Abstract: An imaging apparatus includes: an unpolarized light-emitting portion configured to emit light having an unpolarized component; a polarized light-emitting portion configured to emit light having a predetermined polarized component via a first polarization filter; and an imaging element configured to image a subject, which is irradiated with light by one of the unpolarized light-emitting portion and the polarized light-emitting portion, through a second polarization filter, the first polarization filter and the second polarization filter having polarization directions in an orthogonal relationship to each other, the imaging element being further configured to image the subject irradiated with light by the unpolarized light-emitting portion and the subject irradiated with light by the polarized light-emitting portion in a time division manner and output an unpolarized light image and an orthogonal polarized light image that are obtained as a result of imaging.

Abstract: This application is directed to a method of treating onychomycosis by applying a phototherapeutic agent to a nail structure, waiting for a period of at least three days, and exposing the nail to light that causes an activation reaction. The phototherapeutic agent may be amino levulinic acid, alkylated derivatives of ALA, and their pharmaceutically acceptable salts.

Abstract: Apparatus and method for preventing photosensitive epilepsy in a user includes positioning light sources in front of the users eyes so that light from the light sources is directed toward the user's peripheral visual field of view. The light reduces the intensity difference between light received by the peripheral visual field of view and light received by the central visual field of view.

Abstract: Embodiments may provide an extendable light source with a variable light emitting area. A first device is provided that includes a support, a first substrate movably coupled to the support, and a plurality of lighting devices disposed on the first substrate. The plurality of lighting devices includes a first portion of lighting devices and a second portion of lighting devices. The first device also includes an energizing component that is configured to selectively energize the first portion and the second portion of lighting devices based on a position of the first substrate relative to the support.

Abstract: An extra-oral light therapy device comprises a support that registers against features of a patient's head. A light source is mounted to the support. The light source may comprise an array of light emitting diodes (“LEDs”). A controller controls the extra-oral light therapy device. The support may comprise a tray fitted to the patient's teeth or a head-set fitted to the patient's ears and the bridge of the patient's nose. An external light therapy device has a thin, molded substrate, at least one array of light emitters mounted onto the thin, molded substrate, an attaching means for removably attaching the device to an area of treatment, and a controller for controlling the external light therapy device. Methods for supporting light sources adjacent desired treatment locations and for treating jaw bone disorders and jaw osteonecrosis and biostimulating bone and soft tissue are also disclosed.

Abstract: Stimulation of target cells using light, e.g., in vivo or in vitro, is implemented using a variety of methods and devices. One example involves a vector for delivering a light-activated molecule comprising a nucleic acid sequence that codes for light-activated molecule. The light-activated molecule includes a modification to a location near the all-trans retinal Schiff base, e.g., to extends the duration time of the open state. Other aspects and embodiments are directed to systems, methods, kits, compositions of matter and molecules for ion channels or pumps or for controlling currents in a cell (e.g., in vivo or in vitro environments).

Abstract: A variety of methods, devices, systems and arrangements are implemented for stimulation of the peripheral nervous system. Consistent with one embodiment of the present invention, method is implemented in which light-responsive channels or pumps are engineered in a set of motor units that includes motor units of differing physical volumes. Optical stimuli are also provided to the light-responsive channels or pumps at an optical intensity that is a function of the size of motor units to be recruited. In certain implementations, the intensity of the optical stimuli is increased so as to recruit increasingly larger motor units.

Abstract: A method of operating a hearing instrument for processing an input sound and to provide an output stimulus according to a user's particular needs, and related system, computer readable medium and data processing system. An object is to provide an improved customization of a hearing instrument. The method includes the steps a) providing an estimate of the present cognitive load of the user; b) providing processing of an input signal originating from the input sound according to a user's particular needs; and c) adapting the processing in dependence of the estimate the present cognitive load of the user. The estimate of the present cognitive load of a user is produced by in-situ direct measures of cognitive load (e.g. based on EEG-measurements, body temperature, etc.) or by an on-line cognitive model in the hearing aid system whose parameters have been preferably adjusted to fit to the individual user.

Abstract: A combination of an anti-cancer agent and a metal radiosensitizer potentiates the radiotherapy of cancer. Said anti-cancer agent is preferably cisplatin while the metal radiosensitizer is preferably gold nanoparticles. Both the anti-cancer agent and the metal radiosensitizer bind to DNA and potentiate the radiotherapy of cancer by synergistically increases the amount of double strand breaks induced by the radiation. The anti-cancer agent and the metal radiosensitizer may be encapsulated in liposomes.

Abstract: A photodynamic therapy apparatus as an estimating apparatus is an apparatus for irradiating a tissue having absorbed photo-sensitive pharmaceutical, the photo-sensitive pharmaceutical absorbing an excitation light and emitting fluorescence, with the excitation light emitted from a tip portion of a laser catheter, including a connector, a light source, and a light detection unit. The laser catheter is capable of being attached to and detached from the connector. The light source outputs the excitation light to the laser catheter via the connector. The light detection unit detects intensity or a spectrum of the fluorescence, the fluorescence being entered from the laser catheter via the connector, to estimate whether the tissue has changed because of reaction between the excitation light emitted from the tip portion of the laser catheter and the photo-sensitive pharmaceutical absorbed in the tissue.

Abstract: Methods of treating a brain malfunction include obtaining a subject diagnosed with a brain malfunction and reducing EEG frequency of brainwaves in the subject by applying at least one EEG-slowing stimulus to the subject, whereby production of beta amyloid protein in the brain of the subject is reduced and progression of the brain malfunction is halted or slowed.

Abstract: This invention discloses a topical cooling compressive hemostasis and wound healing device and methods thereof for affecting a percutaneous access wound or an acute surgical wound where the device is compatible with physiological, circulatory and cellular microenvironments of the injury and conforming to the injury site anatomy. The device promotes hemostasis, sustains hemostasis and improves wound healing quality by controlling and affecting vasculature motions of the injury site during various wound healing phases. The device incorporates an elastic material compatible with the elastic nature of the injured vessel to promote comfort and safety. The elastic material is further thermally conductive to deliver and transport cooling and a therapeutic agent to the wound site. The device further incorporates an anatomically conforming lateral stabilization component to stabilize the injury sits and its surroundings.

Abstract: A power tool with a chuck and a tool body having a housing, a motor received in the housing, a light array mounted to the housing, and an output spindle extending through the light array and which is rotationally driven by the motor. The chuck has a chuck body, a plurality of jaws, and an outer sleeve. A rear end of the chuck body is rotatably mounted on the output spindle. The chuck body has a plurality of jaw apertures and a plurality of light holes. The jaw apertures and the light holes extend through a front surface of the chuck body. Each of the jaws is received in a corresponding one of the jaw apertures. The outer sleeve is disposed about the jaws and the chuck body. Light emanating from the light array is transmitted through the light holes to illuminate a zone in front of the chuck body.

Abstract: A flexible LED screen includes a flexible printed circuit board having a front surface and a rear surface, a plurality of SMT-LEDs mounted on the front surface of the flexible printed circuit board, and a plurality of integrated circuits mounted on the rear surface of the flexible printed circuit board.

Abstract: Disclosed is a system and method for treatment of skin disorders. More particularly, the disclosed invention is directed toward the reduction of acne and acne related bacteria using low-intensity light therapy. In an illustrative embodiment, skin containing acne bacteria is treated with a series of pulses of light from a light emitting diode. The LED has a dominant emissive wavelength of about 660 nm and an energy output of about 4 m W. The acne bacteria-containing tissue is exposed to pulses from the light source about 100 times for about 250 milliseconds per pulse, with an interpulse interval of about 100 milliseconds.

Abstract: A high efficiency variable power transmitting apparatus outputs a variable power by modulating, with respect to a time axis, a high frequency signal having a constant amplitude by turning the high frequency signal ON and OFF, amplifying the variable power to satisfy a requested power level of a target device based on a supply voltage having a predetermined level, converting an alternating current (AC) voltage received from a power source to a direct current (DC) voltage, generating the supply voltage having the predetermined level based on the DC voltage, and providing the supply voltage having the predetermined level to the PA.

Abstract: The present disclosure relates to a face support that has a built-in drug carrier containing medicinal ingredients for protecting eyes from diseases and reducing wrinkles around the eyes. The face support having a drug carrier according to the present disclosure is designed to cover a facial area around the eyes and comprises: a housing with a predetermined installation space defined therein and a plurality of vent holes formed in one side in the proximity of the globe of the eye when the face support is worn, the vent holes serving to communicate the installation space with the outside; a main body having a fixing member for fixing the housing to the face of a user; and a drug carrier installed inside the main body and containing medicinal ingredients useful for protecting the eyes from diseases and relieving eye fatigue. The drug carrier comprises a medicinal herb layer containing the medicinal ingredients to enable transdermal delivery of the medicinal ingredients.

Abstract: A system for influencing a state of a user includes a light source for emitting light influencing the state of the user. The system includes a light controller selectively controlling the emission of the light and an analysis engine which provides a signal to the light controller indicating a desired emission of the light. The system selectively directs blue light from the light source onto a material that retransmits it as a light different than blue light.

Abstract: Disclosed is a system and method for treatment of cells and, in particular, visual pathway disorders. More particularly, the disclosed invention is directed toward the photomodulation and/or photorejuvenation of retinal epithelial cells, to treat a variety of vision disorders. The process of treating retinal cells to reduce or reverse the effects of visual pathway disorders employs a narrowband source of multichromatic light applied to the retinal cells to deliver a very low energy fluence.

Abstract: An apparatus has a pump module providing pump energy, a resonator and a controller. The resonator includes a gain medium receiving the pump energy from the pump module and producing light; reflective surfaces reflecting light produced by the gain medium back toward the gain medium; and a variable light attenuator receiving light produced by the gain medium. The controller controls the amount of light attenuated by the variable light attenuator such that the apparatus emits windows of pulses of laser light at spaced time intervals, each window containing a plurality of pulses of laser light and each interval between windows being larger than an interval between pulses within a window. The emitted windows of pulses of laser light heat tissue to a temperature that causes coagulation without vaporization.

Abstract: Organometallic compounds comprising a phenylquinoline or phenylisoquinoline ligand having the quinoline or isoquinoline linked to the phenyl ring of the phenylquinoline or phenylisoquinoline, respectively, via two carbon atoms. These compounds also comprise a substituent other than hydrogen and deuterium on the quinoline, isoquinoline or linker. These compounds may be used as red emitters in phosphorescent OLEDs. In particular, these compounds may provide stable, narrow and efficient red emission.

Abstract: In response to local or systemic inflammation in a patient, photobiomodulation therapy is applied to a cardiac location to reduce the risk and/or occurrence of cardiac arrhythmia. Once inflammation is identified, photobiomodulation therapy can be applied in any suitable fashion (e.g., via a catheter- or transesophageal probe-mounted photoemitter, via an externally-applied photoemitter, or via photoemitter incorporated into an implantable medical device). Photobiomodulation therapy can also be employed to good advantage in conjunction with non-photobiomodulation therapy (e.g., traditional cardiac rhythm management therapies).

Abstract: Skin disorders such as, for example, atopic dermatitis, dyshidrosis, eczema, lichen planus, psoriasis, and vitiligo, are treated by applying high doses of ultraviolet light to diseased regions of a patients skin. The dosage employed exceeds 1 MED, an MED being determined for the particular patient being treated, and may range from about 1 MED to about 20 MED or higher. The ultraviolet light has a wavelength within the range of between about 295 nanometers to about 320 nanometers and preferably is between about 300 nanometers and about 310 nanometers. High doses of ultraviolet light are restricted to diseased tissue areas so as to avoid risk of detrimental side affects in healthy skin, which is more susceptible to damage from UV light. Cooling the skin prior to and/or while exposing the skin to the UV light can be used to minimize tissue damage resulting from exposure to the UV light. Higher doses of UV light can therefore be employed without injurious affects.

Abstract: A light emitting diode-based skin cosmetic device includes a first light emitting panel, a second light emitting panel, a first narrow band filter, a second narrow band filter and an optical window. The first light emitting panel is connected with the second light emitting panel at one side and an angle is formed between the first light emitting panel and the second light emitting panel. Two sides of the optical windows are connected with the first light emitting panel and the second light emitting panel together to form a triangle structure and the angle is faced toward the optical windows. The first and second narrow band filter is disposed on one surface of the first light to emitting panel and one surface of the second light emitting panel respectively.

Abstract: Provided is a lighting device that can suppress decrease in its luminous efficiency and shortening of its life. A lighting device (1) includes a fluorescent member (4) which is irradiated with laser light emitted by a semiconductor laser (2) and emits fluorescent light, a rotation mechanism (6) which rotates the fluorescent member, and a reflecting member (7) which reflects the fluorescent light emitted by the fluorescent member toward the outside.

Abstract: A multi-color light emitting diode device includes a plurality of light sources and a control module. The light sources are a Ultraviolet A light source, a Ultraviolet B light source, and a Ultraviolet C light source, a red light source, a green light source, and a blue light source, an infrared light source, and a YVA light source. The control circuit is configured with a plurality of control channels. Each of the control channels controls he respective light source to emit a light to generate a desired light combination.

Abstract: A light source apparatus includes a light-emitting module and a control unit. The light-emitting module is for providing a light. The control unit switches the light emitted from the light-emitting module between a first light and a second light, wherein the circadian stimulus value (CS/P value) of the second light is less than CS/P value of the first light, and the color temperatures of the second light and the first light are substantially the same as each other.

Abstract: An improvement in a light therapy device including multiple light-emitting diodes (LEDs) positioned in a handheld portable device is disclosed. Where the housing and the LEDs are configured to have direct contact with the skin or tissue of the user without any intermediary materials, and light the surface and underlying layers of tissue for photodynamic stimulation of the cells. Two iterations of the device utilize light known to have a bactericidal effect in the case or acne or Rosacea. The devices are fabricated from an injection molded plastic housing. The housing contains an arrangement of 36-72 LEDs on a circuit board in an arrangement to provide even lighting over the skin or tissue surface.

Abstract: A light source device for endoscopic or exoscopic applications includes a flat first light source, a second light source, an illuminating beam path that is configured to provide a first light beam emanating from the first light source for an endoscopic or exoscopic application, and a coupling device to couple a second light beam from the second light source into the illuminating beam path, whereby the coupling device is configured in such a way that at the coupling site the cross-section surface of the second light beam is smaller than the cross-section surface of the first light beam.

Abstract: A combined heat and current applicator assembly including a heat applicator, a current applicator and a control unit. The heat applicator includes a housing, a heated tip and a cable for receiving electricity from the control unit. The current applicator includes a housing, a current tip, and a cable for receiving a low amperage alternating current from the control unit. The control unit allows a user to adjust a temperature of the heated tip and amperage of the current tip. The current applicator applies the low amperage current through the current tip to a specific, isolated afflicted area of a user or patient in order to strengthen the immune system and decrease local inflammation.

Abstract: An ambulatory device for use in a therapeutic and/or cosmetic treatment, the device comprises an organic light-emitting semiconductor which, in use, covers an area to be treated and emits electromagnetic radiation to cause said therapeutic and/or cosmetic treatment of the area. The light source may be extensive to provide uniform irradiation of the area to be treated and may be pulsed. The device may also include a photopharmaceutical.

Abstract: The present invention discloses a method for preparing noble metal nanoparticles, comprising the following steps: a) preparing an Olea Europaea fruit extract; b) preparing an Acacia Nilotica extract; c) mixing the Olea Europaea fruit extract and the Acacia Nilotica extract for preparing a mixed extract; d) providing an aqueous solution containing a noble metal compound dissolved therein; e) mixing the mixed extract obtained in step c) and the aqueous solution of step d) to form noble metal nanoparticles; noble metal nanoparticles obtained thereby and their use.

Abstract: A method of dynamically adjusting a circadian rhythm comprising the steps of determining a current circadian rhythm status of a circadian rhythm of an observer, accessing a calendar of the observer, and identifying a future event of the observer to precondition for, defined as an identified future event. A preconditioning schedule responsive to the identified future event may then be determined. Furthermore, communication with a light source may be established, and the light source may then be operated to emit light according to the preconditioning schedule.

Abstract: Solid state light emitting devices include multiple LED components providing adjustable melatonin suppression effects. Multiple LED components may be operated simultaneously according to different operating modes according to which their combined output provides the same or similar chromaticity, but provides melatonin suppressing effects that differ by at least a predetermined threshold amount between the different operating modes. Switching between operating modes may be triggered by user input elements, timers/clocks, or sensors (e.g., photosensors). Chromaticity of combined output of multiple LED components may also be adjusted, together with providing adjustable melatonin suppression effects at each selected combined output chromaticity.

Abstract: Pharmaceutical compositions and methods for treating and/or preventing age-related macular degeneration with melatonin analogues are provided.

Abstract: A method for accelerating the release of neurotransmitters includes a step of radiating light from within a cerebral blood vessel to accelerate the release of the neurotransmitters. An optomedical device includes a main body configured to be introduced into a cerebral blood vessel; a light emitting unit arranged on the main body, the light emitting unit configured to radiate light to accelerate the release of neurotransmitters; and a control unit configured to control a light emitting action of the light emitting unit.

Abstract: Dynamic colorectal PDT methods, devices and photosensitizer compositions to treat abnormal cell growth in anal tissue such as perianal and intra-anal intraepithelial neoplasia grade III are presented. Dynamic colorectal PDT method comprises the steps of administering topically, intravenously or orally a photosensitizer composition; irradiating; monitoring treatment parameters before, during and/or after irradiation. Photosensitizer composition comprises Temoporfin and excipients/carriers, appropriate for the application method. An applicator is provided for colorectal PDT treatments enhancing irradiation delivery and monitoring treatment parameters. Preferably, applicator is made of a material, used to monitor the fluence rate simultaneously while doing optical spectroscopy. Measurement probe devices are provided for monitoring PDT treatment parameters in-vivo.

Abstract: A photoacoustic imaging apparatus performs imaging of an optical absorber. The photoacoustic imaging apparatus includes a light source, a detector configured to detect an acoustic wave generated from the optical absorber that has absorbed energy of light emitted from the light source, and a signal processing unit configured to form an image of the optical absorber. The signal processing unit stores information indicating whether a rate of change in pressure of the acoustic wave detected by the detector is positive or negative before performing a waveform process on the acoustic wave.

Abstract: A minimally invasive method for treating varices in especially sensitive areas, including pelvic varices in females, varicoceles, and also oesophageal varices is presented. The method comprises the steps of making a micro incision into the blood vessels of a patient, endoscopically inserting a catheter device into the blood vessel of a patient and advancing the distal end of the catheter to reach the varix or varices. For treatment of male varicocele, insertion is preferably made directly at the testicle. Alternatively, insertion can be made in the femoral vein and advanced using a catheter. Preferably, x-ray, angiography, or other imaging techniques are used to visualize and position the catheter. An optical fiber is then inserted into the catheter and the distal end is advanced to a predetermined point near the varix or varices. Optical fiber distal end is preferably a slim, radial 360 degree emitting fiber end.

Abstract: Apparatuses and methods are disclosed for applying laser energy having desired pulse characteristics, including a sufficiently short duration and/or a sufficiently high energy for the photomechanical treatment of skin pigmentations and pigmented lesions, both naturally-occurring (e.g., birthmarks), as well as artificial (e.g., tattoos). The laser energy may be generated with an apparatus having a resonator with the capability of switching between a modelocked pulse operating mode and an amplification operating mode. The operating modes are carried out through the application of a time-dependent bias voltage, having waveforms as described herein, to an electro-optical device (e.g., a Pockels cell) positioned along the optical axis of the resonator.

Abstract: The invention provides methods for treating a neurological disorder or deficit, such as tinnitus and phantom limb pain.

Abstract: The present invention relates to a method for the cosmetic (non-therapeutic) treatment of oily skin, including the steps: a) exposing the oily skin to a first quasi-monochromatic light of artificial origin having a dominant wavelength peak between 300 and 700 nm, better still between 400 and 600 nm, even better still between 560 and 620 nm, and in particular of around 590 nm, and b) applying to the oily skin a cosmetic composition comprising at least 1% by weight of hollow particles and preferably from 2% to 6% by weight of hollow particles, relative to the total weight of said composition, the hollow particles being hydrophobic silica aerogel particles.

Abstract: A dermatologic treatment device having a first light source emitting a first pulse of optical radiation beneficial to a dermatologic treatment, and a second light source emitting a second pulse of optical radiation and being optically coupled to the first light source. The second pulse enhances the brightness of at least part of the optical radiation in the first pulse upon impinging on the first light source. The dermatologic treatment device further includes a timing circuit adapted to energize the first and second light sources to at least partially overlap emission of the first and second pulses.

Abstract: A light generating circuit is implanted in a subject's body and aimed at a target region such as a tumor. A photosensitizer is introduced into the target region, and an AC electric field is induced in the region. The field causes the light generating circuit to generate light, which activates the photosensitizer; and at certain field strengths and frequencies, the field itself has a beneficial effect. The beneficial effects of the field and the activated photosensitizer are thereby obtained simultaneously.

Abstract: Various endoscopes are integrated with an applicator configured for delivering a therapeutic solution to an internal anatomic target that may be infected by pathogenic microorganisms and a UV light-emitting device transmitting UV light thereto.

Abstract: A light generating circuit is implanted in a subject's body and aimed at a target region such as a tumor. A photosensitizer is introduced into the target region, and an AC electric field is induced in the region. The field causes the light generating circuit to generate light, which activates the photosensitizer; and at certain field strengths and frequencies, the field itself has a beneficial effect. The beneficial effects of the field and the activated photosensitizer are thereby obtained simultaneously.

Abstract: A steerable laser probe may include a handle, an actuation structure of the handle, a housing tube, an optic fiber, and an optic fiber sleeve. The housing tube may have a first housing tube portion having a first stiffness and a second housing tube portion having a second stiffness. The second stiffness may be greater that the first stiffness. The optic fiber may be disposed within an inner bore of the handle, the optic fiber sleeve, the actuation structure, and the housing tube. The optic fiber sleeve may enclose at least a portion of the optic fiber and the optic fiber sleeve may be disposed within the actuation structure and the housing tube. A compression of the actuation structure may be configured to curve the housing tube and the optic fiber.

Abstract: The present invention, in one aspect, relates to a system for stimulating neural tissue of a living subject. The system comprises an energy source capable of generating optical energy, a connector having a first end and a second end capable of transmitting optical energy, and a probe operably coupled to the second end of the connector and having an end portion for delivering optical energy to a target neural tissue. In one embodiment, the energy source comprises a tunable laser.

Abstract: An electrical system including one or more bodies having an underlying structure resembling a double helix may be used to produce useful electromagnetic effects for various applications, including therapy.

Abstract: The invention relates to devices and compositions useful for and methods of female genital skin reduction, improvement of skin tone and treatment of female urinary incontinence, as well as the treatment or improvement of other clinical conditions, including but not limited to those involving the female genitalia.