Solid Dissolved In Liquid Patents (Class 604/92)
  • Patent number: 9629722
    Abstract: A penis erection stimulation system comprises an infusion device (11) adapted for implantation inside the patient's body, at least one reservoir (R1, R2) adapted for implantation inside the patient's body in fluid connection with the infusion device to supply to the infusion device a substance to be injected into the patient's body, and a cooling device implantable along with the reservoir for keeping the content within at least one compartment of the reservoir at a temperature below 37° C. The reservoir preferably comprises at least one first compartment accommodating or adapted to accommodate a first substance and at least one second compartment accommodating or adapted to accommodate as a second substance a drug for stimulating penis erection, wherein the at least one second compartment is cooled by means of the cooling device.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: April 25, 2017
    Inventor: Peter Forsell
  • Patent number: 9234821
    Abstract: The invention relates to a device (1) for monitoring sample-collection carried out using a piston pump (3, 8) such as a syringe, characterized in that said device includes a pressure sensor (11) close to the suction and/or delivery opening (6). Said device is in particular suited for use in an analysis automaton, in particular for analyzing a blood sample. Such a sensor guarantees that the liquid to be analyzed is properly sucked up, in particular that no air is sucked up and that neither the suction or delivery sides are blocked.
    Type: Grant
    Filed: November 8, 2010
    Date of Patent: January 12, 2016
    Assignee: PULSSAR TECHNOLOGIES
    Inventor: Khaled Abousaleh
  • Patent number: 8979791
    Abstract: A medicated module comprising a connecting body configured for attachment to a drug delivery device. A first needle is fixed within the connecting body and an outer body operatively coupled to the connecting body. A needle guard operatively coupled to the outer body and a biasing member positioned between the outer body and needle guard. A second needle fixed within the outer body and a recess within the connecting body defines a reservoir. The reservoir contains at least one dose of a medicament and is configured for fluid communication with the first and second needle.
    Type: Grant
    Filed: June 1, 2010
    Date of Patent: March 17, 2015
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: James Alexander Davies, Steven Wimpenny, Daniel Thomas De Sausmarez Lintell, Malcolm Stanley Boyd, Naceur Rekaya, Simon Lewis Bilton, John David Cross
  • Patent number: 8876801
    Abstract: A valve assembly is provided which includes a housing having an inlet end and an outlet end and defining a fluid channel and a central chamber. A dissolvable valve member is positioned to obstruct flow through the channel within the chamber. The dissolvable valve member is formed of a material which is dissolvable at a predetermined rate upon contact with a preselected fluid. The preselected fluid is selected from the group consisting of blood, urine, saline and antimicrobial solutions. The dissolvable valve member can be formed from a fluid soluble glass or a starch based material.
    Type: Grant
    Filed: July 1, 2013
    Date of Patent: November 4, 2014
    Assignee: Covidien LP
    Inventor: Kurt E. Green
  • Patent number: 8834449
    Abstract: A movable mixing disc is inserted into a regular syringe. The mixing disc has a small hole covered by a fine screen, allowing only saline solution to get behind the disc. When the plunger of the syringe is pressed, the saline solution emerges from the mixing disc hole as a high velocity jet, stirring up the settled particles. As the ejection continues, the mixing disc is pushed forward by the plunger in order to eliminate any unused volume.
    Type: Grant
    Filed: February 28, 2012
    Date of Patent: September 16, 2014
    Assignee: Ikomed Technologies, Inc.
    Inventors: Lindsay S. Machan, Daniel Gelbart
  • Patent number: 8813955
    Abstract: A container for medical products has at least one chamber. At least two lyophilized active substances and/or auxiliary substances are jointly present in the at least one chamber.
    Type: Grant
    Filed: June 18, 2009
    Date of Patent: August 26, 2014
    Assignee: Arzneimittel GmbH Apotheker Vetter & Co. Ravensburg
    Inventors: Frank Böttger, Benjamin Böbst, Patricia Koch
  • Publication number: 20140221978
    Abstract: Devices and methods for balloon delivery of rapamycin and other hydrophobic compounds to the wall of blood vessels. Balloon catheters, such as those used for balloon angioplasty, are modified with the addition of a reservoir of dry micelles, disposed at a suitable location within the balloon or catheter. The reservoir may be installed within the angioplasty balloon, within a lumen in communication with the angioplasty balloon, either as a loose or packed powder or as a film coating. The micelle preparation is reconstituted and the micelles are mobilized when the aqueous solution used to inflate the balloons is injected into the catheter. The micelles are infused into tissue surrounding the balloon when pressurized fluid within the balloon leaks through the wall of the balloon.
    Type: Application
    Filed: April 7, 2014
    Publication date: August 7, 2014
    Applicant: Caliber Therapeutics, Inc.
    Inventors: William R. Baumbach, Darren R. Sherman, Robert S. Burgermeister
  • Publication number: 20140207058
    Abstract: This pharmaceutical injection device comprises a main body case (2) having an injection needle extension/retraction opening (1); a pharmaceutical syringe mounting portion (3) provided inside the main body case (2); a piston (5) capable of moving relative to the pharmaceutical syringe mounting portion (3); a drive mechanism (6) for the piston (5); a controller (7) that is electrically connected to the drive mechanism (6); and an orientation sensor (8) that is electrically connected to the controller (7). The controller (7) controls the speed of the piston (5) in order to reduce liquid leakage during pharmaceutical mixing.
    Type: Application
    Filed: August 6, 2012
    Publication date: July 24, 2014
    Applicant: PANASONIC HEALTHCARE CO., LTD.
    Inventors: Shinsuke Hata, Tatsuya Kawabata, Seiji Kikuchi, Tsuguhiro Kondoh
  • Patent number: 8753670
    Abstract: A fibrin wound dressing is made by mixing quantities of fibrinogen solution and thrombin solution with air. The resulting foam is very light weight, and with the proper attention to the amount of thrombin, is also sufficiently viscous to rest on a vertical surface without dripping. The wound dressing may also be formulated for its ability to continue migration of healing substances, such as PDGF, from the dressing to the wound site. Thrombin substitutes, such as other clotting proteins, may be used instead of thrombin. The resulting foam may also be lyophilized or ground and lyophilized for later reconstitution. A therapeutic drug or other additive may also be added to the wound dressing.
    Type: Grant
    Filed: March 26, 2008
    Date of Patent: June 17, 2014
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventor: Yves A. Delmotte
  • Patent number: 8753310
    Abstract: A system and method for a patch-like, self-contained multi-component substance infusion device which provides one or more substantially hidden patient needles which can be placed in fluid communication with a fluid reservoir assembly that includes a rigid bladder portion used in conjunction with a non-distensible bladder film, such as a metallized film. The device can be attached to a skin surface via an adhesive contact and a pressurization system provides a pressure to the contents of a fluid reservoir assembly. Improvements to dry powdered formulations for reconstitution for preferred use in the device are also disclosed.
    Type: Grant
    Filed: July 18, 2011
    Date of Patent: June 17, 2014
    Assignee: Becton, Dickinson and Company
    Inventors: Vincent J. Sullivan, Ge Jiang, Matthew S. Ferriter, Kenneth G. Powell, P. Spencer Kinsey, Carl R. Sahi, John M. Polidoro
  • Publication number: 20140114240
    Abstract: A device and a method are proposed for actuating a carpule, in which a piston is displaced in the carpule by means of a ram that is telescopically extensible by rotation, and in this way a liquid medicament formulation is expelled. For carrying out different processes, different operating movements are provided, particularly the operation of an operating element in different directions and/or the operation of different operating elements. This promotes simple, intuitive and safe operation.
    Type: Application
    Filed: February 27, 2012
    Publication date: April 24, 2014
    Applicant: BOEHRINGER INGELHEIM MICROPARTS GMBH
    Inventors: Thorsten Joedicke, Berthold Lange, Thomas Willms, Ying Yu
  • Publication number: 20140107621
    Abstract: The invention provides a device and methods suitable for producing a cellular spray of cells. The sprayed cells are of interest for covering and growing on a surface, including a skin wound. In applying the method and/or using the device, cells for grafting onto a patient are dispersed in a solution and sprayed with the device for distribution over the recipient's graft site.
    Type: Application
    Filed: December 20, 2013
    Publication date: April 17, 2014
    Applicant: Janus Acquisition Corp.
    Inventor: Reinhard Bornemann
  • Publication number: 20140025040
    Abstract: A container closure delivery system that is suitable for lyophilized pharmaceutical injectable powder products is disclosed. The system comprises storage stable powder formulations and a container closure assembly design wherein the formulation can be filled and lyophilized with a standard fill finish equipment, and the formulations and lyophilization processes are optimized to produce a powder that readily dissolves upon contact with a diluent, thereby facilitating the direct injection of the lyophilized product without the need for a separate reconstitution/mixing/priming step.
    Type: Application
    Filed: September 22, 2013
    Publication date: January 23, 2014
    Inventor: Byeong Seon Chang
  • Publication number: 20140012223
    Abstract: A drug reconstitution device, method of manufacturing the drug reconstitution device and method of producing a reconstituted drug solution using the drug reconstitution device utilizes a forward osmosis membrane element positioned within a housing of the device between an input chamber and an output chamber to draw liquid from the input chamber to the output chamber via an osmotic process. The output chamber contains draw solutes and a drug to be reconstituted to produce the reconstituted drug solution in the output chamber.
    Type: Application
    Filed: July 9, 2013
    Publication date: January 9, 2014
    Inventor: Benjamin B. Park
  • Patent number: 8622974
    Abstract: A plunger-driven delivery device for use with a feeding tube for delivering an ingestible material to a user is provided. The delivery device includes a device body having a first chamber, a second chamber and an exit orifice through which the ingestible material is delivered to the feeding tube. A first plunger is disposed in the first chamber, and a second plunger is disposed in the second chamber. The delivery device can be provided with the ingestible material disposed in the first chamber and a flushing liquid disposed in the second chamber. The delivery device is operable to provide sequential delivery first of the ingestible material and then the flushing liquid into the feeding tube. In some embodiments, a mechanical interlock is disposed between the first and second plungers to prevent use of the second plunger until the first plunger has been depressed.
    Type: Grant
    Filed: February 21, 2011
    Date of Patent: January 7, 2014
    Assignee: Mead Johnson Nutrition Company
    Inventors: John D. Alvey, Marc S. Velmer
  • Publication number: 20140005636
    Abstract: The present invention is directed to a multi-compartment medical device for segregated storage and on demand mixing of at least two components and expression of a resulting mixture from the device having a tubular barrel with an opening and a gasket sealing the rear end through which a plunger is axially slidable within the tubular barrel. At least one bypass is provided in the barrel in order to enable fluid movement of the components between front and rear compartments and rear compartments. The present invention is also directed to methods for the use of such devices.
    Type: Application
    Filed: June 29, 2012
    Publication date: January 2, 2014
    Inventors: Yi-Lan Wang, Leo B. Kriksunov
  • Patent number: 8613720
    Abstract: The present invention is directed to an automatic reconstitution drug delivery device. The inventive device effects simple and automatic reconstitution of a dry drug. To effect reconstitution, a user displaces a release button which causes first and second chambers of a drug cartridge to communicate, resulting in automatic mixing of a diluent and dry drug to effect reconstitution of the dry drug. The user then simply sets the dose volume using a dose-setting mechanism, and administers the injection in a manner typical of self-injection drug delivery devices. Whole or partial automatic priming can be also achieved by the device.
    Type: Grant
    Filed: December 8, 2011
    Date of Patent: December 24, 2013
    Assignee: Becton Dickinson and Company
    Inventors: Antonio Bendek, John Laiosa
  • Publication number: 20130310739
    Abstract: An administering device for administering an active substance from a multi-chamber container comprising a first chamber holding a solid active substance and a second chamber holding a dissolving liquid for the active substance, wherein the administering device comprises a mixing device for mixing the active substance with the dissolving liquid and a housing accommodating the mixing device, the container being moveable relative to the housing, and the administering device further comprising a first indicator for indicating a position of the container relative to the housing upon completion of a mixing step, and a second indicator for indicating a position of the container relative to the housing upon completion of a venting step.
    Type: Application
    Filed: April 15, 2013
    Publication date: November 21, 2013
    Applicant: TECPHARMA LICENSING AG
    Inventors: Sofia Galbraith, Ulrich Moser, Juerg Hirschel, Ian Thompson
  • Patent number: 8579855
    Abstract: A method of storing and delivery a drug, such as by lyophilizing and reconstituting, comprises performing both storing and delivering with the same container closure assembly. The container closure is assembled in a preparation configuration during which lyophilization occurs. After lyophilizing, the powdered drug is forced into a spiral channel in the container closure assembly by a plunger. The plunger leaves substantially no head space for the powdered drug, and the assembly is sealed thereby now being in the storage configuration. For delivery of the stored powdered drug, a syringe of diluent is introduced to the container assembly thereby changing the assembly to the delivery configuration. The spiral channel is continuous between an input end and a delivery end with the delivery end being in fluid communication with a delivery outlet of the assembly. The assembly includes a diluent flow path that forces the diluent into a spiral channel at only the input end.
    Type: Grant
    Filed: June 13, 2011
    Date of Patent: November 12, 2013
    Inventors: Byeong Seon Chang, Roger Wongjung Liu
  • Patent number: 8578931
    Abstract: The invention provides exemplary aerosolization apparatus and methods for aerosolizing a substance. According to one exemplary method, a liquid is transferred from a first chamber into a second chamber having a substance that is in a dry state to form a solution. The solution is then transferred from the second chamber and onto an atomization member. The atomization member is operated to aerosolize the solution.
    Type: Grant
    Filed: April 18, 2000
    Date of Patent: November 12, 2013
    Assignee: Novartis AG
    Inventors: Yehuda Ivri, Linda R. De Young, Cheng H. Wu, Miro S. Cater, Vijay Kumar, Markus Flierl
  • Patent number: 8529502
    Abstract: A transfer system (100, 100?, 100?) adapted to allow first contents of a first container (20) and second contents of a second container (30) to mix to form a material. The mixed material is retrieved to a syringe (40). The transfer system (100, 100?, 100?) comprises first (17) and second (18) flow control members for controlling fluid flow between the containers (20, 30) and the syringe (40). The invention further relates to a drug mixing kit comprising a container unit containing first and second containers, and a transfer unit comprising ports for receiving the containers and a syringe and a number of flow channels. The container unit and the transfer unit are adapted to be coupled together to form a drug mixing kit.
    Type: Grant
    Filed: April 23, 2007
    Date of Patent: September 10, 2013
    Assignee: Novo Nordisk Healthcare AG
    Inventor: Bo Radmer
  • Publication number: 20130226148
    Abstract: A movable mixing disc is inserted into a regular syringe. The mixing disc has a small hole covered by a fine screen, allowing only saline solution to get behind the disc. When the plunger of the syringe is pressed, the saline solution emerges from the mixing disc hole as a high velocity jet, stirring up the settled particles. As the ejection continues, the mixing disc is pushed forward by the plunger in order to eliminate any unused volume.
    Type: Application
    Filed: February 28, 2012
    Publication date: August 29, 2013
    Inventors: Lindsay S. Machan, Daniel Gelbart
  • Patent number: 8517983
    Abstract: A dual chamber combined container-syringe includes: an outer casing having a bypass portion; a hub lure lock; a front stopper; a middle stopper that seals a pharmaceutical preparation together with the front stopper; an end stopper that seals a liquid medicine together with the middle stopper; a finger grip; and a plunger rod that is connected to the end stopper from the rear end side, wherein a female screw portion twisted around an axis is formed on an inner peripheral surface of the finger grip, and a first male screw portion, a tip of which comes into contact with a rear end of the female screw portion and can be screwed into the female portion, and a first guide plate are formed on an outer peripheral surface of the plunger rod when a part of the middle stopper enters the bypass portion.
    Type: Grant
    Filed: October 18, 2011
    Date of Patent: August 27, 2013
    Assignee: Arte Corporation
    Inventors: Makoto Kakiuchi, Seiji Shimazaki, Teruo Matsuda
  • Patent number: 8425453
    Abstract: A container usable for lyophilization, storage, and reconstitution of medication having only two parts, one of which is a plug component having a flow path terminating in a side outlet port and a second of which is a barrel component. The barrel component has a spiral mixing channel near its distal end in which powder medication is stored and upon reconstitution, yields a gradient concentration. The inner wall of the barrel includes a longitudinal diluent groove. To connect the plug outlet port with the longitudinal diluent groove, the plug or barrel has a 360° distribution groove encircling the plug and connecting to the plug outlet port. Regardless of what rotational orientation the plug has to the barrel, the diluent will always reach the mixing channel.
    Type: Grant
    Filed: January 10, 2012
    Date of Patent: April 23, 2013
    Assignee: Integrity Bio, Inc.
    Inventor: Byeong Seon Chang
  • Patent number: 8419722
    Abstract: An apparatus for percutaneous delivery of a sealant comprising: at least two fluid reservoirs, an introducer needle having a distal tip that is in fluid communication with at least one reservoir, a fluid delivery tube that is in fluid communication with a second reservoir, wherein the fluid delivery tube has a tip and wherein the fluid delivery tube is configured so that the tip of the fluid delivery tube does not extend past the distal tip of the introducer needle during use.
    Type: Grant
    Filed: January 5, 2007
    Date of Patent: April 16, 2013
    Assignee: Spinal Restoration, Inc.
    Inventors: Mark Richards, Brian D. Burkinshaw, Kevin Pauza, James B. Rogan, John Wheeler
  • Patent number: 8403923
    Abstract: A method and kit for treating a disc that is leaking nucleus pulposus through at least one defect in the annulus fibrosus. The method includes injecting a fibrin sealant into the disc to reduce at least a portion of the at least one defect, wherein the fibrin sealant injected into the disc comprises fibrinogen and an activating compound, wherein at least a portion of the fibrin forms after injection, with the proviso that a corticosteroid is absent from the fibrin sealant injected into the disc.
    Type: Grant
    Filed: August 17, 2005
    Date of Patent: March 26, 2013
    Assignee: Spinal Restoration, Inc.
    Inventors: Steven I. Whitlock, Brian D. Burkinshaw, Kevin Pauza
  • Publication number: 20130035635
    Abstract: The present invention relates to a prodrug or a pharmaceutically acceptable salt thereof, comprising a drug linker conjugate D-L, wherein D being a biologically active moiety containing an aromatic hydroxyl group is conjugated to one or more polymeric carriers via secondary carbamate-containing linkers L. Such carrier-linked prodrugs achieve drug releases with therapeutically useful half-lives. The invention also relates to pharmaceutical compositions comprising said prodrugs and their use as medicaments.
    Type: Application
    Filed: January 21, 2011
    Publication date: February 7, 2013
    Applicant: ASCENDIS PHARMA A/S
    Inventors: Harald Rau, Torben Lessmann
  • Patent number: 8361012
    Abstract: The present disclosure relates to an apparatus and method for combining a solid particulate with a solvent prior to an injection protocol within an injector device. The solid particulate may be a pharmaceutical compound and the microcapsules contain a solvent for such particulate. Upon application of pressure, the microcapsules may be configured to burst and release the solvent, thereby dispersing and/or partially dissolving the particulate. The injector therefore allows for the use of relatively unstable pharmaceutically active compounds in a device that requires relatively long storage times and the use of pharmaceutical compounds that are relatively stable in the dry state.
    Type: Grant
    Filed: July 14, 2009
    Date of Patent: January 29, 2013
    Assignee: Southwest Research Institute
    Inventors: Joseph T. Persyn, Joseph A McDonough, James D Oxley
  • Patent number: 8357147
    Abstract: A method of repairing a defect in an annulus fibrosus of an intervertebral disc, without excising the entire nucleus pulposus of the disc. The method includes inserting an introducer needle through the annulus fibrosus by puncturing the annulus fibrosus with the introducer needle, injecting an in situ curable, bio-compatible polymerizable or polymeric material composition into the disc through the introducer needle directly or indirectly so that the in situ curable composition contacts a defect in the annulus fibrosus; and curing said material in situ.
    Type: Grant
    Filed: February 16, 2007
    Date of Patent: January 22, 2013
    Assignee: Spinal Restoration, Inc.
    Inventors: Brian D. Burkinshaw, John L. Wheeler, James B. Rogan, Steven I. Whitlock
  • Publication number: 20130012921
    Abstract: A system for extracting and processing adipose tissue to generate a therapeutically effective amount of adipose-derived stem cells, comprising an adipose tissue extraction device and a modified centrifuge tube comprising a plurality of lipoaspirate inlet fittings, a plurality of processing fluid inlet fittings, and a plurality of pellet extraction tubes. The adipose tissue extraction device is used to extract a quantity of adipose tissue from a human being, the lipoaspirate is moved into the first modified centrifuge tube via a sterile transfer, a plurality of processing steps are performed to clean and dissociate the lipoaspirate, and a pellet containing an enhanced fraction of stem cells is obtained by centrifuging the modified centrifugal tube. The pellet is resuspended in a fluid and administered to a human patient for a therapeutic or cosmetic purpose.
    Type: Application
    Filed: July 9, 2012
    Publication date: January 10, 2013
    Inventors: Felix Pustilnik, Nathan Katz
  • Patent number: 8323237
    Abstract: A drug mixing and expelling device (1) for mixing a drug with a liquid, thereby forming a reconstituted liquid drug. The device comprises a reservoir (2) containing a liquid, a vial (4) containing a drug, a vial, means (5) for establishing a fluid connection between the reservoir and a vial positioned in the vial adapter (3), means (7, 8) for forcing the liquid from the reservoir to a vial, and means (9) for activating said forcing means during establishment of the fluid connection between the reservoir and the vial. The forcing of liquid into the vial provides a pressure therein, which can be used for infusion of the reconstituted drug directly from the vial. The device also comprises a suction unit (13) for aspiration.
    Type: Grant
    Filed: June 7, 2007
    Date of Patent: December 4, 2012
    Assignee: Novo Nordisk HealthCare AG
    Inventors: Bo Radmer, Morten Revsgaard Frederiksen
  • Publication number: 20120265129
    Abstract: A gonadotropin is administered within a surprisingly effective narrow range for the purpose of treating chronic pain or other central sensitization sequelae. In one aspect, a recipient is provided with at least one of human chorionic gonadotropin (uHCG and/or rHCG), a pharmaceutically active HCG analogue, and a pharmaceutically active metabolite of the HCG or analogue at a dosage selected to provide, or be equivalent to, a human subcutaneous dosage of between 120 IU/day and 170 IU/day of HCG, and more preferably between 140 IU/day and 160 IU/day of HCG. A kit is also described, which includes a supply of the HCG-related drug, a delivery device, and a label that identifies chronic pain or central sensitization as an indication of the drug.
    Type: Application
    Filed: December 5, 2011
    Publication date: October 18, 2012
    Applicant: NEURALIGHT HD, LLC
    Inventors: Edson Conrad Hicks, JR., Constance T. Dutton
  • Patent number: 8262608
    Abstract: One aspect of the invention relates to an applicator system, and methods of use thereof, that can be used to house separately one or more liquids and one or more solids (e.g., components of a polymerizable hydrogel). In certain embodiments, the applicator systems are further designed to facilitate the mixing of the solids and liquids inside the applicator. In addition, in certain embodiments, the applicator systems are also designed to facilitate the application of the mixture to a surface.
    Type: Grant
    Filed: January 25, 2008
    Date of Patent: September 11, 2012
    Assignee: HyperBranch Medical Technology, Inc.
    Inventors: Jeffrey G. Clark, Keith R. D'Alessio
  • Patent number: 8252228
    Abstract: A kit is described including at least one container including a predetermined quantity of sterilized biodegradable carriers in a powder form having a treatment agent disposed therein. The kit further includes a delivery device for delivering the predetermined quantity of sterilized biodegradable carriers with the treatment agent disposed therein to a treatment site. In other embodiments, methods are described for producing the sterilized treatment agent loaded biodegradable carriers and delivering the sterilized carriers to a treatment site.
    Type: Grant
    Filed: October 13, 2008
    Date of Patent: August 28, 2012
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Abigail Freeman, Thierry Glauser, Paul M. Consigny
  • Publication number: 20120191039
    Abstract: The present invention relates to a carrier linked pramipexole prodrug or a pharmaceutical acceptable salt thereof, wherein pramipexole is bound via a linker to a polymeric carrier. The invention also relates to pharmaceutical compositions comprising said polymeric pramipexole prodrug and their use as medicaments.
    Type: Application
    Filed: July 30, 2010
    Publication date: July 26, 2012
    Applicant: ASCENDIS PHARMA A/S
    Inventors: Harald Rau, Julia Baron, Ulrich Hersel
  • Publication number: 20120165731
    Abstract: Methods and compositions are disclosed for an intra-articular injection for the treatment of osteoarthritis. The methods and compositions comprising combinations of hyaluronic acid and a bone morphogenetic protein, like rhGDF-5, can be useful for any synovial joint, including the knee, shoulder, hip, ankle, hands, spinal facet, or temporomandibular joint, both for the relief of pain and for slowing disease progression.
    Type: Application
    Filed: December 28, 2010
    Publication date: June 28, 2012
    Applicant: DePuy Mitek, Inc.
    Inventors: Ben Byers, Dongling Su, Julia Hwang
  • Publication number: 20120116301
    Abstract: Dispensing unit for mixers of biphasic compounds, for dispensing a quantity of mixed biphasic compound through a channel of at least a mixing unit by means of at least a piston sliding inside at least a mixing chamber, wherein it includes at least a drive element for said piston which can be remotely controlled.
    Type: Application
    Filed: February 6, 2009
    Publication date: May 10, 2012
    Applicant: TECRES S.P.A.
    Inventors: Giovanni Faccioli, Renzo Soffiatti
  • Publication number: 20120078172
    Abstract: The present invention is directed to an automatic reconstitution drug delivery device. The inventive device effects simple and automatic reconstitution of a dry drug. To effect reconstitution, a user displaces a release button which causes first and second chambers of a drug cartridge to communicate, resulting in automatic mixing of a diluent and dry drug to effect reconstitution of the dry drug. The user then simply sets the dose volume using a dose-setting mechanism, and administers the injection in a manner typical of self-injection drug delivery devices. Whole or partial automatic priming can be also achieved by the device.
    Type: Application
    Filed: December 8, 2011
    Publication date: March 29, 2012
    Applicant: BECTON, DICKINSON AND COMPANY
    Inventors: Antonio Bendek, John Laiosa
  • Patent number: 8123719
    Abstract: An apparatus includes a housing, a medicament container disposed within the housing, a first energy storage member and second energy storage member. The medicament container includes a first plunger disposed within a proximal end portion of the medicament container and a second plunger disposed within the medicament container spaced apart from the first plunger. The first energy storage member is configured to produce a force when actuated to move at least the second plunger within the medicament container. The second energy storage member is configured to produce a force when actuated to move the first plunger and the second plunger within the medicament container. The second energy storage member is different than the first energy storage member.
    Type: Grant
    Filed: March 28, 2007
    Date of Patent: February 28, 2012
    Assignee: Intelliject, Inc.
    Inventors: Eric Shawn Edwards, Evan Thomas Edwards, Mark J. Licata, Paul F. Meyers
  • Patent number: 8123716
    Abstract: An implantable cardiac therapeutic device having at least one implantable sensor arranged to sense at least one physiologic characteristic of a patient, an implantable therapeutic agent delivery assembly wherein the delivery assembly and a therapeutic agent to be delivered are configured for placement in a patient's pericardial space, and a controller in communication with the at least one implantable sensor and with the therapeutic agent delivery assembly wherein the controller evaluates the at least one physiologic characteristic for indications of a condition indicating administration of the therapeutic agent and wherein, upon detection of such indications, induces the therapeutic agent delivery assembly to deliver the agent.
    Type: Grant
    Filed: June 26, 2007
    Date of Patent: February 28, 2012
    Assignee: Pacesetter, Inc.
    Inventors: Mark W. Kroll, Yougandh Chitre
  • Patent number: 8092420
    Abstract: The present invention is directed to an automatic reconstitution drug delivery device. The inventive device effects simple and automatic reconstitution of a dry drug. To effect reconstitution, a user displaces a release button which causes first and second chambers of a drug cartridge to communicate, resulting in automatic mixing of a diluent and dry drug to effect reconstitution of the dry drug. The user then simply sets the dose volume using a dose-setting mechanism, and administers the injection in a manner typical of self-injection drug delivery devices. Whole or partial automatic priming can be also achieved by the device.
    Type: Grant
    Filed: November 22, 2005
    Date of Patent: January 10, 2012
    Assignee: Becton, Dickinson and Company
    Inventors: Antonio Bendek, John Laiosa
  • Patent number: 8079977
    Abstract: A device for automatically mixing powder for injection, includes an injector body, a solvent bottle, a needle, a first impelling unit and a second impelling unit. The injector body has a solute bottle and its mouth is opposite the mouth of the solvent bottle. The first impelling unit is disposed upon the solvent bottle. The second impelling unit is sleeved with a needle and located between the mouth of solute bottle and mouth of solvent bottle. A first and a second impelling sleeve-are driven by the solvent bottle to slide along the solute bottle, so the first end of the needle is fixed and extend through the solute bottle. The solvent bottle drives the first impelling sleeve and second impelling sleeve to turn with each other. The second impelling sleeve slides opposite the first impelling sleeve to make the second end of the needle extend through the solvent bottle.
    Type: Grant
    Filed: February 2, 2008
    Date of Patent: December 20, 2011
    Inventor: Yuying Ding
  • Patent number: 8075548
    Abstract: In an apparatus for storing and administering active substances, at least one transfer mechanism is provided, and a first reservoir that contains an active substance in dissolved form is also provided, the active substance being administered by way of the transfer mechanism. A second reservoir having the active substance in solid form is additionally provided in the apparatus.
    Type: Grant
    Filed: June 27, 2008
    Date of Patent: December 13, 2011
    Assignee: Robert Bosch GmbH
    Inventors: Julia Cassemeyer, Sandra Kruse
  • Patent number: 8057427
    Abstract: A drug delivery system includes an automatic injector that can deliver a small, precise amount of a therapeutic agent. The automatic injector includes a chamber for containing a liquid component and a thin porous member that carries thereon and/or therein the small, precise amount of therapeutic agent. Upon activation of the automatic injector, a flow path opens from the chamber through the porous member, enabling the liquid component to rapidly mix with the therapeutic agent before being injected.
    Type: Grant
    Filed: May 7, 2008
    Date of Patent: November 15, 2011
    Assignee: Meridian Medical Technologies, Inc.
    Inventors: Steven M. Griffiths, Robert L. Hill, Gerald L. Wannarka
  • Publication number: 20110245799
    Abstract: Disclosed herein are systems and methods useful for delivery of suspensions and other microparticle compositions, and, in particular, for delivering microparticles at desired dosing levels and eliminating blockages within microparticle suspensions positioned within a delivery device.
    Type: Application
    Filed: March 31, 2011
    Publication date: October 6, 2011
    Inventors: SIGNE R. ERICKSON, Charles J. Hagemeier, Gary A. Winchester
  • Patent number: 7980243
    Abstract: A cartridge for propellant-free administration of a liquid pharmaceutical composition by inhalation includes: an elongate displacing device including an upper end and a lower end, the lower end for at least partial insertion into a container; a cartridge chamber disposed at the lower end of the displacing device and operable store a pharmaceutical formulation, the cartridge chamber including at least one pierceably sealed opening; and a cannula guide extending from the upper end of the displacing device to the cartridge chamber, wherein insertion of a cannula through the guide pierces the sealed opening and releases the pharmaceutical formulation into a liquid solvent in the container to form the liquid pharmaceutical composition.
    Type: Grant
    Filed: June 7, 2007
    Date of Patent: July 19, 2011
    Assignee: Boehringer Ingelheim Pharma GmbH & Co., KG
    Inventor: Dieter Hochrainer
  • Patent number: 7959600
    Abstract: A container closure delivery system that is suitable for lyophilized pharmaceutical injectable powder products is disclosed. The system comprises storage stable powder formulations and a container closure assembly design wherein the formulation can be filled and lyophilized with a standard fill finish equipment, and the formulations and lyophilization processes are optimized to produce a powder that readily dissolves upon contact with a diluent, thereby facilitating the direct injection of the lyophilized product without the need for a separate reconstitution/mixing/priming step.
    Type: Grant
    Filed: March 9, 2007
    Date of Patent: June 14, 2011
    Inventors: Byeong Seon Chang, Roger Wongjung Liu
  • Patent number: 7938816
    Abstract: The invention relates to a medical bag which is intended for the infusion of a medicament by means of gravity. The inventive bag comprises: at least two compartments, namely a first compartment (1) containing a medicament in the form of a solution and a second compartment (2) containing a rinsing solution; and means for separating/communicating the compartments, which prevent the rinsing solution from automatically entering the medicament compartment except at the end of the infusion period. The rinsing solution ends the infusion, by rinsing the medicament bag and the infusion line, such as to prevent any risk of contamination or leakage of residual medicament from the bag or line.
    Type: Grant
    Filed: April 8, 2010
    Date of Patent: May 10, 2011
    Assignee: Laboratoire Aguettant
    Inventor: Pierre Frezza
  • Patent number: 7927618
    Abstract: This invention relates to kits for the preparation of a composition, which comprises a carrier phase that forms an implant or particles in the body, on the body or under physiological conditions. The carrier phase comprises at least one solid carrier material and a solvent, wherein the carrier material and the solvent are stored separately in the kit. The kit can also include an additional liquid phase to aid in forming the particles. An active compound included in the carrier phase is generally released in an extended manner. This invention also relates to compositions prepared from this kit and to methods for the preparation of the kits and the composition.
    Type: Grant
    Filed: July 10, 2002
    Date of Patent: April 19, 2011
    Assignee: Laboratorios Farmacéuticos Rovi S.A.
    Inventor: Roland Bodmeier
  • Publication number: 20110086010
    Abstract: Methods and devices for the preparation of a biological pharmaceutical composition outside of a classified environment, such as Biological Safety Cabinet type environment, are described. In one aspect of the present technology, a method is provided to prepare a biological pharmaceutical composition preferably in an area next to a patient's bedside or at a facility's pharmacy. The method comprises transferring an appropriate amount of a diluent from a diluent component (645) into a mixing receptacle (605) using a transfer device (620), connecting a pooling (630) harness between a biological pharmaceutical component (640) and the mixing receptacle, transferring a biological pharmaceutical composition through the pooling harness to the mixing receptacle, mixing the diluent and the biological pharmaceutical composition to form a biological pharmaceutical composition mixture and administering the biological pharmaceutical composition mixture to a patient for either flat based or weight based dosing needs.
    Type: Application
    Filed: April 23, 2008
    Publication date: April 14, 2011
    Inventors: Robert E. Newman, Roman M. Salasznyk