Solid Dissolved In Liquid Patents (Class 604/92)
  • Patent number: 4985017
    Abstract: A formulation chamber is disclosed comprising a wall surrounding a lumen containing a device for delivering a beneficial agent. The chamber has an inlet for admitting a fluid into the chamber and an outlet for letting an agent formulation leave the chamber. The chamber is adapted for parenteral use including intravenous delivering for delivering an agent formulation to a patient.
    Type: Grant
    Filed: April 25, 1989
    Date of Patent: January 15, 1991
    Assignee: ALZA Corporation
    Inventor: Felix Theeuwes
  • Patent number: 4832690
    Abstract: A needle-pierceable cartridge for drug delivery comprises a housing containing a drug-containing bag having wallls of hydrophilic material capable of diffusing water across the walls, whereby osmosis can take place. The bag walls also define macroscopic holes, so that water on the outside of the bag diffuses by osmosis into the bag, and osmotic pressure forces water containing dissolved drug out of the bag through the macroscopic holes for removal and use.
    Type: Grant
    Filed: January 23, 1987
    Date of Patent: May 23, 1989
    Assignee: Baxter International Inc.
    Inventor: Wei-Youh Kuu
  • Patent number: 4820269
    Abstract: An intravenous drug infusion apparatus for controlling the delivery of a drug includes an in-line mixing vessel with tubular needle-like inlets which produce turbulent mixing of a drug solution contained in the vessel with an aqueous carrier. An admixed solution is discharged from the mixing vessel which provides intravenous infusion of a drug at progressively decreasing concentrations.
    Type: Grant
    Filed: November 6, 1986
    Date of Patent: April 11, 1989
    Assignee: Vanderbilt University
    Inventor: James G. Riddell
  • Patent number: 4741735
    Abstract: A formulation chamber is disclosed comprising a wall surrounding a lumen containing a device for delivering a beneficial agent. The chamber has an inlet for admitting a fluid into the chamber and an outlet for letting an agent formulation leave the chamber. The chamber is adapted for use in an intravenous delivery system for delivering an agent formulation to a patient.
    Type: Grant
    Filed: February 14, 1985
    Date of Patent: May 3, 1988
    Assignee: Alza Corporation
    Inventor: Felix Theeuwes
  • Patent number: 4740200
    Abstract: A formulation chamber is disclosed comprising a wall surrounding a lumen containing a device for delivering a beneficial agent. The chamber has an inlet for admitting a fluid into the chamber and an outlet for letting an agent formulation leave the chamber. The chamber is adapted for use in an intravenous delivery system for delivering an agent formulation to a patient.
    Type: Grant
    Filed: February 15, 1985
    Date of Patent: April 26, 1988
    Assignee: ALZA Corporation
    Inventor: Felix Theeuwes
  • Patent number: 4740201
    Abstract: A formulation chamber is disclosed comprising a wall surrounding a lumen containing a device for delivering a beneficial agent. The chamber has an inlet for admitting a fluid into the chamber and an outlet for letting an agent formulation leave the chamber. The chamber is adapted for use in an intravenous delivery system for delivering an agent formulation to a patient.
    Type: Grant
    Filed: February 19, 1985
    Date of Patent: April 26, 1988
    Assignee: ALZA Corporation
    Inventor: Felix Theeuwes
  • Patent number: 4698055
    Abstract: A syringe in which a first medicament is stored in an elongated barrel, adjacent its distal end, while a second medicament is stored in an exterior compartment between the distal and proximal ends in communication with the barrel. A plunger having a piston head with spaced apart sealing rings is located in the syringe barrel with the opposing sealing rings occluding the exterior compartment so as to isolate the medicaments from each other. The piston is normally locked in this position. In use, the piston is moved adjacent the proximal end of the barrel to allow the medicament in the exterior compartment to intermix with the first medicament before dispensing.
    Type: Grant
    Filed: November 24, 1986
    Date of Patent: October 6, 1987
    Inventor: Andrew I. Sealfon
  • Patent number: 4592743
    Abstract: This invention relates to a device for dosing and mixing of two or more liquids. According to the invention, the liquids are led to a chamber (26) where they are mixed, an outlet (30) from the chamber being closed at the same time. When the chamber (26) has been filled, the outlet (30) is opened while the inlets (21, 22) for the starting liquids are simultaneously closed, and when the chamber (26) has been emptied, the outlet (30) is closed again and the inlet or inlets (21, 22) are opened. This cyclic process is repeated any desired number of times. The chamber has a variable volume, and changes of the volume are sensed by a sensor (28), which controls the opening and closing of the inlets and the outlets.The device for carrying out the method is provided with a mechanical bistable flip-flop device, which in one of its stable positions opens the inlets (21, 22) and closes the outlet (30), and in the other stable position closes the inlets and opens the outlet.
    Type: Grant
    Filed: January 10, 1985
    Date of Patent: June 3, 1986
    Assignee: KabiVitrum AB
    Inventors: Birger T. Hjertman, Percy E. Bennwik
  • Patent number: 4583981
    Abstract: A parenteral delivery set is disclosed for administering a beneficial agent to a recipient. The set comprises (a) a primary container of a medical fluid; (b) a primary tubing in fluid communication with the primary container; (c) a secondary container of a medical fluid; (d) a secondary tubing in fluid communication with the secondary container; (e) a formulation chamber connected to the secondary tubing and housing an agent dispensing device or the beneficial agent; and (f) a common tubing in communication with the primary tubing and the secondary tubing for communicating the set to the recipient.
    Type: Grant
    Filed: January 7, 1985
    Date of Patent: April 22, 1986
    Assignee: ALZA Corporation
    Inventors: John Urquhart, Felix Theeuwes
  • Patent number: 4581016
    Abstract: A multi-cartridge syringe assembly includes one cartridge containing a diluent and insertable within another cartridge containing dry medication. The nose of the diluent cartridge supports a cannula and is surrounded by a lock head member. In an initial mode, the exposed cannula is surrounded by a resilient cover. A retaining element extending rearwardly from a piston in the medication cartridge includes lock elements sequentially engageable with first and second annular devices on the lock head member as the two cartridges are axially displaced towards each other. In a first position the two cartridges are locked together without any axial displacement between the cannula and its cover while in a second position the cover is forced rearwardly of the cannula as the point of the cannula pierces the cover as well as the piston in the medication cartridge.
    Type: Grant
    Filed: February 29, 1984
    Date of Patent: April 8, 1986
    Assignee: Gettig Pharmaceutical Instrument Co.
    Inventor: William A. Gettig
  • Patent number: 4579553
    Abstract: A parenteral delivery set is disclosed for administering a beneficial agent to a recipient. The set comprises (a) a primary container of a medical fluid; (b) a primary tubing in fluid communication with the primary container; (c) a secondary container of a medical fluid; (d) a secondary tubing in fluid communication with the secondary container; (e) a formulation chamber connected to the secondary tubing and housing an agent dispensing device or the beneficial agent; and (f) a common tubing in communication with the primary tubing and the secondary tubing for communicating the set to the recipient.
    Type: Grant
    Filed: January 7, 1985
    Date of Patent: April 1, 1986
    Assignee: ALZA Corporation
    Inventors: John Urquhart, Felix Theeuwes
  • Patent number: 4573967
    Abstract: An apparatus for connecting a vial into the delivery tube of an intravenous administration set, the set including a container of fluid connected to one end of a delivery tube with the other end of the delivery tube adapted for insertion into the patient. The apparatus includes a penetrating spike penetrating an end of the vial which provides two pathways into the interior of the vial with two sections of the delivery tube connected to the two pathways of the penetrating spike. The apparatus also includes a frame for maintaining the two sections of the delivery tube adjacent to each other and clamp for releasably closing the adjacent sections of the delivery tube to temporarily prevent flow of fluid through the penetrating spike.
    Type: Grant
    Filed: December 6, 1983
    Date of Patent: March 4, 1986
    Assignee: Eli Lilly and Company
    Inventors: William W. Hargrove, Dale C. Harris, Michael J. Akers, Charles R. Sperry
  • Patent number: 4568331
    Abstract: A medication dispensing device for administering medicine to patients unable to swallow includes a flexible chamber in which solid medicinals, such as tablets, can be pulverized and dissolved or placed in suspension in a liquid medium which thereafter can be administered to the patient from the chamber through an elongate feeding tube through the mouth or nose.
    Type: Grant
    Filed: October 17, 1983
    Date of Patent: February 4, 1986
    Inventors: Marcus Fischer, Robert Campitelli
  • Patent number: 4552556
    Abstract: A parenteral delivery set is disclosed for administering a beneficial agent to a recipient. The set comprises (a) a primary container of a medical fluid; (b) a primary tubing in fluid communication with the primary container; (c) a secondary container of a medical fluid; (d) a secondary tubing in fluid communication with the secondary container; (e) a formulation chamber connected to the secondary tubing and housing an agent dispensing device or the beneficial agent; and (f) a common tubing in communication with the primary tubing and the secondary tubing for communicating the set to the recipient.
    Type: Grant
    Filed: January 4, 1985
    Date of Patent: November 12, 1985
    Assignee: ALZA Corporation
    Inventors: John Urquhart, Felix Theeuwes
  • Patent number: 4551135
    Abstract: The invention comprises a syringe for extrusion of a semi-plastic mass, or a mass having a paste-like consistency. In a preferred embodiment, the syringe is so-designed to permit mixing of two components of a plasticizable mixture within the syringe barrel. The bore of the syringe barrel is flared to facilitate extrusion of the plastic mass therefrom. The parts of the syringe ready for use are packaged in a one-piece tray which serves not only for shipping and storing of the syringe, which may be preloaded with one of the components of the plasticizable mixture, together with the associated syringe parts, but which also serves, when opened for use, as a convenient tray for handling the syringe while mixing the two components of the plasticizable mixture prior to extrusion.
    Type: Grant
    Filed: May 19, 1982
    Date of Patent: November 5, 1985
    Assignee: Sterling Drug Inc.
    Inventors: William G. Gorman, David A. Byron
  • Patent number: 4548599
    Abstract: A parenteral delivery set is disclosed for administering a beneficial agent to a recipient. The set comprises (a) a primary container of a medical fluid; (b) a primary tubing in fluid communication with the primary container; (c) a secondary container of a medical fluid; (d) a secondary tubing in fluid communication with the secondary container; (e) a formulation chamber connected to the secondary tubing and housing an agent dispensing device or the beneficial agent; and (f) a common tubing in communication with the primary tubing and the secondary tubing for communicating the set to the recipient.
    Type: Grant
    Filed: January 5, 1984
    Date of Patent: October 22, 1985
    Assignee: ALZA Corporation
    Inventors: John Urquhart, Felix Theeuwes
  • Patent number: 4533348
    Abstract: A formulation dispenser is disclosed for use in a parenteral delivery system. The dispenser comprises an inlet for admitting fluid into the dispenser and an outlet for letting fluid leave the dispenser. A beneficial agent is housed in a formulation chamber in the dispenser and a membrane permeable to fluid and agent defines one boundary of the formulation chamber. A piston is slideably disposed in the dispenser for governing the flow of fluid through the dispenser, or for permitting fluid to contact the membrane and enter the formulation chamber for forming a solution containing agent that flows through the outlet into the parenteral system.
    Type: Grant
    Filed: September 12, 1984
    Date of Patent: August 6, 1985
    Assignee: ALZA Corporation
    Inventors: Allan M. Wolfe, James M. Davenport, Felix Theeuwes, Su I. Yum
  • Patent number: 4515586
    Abstract: A pre-filled chamber having a piston plug at one end and a stopper at the other end. The chamber is filled with a powdered medicament that is to be intermixed with a diluent in a container. Rotatable attachments join the chamber containing the powder with a receptacle on the container. The powdered medicament is expelled from the chamber by the force of a plunger acting on the piston plug. The stopper at the end of the chamber containing the powder serves as a mounting for a piercing tip which breaks a membrane over the neck of the container allowing fluid connection between the chamber and the container and transferral of the powdered medicament from the chamber to the container.
    Type: Grant
    Filed: November 30, 1982
    Date of Patent: May 7, 1985
    Assignee: Abbott Laboratories
    Inventors: Douglas W. Mendenhall, Ping Li
  • Patent number: 4511351
    Abstract: A formulation cell consisting essentially of a hollow fiber surrounded by a beneficial agent is disclosed for use in an intravenous delivery system. An intravenous system is disclosed that uses the formulation cell.
    Type: Grant
    Filed: May 14, 1984
    Date of Patent: April 16, 1985
    Assignee: ALZA Corporation
    Inventor: Felix Theeuwes
  • Patent number: 4511352
    Abstract: A parenteral delivery system is disclosed for delivering a beneficial agent to an agent recipient. The delivery system comprises a reservoir, a drip chamber and a flexible container that collapses as agent formulation leaves the system.
    Type: Grant
    Filed: May 14, 1984
    Date of Patent: April 16, 1985
    Assignee: ALZA Corporation
    Inventors: Felix Theeuwes, John Urquhart
  • Patent number: 4509861
    Abstract: The invention refers to a method of mixing, for example, cytostatica stored in an ampule (1) provided with a rubber closure (8) or corresponding closure, with, for example, sterile water stored in a second ampule (2) provided with a rubber closure (12) or corresponding closure. The invention is characterized in that a first tube (7) of hypodermic needle shape, which is connected by a hose connection (6) to a first port (5) of a multi-way valve (4), is pierced through the rubber closure (8) of one ampule (1), that a second tube (11) of hypodermic needle shape, which is connected by a hose connection (10) to a second port (9) of the multi-way valve (4), is pierced through the rubber closure (12) of said second ampule (2). The interior of the ampules is interconnected by a hose connection (13), the two respective ends of which have the shape of hypodermic needles (14,15) and are pierced each through one rubber closure (8,12).
    Type: Grant
    Filed: January 27, 1983
    Date of Patent: April 9, 1985
    Inventor: Goran Sjonell
  • Patent number: 4505703
    Abstract: A patient-care apparatus is disclosed for providing a biocide for controlling the presence of unwanted pathogens in a liquid. The patient-care apparatus comprises a container having means for maintaining a biocide dispensing device in a position in the container such that it dispenses an amount of biocide relative to the amount of liquid present in the container.
    Type: Grant
    Filed: September 29, 1982
    Date of Patent: March 19, 1985
    Assignee: ALZA Corporation
    Inventors: Robert M. Gale, John Urquhart
  • Patent number: 4501582
    Abstract: A kit for the perfusion of sodium nitroprusside and sodium thiosulfate contains as components (1) a container of sodium thiosulfate aqueous solution, (2) a light-opaque syringe, (3) light-opaque tubing, and (4) an ampoule containing lyophilized sodium nitroprusside. Alternatively the kit includes (1) a light-opaque container of mixed sodium nitroprusside-sodium thiosulfate solution, (2) a light-opaque syringe, and (3) light-opaque tubing.
    Type: Grant
    Filed: December 5, 1983
    Date of Patent: February 26, 1985
    Inventor: Volker Schulz
  • Patent number: 4479578
    Abstract: A single barrel two compartment assembly for medicaments comprising an elongated cylindrical hollow barrel having a normally sealed discharge end, a bypass plunger made of a pliable resilient material having a forward section of a diameter slightly greater than the diameter of the barrel, means defining a seat in the bypass plunger, a plunger rod having a tip engageable in said seat for actuating said bypass plunger axially in said barrel and seal means for sealing the open end of the said barrel remote from said discharge end, said bypass plunger normally dividing said barrel into a first compartment to one side of the bypass plunger for a powder medicament and a diluent compartment on the opposite side of said bypass plunger, actuation of said bypass plunger in one direction creating internal diluent pressure whereby said diluent bypasses the periphery of said plunger to mix with said powder medicament.
    Type: Grant
    Filed: April 9, 1981
    Date of Patent: October 30, 1984
    Assignee: The West Company
    Inventors: Dominic J. Brignola, Homer J. Brown, Caroll S. Sutryn, Ralph Walters
  • Patent number: 4474574
    Abstract: A formulation dispenser is disclosed for use in a parenteral delivery system. The dispenser comprises an inlet for admitting fluid into the dispenser and an outlet for letting fluid leave the dispenser. A beneficial agent is housed in a formulation chamber in the dispenser and a membrane permeable to fluid and agent defines one boundary of the formulation chamber. A piston is slideably disposed in the dispenser for governing the flow of fluid through the dispenser, or for permitting fluid to contact the membrane and enter the formulation chamber for forming a solution containing agent that flows through the outlet into the parenteral system.
    Type: Grant
    Filed: July 29, 1983
    Date of Patent: October 2, 1984
    Assignee: ALZA Corporation
    Inventors: Allan M. Wolfe, James M. Davenport, Felix Theeuwes, Su I. Yum
  • Patent number: 4467588
    Abstract: Provided is a process for preparing an aseptic container for separately storing a sterilized powdered component and a sterilized liquid component under clean conditions. The container includes two sealed chambers having a frangible, sterilized connection therebetween, one said chamber containing the liquid component, and the other said chamber including a sealed vial containing a powdered component. The vial has an outer surface that is aseptic throughout its entire surface area, and the frangible connection provides a sterile pathway, when desired, between the interior of the vial and the interior of the liquid-containing chamber.
    Type: Grant
    Filed: April 6, 1982
    Date of Patent: August 28, 1984
    Assignee: Baxter Travenol Laboratories, Inc.
    Inventor: Peter Carveth
  • Patent number: 4465471
    Abstract: The system of this invention provides a method and apparatus for the sterile intravenous administration of dry medicine. Such a system can include standard IV set components such as a source of liquid, means to inject liquid into a human vein, means forming a passageway between the source of liquid and said injection means, a valve to control the flow of liquid through the passageway, and a cartridge-like dry medicine package adapted for use with the system. Such a package can include conduit means adapted to perforate and communicate with the passageway, means forming a cell for dry, particulate medicine with portions forming a liquid-pervious barrier to the dry medicine and an air vent with an air-pervious, liquid barrier.
    Type: Grant
    Filed: July 26, 1982
    Date of Patent: August 14, 1984
    Assignee: Eli Lilly and Company
    Inventors: Dale C. Harris, William W. Hargrove
  • Patent number: 4432756
    Abstract: A parenteral delivery set is disclosed for administering a beneficial agent to a recipient. The set comprises (a) a primary container of a medical fluid; (b) a primary tubing in fluid communication with the primary container; (c) a secondary container of a medical fluid; (d) a secondary tubing in fluid communication with the secondary container; (e) a formulation chamber connected to the secondary tubing and housing an agent dispensing device or the beneficial agent; and (f) a common tubing in communication with the primary tubing and the secondary tubing for communicating the set to the recipient.
    Type: Grant
    Filed: November 27, 1981
    Date of Patent: February 21, 1984
    Assignee: Alza Corporation
    Inventors: John Urquhart, Felix Theeuwes
  • Patent number: 4424056
    Abstract: A parenteral delivery system is disclosed for administering a beneficial agent to a recipient. The system comprises (a) a container of a medical fluid; (b) a primary tubing in communication with the container; (c) a parallel tubing connected to the primary tubing having a formulation chamber connected thereto, the formulation chamber housing a beneficial agent, or a device for deliverying a beneficial agent; and (d) a common tubing connected to the primary tubing and the parallel tubing for administering the fluid and the agent to a recipient.
    Type: Grant
    Filed: November 27, 1981
    Date of Patent: January 3, 1984
    Assignee: Alza Corporation
    Inventors: John Urquhart, Felix Theeuwes