    Type: Grant
    Filed: October 25, 2005
    Date of Patent: August 26, 2014
    Assignee: Pharma Consult Ges.m.b.H. & Co Nfg KG
    Inventor: Ewald Pickhard
  • Publication number: 20140236121
    Abstract: A syringe (1) for mixing and ejecting an active pharmaceutical ingredient is disclosed. The syringe (1) comprises a syringe body (2) defining a first lumen (8), a first plunger (4) arranged movably in said first lumen (8), said first plunger (4) being hollow, thereby defining a second lumen (9) being separated from the first lumen (8), and a second plunger (5) arranged movably in said second lumen (9). A liquid diluent is contained in one of the first lumen (8) and the second lumen (9), and an active pharmaceutical ingredient is contained in the other of the first lumen (8) and the second lumen (9). The second plunger (5) is movable in such a manner that the active pharmaceutical ingredient and the liquid diluent are brought together, e.g.
    Type: Application
    Filed: February 2, 2012
    Publication date: August 21, 2014
    Applicant: BIONEER A/S
    Inventor: Daniel Bar-Shalom
  • Patent number: 8801659
    Abstract: Described herein are injection devices capable of automatically injecting substances into the soft tissue of a patient. The devices can inject low to high viscosity materials at predetermined, user selected injection rates, allowing the operator more control than a traditional syringe. The devices can allow mixing of more than one substance and/or reconstitution of a solid substance for injection. The injection devices described herein can allow the operator to easily inject one or more low to high viscosity liquid or gel soft-tissue augmentation fillers, one or more drugs, one or more other biocompatible materials, or combinations thereof.
    Type: Grant
    Filed: June 1, 2009
    Date of Patent: August 12, 2014
    Assignee: Allergan, Inc.
    Inventors: Christopher S. Mudd, Ahmet Tezel
  • Patent number: 8795226
    Abstract: A cannula assembly (10) comprising a hub (76) and a cannula (12) mounted in the hub (76). The cannula defines an inner space (36). The cannula comprises a distal end (16) and a proximal end (18). A first medicament (40) is provided in the inner space of the cannula. In one arrangement, the hub of the cannula assembly is configured to be coupled to an injection device (26). The cannula assembly may be removably or permanently coupled to the injection device containing a second medicament (17).
    Type: Grant
    Filed: June 24, 2010
    Date of Patent: August 5, 2014
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Bernd Kuhn, Gerrit Hauck
  • Patent number: 8763798
    Abstract: The present invention relates to a closure for filling and sealing receptacles containing medicinal fluids, a method for filling a receptacle with a medicinal fluid and sealing the receptacle. The closure used in the method comprises a mounting piece that may be attached to the receptacle and a connector piece that may be connected to a connector piece of a filling device. A closure body is arranged between the mounting piece and the connector piece, in which a closure piece for sealing the closure sits. The closure piece may be slid between a position sealing the closure and a position which opens the closure. The closure is sealed tight with a removable protective cap. The present method is characterized in that with the protective cap removed the receptacle is filled through the closure in a clean room, whereupon after filling, the closure is sealed by pressing the closure piece into the closure.
    Type: Grant
    Filed: January 22, 2008
    Date of Patent: July 1, 2014
    Assignee: Fresenius Medical Care Deutschland GmbH
    Inventor: Michael Paul
  • Patent number: 8758292
    Abstract: An apparatus for administering a fluid product, including a housing, a product member for accomodating the fluid product and/or a reservoir for the fluid product, which product member can be moved relative to the housing from a start position to an inserted position along a longitudinal axis of the housing, a drive member in the housing and movable relative to the product member for emptying the fluid product from the product member and/or the reservoir, wherein the drive member has at least one holding element which holds the drive member in the start position of the product member and wherein, by the movement of the product member, the holding element is moved from the holding position to a released position in which the drive member is movable relative to the housing.
    Type: Grant
    Filed: June 6, 2012
    Date of Patent: June 24, 2014
    Assignee: TecPharma Licensing AG
    Inventors: Markus Tschirren, Ulrich Moser, Juerg Hirschel, Jan Baumert, Eric Hattler