Plural Sensed Conditions Patents (Class 607/18)
  • Patent number: 11077307
    Abstract: An intracardiac pacemaker system is configured to produce physiological atrial event signals by a sensing circuit of a ventricular intracardiac pacemaker and select a first atrial event input as the physiological atrial event signals. The ventricular intracardiac pacemaker detects atrial events from the selected first atrial event input, determines if input switching criteria are met, and switches from the first atrial event input to a second atrial event input in response to the input switching criteria being met. The second atrial event input includes broadcast atrial event signals produced by a second implantable medical device and received by the ventricular intracardiac pacemaker.
    Type: Grant
    Filed: June 24, 2019
    Date of Patent: August 3, 2021
    Assignee: Medtronic, Inc.
    Inventors: Wade M. Demmer, Yong K. Cho, Mark K. Erickson, Todd J. Sheldon
  • Patent number: 11071866
    Abstract: Systems and methods for pacing cardiac conductive tissue are described. A medical system includes electrostimulation circuit that may generate His-bundle pacing (HBP) pulses for delivery at or near the His bundle. A capture verification circuit may detect, from a far-field signal representing ventricular response to the HBP pulses, a His-bundle response representative of excitation of the His bundle directly resulting from the HBP pulses, and a myocardial response representative of excitation of the myocardium directly resulting from the HBP pulses. A control circuit may adjust one or more stimulation parameters based on the His-bundle response and myocardial response. The electrostimulation circuit may generate and deliver the HBP pulses according to the adjusted stimulation parameters to excite the His bundle.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: July 27, 2021
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: David Arthur Casavant, David L. Perschbacher, Ramesh Wariar, Stephen J. Hahn, Allan Charles Shuros
  • Patent number: 11033742
    Abstract: Techniques are disclosed for using probabilistic entropy to select electrodes with fewer artifacts for controlling adaptive electrical neurostimulation. In one example, a plurality of electrodes sense bioelectrical signals of a brain of a patient. Processing circuitry determines, for each bioelectrical signal sensed at a respective electrode of the plurality of electrodes, a probabilistic entropy value of the bioelectrical signal. The processing circuitry compares each of the respective probabilistic entropy values of the bioelectrical signal to respective entropy threshold values and selects, based on the comparisons, a subset of electrodes of the plurality of electrodes. The processing circuitry controls, based on the bioelectrical signals sensed via respective electrodes of the subset of electrodes and excluding the bioelectrical signals of the plurality of bioelectrical signals sensed via respective electrodes not in the subset of electrodes, delivery of electrical stimulation therapy to the patient.
    Type: Grant
    Filed: April 23, 2019
    Date of Patent: June 15, 2021
    Assignee: MEDTRONIC, INC.
    Inventors: Eric J. Panken, Jadin C. Jackson, Yizi Xiao, Christopher L. Pulliam
  • Patent number: 11033741
    Abstract: Neuromodulation is used to enhance left ventricular relaxation. An exemplary neuromodulation system includes a therapy element positionable in proximity to at least one nerve fiber, and a stimulator configured to energize the therapy element to delivery therapy to the at least one nerve fiber such that left ventricular relaxation and left ventricular contractility are contemporaneously enhanced.
    Type: Grant
    Filed: January 31, 2018
    Date of Patent: June 15, 2021
    Assignee: NuXcel Limited
    Inventors: Michael Cuchiara, Stephen C Masson
  • Patent number: 11016165
    Abstract: Devices and methods are described for transmitting acoustic waves through a fluid medium to communicate between a macro-scale transceiver and micro-devices or to communicate between micro-devices. Acoustical transmission can be used to communicate data or to provide power to the micro-device(s). The ability to transmit and receive on multiple frequencies can optimize the transmission for a particular situation.
    Type: Grant
    Filed: June 14, 2018
    Date of Patent: May 25, 2021
    Assignee: CBN Nano Technologies Inc.
    Inventors: Tad Hogg, Robert A. Freitas, Jr.
  • Patent number: 11006296
    Abstract: A method for determining quality of a communications link between an external instrument (EI) and an implantable medical device (IMD) is provided. The method includes receiving, with a receiver of an EI, data packets sent at intervals from an IMD and determining, with a processor of the EI, an expected time interval between a first data packet and a second data packet. The processor of the EI determines a difference between the expected time interval between the first data packet and the second data packet and an actual time interval between the first data packet and the second data packet. The processor of the EI also provides a time variant communication quality indicator based on the difference between the expected time interval between the first data packet and the second data packet and the actual time interval between the first data packet and the second data packet.
    Type: Grant
    Filed: November 19, 2018
    Date of Patent: May 11, 2021
    Assignee: PACESETTER, INC.
    Inventor: Xing Pei
  • Patent number: 10993659
    Abstract: Described embodiments include an apparatus, including a display and a processor. The processor is configured to navigate a catheter to a particular location within a body of a subject, using each one of a plurality of electrodes coupled to the body of the subject. The processor is further configured to identify, subsequently, from a signal that represents an impedance between a given pair of the electrodes, that a phrenic nerve of the subject was stimulated by a pacing current passed from the catheter into tissue of the subject at the particular location, and to generate an output on the display, in response to the identifying. Other embodiments are also described.
    Type: Grant
    Filed: June 1, 2017
    Date of Patent: May 4, 2021
    Assignee: Biosense Webster (Israel) Ltd.
    Inventors: Lior Botzer, Daniel Osadchy
  • Patent number: 10939820
    Abstract: A patient monitoring system includes at least two wireless sensing devices, each configured to measure a different physiological parameter from a patient and wirelessly transmit a parameter dataset. The system further includes a receiver that receives each parameter dataset, a processor, and a monitoring regulation module executable on the processor to assign one of the at least two wireless sensing devices as a dominant wireless sensing device and at least one of the remaining wireless sensing devices as a subordinate wireless sensing device. The physiological parameter measured by the dominant wireless sensing device is a key parameter and the parameter dataset transmitted by the dominant wireless sensing device is a key parameter dataset. The key parameter dataset from the dominant wireless sensing device is processed to determine a stability indicator. The subordinate wireless sensing device is then operated based on the stability indicator for the key parameter.
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: March 9, 2021
    Assignee: General Electric Company
    Inventors: Stanislava Soro, Robert F. Donehoo, Otto Valtteri Pekander
  • Patent number: 10918300
    Abstract: A system and method for non-invasively monitoring the hemodynamic state of a patient by determining on a beat-by-beat basis the ratio of lusitropic function to inotropic function as an index of myocardial well-being or pathology for use by clinicians in the hospital or by the patient at home. In one embodiment of the system a smartphone running an application program that is connected through the internet to the cloud processes electronic signals, first, from an electrocardiogram device monitoring electrical cardiac activity, and second, from a seismocardiogram device monitoring mechanical cardiac activity in order to determine such ratio as an instantaneous measurement of the hemodynamic state of the patient, including such states as sepsis, myocardial ischemia, and heart failure.
    Type: Grant
    Filed: August 22, 2018
    Date of Patent: February 16, 2021
    Inventor: Robert Alan Hirsh
  • Patent number: 10918862
    Abstract: Described is a system for adaptable neurostimulation intervention. The system monitors a set of neurophysiological signals in real-time and updates a physiological and behavioral model. The set of neurophysiological signals are classified in real-time based on the physiological and behavioral model. A neurostimulation intervention schedule is generated based on the classified set of neurophysiological signals. The system activates electrodes via a neurostimulation intervention system to cause a timed neurostimulation intervention to be administered based on the neurostimulation intervention schedule. The neurostimulation intervention schedule and timed neurostimulation intervention are refined based on new sets of neurophysiological signals.
    Type: Grant
    Filed: August 9, 2018
    Date of Patent: February 16, 2021
    Assignee: HRL Laboratories, LLC
    Inventors: Jaehoon Choe, Praveen K. Pilly, Steven W. Skorheim
  • Patent number: 10918870
    Abstract: A system and method of positioning an atrial pacing lead for delivery of a cardiac pacing therapy that includes sensing electrical activity of tissue of a patient from a plurality of external electrodes and determining a distribution of bi-atrial activation in response to the sensed electrical activity. A target site for delivering the atrial pacing therapy is adjusted based on a change in bi-atrial dyssynchrony that is determined in response to the determined distribution of bi-atrial activation, and placement of the atrial pacing lead for delivery of the atrial pacing therapy is determined in response to the adjusting.
    Type: Grant
    Filed: March 7, 2018
    Date of Patent: February 16, 2021
    Assignee: Medtronic, Inc.
    Inventors: Subham Ghosh, Zhongping Yang
  • Patent number: 10874861
    Abstract: A ventricular implantable medical device that is configured to detect an atrial timing fiducial from the ventricle. The ventricular implantable medical is configured to deliver a ventricular pacing therapy to the ventricle based on the detected atrial timing fiducial. If the ventricular implantable medical device temporarily fails to detect atrial activity because of noise, posture, patient activity or for any other reason, an atrial implantable medical device may be configured to communicate atrial events to the ventricular implantable medical device and the ventricular implantable medical device may synchronize the ventricular pacing therapy with the atrium activity based on those communications.
    Type: Grant
    Filed: January 3, 2019
    Date of Patent: December 29, 2020
    Assignee: CARDIAC PACEMAKERS, INC.
    Inventors: Brendan Early Koop, Jeffrey E. Stahmann, Allan Charles Shuros, Keith R. Maile, Benjamin J. Haasl
  • Patent number: 10870008
    Abstract: Methods, systems and devices for providing cardiac resynchronization therapy (CRT) to a patient using a leadless cardiac pacemaker and an extracardiac device. The extracardiac device is configured to analyze one or more QRS complexes of the patient's heart, determine whether fusion pacing is taking place, and, if not, to communicate with the leadless cardiac pacemaker to adjust intervals used in the CRT in order to generate desirable fusion of the pace and intrinsic signals. The extracardiac device may take the form of a subcutaneous implantable monitor, a subcutaneous implantable defibrillator, or other devices including wearable devices.
    Type: Grant
    Filed: August 23, 2017
    Date of Patent: December 22, 2020
    Assignee: CARDIAC PACEMAKERS, INC.
    Inventors: Stephen J. Hahn, Kenneth M. Stein, Yinghong Yu, Scott J. Healy, John Morgan
  • Patent number: 10744329
    Abstract: A pacemaker having a motion sensor delivers atrial-synchronized ventricular pacing by detecting events from a signal produced by the motion sensor and delivering ventricular pacing pulses at a rate that tracks the rate of the detected events. The pacemaker is configured to confirm atrial tracking of the ventricular pacing pulses by determining if detected events from the motion sensor signal are atrial events. The pacemaker is configured to adjust a control parameter used for detecting events from the motion sensor signal if atrial tracking is not confirmed.
    Type: Grant
    Filed: July 5, 2018
    Date of Patent: August 18, 2020
    Assignee: Medtronic, Inc.
    Inventors: Todd J. Sheldon, Wade M. Demmer, Greggory R. Herr
  • Patent number: 10687725
    Abstract: A method of tracking a position of a catheter within a patient includes securing a navigational reference at a reference location within the patient, defining the reference location as the origin of a coordinate system, determining a location of an electrode moving within the patient relative to that coordinate system, monitoring for a dislodgement of the navigational reference from the initial reference location, for example by measuring the navigational reference relative to a far field reference outside the patient's body, and generating a signal indicating that the navigational reference has dislodged from the reference location. Upon dislodgement, a user may be provided with guidance to help reposition and secure the navigational reference to the initial reference location, or the navigational reference may be automatically repositioned and secured to the initial reference location. Alternatively, a reference adjustment may be calculated to compensate for the changed reference point/origin.
    Type: Grant
    Filed: November 20, 2015
    Date of Patent: June 23, 2020
    Assignee: St. Jude Medical, Atrial Fibrillation Division, Inc.
    Inventor: John A. Hauck
  • Patent number: 10591570
    Abstract: Wireless markers having predetermined relative positions with respect to each other are employed for motion tracking and/or correction in magnetic resonance (MR) imaging. The markers are inductively coupled to the MR receive coil(s). The correspondence between marker signals and markers can be determined by using knowledge of the marker relative positions in various ways. The marker relative positions can be known a priori, or can be obtained from a preliminary scan. This approach is applicable for imaging (both prospective and retrospective motion correction), spectroscopy, and/or intervention.
    Type: Grant
    Filed: December 17, 2013
    Date of Patent: March 17, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Melvyn B. Ooi, Julian Maclaren, Murat Aksoy, Roland Bammer, Ronald D. Watkins
  • Patent number: 10511929
    Abstract: Techniques are provided to initiate signal transmissions for possible opportunistic reception by a mobile device, and/or to initiate opportunistic reception of signal transmissions for use in mobile device position location estimation. For example, a mobile device may use assistance data to identify a first signal to be transmitted over a first frequency band and a second signal to be transmitted over a second frequency band during a specific period of time. At least a portion of the second frequency band may be outside of the first frequency band. The mobile device subsequently attempts to opportunistically receive at least the first signal and the second signal via a receiver tuned to a reception frequency band that encompasses at least the first frequency band and the second frequency band. The mobile device may then process the opportunistically received signals to obtain measurements corresponding to at least the first and second signals.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: December 17, 2019
    Assignee: QUALCOMM Incorporated
    Inventors: Akash Kumar, Amit Jain, Ankita, Muthukumaran Dhanapal, Shravan Raghunathan, Parthasarathy Krishnamoorthy, Hargovind Bansal
  • Patent number: 10478131
    Abstract: A method for monitoring a health characteristic of a user based on one or more biological measurements may include selecting a context from a plurality of contexts, each context corresponding to a baseline health value, and each context being defined by a plurality of recorded events each comprising one or more of repeated biological states, repeated user activity, or space-time coordinates of the user, and then monitoring the health characteristic of the user based on one or more bio-sensing measurements in comparison to the baseline health value corresponding to the selected context.
    Type: Grant
    Filed: June 15, 2016
    Date of Patent: November 19, 2019
    Assignee: Samsung Electronics Company, Ltd.
    Inventors: Jawahar Jain, James Young, Cody Wortham, Sajid Sadi, Pranav Mistry
  • Patent number: 10456046
    Abstract: Aspects of the invention relates to systems and methods for detecting volume status, volume overload, dehydration, hemorrhage and real time assessment of resuscitation, as well as organ failure including but not limited cardiac, renal, and hepatic dysfunction, of a living subject using non-invasive vascular analysis (NIVA). In one embodiment, a non-invasive device, which includes at least one sensor, is used to acquire vascular signals from the living subject in real time. The vascular signals are sent to a controller, which processes the vascular signals to determine at least one hemodynamic parameter, such as the volume status of the living subject. In certain embodiments, the vascular signals are processed by a spectral fast Fourier transform (FFT) analysis to obtain the peripheral vascular signal frequency spectrum, and the volume status of the living subject may be determined by comparing amplitudes of the peaks of the peripheral vascular signal frequency spectrum.
    Type: Grant
    Filed: November 13, 2015
    Date of Patent: October 29, 2019
    Assignee: Vanderbilt University
    Inventors: Susan Eagle, Colleen Brophy, Kyle Hocking, Franz Baudenbacher, Richard Boyer
  • Patent number: 10426399
    Abstract: The present invention provides a method of conducting a sleep analysis by collecting physiologic and kinetic data from a subject, preferably via a wireless in-home data acquisition system, while the subject attempts to sleep at home. The sleep analysis, including clinical and research sleep studies and cardiorespiratory studies, can be used in the diagnosis of sleeping disorders and other diseases or conditions with sleep signatures, such as Parkinson's, epilepsy, chronic heart failure, chronic obstructive pulmonary disorder, or other neurological, cardiac, pulmonary, or muscular disorders. The method of the present invention can also be used to determine if environmental factors at the subject's home are preventing restorative sleep.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: October 1, 2019
    Assignee: Cleveland Medial Devices Inc.
    Inventors: Hani Kayyali, Craig A. Frederick, Christian Martin, Robert N. Schmidt, Brian Kolkowski
  • Patent number: 10390721
    Abstract: A medical lead with at least a distal portion thereof implantable in the brain of a patient is described, together with methods and systems for using the lead. The lead is provided with at least two sensing modalities (e.g., two or more sensing modalities for measurements of field potential measurements, neuronal single unit activity, neuronal multi unit activity, optical blood volume, optical blood oxygenation, voltammetry and rheoencephalography). Acquisition of measurements and the lead components and other components for accomplishing a measurement in each modality are also described as are various applications for the multimodal brain sensing lead.
    Type: Grant
    Filed: April 3, 2017
    Date of Patent: August 27, 2019
    Assignee: NeuroPace, Inc.
    Inventor: Thomas K. Tcheng
  • Patent number: 10368746
    Abstract: Power saving communication techniques for communicating in a medical device system. One example medical device system may be for delivering electrical stimulation therapy to a heart of a patient, and may include a first implantable medical device implanted in a first chamber of the heart and configured to determine one or more parameters, a medical device physically spaced from and communicatively coupled to the first implantable medical device, the medical device configured to deliver electrical stimulation therapy to the heart of the patient, wherein the first implantable medical device is further configured to: compare a value of a first determined parameter to a first threshold; if the value of the first determined parameter passed the first threshold, communicate a first indication to the medical device; and if the value of the first determined parameter has not passed the first threshold, not communicating the first indication to the medical device.
    Type: Grant
    Filed: April 17, 2017
    Date of Patent: August 6, 2019
    Assignee: CARDIAC PACEMAKERS, INC.
    Inventors: Paul Huelskamp, Keith R. Maile
  • Patent number: 10328270
    Abstract: An intracardiac pacemaker system is configured to produce physiological atrial event signals by a sensing circuit of a ventricular intracardiac pacemaker and select a first atrial event input as the physiological atrial event signals. The ventricular intracardiac pacemaker detects atrial events from the selected first atrial event input, determines if input switching criteria are met, and switches from the first atrial event input to a second atrial event input in response to the input switching criteria being met. The second atrial event input includes broadcast atrial event signals produced by a second implantable medical device and received by the ventricular intracardiac pacemaker.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: June 25, 2019
    Assignee: Medtronic, Inc.
    Inventors: Wade M Demmer, Yong K Cho, Mark K Erickson, Todd J Sheldon
  • Patent number: 10279180
    Abstract: A method of treating heart failure in a patient is disclosed that includes implanting a stimulation device into the identified patient to electrically stimulate the spinal cord, and activating the device to deliver electrical stimulation to the spinal cord.
    Type: Grant
    Filed: April 17, 2017
    Date of Patent: May 7, 2019
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Robert D. Foreman, Jeffrey L. Ardell, John A. Armour, Michael J. L. DeJongste, Bengt G. S. Linderoth
  • Patent number: 10183167
    Abstract: An example of a system for programming a neurostimulator may include a storage device and a pattern generator. The storage device may store a pattern library and one or more neuronal network models. The pattern library may include fields and waveforms of neuromodulation. The one or more neuronal network models may each be configured to allow for evaluating effects of one or more fields in combination with one or more waveforms in treating one or more indications for neuromodulation. The pattern generator may be configured to construct and approximately optimize a spatio-temporal pattern of neurostimulation and/or its building blocks using at least one neuronal network model. The spatio-temporal pattern of neurostimulation may include a series of sub-patterns for treating an indication of the one or more indications for neuromodulation.
    Type: Grant
    Filed: December 29, 2016
    Date of Patent: January 22, 2019
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: G. Karl Steinke, Michael A. Moffitt, Hemant Bokil
  • Patent number: 10154813
    Abstract: Methods and apparatus for determining the efficacy of a drug by diagnosing cardiovascular health in a patient by monitoring changes in skin redness levels, which is associated with perfusion and ability of circulatory system to adapt to physical exertion. Color detectors including colorimeters and spectrophotometers may be used to monitor and quantify skin color. Wet run solutions such as acetylcholine solutions may be applied to the skin area being monitored. Skin redness can be monitored during the course of exercise or a stress test, as well as during recovery. Wearable color detector devices can be worn by patients during exercise.
    Type: Grant
    Filed: June 21, 2018
    Date of Patent: December 18, 2018
    Inventor: Spyros Kokolis
  • Patent number: 10086206
    Abstract: Techniques and systems for monitoring cardiac arrhythmias and delivering electrical stimulation therapy using a subcutaneous device (e.g. subcutaneous implantable (SD)) and a leadless pacing device (LPD) are described. In one or more embodiments, a computer-implemented method includes sensing a first electrical signal from a heart of a patient through a SD. The first signal is stored into memory and serves as a baseline rhythm for a patient. Subsequently, a second signal is sensed from the heart through the SD. A cardiac condition can be detected within the sensed second electrical signal through the SD. A determination is made as to whether cardiac resynchronization therapy (CRT) is appropriate to treat the detected cardiac condition. A determination can then be made as to the timing of pacing pulse delivery to cardiac tissue through a leadless pacing device (LPD).
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: October 2, 2018
    Assignee: Medtronic, Inc.
    Inventor: Aleksandre T. Sambelashvili
  • Patent number: 10032377
    Abstract: Based on the interaction between a mobile end device and a parked vehicle, it is determined whether a parked car will soon exit a parking space within a period of time. A report is selectively sent to a server in accordance with the determination. The report indicates the imminent exit of the motor vehicle.
    Type: Grant
    Filed: July 10, 2015
    Date of Patent: July 24, 2018
    Assignee: VOLKSWAGEN AKTIENGESELLSCHAFT
    Inventor: Patrick Bartsch
  • Patent number: 10028698
    Abstract: The various embodiments of the method of the present invention include a method to improving or expanding the capacity of a sleep analysis unit or laboratory, a method sleep analysis testing a patient admitted for diagnosis or treatment of another primary medical condition while being treated or diagnosed for that condition, a method of sleep analysis testing a patient that cannot be easily moved or treated in a sleep analysis unit or laboratory and other like methods.
    Type: Grant
    Filed: October 15, 2015
    Date of Patent: July 24, 2018
    Assignee: Cleveland Medical Devices Inc.
    Inventors: Craig A Frederick, Hani Kayyali, Robert N. Schmidt, Brian M. Kolkowski
  • Patent number: 9958351
    Abstract: A pressure sensing system provides signals representative of a magnitude of pressure at a selected site. A sensor module includes a first transducer producing a first signal having an associated first response to pressure and strain applied to the sensor module and a second transducer producing a second signal having an associated second response to pressure and strain applied to the sensor module. A calculated pressure, a bending pressure error and a bend-compensated pressure are computed in response to the first signal and the second signal.
    Type: Grant
    Filed: March 23, 2012
    Date of Patent: May 1, 2018
    Assignee: Medtronic, Inc.
    Inventors: Jonathan L. Kuhn, Richard J. O'Brien, Jonathan P. Roberts, James D. Reinke, Michael B. Terry, Kamal Deep Mothilal
  • Patent number: 9826940
    Abstract: Systems and methods are provided for determining a pulse rate based on a photoplethysmographic measurement of blood in a portion of subsurface vasculature. A plurality of samples of the photoplethysmographic signal are obtained and a plurality of digital phase-locked loops are operated to generate respective oscillating signals based on the plurality of samples. Respective correlations between the plurality of samples and each of the generated oscillating signals are determined and used to select a subset of the plurality of phase-locked loops. The frequencies of the selected oscillating signals generated by the selected phase-locked loops are determined and used to determine a cardiovascular pulse rate. This method can be performed a plurality of times for a respective plurality of overlapping sets of the obtained plurality of samples to determine pulse rates over time.
    Type: Grant
    Filed: May 26, 2015
    Date of Patent: November 28, 2017
    Assignee: Verily Life Sciences LLC
    Inventor: Christopher Towles Lengerich
  • Patent number: 9764143
    Abstract: Systems and methods are described herein for assisting a user in identification of interventricular (V-V) delay for cardiac therapy. The systems and methods may monitor electrical activity of a patient using external electrode apparatus to provide electrical heterogeneity information for a plurality of different V-V intervals and may identify a V-V interval based on the electrical heterogeneity information.
    Type: Grant
    Filed: May 4, 2015
    Date of Patent: September 19, 2017
    Assignee: Medtronic, Inc.
    Inventors: Subham Ghosh, Jeffrey Gillberg
  • Patent number: 9743859
    Abstract: A device and method can monitor or trend a patient's respiration rate measurements according to the time of day. The device, which may be implantable or external, collects and classifies respiration rate measurements over time. The trended information about particular classes of respiration rate measurements is then communicated to a remote external device, which in turn provides an indication of heart failure decompensation. Examples of classes of respiration rate measurements include a daily maximum respiration rate value, a daily minimum respiration rate value, a daily maximum respiration rate variability value, a daily minimum respiration rate variability value, and a daily central respiration rate value. These respiration rate measurements can be further classified into daytime or nighttime respiration rate measurements.
    Type: Grant
    Filed: February 19, 2010
    Date of Patent: August 29, 2017
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Aaron Lewicke, Yi Zhang, John D. Hatlestad
  • Patent number: 9675282
    Abstract: The invention relates to a method and apparatus for determining a respiration of a subject (305) in which, with a single multi-axial accelerometer (310) positioned on a body of the subject (305), accelerometer signals are generated (101) indicative of the acceleration of the subject (305) along different spatial axes, a vector magnitude signal of the acceleration of the subject (305) along the different spatial axes is calculated (102) from the accelerometer signals, a non-respiratory motion contribution to the acceleration along the different spatial axes is identified (103, 203) from the vector magnitude signal, which non-respiratory motion contribution is not caused by the respiration, and a respiration signal indicative of the respiration of the subject is determined (104, 204) by filtering the non-respiratory motion contribution from at least one of the accelerometer signals.
    Type: Grant
    Filed: February 7, 2011
    Date of Patent: June 13, 2017
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventor: Geert Guy Georges Morren
  • Patent number: 9610020
    Abstract: Systems and associated methods are provided for automatically identifying a problem with sensing heart activity. In use, a plurality of heartbeats is sensed utilizing an implantable medical device. Further, data associated with the heartbeats is collected and stored. To this end, a problem with the sensing of the heartbeats (e.g., oversensing, undersensing, etc.) may be automatically identified and corrected, utilizing the data.
    Type: Grant
    Filed: January 21, 2008
    Date of Patent: April 4, 2017
    Assignee: Pacesetter, Inc.
    Inventor: Daniel S. Hecker
  • Patent number: 9566439
    Abstract: The invention is a distributed implantable neuro-stimulation system, comprising an implant controller including control logic to transmit two time-varying power signals, varying between two levels and out of phase with the other, and a command signal modulated onto at least one of the power signals. One or more electrode cells, each having control logic to extract charge from the power signals and recover commands from the command signal. A two-wire bus interconnecting the implant controller and all the electrode cells, to carry one of the time varying signals in each of the two wires, and to carry the command signal.
    Type: Grant
    Filed: July 19, 2010
    Date of Patent: February 14, 2017
    Assignee: SALUDA MEDICAL PTY LIMITED
    Inventors: Peter Single, David Robinson, John Parker, Peter Ayre, Dean Karantonis
  • Patent number: 9549674
    Abstract: An implantable medical device applies an electric signal to at least a portion of a heart in a subject. A resulting electric signal is collected from the heart and is used together with the applied signal for determining a cardiogenic impedance signal. The impedance signal is processed in order to estimate an isovolumetric contraction time, an isovolumetric relaxation time and an ejection time for a heart cycle. These three time parameters are employed for calculating a Tei-index of the heart. The Tei-index can be used as myocardial performance parameter in heart diagnosis and/or cardiac therapy adjustment.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: January 24, 2017
    Assignee: ST. JUDE MEDICAL AB
    Inventors: Michael Broome, Andreas Blomqvist
  • Patent number: 9504834
    Abstract: Methods of threshold testing and setting a voltage on an artificial pacemaker based on the output of a plethymograph, such as an oximeter, are disclosed herein. This is accomplished by determining blood volume in a limb or area of the body, and its change over time. As voltage is decreased in the pacemaker, a change in blood volume of the limb being measured by the oximeter is determined. This change can be a change in how often the blood volume level rises to its peak level and/or the blood volume level no longer rises substantially. Such changes, or lack thereof, can be based on a backup heart rate or no heart rate at all. Once the threshold voltage is determined where the artificial pacemaker ceases to cause a heartbeat, the voltage of the pacemaker can be set accordingly.
    Type: Grant
    Filed: June 1, 2015
    Date of Patent: November 29, 2016
    Inventors: Vladimir Fridman, Cesare Saponieri
  • Patent number: 9498629
    Abstract: A method of counterpulsation therapy is provided, the method comprising use of a combination of cardiac electrical activity and acoustic signals in such a manner that initially R wave on a cardiogram and then II (aortic) sound are determined, and, after the II sound has been determined, stimulation of muscles by means of electric impulses is initiated. A device for performing the above described method comprises a sensor of the signal of cardiac electrical activity and a sensor of cardiac acoustic signal; a unit for blocking the cardiac electrical activity signal; a unit for blocking the acoustic signal; and a control device coupled with muscle stimulating devices.
    Type: Grant
    Filed: September 25, 2012
    Date of Patent: November 22, 2016
    Assignee: MARJI LD.
    Inventors: Leri Lapanashvili, Dmitry Ivanovich Minaev, Vladislav Evgenevich Kuzmin, Mikhael Alexandrovich Bajin
  • Patent number: 9399140
    Abstract: A leadless pacing device (LPD) includes a motion sensor configured to generate a motion signal as a function of heart movement. The LPD is configured to analyze the motion signal within an atrial contraction detection window that begins an atrial contraction detection delay period after activation of the ventricle, and detect a contraction of an atrium of the heart based on the analysis of the motion signal within the atrial contraction detection window. If the LPD does not detect a ventricular depolarization subsequent to the atrial contraction, e.g., with an atrio-ventricular (AV) interval beginning when the atrial contraction was detected, the LPD delivers a ventricular pacing pulse.
    Type: Grant
    Filed: December 22, 2014
    Date of Patent: July 26, 2016
    Assignee: Medtronic, Inc.
    Inventors: Yong K. Cho, Aleksandre T. Sambelashvili, Todd J. Sheldon
  • Patent number: 9387330
    Abstract: Methods and/or devices used in delivering cardiac resynchronization therapy based on a plurality of device parameters (e.g., A-V delay, V-V delay, etc.) are optimized by setting a device parameter based on selection data. The selection data may be acquired by acquiring temporal fiducial points (e.g., heart sounds) associated with at least a part of a systolic portion of at least one cardiac cycle and/or temporal fiducial points associated with at least a part of a diastolic portion of the at least one cardiac cycle for each of a plurality of electrode vector configurations, and extracting measurements from the intracardiac impedance signal acquired for each of a plurality of electrode vector configurations based on the temporal fiducial points. The acquired selection data may be scored and used to optimize the device parameter.
    Type: Grant
    Filed: January 17, 2014
    Date of Patent: July 12, 2016
    Assignee: Medtronic, Inc.
    Inventors: Todd M. Zielinski, Yong Kyun Cho, Douglas Hettrick, Xusheng Zhang
  • Patent number: 9327070
    Abstract: This disclosure describes techniques implemented by a medical device, such as an implantable medical device (IMD). The IMD may be configured to detect a posture state of a patient, and deliver posture-responsive therapy. In particular, the IMD not only detects the posture state of a patient, but also detects timing associated with the detected posture state, such as the time of day, the day of the week, or a specific time of day associated with a specific day. In this way, the posture-responsive therapy delivered by the IMD may be dependent not only on the posture state of the patient, but also on the timing associated with the posture state. The same posture state, therefore, may result in different types of therapy to the patient if the same posture occurs at different times of the day.
    Type: Grant
    Filed: April 30, 2009
    Date of Patent: May 3, 2016
    Assignee: Medtronic, Inc.
    Inventors: Dennis M. Skelton, Jon P. Davis, Timothy J. Denison
  • Patent number: 9271675
    Abstract: An orthopedic implant having a three-axis accelerometer is disclosed. The three-axis accelerometer is used to detect micro-motion in the implant. The micro-motion can be due to loosening of the implant. The implant is configured to couple to the muscular-skeletal system. In one embodiment, the implant is configured to couple to bone. An impact force is imparted to the bone or implant. The impact force can be provided via a transducer coupled to the implant. In the example, the impact force is imparted along a single axis. The three-axis accelerometer measures the impact force along each axis. Resultant peaks of the quantitative measurement and the frequencies at which they occur are measured. The peaks and frequencies of the measurements correspond to micro-motion. Typically, the frequency of interest is less than 1 KHz to determine if micro-motion is occurring.
    Type: Grant
    Filed: June 3, 2014
    Date of Patent: March 1, 2016
    Assignee: Orthosensor Inc.
    Inventors: Marc Stein, Yoong-Joong Kim, Matthew J. Cohen, Chelsea A. Liddell
  • Patent number: 9265954
    Abstract: A method and system of cardiac pacing is disclosed. A baseline rhythm is determined. The baseline rhythm includes a baseline atrial event and a baseline right ventricular RV event from an implanted cardiac lead or a leadless device, a pre-excitation interval determined from the baseline atrial event and the baseline RV event, and a plurality of activation times determined from a plurality of body-surface electrodes. A determination is made as to whether a time interval measured from an atrial event to a RV event is disparate from another time interval measured from the atrial event to an earliest RV activation time of the plurality of activation times. A correction factor is applied to the pre-excitation interval to obtain a corrected pre-excitation interval in response to determining the RV event is disparate from the earliest RV activation time.
    Type: Grant
    Filed: July 26, 2013
    Date of Patent: February 23, 2016
    Assignee: Medtronic, Inc.
    Inventor: Subham Ghosh
  • Patent number: 9254100
    Abstract: An implantable activity detector can detect metabolic stress levels, which can be normalized, such as to identify times of activities such as walking and running or to identify trends such as a decrease in metabolic activity. The data can be derived from different sources such as an accelerometer and pedometer. This data can be compared to independently specifiable thresholds, such as to trigger an alert or responsive therapy, or to display one or more trends. The information can also be combined with other congestive heart failure (CHF) indications. The alert can notify the patient or a caregiver, such as via remote monitoring. Metabolic activity data from one or more of the activity detectors can be used to establish a model of metabolic stress, to which further activity data can be compared for identifying periods of increased or decreased metabolic stress.
    Type: Grant
    Filed: September 12, 2007
    Date of Patent: February 9, 2016
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Kenneth Beck, Ramesh Wariar, Chie Kawahara, Gerrard M. Carlson
  • Patent number: 9241653
    Abstract: An implantable medical device applies an electric signal to at least a portion of a heart in a subject. A resulting electric signal is collected from the heart and is used together with the applied signal for determining a cardiogenic impedance signal. The impedance signal is processed in order to estimate an isovolumetric contraction time, an isovolumetric relaxation time and an ejection time for a heart cycle. These three time parameters are employed for calculating a Tei-index of the heart. The Tei-index can be used as myocardial performance parameter in heart diagnosis and/or cardiac therapy adjustment.
    Type: Grant
    Filed: August 28, 2008
    Date of Patent: January 26, 2016
    Assignee: ST. JUDE MEDICAL AB
    Inventors: Michael Broomé, Andreas Blomqvist
  • Patent number: 9220904
    Abstract: A rules engine acquires sensor data from sensors applied to the heart and detects an intrinsic beat of the heart. The rules engine determines whether an electrical waveform should be applied to the heart and, if so, the type of electrical waveform.
    Type: Grant
    Filed: May 23, 2014
    Date of Patent: December 29, 2015
    Assignee: MR3 Medical, LLC
    Inventor: Morton M. Mower
  • Patent number: 9211415
    Abstract: A method and a system of phrenic nerve stimulation detection in conjunction with posture sensing is disclosed. In an embodiment, the method may include receiving a trigger for conducting a pace-induced phrenic nerve stimulation (PS) search using the IMD within the patient. On receiving the trigger, the IMD may be used for conducting the PS search. A procedure of conducting the PS search may include measuring a posture of the patient using an implantable posture sensor, searching for PS while the patient is in the measured posture and obtaining a PS result from the PS search for the measured posture. The method may include recording both the PS result and the measured posture in a memory of the IMD.
    Type: Grant
    Filed: February 26, 2014
    Date of Patent: December 15, 2015
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Sunipa Saha, Holly Rockweiler, Aaron R. McCabe, Krzysztof Z. Siejko, John D. Hatlestad
  • Patent number: 9186077
    Abstract: A wireless communication device (200) and method (300) customizable power management. The method (300) can include: providing (310) a wireless communication device including an energy storage device; sensing (320) heart rate data of a user; and configuring (330) the wireless communication device's functionality based on the sensed heart rate data. Advantageously, the device (200) and method (300) can provide a real-time attribute of a user, which can be used to configure the functionality of a device and conserve power.
    Type: Grant
    Filed: February 16, 2012
    Date of Patent: November 17, 2015
    Assignee: Google Technology Holdings LLC
    Inventor: Jeong J. Ma
  • Patent number: RE48197
    Abstract: A leadless pacing device (LPD) includes a motion sensor configured to generate a motion signal as a function of heart movement. The LPD is configured to analyze the motion signal within an atrial contraction detection window that begins an atrial contraction detection delay period after activation of the ventricle, and detect a contraction of an atrium of the heart based on the analysis of the motion signal within the atrial contraction detection window. If the LPD does not detect a ventricular depolarization subsequent to the atrial contraction, e.g., with an atrio-ventricular (AV) interval beginning when the atrial contraction was detected, the LPD delivers a ventricular pacing pulse.
    Type: Grant
    Filed: July 25, 2018
    Date of Patent: September 8, 2020
    Assignee: Medtronic, Inc.
    Inventors: Yong K. Cho, Aleksandre T. Sambelashvili, Todd J. Sheldon