Parameter Control In Response To Sensed Physiological Load On Heart Patents (Class 607/17)
  • Patent number: 11504048
    Abstract: Techniques are disclosed for detecting arrhythmia episodes for a patient. A medical device may receive one or more sensor values indicative of motion of a patient. The medical device may determine, based at least in part on the one or more sensor values, an activity level of the patient. The medical device may determine a heart rate threshold for triggering detection of an arrhythmia episode based at least in part on the activity level of the patient. The medical device may determine whether to trigger detection of the arrhythmia episode for the patient based at least in part on comparing a heart rate of the patient with the heart rate threshold. The medical device may, in response to triggering detection of the arrhythmia episode, collect information associated with the arrhythmia episode.
    Type: Grant
    Filed: June 10, 2020
    Date of Patent: November 22, 2022
    Assignee: Medtronic Monitoring, Inc.
    Inventors: Niranjan Chakravarthy, Rodolphe Katra
  • Patent number: 11426590
    Abstract: A leadless pacemaker device for providing an intra-cardiac pacing includes processing circuitry configured to generate ventricular pacing signals for stimulating ventricular activity at a ventricular pacing rate, a first sensor configuration receiving a first sense signal, and a second sensor configuration receiving a second sense signal. The processing circuitry derives, in a first sensing state, atrial events from the first sense signal for controlling the ventricular pacing rate based on the atrial events. The processing circuitry switches, based on at least one switching criterion, from the first sensing state to a second sensing state in which the processing circuitry derives atrial events from the second sense signal. The second sense signal is received by the second sensor configuration for detection of atrial events and the second sensor configuration is a motion sensor or a sound sensor. A method for operating the pacemaker device is also provided.
    Type: Grant
    Filed: June 18, 2020
    Date of Patent: August 30, 2022
    Assignee: BIOTRONIK SE & Co. KG
    Inventors: Madeline Anne Midgett, R. Hollis Whittington, Ravi Kiran Kondama Reddy, Christopher Jones, Shayan Guhaniyogi, Dirk Muessig, Larry Stotts
  • Patent number: 11419575
    Abstract: The present invention relates to an apparatus (1) comprising a signal processor (2) for processing measurement signals (3) from a motion-mode ultrasound measurement and a rendering device (4) coupled to a processor (2) for rendering a one-dimensional representation (40) along a temporal axis (41) indicative of a property within a tissue. The values (42) in the one-dimensional representation (40) are derived on the basis of measured values in an observation window (12, 22, 32) defined on an M-mode ultrasound image (10), a tissue velocity image (20) or a strain rate image (30).
    Type: Grant
    Filed: November 11, 2015
    Date of Patent: August 23, 2022
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Caifeng Shan, Godefridus Antonius Harks, Harm Jan Willem Belt
  • Patent number: 11410768
    Abstract: A system that comprises a memory device storing instructions, and a processing device communicatively coupled to the memory device. The processing device executes the instructions to: receive user data obtained from records associated with a user; generate a modified treatment plan based on the user data; and send, to a treatment apparatus accessible to the user, the modified treatment plan, wherein the modified treatment plan causes the treatment apparatus to update at least one operational aspect of the treatment apparatus, and update at least one operational aspect of at least one other device communicatively coupled to the treatment apparatus.
    Type: Grant
    Filed: July 19, 2021
    Date of Patent: August 9, 2022
    Assignee: ROM TECHNOLOGIES, INC.
    Inventors: Steven Mason, Daniel Posnack, Peter Arn, Wendy Para, S. Adam Hacking, Micheal Mueller, Joseph Guaneri, Jonathan Greene
  • Patent number: 11376430
    Abstract: Auricular nerve stimulation techniques for addressing patient disorders, and associated systems and methods. A representative system includes a signal generator having instructions to generate an electrical therapy signal, at least a portion of the electrical therapy signal having a frequency at or above the patient's auditory frequency limit, an amplitude in an amplitude range from about 0.1 mA to about 10 mA, and a pulse width in a pulse width range from 5 microseconds to 30 microseconds. The system further includes at least one earpiece having a contoured outer surface shaped to fit against the skin of the patient's external ear, external ear canal, or both, the at least one earpiece carrying at least two transcutaneous electrodes positioned to be in electrical communication with the auricular innervation of the patient, e.g., the auricular vagal nerve.
    Type: Grant
    Filed: October 8, 2020
    Date of Patent: July 5, 2022
    Assignee: Nesos Corp.
    Inventors: Vivek K. Sharma, Konstantinos Alataris, Gary Heit, Jason Sutor, Pankaj Sunkeri
  • Patent number: 11350832
    Abstract: In part, the disclosure relates to computer-based methods, and systems suitable for evaluating a cardiac system using a diagnostic metric such as a pressure value-based ratio. Selection of a subset or portion of a cardiac cycle is avoided in one embodiment to increase reliability and usability of a diagnostic ratio and parameters described herein. In one embodiment, a minimum or a relative extrema of a series of diagnostic metrics plotted on a per cycle basis are used to inform diagnosis of a stenosis or other intravascular event or phenomena.
    Type: Grant
    Filed: August 27, 2015
    Date of Patent: June 7, 2022
    Assignee: ST. JUDE MEDICAL COORDINATION CENTER BVBA
    Inventor: Johan Svanerudh
  • Patent number: 11338076
    Abstract: A system for controlling a fluid procedure comprising a reusable separation apparatus controlled by a microprocessing controller. A sterile circuit is configured to associate with the reusable separation apparatus and provide a first fluid flow path in association with a pressure sensor in communication with the controller and a first pump configured to transmit pulsatile pressure signals to the pressure sensor during operation in association with the first fluid flow path. The reusable apparatus and the controller are configured to receive from the pressure sensor pressure signals comprising the pulsatile pressure signals, perform a frequency analysis of the pressure signals received by the pressure sensor over a time duration, derive a first rotation rate of the first pump or a first fluid flow rate at the first pump from the frequency analysis, and provide a response action based on the first rotation rate or the first fluid flow rate.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: May 24, 2022
    Assignee: Fenwal, Inc.
    Inventors: Benjamin E. Kusters, Kyungyoon Min
  • Patent number: 11321967
    Abstract: The present invention discloses a method and system for obtaining and tracking motions and gestures of a body part (e.g. a hand) of a user, by using antennas worn on the body (e.g. on a wrist band). The antennas may be near-field antennas which transmit and receive short-range electromagnetic fields. The electromagnetic fields may be modified by interaction with the body part, depending on the exact position of the body part. The modified electromagnetic field may be received by the antennas. The received signal may be processed, to provide additional spatial information (e.g. beamforming). The processed signal may be interpreted by pattern recognition (e.g. neural network, database table). The pattern recognition may be trained using labeled pair data (e.g. known hand positions and corresponding processed signals).
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: May 3, 2022
    Inventor: Xiao Hu
  • Patent number: 11318313
    Abstract: This document discusses, among other things, systems and methods to determine a response between received cardiac electrical information from a subject, such as a time of a P wave, and received cardiac acceleration information of the subject, such as a time of a first heart sound (S1) or a second heart sound (S2), across a set of stimulation signals provided to the subject at different AVD intervals, and determining one or more cardiac resynchronization therapy (CRT) parameters using an inflection point of the determined response.
    Type: Grant
    Filed: April 10, 2020
    Date of Patent: May 3, 2022
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Yinghong Yu, Krzysztof Z. Siejko, Qi An
  • Patent number: 11311731
    Abstract: This document discusses, among other things, systems and methods to determine a response curve between received cardiac electrical information from a subject, such as a time of a P wave, and received cardiac acceleration information of the subject, such as a time of a first heart sound (S1) or a second heart sound (S2), to a set of stimulation signals provided to the subject at different AVD intervals. In certain examples, one or more cardiac resynchronization therapy (CRT) parameters can be determined for the subject using the determined response curve.
    Type: Grant
    Filed: April 10, 2020
    Date of Patent: April 26, 2022
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Yinghong Yu, Krzysztof Z. Siejko, Qi An
  • Patent number: 11285327
    Abstract: This document discusses, among other things, systems and methods to receive physiologic information from a patient during different first and second pacing periods having respective, different first and second atrioventricular (AV) delays, determine first and second physiologic parameters using respective received physiologic information from the first and second pacing periods, and adjust the first AV delay using the determined first and second physiologic parameters, wherein the second AV delay is longer than the first AV delay.
    Type: Grant
    Filed: March 27, 2019
    Date of Patent: March 29, 2022
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Stephen J. Hahn, Pramodsingh Hirasingh Thakur, Qi An, Viktoria A. Averina, Krzysztof Z. Siejko, Ramesh Wariar
  • Patent number: 11276483
    Abstract: Systems, methods, and apparatus are disclosed aggregating at least two of vital signs data, diagnostic test results, medical data, and user parameters into a single medical record. In one example, a method may include periodically receiving vital signs data and/or diagnostic test results performed on a user; periodically receiving medical data in response to a medical examination of the user performed by a health care practitioner; receiving user parameters about the user; aggregating the vital signs data and/or diagnostic test results, the medical data, and the user parameters into a single medical record; associating the single personal medial record with the user; and storing the single personal medial record into a database of personal medical records. Life expectancy can be calculated. Data aggregation can be performed over time for comparison in real time to medical standard values allowing the user to set personal goals towards greater life expectancy.
    Type: Grant
    Filed: January 22, 2017
    Date of Patent: March 15, 2022
    Assignee: HEALTHY.IO LTD.
    Inventors: Walter De Brouwer, Alexander Cristoff, Scott Thomas
  • Patent number: 11260234
    Abstract: A pacemaker is configured to operate in an atrial synchronous ventricular pacing mode and, after expiration of a conduction check time interval, switch to an asynchronous ventricular pacing mode that includes setting a ventricular pacing interval to a base pacing rate interval. The pacemaker is further configured to determine when atrioventricular block detection criteria are satisfied during the asynchronous ventricular pacing mode and, responsive to the atrioventricular block detection criteria being satisfied, switch back to the atrial synchronous ventricular pacing mode.
    Type: Grant
    Filed: December 4, 2019
    Date of Patent: March 1, 2022
    Assignee: Medtronic, Inc.
    Inventors: Juliana E. Pronovici, James W. Busacker, Keelia Doyle, Vincent P. Ganion, Greggory R. Herr, Todd J. Sheldon, Vincent E. Splett
  • Patent number: 11260216
    Abstract: A ventricularly implantable medical device that includes a sensing module that is configured to detect an artifact during ventricular filling and to identify an atrial event based at least on part on the detected artifact. Control circuitry of the implantable medical device is configured to deliver a ventricular pacing therapy to a patient's heart, wherein the ventricular pacing therapy is time dependent, at least in part, on the identified atrial event.
    Type: Grant
    Filed: November 27, 2018
    Date of Patent: March 1, 2022
    Assignee: CARDIAC PACEMAKERS, INC.
    Inventors: Jeffrey E. Stahmann, Keith R. Maile, Krzysztof Z. Siejko, Allan Charles Shuros, William J. Linder, Benjamin J. Haasl, Michael J. Kane, Brendan Early Koop
  • Patent number: 11241158
    Abstract: Some embodiments of the present disclosure discuss an apparatus comprising a transceiver configured to generate and/or receive radio frequency (RF) electromagnetic signals, one or more antennae configured to radiate the generated RF electromagnetic signals toward a surface and to output signals corresponding to received reflections of the RF electromagnetic signals, and a processing circuitry configured to process the received reflections and/or the output signals so as to determine change in position of the apparatus with respect to the surface. The apparatus may be incorporated into a wearable garment and/or an adhesive patch, and it may be attached to an outer surface of a human or an animal body.
    Type: Grant
    Filed: December 16, 2019
    Date of Patent: February 8, 2022
    Assignee: ZOLL MEDICAL ISRAEL LTD.
    Inventors: Gil Arditi, Roman Vaistikh, Uriel Weinstein
  • Patent number: 11213670
    Abstract: A medical device system includes a cardiac electrical stimulation device and a ventricular assist device (VAD). The cardiac stimulation device and the VAD are capable of communication with each other to confirm detection of cardiac events.
    Type: Grant
    Filed: March 8, 2019
    Date of Patent: January 4, 2022
    Assignee: Medtronic, Inc.
    Inventor: Mark L. Brown
  • Patent number: 11207537
    Abstract: A subcutaneous implantable cardioverter-defibrillator (S-ICD) comprising shocking electrodes configured to reduce the defibrillation threshold. The S-ICD may include a canister housing a source of electrical energy, a capacitor, and operational circuitry that senses heart rhythms and an electrode and lead assembly. The electrode and lead assembly may comprise a lead, at least one sensing electrode, and at least one shocking electrode. The at least one shocking electrode may extend over a length in the range of 50 to 110 millimeters and a width in the range of 1 to 40 millimeters.
    Type: Grant
    Filed: July 11, 2019
    Date of Patent: December 28, 2021
    Assignee: CARDIAC PACEMAKERS, INC.
    Inventors: Andrew L. De Kock, G. Shantanu Reddy, Robert D. Brock, II, Stephen J. Hahn, Brendan E. Koop, Moira B. Sweeney, Wyatt K. Stahl
  • Patent number: 11202908
    Abstract: In some examples, electrical stimulation is delivered to a patient such that selective termination of the stimulation causes a therapeutic effect in the patient after termination of the electrical stimulation to the patient. The electrical stimulation may be insufficient to produce a desired therapeutic effect in the patient during stimulation, but sufficient to induce a post-stimulation desired therapeutic effect following termination of the stimulation. In some examples, the electrical stimulation may be sub-threshold electrical stimulation. In some examples, the desired therapeutic effect may alleviate bladder dysfunction, bowel dysfunction, or other disorders. The stimulation may be selectively terminated in response to one or more therapy trigger events to induce the post-stimulation therapeutic effect.
    Type: Grant
    Filed: December 30, 2019
    Date of Patent: December 21, 2021
    Assignee: Medtronic, Inc.
    Inventors: Xin Su, Dwight E. Nelson
  • Patent number: 11197617
    Abstract: A system and method for hemodynamic dysfunction detection may include at least one sensor configured to received one or more signals from a patient, a computing device in data communication with the at least one sensor, a computer-readable storage medium in communication with the computing device, an input device, and an output device. The system may include computer readable instructions to cause the system to receive at least one signal in the time domain from the sensor, determine at least one metric in the frequency domain from the at least one signal in the time domain, and determine the cardiovascular state of the patient from a combination of the at least one metric in the frequency domain and information contained in at least one database of cardiovascular states. The system may also notify a user of a immanent patient cardiovascular event and recommend one or more interventions to mitigate it.
    Type: Grant
    Filed: November 6, 2017
    Date of Patent: December 14, 2021
    Assignee: Intelomed, Inc.
    Inventors: Jan Berkow, Anne Brumfield
  • Patent number: 11191959
    Abstract: The invention provides a system for inhibition or treatment of an aberrant neurological event in a subject. The system comprises: one or more detectors; a controller; and one or more stimulators of the vagus nerve. The invention also provides a method for treating and preventing epileptic seizures and the onset or pre-onset of epileptic seizures. The method includes the steps of: collecting signals from each of one or more detector indicating the presence of a repetitive movement; analyzing signals received from the one or more detector to determine the intensity of the stimulation of the auricular branch of the vagus nerve (ABVN) required to control, moderate or prevent current and future repetitive movements; and when required, signaling one or more stimulator to stimulate the ABVN so that the repetitive motion ceases using the determined stimulation intensities.
    Type: Grant
    Filed: December 11, 2017
    Date of Patent: December 7, 2021
    Assignee: COGNIGUARD MEDICAL HOLDINGS LIMITED
    Inventors: Tamir Ben-David, Nimrod Kadim, Shmuel Glasberg, Ra'anan Gefen
  • Patent number: 11160495
    Abstract: The present invention relates to a sleep apnea monitoring system for monitoring the sleeping state of a user by means of impedance tomographic image information about the properties of biological tissue and biological signals of the user's body parts to be monitored. The present invention can be manufactured into a very simple portable device and thus enables monitoring during natural sleep at home. Therefore, the present invention enables utilization of obtained information during a sleeping state for diagnosis of and therapeutic plans for sleep apnea.
    Type: Grant
    Filed: March 7, 2017
    Date of Patent: November 2, 2021
    Assignee: BiLab Co., Ltd.
    Inventors: Eung Je Woo, Tong In Oh
  • Patent number: 11158179
    Abstract: A system for determining that a monitored person has experienced an event wherein the event is detrimental to the monitored person. The system comprises a first sensing component for producing a first sensed parameter value representative of a first sensed condition of the monitored person and a second sensing component activated responsive to the first sensed parameter value for producing a second sensed parameter value representative of a second sensed condition. A detecting component receives the first and second sensed parameter values for determining that the monitored person has experienced the event.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: October 26, 2021
    Assignee: NXT-ID, INC.
    Inventor: David Tunnell
  • Patent number: 11097106
    Abstract: An implantable neurostimulator-implemented method for managing tachyarrhythmias through vagus nerve stimulation is provided. An implantable neurostimulator, including a pulse generator, is configured to deliver electrical therapeutic stimulation in a manner that results in creation and propagation (in both afferent and efferent directions) of action potentials within neuronal fibers of a patient's cervical vagus nerve. Operating modes of the pulse generator are stored. A maintenance dose of the electrical therapeutic stimulation is delivered to the vagus nerve via the pulse generator to restore cardiac autonomic balance through continuously-cycling, intermittent and periodic electrical pulses. A restorative dose of the electrical therapeutic stimulation is delivered to prevent initiation of or disrupt tachyarrhythmia through periodic electrical pulses delivered at higher intensity than the maintenance dose.
    Type: Grant
    Filed: February 1, 2019
    Date of Patent: August 24, 2021
    Assignee: LivaNovaUSA, Inc.
    Inventors: Imad Libbus, Badri Amurthur, Bruce H. KenKnight
  • Patent number: 11089958
    Abstract: Systems and methods for managing machine-generated medical events detected from one or more patients are described herein. A medical event management system includes an event analyzer circuit to detect a medical event using physiological data from a patient-triggered episode acquired from a medical device. The event analyzer circuit determines a confidence score of the medical event detection, and generates an alignment indicator indicating a degree of concordance between the detected medical event and the information about the patient-triggered episode. The system assigns priority information to the patient-triggered episode using the generated alignment indicator and the confidence score of the detection. An output circuit can output the received physiological information to a user or a process according to the assigned priority information.
    Type: Grant
    Filed: July 5, 2018
    Date of Patent: August 17, 2021
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Amy Jean Brisben, Qi An, Pramodsingh Hirasingh Thakur, David J. Ternes, JoAnna Trapp Simpson, Viktoria A. Averina, Deepa Mahajan, Sunipa Saha, Krzysztof Z. Siejko
  • Patent number: 11071476
    Abstract: A method of monitoring respiration with an acoustic measurement device, the acoustic measurement device having a sound transducer, the sound transducer configured to measure sound associated with airflow through a mammalian trachea, the method includes correlating the measured sound into a measurement of tidal volume and generating at least one from the group consisting of an alert and an alarm if the measured tidal volume falls outside of a predetermined range.
    Type: Grant
    Filed: August 22, 2019
    Date of Patent: July 27, 2021
    Assignees: Thomas Jefferson University, RTM Vital Signs LLC
    Inventors: Jeffrey I Joseph, Noud Van Helmond, Marc C Torjman, Denise L Devine, Nance K Dicciani, Channy Loeum
  • Patent number: 11013914
    Abstract: An implantable device for providing electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction is provided. A stimulation therapy lead includes helical electrodes configured to conform to an outer diameter of a cervical vagus nerve sheath, and a set of connector pins electrically connected to the helical electrodes. A neurostimulator includes an electrical receptacle into which the connector pins are securely and electrically coupled. The neurostimulator also includes a pulse generator configured to therapeutically stimulate the vagus nerve through the helical electrodes in alternating cycles of stimuli application and stimuli inhibition that are tuned to both efferently activate the heart's intrinsic nervous system and afferently activate the patient's central reflexes by triggering bi-directional action potentials.
    Type: Grant
    Filed: January 25, 2019
    Date of Patent: May 25, 2021
    Assignee: LivaNova USA, Inc.
    Inventors: Imad Libbus, Badri Amurthur, Bruce H. Kenknight
  • Patent number: 11013416
    Abstract: An earphone includes a loudspeaker, a microphone, a housing supporting the loudspeaker and microphone, and an ear tip surrounding the housing and configured to acoustically couple both the loudspeaker and the microphone to an ear canal of a user, and to acoustically close the entrance to the user's ear canal. A processor receives input audio signals from the microphone, detects peaks having a frequency of around 1 Hz in the input audio signals, based on the detected peaks, computes an instantaneous heart rate, measures a frequency of an oscillation within the instantaneous heart rate, and based on the frequency of the oscillation, computes a rate of respiration.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: May 25, 2021
    Assignee: Bose Corporation
    Inventors: Romain Kirszenblat, Mikhail Ioffe
  • Patent number: 10987004
    Abstract: The invention provides a body-worn monitor that measures a patient's vital signs (e.g. blood pressure, SpO2, heart rate, respiratory rate, and temperature) while simultaneously characterizing their activity state (e.g. resting, walking, convulsing, falling). The body-worn monitor processes this information to minimize corruption of the vital signs by motion-related artifacts. A software framework generates alarms/alerts based on threshold values that are either preset or determined in real time. The framework additionally includes a series of ‘heuristic’ rules that take the patient's activity state and motion into account, and process the vital signs accordingly. These rules, for example, indicate that a walking patient is likely breathing and has a regular heart rate, even if their motion-corrupted vital signs suggest otherwise.
    Type: Grant
    Filed: February 26, 2018
    Date of Patent: April 27, 2021
    Assignee: SOTERA WIRELESS, INC.
    Inventors: Devin McCombie, Matt Banet, Marshal Dhillon, Jim Moon
  • Patent number: 10987059
    Abstract: A device comprising a three-dimensional polymeric element and an electronic element integrated with the polymeric element is disclosed. The electronic element is made up of one or more electrode(s) each individually connectable to a measuring device and/or a controller, and each independently having a thin electrically-isolating layer deposited thereon such that the electrode is exposed to an environment surrounding the electrode at one or more pre-determined locations over the electrode. The device can include cells and/or tissue and/or a therapeutically active agent incorporated within the polymeric material. Processes of fabricating the device, systems for operating the device and methods utilizing same are also disclosed.
    Type: Grant
    Filed: November 17, 2014
    Date of Patent: April 27, 2021
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Tal Dvir, Yosi Shacham-Diamand, Ron Feiner, Leeya Engel
  • Patent number: 10967188
    Abstract: Systems and methods for controlling blood pressure by controlling atrial pressure and atrial stretch are disclosed. In some embodiments, a stimulation circuit may be configured to deliver a stimulation pulse to at least one cardiac chamber of a heart of a patient, and at least one controller may be configured to execute delivery of one or more stimulation patterns of stimulation pulses to the at least one cardiac chamber, wherein at least one of the stimulation pulses stimulates the heart such that an atrial pressure resulting from atrial contraction of an atrium overlaps in time a passive pressure build-up of the atrium, such that an atrial pressure of the atrium resulting from the stimulation is a combination of the atrial pressure resulting from atrial contraction and the passive pressure build-up and is higher than an atrial pressure of the atrium would be without the stimulation, and such that the blood pressure of the patient is reduced.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: April 6, 2021
    Assignee: BackBeat Medical, LLC
    Inventors: Yuval Mika, Darren Sherman, Robert S. Schwartz, Robert A. Van Tassel, Daniel Burkhoff
  • Patent number: 10893813
    Abstract: Various system embodiments comprise a stimulator adapted to deliver a stimulation signal for a heart failure therapy, a number of sensors adapted to provide at least a first measurement of a heart failure status and a second measurement of the heart failure status, and a controller. The controller is connected to the stimulator and to the number of sensors. The controller is adapted to use the first and second measurements to create a heart failure status index, and control the stimulator to modulate the signal using the index. Other aspects and embodiments are provided herein.
    Type: Grant
    Filed: January 24, 2018
    Date of Patent: January 19, 2021
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Imad Libbus, Krzysztof Z. Siejko, Marina V. Brockway, Robert J. Sweeney
  • Patent number: 10881862
    Abstract: Methods and/or devices may be configured to estimate right ventricular-timings from left ventricular (LV) sensing times for adaptive cardiac therapy using DDD/VDD LV pacing without using a right ventricular (RV) lead. One embodiment employs a subcutaneous device (SD) in a patient and a leadless pacing device (LPD) coupled to a patient's heart. Heart activity including atrial and ventricular events are sensed from the patient's heart using the SD. Left ventricular events (LVS) are sensed using the LPD. The SD is used to determine whether cardiac resynchronization pacing therapy (CRT pacing) is appropriate based upon the heart activity sensed by the SD. The SD is further configured to determine timing of CRT pacing pulses for delivery to cardiac tissue through the LPD.
    Type: Grant
    Filed: May 9, 2018
    Date of Patent: January 5, 2021
    Assignee: Medtronic, Inc.
    Inventor: Subham Ghosh
  • Patent number: 10874860
    Abstract: A leadless cardiac pacemaker (LCP) is configured to sense cardiac activity and to pace a patient's heart and is disposable within a ventricle of the patient's heart. The LCP MAY include a housing, a first electrode and a second electrode that are secured relative to the housing and are spaced apart. A controller is disposed within the housing and is operably coupled to the first electrode and the second electrode such that the controller is capable of receiving, via the first electrode and the second electrode, electrical cardiac signals of the heart. The LCP may include a pressure sensor and/or an accelerometer. The controller may determine a pace time within a cardiac cycle based at least in part upon an indication of metabolic demand.
    Type: Grant
    Filed: July 19, 2017
    Date of Patent: December 29, 2020
    Assignee: CARDIAC PACEMAKERS, INC.
    Inventors: Qi An, Michael J. Kane, Yinghong Yu, Jeffrey E. Stahmann, Pramodsingh Hirasingh Thakur, Keith R. Maile
  • Patent number: 10877444
    Abstract: Described is a system for biofeedback, the system including one or more processors and a memory, the memory being a non-transitory computer-readable medium having executable instructions encoded thereon, such that upon execution of the instructions, the one or more processors perform operations including using a first biometric sensor during performance of a current task, acquiring first biometric data, and producing a first biometric value by assessing the first biometric data. The one or more processors further perform operations including determining a first relevance based on a first significance of a first correlation between the first biometric value and the current task, and controlling a device based on the first relevance and the first biometric value.
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: December 29, 2020
    Assignee: HRL Laboratories, LLC
    Inventors: Shane M. Roach, Michael D. Howard, Praveen K. Pilly
  • Patent number: 10856814
    Abstract: A device and method for detecting biological information without being affected by sudden-onset signal even when sudden-onset large vibration is caused while driving a vehicle or the like. Peak input and output values of a variable delay device are detected, and the difference between the values is determined by a subtractor. The difference is compared to a predetermined threshold to obtain a positive or negative output as an up/down selection output for an up/down counter. The output of the up/down counter is sent to a variable delay device with a clock generated based on an inputted peak signal of biological information to obtain a variable delay amount corresponding to one cycle of the biological information. When the subtractor output exceeds the predetermined threshold, a predetermined output voltage is generated, and an amplifier connected to the variable delay device is controlled so that the gain of the amplifier becomes zero.
    Type: Grant
    Filed: March 22, 2016
    Date of Patent: December 8, 2020
    Assignees: KYUSHU INSTITUTE OF TECHNOLOGY, AI TECHNOLOGY INC.
    Inventor: Yasushi Sato
  • Patent number: 10856760
    Abstract: A system for processing cardiac activation information associated with a complex rhythm disorder identifies a location of the heart rhythm disorder by determining activations within cardiac signals obtained at neighboring locations of the heart and arranging the activations to identify an activation trail. The activation trail may define a rotational pattern or radially emanating pattern corresponding to an approximate core of the heart rhythm disorder.
    Type: Grant
    Filed: July 13, 2017
    Date of Patent: December 8, 2020
    Assignees: The Regents of the University of California, Topera, Inc., The United States of America as Represented by the Department of Veterans Affairs
    Inventors: Sanjiv M. Narayan, Ruchir Sehra
  • Patent number: 10835751
    Abstract: Intermittent delivery of ventricular pacing pulses synchronized to occur during an atrial diastole time period can be used to provide atrial stretch therapy and augment the production and release of atrial natriuretic hormone.
    Type: Grant
    Filed: May 30, 2018
    Date of Patent: November 17, 2020
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Jeffrey E. Stahmann, Ramesh Wariar, Stephen B. Ruble
  • Patent number: 10835749
    Abstract: Disclosed herein are methods, systems, and apparatus for treating a medical condition of a patient, involving detecting a physiological cycle or cycles of the patient and applying an electrical signal to a portion of the patient's vagus nerve through an electrode at a selected point in the physiological cycle(s). The physiological cycle can be the cardiac and/or respiratory cycle. The selected point can be a point in the cardiac cycle correlated with increased afferent conduction on the vagus nerve, such as a point from about 10 msec to about 800 msec after an R-wave of the patient's ECG, optionally during inspiration by the patient. The selected point can be a point in the cardiac cycle when said applying increases heart rate variability, such as a point from about 10 msec to about 800 msec after an R-wave of the patient's ECG, optionally during expiration by the patient.
    Type: Grant
    Filed: April 9, 2014
    Date of Patent: November 17, 2020
    Assignee: DiGnity Health
    Inventor: Arthur D. Craig
  • Patent number: 10806938
    Abstract: Receiver-stimulator with folded or rolled up assembly of piezoelectric components, causing the receiver-stimulator to operate with a high degree of isotropy are disclosed. The receiver-stimulator comprises piezoelectric components, rectifier circuitry, and at least two stimulation electrodes. Isotropy allows the receiver-stimulator to be implanted with less concern regarding the orientation relative the transmitted acoustic field from an acoustic energy source.
    Type: Grant
    Filed: July 31, 2018
    Date of Patent: October 20, 2020
    Assignee: EBR Systems, Inc.
    Inventors: David F. Moore, Paul Mohr, N. Parker Willis, Axel F. Brisken
  • Patent number: 10792499
    Abstract: Electrode structures for transvascular nerve stimulation combine electrodes with an electrically-insulating backing layer. The backing layer increases the electrical impedance of electrical paths through blood in a lumen of a blood vessel and consequently increases the flow of electrical current through surrounding tissues. The electrode structures may be applied to stimulate nerves such as the phrenic, vagus, trigeminal, obturator or other nerves.
    Type: Grant
    Filed: January 15, 2020
    Date of Patent: October 6, 2020
    Assignee: Lungpacer Medical Inc.
    Inventor: Joaquin Andres Hoffer
  • Patent number: 10765871
    Abstract: An implantable medical device (IMD) is configured with a pressure sensor. The IMD includes a housing, a pressure sensor and a fluid filled cavity. The housing has a diaphragm that is exposed to the environment outside of the housing. The pressure sensor has a pressure sensor diaphragm that is responsive to a pressure applied to the pressure sensor diaphragm and provides a pressure sensor output signal that is representative of the pressure applied to the pressure sensor diaphragm. The fluid filled cavity is in fluid communication with both the diaphragm of the housing and the pressure sensor diaphragm of the pressure sensor. The fluid filled cavity is configured to communicate a measure related to the pressure applied by the environment to the diaphragm of the housing to the pressure sensor diaphragm of the pressure sensor.
    Type: Grant
    Filed: October 23, 2017
    Date of Patent: September 8, 2020
    Assignee: CARDIAC PACEMAKERS, INC.
    Inventors: Michael J. Kane, Benjamin J. Haasl, Keith R. Maile
  • Patent number: 10765869
    Abstract: An example method for controlling delivery of electrical stimulation therapy includes maintaining, by one or more processors of a medical device configured to deliver electrical stimulation to a patient, a counter tied to a clock used by the medical device to deliver the electrical stimulation to the patient; and obtaining, by the one or more processors, one or more representations of sensed electrical signals for the patient that are referenced to counts of the counter. In this example, the method also includes identifying, based on the one or more representations of the sensed electrical signals for the patient, a count of the counter at which stimulation is to be delivered to the patient; and delivering, by the medical device and to the patient, electrical stimulation based on the identified count of the counter.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: September 8, 2020
    Assignee: Medtronic, Inc.
    Inventors: David L. Carlson, Heather D. Orser, Dale G. Suilmann, Kenneth J. Gutzman, Gregory J. Loxtercamp
  • Patent number: 10751543
    Abstract: Cardiac therapy devices in the form of pacemakers and/or defibrillators including one or more leads with electrodes implanted in a vein in a posterior position in combination with one or more leads with electrodes implanted in an anterior position. The posterior position may be chosen from one or more of the azygos, hemiazygos, accessory hemiazygos, or posterior intercostal veins. The anterior position may be chosen from the internal thoracic vein, an anterior intercostal vein, or an anterior subcutaneous location. In other examples, sensors are placed for use by a cardiac monitoring or therapy system in one or more of the internal thoracic vein, the azygos vein, the hemiazygos vein, the accessory hemiazygos vein, and/or an anterior or posterior intercostal vein.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: August 25, 2020
    Assignee: CARDIAC PACEMAKERS, INC.
    Inventors: G. Shantanu Reddy, Eric Falbe Hammill, James O. Gilkerson, Ramesh Wariar, Pramodsingh Hirasingh Thakur
  • Patent number: 10744328
    Abstract: Systems and methods for stimulation of neurological tissue apply a stimulation waveform that is derived by a developed genetic algorithm (GA), which may be coupled to a computational model of extracellular stimulation of a mammalian myelinated axon. The waveform is optimized for energy efficiency.
    Type: Grant
    Filed: July 17, 2017
    Date of Patent: August 18, 2020
    Assignee: Duke University
    Inventors: Warren M. Grill, Amorn Wongsarnpigoon
  • Patent number: 10736516
    Abstract: An implantable monitoring device is disclosed for monitoring a patient's heart rate variability over time. The device includes a cardiac electrogram amplifier, a sensing electrode coupled to an input of the amplifier, timing circuitry, processing circuitry and a memory. The timing circuitry defines successive shorter time periods during each monitoring period. The processing circuitry relies upon electrogram activity that occurs during rest periods that extend as long as T1, all of which is stored into memory. Active periods are not considered as part of the heart rate variability calculation. The processing circuitry calculates median intervals between depolarizations of the patient's heart sensed by the amplifier during the shorter time periods and calculates a standard deviation of the median intervals during T2, a longer monitoring period.
    Type: Grant
    Filed: February 4, 2014
    Date of Patent: August 11, 2020
    Assignee: Medtronic, Inc.
    Inventor: Vinod Sharma
  • Patent number: 10729898
    Abstract: An apparatus comprises a cardiac signal sensing circuit configured for coupling electrically to a plurality of electrodes and to sense intrinsic cardiac activation at three or more locations within a subject's body using the electrodes; a stimulus circuit configured for coupling to the plurality of electrodes; a signal processing circuit electrically coupled to the cardiac signal sensing circuit and configured to determine a baseline intrinsic activation vector according to the sensed intrinsic cardiac activation; and a control circuit electrically coupled to the cardiac signal sensing circuit and stimulus circuit and configured to: initiate delivery of electrical pacing therapy using initial pacing parameters determined according to the baseline intrinsic activation vector; initiate sensing of a paced activation vector; and adjust one or more pacing therapy parameters according to the paced activation vector.
    Type: Grant
    Filed: April 3, 2017
    Date of Patent: August 4, 2020
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Allan Charles Shuros, Yinghong Yu, David J. Ternes, Michael J. Kane, William J. Linder
  • Patent number: 10716944
    Abstract: A leadless pacing device may include a housing, a distal extension extending distally of a distal end of the housing, one or more electrodes supported by the housing, a distal electrode supported by the distal extension, and a processing module located within an interior space of the housing and electrically coupled to the one or more electrodes supported by the housing and the distal electrode supported by the distal extension. The housing may be positioned within a coronary sinus and the distal extension may be positioned within a vessel extending from the coronary sinus. The processing module may determine whether cardiac events occurred based on near-field signals and/or far-field signals sensed using the one or more electrodes supported by the housing and the distal electrode. The processing module may generate cardiac stimulation pulses based on the determination of whether a cardiac event occurred and where it occurred.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: July 21, 2020
    Assignee: CARDIAC PACEMAKERS, INC.
    Inventors: Benjamin J. Haasl, Lili Liu, Allan Charles Shuros
  • Patent number: 10708191
    Abstract: Systems, methods, and computer program product embodiments are disclosed for performing electrophysiology (EP) signal processing. An embodiment includes an electrocardiogram (ECG) circuit board configured to process an ECG signal. The embodiment further includes a plurality of intracardiac (IC) circuit boards, each configured to process a corresponding IC signal. The embodiment further includes a communications interface communicatively coupled to a remote device, and a processor, coupled to the ECG circuit board, the plurality of IC circuit boards, and the communications interface. The processor is configured to receive, via the communications interface, feedback from the remote device. The processor is further configured to control, via the communication interface, the remote device based on the ECG signal, the IC signals, or the feedback from the remote device.
    Type: Grant
    Filed: September 26, 2019
    Date of Patent: July 7, 2020
    Assignees: BioSig Technologies, Inc., Mayo Foundation for Medical Education and Research
    Inventors: Budimir S. Drakulic, Sina Fakhar, Thomas G. Foxall, Branislav Vlajinic, Samuel J. Asirvatham
  • Patent number: 10668277
    Abstract: Detecting dislodgement of a ventricular lead coupled to an implantable medical device comprises sensing a near-field cardiac EGM via a first electrode of the ventricular lead and a far-field cardiac EGM via a second electrode of the ventricular lead, identifying, R-waves in the near-field cardiac EGM and the far-field cardiac EGM. determining a near-field value of one or more R-wave amplitude metrics based on amplitudes of R-waves identified in the near-field cardiac EGM and a far-field value of the one or more R-wave amplitude metrics based on amplitudes of R-waves identified in the far-field cardiac EGM, detecting dislodgement of the ventricular lead based on at least one of the near-field value or the far-field value of the one or more R-wave amplitude metrics; and providing a lead dislodgment alert in response to detecting the dislodgement of the ventricular lead.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: June 2, 2020
    Assignee: Medtronic, Inc.
    Inventors: Bruce D. Gunderson, Charles D. Swerdlow
  • Patent number: RE49122
    Abstract: A method of detecting an early onset of neurocardiogenic syncope in a patient uses respiratory functions as a predictor of the syncope. According to the method, at least one sample of baseline minute ventilation, tidal volume and respiratory rate of the patient is obtained. The detection unit is set to detect an increase in tidal volume and in minute ventilation over a predetermined respiratory period. The detecting unit also detects any rate of change in respiratory rate and sends a signal to a microprocessor to determine whether the increase in minute ventilation is a sole function of increased tidal volume. The impending syncope is diagnosed if variance in respiratory rate is less than 25% in relation to the sampled baseline during the predetermined period of time.
    Type: Grant
    Filed: September 10, 2020
    Date of Patent: July 5, 2022
    Assignee: PHYSIOVOYANCE, LLC
    Inventor: Paul Lelorier