Abstract: Methods for the formulation of biodegradable microparticles for delivery of protein drugs, such as botulinum toxin, have been developed. The methods include the steps of precipitating and washing proteins with organic solvent to remove water prior to dispersing in polymer-dissolved organic solvent to prevent exposure to water/solvent interfaces and maintain bioactivity of the protein drugs and fabrication of microparticles by either template or emulsion method. Biodegradable microparticles, formed of one or more biodegradable polymers having entrapped in the polymer one or more protein agents, such as botulinum toxin, are also provided. Precipitated botulinum toxin and botulinum toxin-loaded microparticles can also be formulated into thermogels or crosslinked hydrogels. The stability of the protein within these microparticles, as well as the controlled release of the entrapped agents, provides for sustained efficacy of the agents.

Abstract: Drive systems for a drug delivery device are provided. The drive systems can be positioned within a container that stores a liquid drug to be delivered to a user. The drive systems can be coupled to a plunger positioned within the container. The drive systems can be incrementally advanced to drive the plunger further into the container, thereby expelling a portion of the stored liquid drug from the container for delivery to the user. The container can be any type of container including a pre-filled, standardized drug cartridge. The drive systems and container can be components of a wearable drug delivery device.

Abstract: An injection apparatus and related methods. The injection apparatus includes a housing with a proximate end and a distal end. The housing further defines a fluid pathway. A defeatable seal is fixedly positioned within the fluid pathway to separate an internal volume of the housing into a first compartment and a second compartment downstream from the first compartment. The defeatable seal is configured to fail in response to an increase in fluid pressure within the first compartment, allowing a fluid in the first compartment to pass through the second compartment and through the fluid outlet.

Abstract: Various systems and methods for the pressure-regulated transfer of medical fluids are disclosed. The system can include an adapter assembly that connects with a medical container and with a syringe assembly. The syringe assembly can include a first reservoir and a second reservoir. In various embodiments, when the adapter assembly and the syringe assembly are coupled, the first reservoir and the container can exchange regulating fluid and the second reservoir and the container can exchange medical liquid from the medical container.

Abstract: The present disclosure provides aseptic vial piercing and sterilization systems, and methods of assembling, using and sterilizing same. The systems and methods utilize a pre-sterilized primary container including a first end, a first cavity, a second end with an opening in communication with the first cavity, a septum at least partially sealing the opening, and a product within the first cavity. The systems and methods include an injection assembly including a first end portion of a hollow flowpath forming member. The injection assembly and the primary container may be assembled in a non-sterile environment to form a second cavity extending about the first end portion of the flowpath forming member and to the primary container. The second cavity may then be selectively sterilized in a non-deleterious manner to the product to allow the first end portion to aseptically pierce the septum to extend into the first cavity.

Abstract: A female syringe of a syringe kit includes a female syringe barrel including a cylindrical portion into which a nozzle of a male syringe is insertable, a hollow cylindrical packing arranged in the cylindrical portion, and a cap detachably attached to the cylindrical portion. When the cap is detached from the cylindrical portion, the packing remains in the cylindrical portion, a distal end opening is opened, and the nozzle of the male syringe is fitted in a liquid-tight manner to an inner side of the packing.

Abstract: A needle hub assembly for a pen needle includes a needle hub, an inner shield and an outer cover. The open end of the outer cover is closed by a removable seal to access the needle hub. The needle hub has a body with a shoulder and a tower extending from the body for supporting a cannula. The inner shield fits over the tower and the cannula and includes a flange that has an outer dimension complementing the outer dimension of the needle hub and contacts the shoulder of the needle hub in the assembled condition. The outer cover encloses the needle hub and the inner shield and includes a stop member on an inner surface that contacts the flange of the inner shield to capture the inner shield between the shoulder of the needle hub and the outer cover.

Abstract: An injection device with a feedback mechanism includes a housing for a medicament container having a stopper, a plunger rod for acting on the stopper, a button interactively connected to the plunger rod, an activation member having a flexible locking device releasably connected to the plunger rod, a drive force device, a locking member slidable between positions in which the locking member either completely or partially surrounds the flexible locking device, and a guide rod. Audible and tactile information that an injection has started is provided by the plunger rod's hitting the stopper.

Abstract: A fluid transfer system includes a container having a body having a sidewall extending between an open top end and a bottom end along a central axis to define an interior cavity, and at least one protrusion extending from an interior portion of the sidewall into the interior cavity. The system further including a connector configured for receipt within the interior cavity. The connector having a body having a distal end, a proximal end, and a sidewall extending between the distal end and the proximal end and defining a fluid passageway therethrough, and a locking arrangement provided on at least a portion of an inner member of the connector and accessible through at least a portion of an outer member of the connector. The locking arrangement is configured for cooperating with the at least one protrusion to prevent rotation of the inner member relative to the outer member.

Abstract: A syringe including a first hollow cylinder including a first end, a second end and a first inner diameter; a second hollow cylinder including a first end, a second end and a second inner diameter, wherein the second end of the second hollow cylinder is fixed with respect to the first end of the second hollow cylinder; a tube including a first end having the first inner diameter and a second end having the second inner diameter, wherein the tube is configured to connect the first hollow cylinder at the second end of the first hollow cylinder and the second hollow cylinder at the first end of the second hollow cylinder; and a piston configured to slide within the first hollow cylinder, the tube and the second hollow cylinder.

Abstract: The present disclosure relates to devices and methods for neutralizing an acidic anesthesia solution. An anesthesia neutralization device includes an outer housing and an inner housing. The inner housing holds a buffer carpule and an anesthetic carpule in a side by side arrangement, with the buffer solution maintained under pressure prior to deployment. A curved transfer needle is coupled to the outer housing and includes ends that both point respectively toward the buffer carpule and anesthetic carpule. The device is actuated by moving the inner housing relative to the outer housing to bring the anesthesia carpule and buffer carpule into contact with the transfer needle and to force buffer solution through the transfer needle and into the anesthesia carpule.

Abstract: An automatic mixing device, an actuating device having integrated plunger and configured to be removably mounted to the automatic mixing device, and a retractable syringe having the automatic mixing device are provided. The actuating device has an initially compressed spring and a trigger member that is rotatable to initiate spring decompression to drive depression of a mixing plunger seal of the automatic mixing device. Another seal located in an outer chamber of the mixing device is capable of axial movement upon depression of the mixing plunger, from a first position in sealing engagement with one or more apertures in an inner barrel to a second position intermediate the apertures and vents in an outer barrel. This allows depression of the mixing plunger to force a first substance from the outer chamber through the apertures to mix with a second substance in an inner chamber of the inner barrel. The mixed substance in the inner barrel is then delivered by the syringe with subsequent needle retraction.

Abstract: Provided herein are systems, devices, and methods for sample collection. A sample collection device may comprise a vessel, a lid, and pre-loaded liquid solutions. The sample collection device may collect a liquid sample, such as a biological sample. The liquid solutions may comprise reagents for preserving and/or stabilizing biological samples, such as saliva, collected in the vessel. A chamber comprising the liquid solutions may be located in the vessel and/or the lid. In some instances, the liquid solution may be released from the chamber upon closure of the vessel with the lid. In some instances, the liquid solution may be released from the chamber upon actuation of an implement, such as a plunger. In some instances, the liquid solution may be released upon compression of an absorbent member. The sample collecting device may be delivered to a remote location for further processing and/or analysis.

Abstract: An injection device uses telescoping and/or nested components and other features to make the overall device compact in size. The device is configured to have a storage position and an extended position, such that its needle is positioned within the housing of the device in a storage position, with the needle extending beyond the device housing when needed for an injection. The telescoping plunger mechanism has a storage position and an extended position for use. The device includes a needle depth cover, which extends from the device housing for use, and guides the user as to the correct depth for the needle to penetrate the user's skin. A switch allows different depth settings, for example allowing a deeper penetration for injection into a leg, and shallower penetration for injection into an arm.

Abstract: A self-admixing disposable hypodermic needle (admixing needle) includes a reservoir containing an additive, such as a buffering agent, to facilitate homogeneous mixing of the additive with an injection fluid, such as Lidocaine, contained in a cartridge held within a mechanically conjoined syringe. The admixing needle establishes a fluid communication pathway for hypodermically delivering the injection mixture to a patient preceding a potentially painful dental or medical procedure. Prior to removal, a delivery needle cap is pushed toward the syringe to dispense the additive into the cartridge. The delivery needle is then placed within the patient's tissues and the syringe is operated to force the injection mixture from the cartridge. Mixing surfaces on the male body (reservoir plunger) and the female body (reservoir) and other mechanical features homogeneously combine the injection fluid with the additive as the injection mixture travels through the admixing needle during the hypodermic injection.

Abstract: A method and apparatus for use in controlling a dispensing rate of medication or other substance via a syringe, including, without limitation, into a patient, intravenous line port or heparin lock. A force (typically manual) is applied to an input plunger of a dashpot, which is directly coupled to a piston which, in turn, is coupled to an output plunger. The force applied to the input plunger is buffered and transmitted to the output plunger. The output plunger acts upon the plunger of a conventional syringe, thereby resulting in flow of medicine or any other substance from the syringe at a desired and controlled flow rate.

Abstract: Described are multi-chambered vessels comprising a first chamber, a second chamber, and a seal comprising a first member and a second member, wherein the first and second members are engageable with one another to form a barrier separating the first and second chambers. The first and second members are disengageable from one another to open a channel between the first chamber and second chambers. The vessels allow communication between the first and second chambers at a desired time, for example in order to contact components contained within the chambers or in order to sequentially release components or doses of components from the vessel. Also provided is a kit comprising a seal of the invention. The kit allows a single-chambered vessel to be converted into a multi-chambered vessel capable of controlling communication between the chambers at the final stage of the filling process.

Abstract: This invention relates to a method of identifying an accurate dosage of medicine in a dosage chamber of a syringe including the steps of providing an accurate dosage of a detailed single dosage medicine for insertion into a dosage chamber of a syringe; identifying the accurate dosage of medicine in the dosage chamber by retaining a notifier of the accurate dosage; securing the notifier with the syringe wherein the accurate dosage of medicine in a dosage chamber of a syringe is shown by the details on the notifier when secured with the syringe and allowing usage of the syringe to dispense the accurate dosage.

Abstract: A mixing device and a retractable syringe comprising same are provided. The mixing device comprises concentric outer and inner barrels that form an outer chamber, the inner barrel having an inner chamber. A mixing plunger is slidably located in the outer chamber. A seal located in the outer chamber is capable of axial movement, in response to depression of the mixing plunger, from a first position in sealing engagement with one or more apertures in the inner barrel to a second position intermediate the apertures and vents in the outer barrel. This allows depression of the mixing plunger to force a first substance from the outer chamber through the apertures to mix with a second substance in the inner chamber. The mixed substance in the inner barrel is then delivered by the syringe with subsequent needle retraction.

Abstract: An injection device with a feedback mechanism includes a housing for a medicament container having a stopper, a plunger rod for acting on the stopper, a button interactively connected to the plunger rod, an activation member having a flexible locking device releasably connected to the plunger rod, a drive force device, a locking member slidable between positions in which the locking member either completely or partially surrounds the flexible locking device, and a guide rod. Audible and tactile information that an injection has started is provided by the plunger rod's hitting the stopper.

Abstract: The present invention relates to a medicament delivery device. The medicament delivery device may include an operation member configured to act on a medicament container for expelling a medicament. The device may configured to hold the operation member in a pre-tensioned state. The device may include an activation member configured to interact with the operation member to release it from the pre-tensioned state. The device may further comprise feedback. For example, the feedback may include generating an audible and/or tactile and/or visual signal indicating that the medicament has been completely expelled.

Abstract: A gasket insertion method for inserting a gasket into an outer cylinder includes providing an outer cylinder having a base end opening section; providing a gasket having a recessed section that is open at a base end of the gasket and that includes a flat bottom surface; pushing the gasket into a sleeve configured to be inserted into the outer cylinder, by relatively moving an inserter in a tip end direction with respect to the sleeve while a flat tip end surface of a tip end section of the inserter abuts the bottom surface of the recessed section; inserting the sleeve into the outer cylinder through the base end opening section; and arranging the gasket inside the outer cylinder by relatively moving the sleeve in a base end direction with respect to the outer cylinder while maintaining relative axial positions of the outer cylinder, the gasket, and the inserter.

Abstract: A syringe assembly having a barrel for containing one or more medicaments and a stopper disposed in the barrel defining and separating a first volume and a second volume within the syringe assembly. The stopper includes a permanent seal fluidly sealing the stopper to the barrel about the entire perimeter of the stopper intermediate the first volume and second volume, and a channel bypassing the permanent seal, the channel having a first opening in fluid communication with the second volume and a second opening selectively sealed from the first volume by a resilient seal. The resilient seal is moveable between a sealing configuration and an open configuration to selectively seal the channel from the first volume and is moveable from the sealing configuration to the open configuration upon fluid pressure in the first volume or second volume exceeding a first pressure threshold.

Abstract: Various embodiments of needle assemblies for use with a drug delivery device to deliver two or more medicaments are provided. Additionally, various embodiments of methods for delivering two or medicaments are provided. In one embodiment, a needle assembly comprises an injection needle, a proximal housing member, a distal housing member, and a medicament transfer element. The proximal housing member contains a first medicament and is configured to attach to a drug delivery device containing a second medicament. The distal housing member is movably engaged with the proximal housing member such that relative axial movement between the proximal and distal housing members causes the first medicament to be delivered. Upon activation of the drug delivery device (e.g.

Abstract: Modified medical syringe with a flow regulator for the administration of anaesthesia, which allows for anaesthesiologists to handle the needle, control continuous aspiration and administer the anaesthetic with a single hand, thereby preventing intravascular injections. It comprises a flexible tube, designed to be introduced inside the barrel, which supplies the anaesthetic; a cylindrical body located on the rod, equipped with a protuberance along a semicircle located on the proximal side of the body and a through-hole wherein one end of the flexible tube may be introduced; a cylindrical cap located inside the syringe barrel, equipped with a longitudinal groove along its cylindrical side, which is designed to house the aforementioned flexible tube; a preloaded spring around the rod located between the cap and the support disk; and a pressurization device connected to the flexible tube.

Abstract: A movable mixing disc may be utilized in connection with a syringe. The mixing disc may comprise a hole which may be covered by a fine screen or coupled to a porous member, allowing only certain elements of a solution to pass through the mixing disc. Actuation of a plunger of the syringe may cause liquid to emerge from the mixing disc hole as a high velocity jet or other turbulent flow, stirring up any settled particles on a distal side of the mixing disc. As the ejection continues, the mixing disc may be pushed forward by the plunger in order to eliminate any unused volume. Also, the mixing disc may be moved forward by virtue of a pressure difference created by a pressure drop across the mixing disc, such as a pressure drop created as the plunger is displaced to induce fluid flow across the mixing disc.

Abstract: An auto-injector with an interlock mechanism for defining an operation sequence of the auto-injector in a manner to allow a lateral trigger button to be operated only when a proximal end of the auto-injector is pressed against an injection site.

Abstract: Disclosed are a piston for a micro-volume syringe and a plunger. The micro-volume syringe has a syringe barrel with a space defined in it. The piston is slidable on and along a wall of the space. A leading member to be arranged on a side where the piston comes into contact with a solution filled in the space and a trailing member to be arranged on a side where a plunger rod is to be connected, the latter side being opposite to a solution side of the leading member, have been integrated with each other. The trailing member has a higher hardness than the leading member. With the micro-volume syringe in which a drug solution can be filled in a very small quantity, the piston makes it possible to perform smooth drawing and ejection of the drug solution without leakage. Even if the small piston connected to a tip of the plunger rod is operated in a direction that the piston is to be pulled out of the syringe, the plunger rod does not slip off from the piston accidentally.

Abstract: Apparatus for use in a drug mixing system including a vial adapter assembly including a main body element having a vial receiving portion and a needle puncturable port, the main body element including an axial hollow tubular portion which is in fluid flow engagement with a bore of a vial puncturing spike, the main body element further including a membrane support surface that supports a first membrane which is in fluid flow engagement with the vial puncturing spike via the bore and via a recess formed in an intermediate portion of the main body element, and a second membrane supported by a membrane support member and separated by a gap from the first membrane.

Abstract: A container usable for lyophilization, storage, and reconstitution of medication having only two parts, one of which is a plug component having a flow path terminating in a side outlet port and a second of which is a barrel component. The barrel component has a spiral mixing channel near its distal end in which powder medication is stored and upon reconstitution, yields a gradient concentration. The inner wall of the barrel includes a longitudinal diluent groove. To connect the plug outlet port with the longitudinal diluent groove, the plug or barrel has a 360° distribution groove encircling the plug and connecting to the plug outlet port. Regardless of what rotational orientation the plug has to the barrel, the diluent will always reach the mixing channel.

Abstract: Methods and apparatus are disclosed for disposing a valve within a barrel of a conventional syringe to provide, first, a mixing syringe embodiment and, second, a sequential delivery syringe embodiment. Generally, the valve divides the syringe barrel into a proximal and a distal chamber. When used for mixing, the valve is self-displaceable by expansion of decompressing matter disposed within the valve against exterior matter permitting proximal displacement of the valve independent of character of matter in the distal chamber. For sequential delivery, switching of the valve occurs after switch opening causing pressure is relieved, thereby reducing inadvertent uncontrolled flow when the valve opens. In addition, a combination mixing and flush syringe is disclosed whereby a mixing and a flush capability is provided within a conventional syringe.

Abstract: A medicament container having an opening that provides access to a cavity defined by the medicament container. A stopper is sealingly positioned within the opening of the medicament container and configured to be forced into the cavity to open the medicament container. The medicament container also includes a mating member configured to mate with a complementary receiver associated with a second container to connect the medicament container to a second container. The medicament container further includes a radial seal configured to engage and seal against an interior seal wall associated with a second container prior to the stopper being forced into the cavity defined by the medicament container. A system is also provided for establishing fluid communication between a first container and a second container. The system includes a first container (e.g., a medicament container) having a radial seal, a second container, and a port assembly.

Abstract: An apparatus includes a housing, a medicament container, and a movable assembly. The movable assembly includes a first movable member and a second movable member. The second movable member is configured to move relative to the first movable member to move the movable assembly from a first configuration to a second configuration. A distal end portion of the second movable member is configured to move a plunger disposed within the medicament container in a distal direction when the movable assembly is moved to the second configuration. The movable assembly is configured to move between a first position and a second position to move the medicament container within the housing between a first container position and a second container position.

Abstract: A prefilled syringe has a gasket composed of a gasket body and a plunger-mounting member mounted. The plunger-mounting member has a distal part, spiral ribs formed on an outer surface of the distal part, a flange part, and a plunger-mounting part formed on an inner surface of a hollow part. The gasket body has a spiral screwing part which screws the spiral ribs and an accommodation part for accommodating a portion where the spiral ribs are formed. A plunger has a mounting distal part. The plunger-mounting part has a spiral concave portion and an engaging rib disposed at a side distal from the spiral concave portion. The mounting distal part of the plunger has a spiral projected portion capable of screwing the spiral concave portion and an engaging portion which engages the engaging rib of the plunger-mounting member.

Abstract: An injector for inserting an intraocular lens into an eye, comprising a main body (10) and a plunger (50). A guide element (30) is connected to the distal end of the plunger to laterally guide the plunger during movement along a longitudinal axis (L). The distal end of the guide element has a structure for fastening a plunger needle to the guide element. A radial guide pin (40) is in aligned radial bores of the guide element and plunger and extends into a longitudinal slot (17) of the main body to prevent twisting and to secure the guide element to the plunger. A retaining element (24) interacts with a running surface on the perimeter of the plunger, the running surface having a variable radial distance from the longitudinal axis so as to cause an axial resistance force which depends on the axial position of the plunger.

Abstract: A delivery system includes a reservoir for storing pressurized fluid and a piston rod passing through the reservoir and having an end portion with a dimension larger than the piston rod. A sleeve is configured to engage the end portion of the piston rod such that when the piston rod is advanced, the end portion seals an opening in the sleeve. The sleeve and the end portion function as a piston for extracting fluid from a delivery chamber. When the piston rod is retracted, the sleeve engages a portion of the end portion to permit the reservoir to communicate with the delivery chamber through the opening. Methods of use are disclosed.

Abstract: A drug delivery device having a fixed dose setting mechanism with a biasing element. The drug delivery device includes a first dose setting mechanism, where the first dose setting mechanism is operably coupled to a primary reservoir holding a first medicament. The device also includes a dose setter operably coupled to the first dose setting mechanism. The device further includes second dose setting mechanism, where the second dose setting mechanism is operably coupled to a secondary reservoir holding a second medicament. The second dose setting mechanism is mechanically linked to the first dose setting mechanism, and the second dose setting mechanism includes a biasing element. The dose setter is configured to set a variable dose of the first medicament and automatically set a fixed dose of the second medicament upon activation. In addition, the biasing element is configured to assist with dispense of the second medicament.

Abstract: In one aspect, a medical injector is provided herein having a body and an overcap releasably attached to the body configured to prevent mounting of a needle prior to mixing of components within the body. In a further aspect, a slidable collet may be provided useable to urge resilient members from an outward disrupted state inwardly to collectively define a needle mount. Advantageously, a medical injector is provided which ensures proper sequence in preparation of the device, particularly with respect to the step of allowing mounting of a medical needle to the device subsequent to preparation of the medicament to be administered.

Abstract: A method for combining a first liquid component with a second lyo component in a drug mixing apparatus is provided. The method comprises displacing a seal that prevents the first liquid component within a first barrel from coming into contact with the second lyo/liquid component within a second barrel. The method also comprises using an activating mechanism to move the first liquid component from the first barrel through at least one communication channel to an area within the second barrel holding the second lyo component, allowing the first liquid component to mix with the second lyo component to form a medicament. Additionally the method comprises displacing a second seal that prevents a medicament from entering an outlet channel. The method also comprises using the activating mechanism to eject the mixed medicament from the drug mixing apparatus through the outlet channel.

Abstract: The control device is used to control delivery of fluids from a multi-fluid delivery system during a medical injection procedure. The fluid delivery system includes an injector used to deliver injection fluids to a patient. The control device is operatively associated with the injector for controlling discrete flow rates of injection fluids delivered to the patient. The control device includes a housing, first and second actuators associated with the housing, and an electronic substrate disposed within the housing and having a conductive pattern. The first actuator is operatively associated with the conductive pattern. The conductive pattern includes a plurality of predetermined digital values corresponding to discrete flow rates of injection fluids to be delivered by the injector. The second actuator is operatively associated with the electronic substrate and initiates output signals to the injector corresponding to desired mixture ratios of the injection fluids to be delivered by the injector.

Abstract: A medicament delivery device includes a distal housing part; a proximal housing part in which a multi-chamber medicament container is arranged, with the proximal housing part movable relative to the distal housing part for mixing substances in the container; a plunger rod arranged to act on a stopper in the container, where movement of the housing parts toward each other forces the stopper against the plunger rod for mixing the substances in the container; a drive force unit for forcing the plunger rod for subsequent delivery of medicament; an activation member slidable through the distal housing part and releasably connected to the drive force unit; and a guide shell one-way rotatable in the distal housing part with threads that cooperate with threads on the proximal housing part. The guide shell and plunger rod have guide members such that they are rotationally locked but slidable in relation to each other.

Abstract: Injection device for manual penetration and injection comprising a distal housing part (10); a proximal housing part (12) with a multi-chamber container (20); a plunger rod (40); a push button (70); an activation member (30); a drive force means(100) and a locking member (50), wherein the device further comprises a guide rod (60) arranged to generate an audible and tactile indication of the start of an injection.

Abstract: A cartridge system for mixing and applying a mixing ware. The cartridges are arranged parallel and they are connected to a mixing space and an outlet opening. The cartridges each comprise a feed plunger for expelling starting components of the mixing ware from the cartridges through the openings, and each cartridge has at least one closure allocated to it that is shiftable in longitudinal direction of the cartridges, whereby the closures close the openings of the cartridges in a starting position, and the openings are open, at least in part, in an end position of the shiftable closures. In open position, the closure is shifted into a hollow space. The closures are cylindrical in shape and in their end position are capable of being lowered into cylindrical hollow spaces of the cartridges in order to uncover the openings.

Abstract: Mixing systems and methods include a mixing device comprising a primary tube having a proximal end, a distal end, an outer surface and an inner lumen and at least one secondary tube having a proximal end, a distal end, an outer surface and an inner lumen. The at least one secondary tube is substantially parallel to the primary tube. The distal end of the at least one secondary tube is fluidly connected to the primary tube at a junction located on the primary tube close to the distal end of the primary tube.

Abstract: An automatic injection device including a housing, a chamber with a first compartment and a second compartment, and a seal structure between the compartments. The seal structure is initially in a sealing condition that seals the first compartment from the second compartment, where the seal includes a plug and an outer sealing member. The plug is slidably movable within the outer sealing member to convert the seal structure from the sealing condition to a mixing condition by opening a path between the first compartment and the second compartment. The automatic injection device also includes a needle assembly and an activation assembly. Activation of the activation assembly causes (1) pressurization of the first compartment, (2) the seal structure to convert from the sealing condition to the mixing condition, and (3) the first and second medicament components to be mixed and forced through the needle assembly.

Abstract: A medicament delivery device comprising a housing (10; 110); a medicament container holder (12; 120) rotatably locked but slidable connected to said housing, the medicament holder comprising first mix engagement means (28; 126) on its outer surface, and second linear guide means; a multi-chamber medicament container (14; 130) arranged within the container holder, a plunger rod (60; 140) comprising first holding means (58; 146) on its outer circumferential surface; drive force means (64; 142) capable of pushing said plunger rod; characterized in that said device further comprises manual mixing means (44, 148) comprising a rotatable manual knob (62,186) protruding from the distal end of the housing and a mix member (48, 149) comprising flexible holding means (52; 160) releasibly engaged to the first holding means (58; 146) for holding the plunger rod and thereby the drive force means in a pre-tensioned state and second mix engagement means (46; 150) arranged to cooperate with the first mix engagement means (28;

Abstract: An apparatus includes a medicament container assembly, a movable assembly, and a spring. The medicament container assembly includes a first plunger defining a first volume, and a second plunger defining a second volume. The movable assembly includes a first movable member and a second movable member. The second movable member can move the second plunger within the medicament container assembly. The first movable member can move the first plunger in a first direction within the medicament container assembly to expel a contents of at least the first volume via a needle. The spring is configured to urge the needle in a second direction. The release portion of the first movable member is configured to contact the second movable member after the first movable member moves the first plunger to enable the spring to move the needle in the second direction.

Abstract: A medicament delivery device for a reconstituted medicament, comprising a proximal housing part (12; 12?; 12??), a distal housing part (10; 10?; 10??), a medicament delivery drive unit and actuation means, wherein the medicament delivery drive unit is mounted in said distal housing part and wherein the actuation means further include an activation member (74; 101; 201) which is displaceable between an inactive position wherein the actuator is prevented from engaging the medicament delivery drive unit and an active position wherein the actuator is able to engage the medicament delivery drive, whereby the actuator is capable of interacting with said medicament delivery drive unit to perform a delivery of the reconstituted medicament only in the active position of the activation member and in the second position of the medicament delivery drive unit.

Abstract: The present invention relates to a container comprising: a body; a pusher movable with respect to the body between an initial position and an end-of-use position; a locker located on the pusher and forming an abutment so as to be able to abut against the body between the initial position and the end-of-use position, wherein, the abutment abuts against the body to limit distal movement of the pusher relative to the body to a pusher locking position located between the initial position and the end-of-use position; a locking arrangement capable of, temporarily, locking the locker on the pusher so as to define a locker locking position of the locker on the pusher, the locker locking position establishing the position of the abutment relative to the pusher so as to set the pusher locking position; and, an unlocking arrangement designed so that, with triggering, the locking arrangement is released so as to allow the locker to be displaced relative to the pusher and for the pusher to be moved past the pusher locking

Abstract: Disclosed herein is a fluid infusion device of the type that delivers medication fluid to the body of a patient. The device includes or cooperates with a fluid reservoir, and the device has a sealing assembly to receive and form a fluid seal with the fluid reservoir. A retractable sealing element surrounding a hollow fluid delivery needle may be used to seal a port of the fluid reservoir. The port may include a pressure vent that is sealed by the retractable sealing element. In one variation, the reservoir includes a moving valve sleeve that holds a septum. The septum moves to allow the reservoir to vent, and to form a seal with the port when the needle pierces the septum. In another variation, the device includes a needleless sealing assembly. In yet other variations, the device uses a needled fluid reservoir.