Abstract: An IV pole mountable, therapeutic infusate processing device is incorporated into a hypothermia system to receive therapeutic fluid(s), such as normal saline, peritioneal dialysis solution, or other crystalloid solution, to heat such therapeutic fluid(s) a few degrees centigrade above normal body temperature and to direct the resulting heated infusate to and through a selected anatomical portion of a patients body to raise the temperature of that body portion so as to affect any cancerous or other tumors that may be located therein. The processing device is provided with touch screen controls and visual indicators to facilitate its proper use; while the system further includes temperature and pressure sensors to monitor the hyperthermia processing to insure patient safety.

Abstract: The invention includes a method for performing non-surgical lung volume reduction in a patient by applying an amount of energy with a catheter to a diseased alveolar region of the lung of a patient having emphysema, wherein the amount of energy is sufficient to damage the epithelial cells and the epithelial barrier within the diseased alveolar region of the lung and collapse at least a portion of said region thereby reducing the lung volume, and wherein the energy comprises thermal energy, electrical energy, and ultrasonic energy.

Abstract: An adjustable pressure cuff device is provided for the arm or leg of a user for stimulating blood flow and preventing blood clots. The pressure cuff contains a number of bladders which wrap in the direction of the cuff and which are arranged in succession down the arm or leg of a user. An air compressor is connected to the bladders via a multiplicity of tubes, each of which contain a valve. A control module runs the air compressor and sequentially opens the valves to provide air pressure to the bladders in succession along the arm or leg of a user. Further, between the bladders and the valves, additional tubes containing valves are provided to equalize pressure between bladders before exhausting the air from a previously pressurized bladder to save power and allow for increased patterns of bladder pressure. The pressure levels and bladder dwell times may be adjusted by the user or based on predetermined settings. Optionally, the device provides electrical stimulation, pulsations, heating, and cooling.

Abstract: A method and apparatus of treating tissue adjacent to a bodily conduit using thermotherapy, while preventing obstructions of the bodily conduit due to edema employs the circulation of warmed fluid to maintain the temperature of the bodily conduit walls and compresses the tissue to be treated to increase the effectiveness of the irradiated heat. An energy-emitting source containing catheter is inserted in a bodily conduit and is positioned in a region of the tissue to be treated so that the energy-emitting source radiates energy to the tissue to be treated. Fluid warmed to over 30° C. is circulated into and through the catheter to warm walls of the bodily conduit adjacent the catheter. The circulated fluid inflates a balloon to a pressure to compress the tissue to be treated. The combination of warmed fluid over 30° C.

Abstract: A non-ambulatory thermotherapy device for contacting and applying hot or cold therapy to a treatment area of a user of the non-ambulatory thermotherapy device. The device has at least one pad made of a pliable single piece of gel material for contacting a part of the user's treatment area and for undergoing selective heating or cooling to specific temperatures to selectively apply hot or cold therapy, respectively, to the part of the user's treatment area. The pad has opposite main surfaces and a plurality of bumps extending from one of the main surfaces for increasing a surface contact between the gel material and irregularly shaped contours of the part of the user's treatment area during application of hot or cold therapy to the part of the user's treatment area.

Abstract: Methods and apparatuses for temperature modification of a patient, or selected regions thereof, including an induced state of hypothermia. The temperature modification is accomplished using an in-dwelling heat exchange catheter within which a fluid heat exchange medium circulates. A heat exchange cassette is attached to the circulatory conduits of the catheter, the heat exchange cassette being sized to engage a cavity within a control unit. The control unit includes a heater/cooler device for providing heated or cooled fluid to a heat exchanger in thermal communication with the fluid heat exchange medium circulating to the heat exchange catheter, a user input device, and a processor connected to receive input from various sensors around the body and the system. A temperature control scheme for ramping the body temperature up or down without overshoot is provided.

Abstract: A heat generating device includes a heat generating element enclosed in an air-permeable stretch bag. The heat generating element includes an air-permeable first side adapted to be located proximal to the skin of a wearer, a second side adapted to be located distal to the skin of a wearer, and a heat generating member interposed between the first side and the second side. It is preferred that a part of the heat generating element is fixed to a part of the inner side of the stretch bag in the overlap between the stretch bag and the heat generating element in a plan view of the heat generating device.

Abstract: The sensor device has a housing. The housing is made of a material having a first high heat-conductivity index. A holder is attached to the housing and made of a material with a second low heat-conductivity index that is substantially lower than the first high heat conductivity index. The holder holds a peltier element and is connected to a power source so that the element has a cooled layer and a heated layer. A rotatable roller is in operative engagement with the layer so that the layer cools the roller. The roller may be rolled on the skin of the patient to determine the scope and effect of anesthetic treatment.

Abstract: An infected nail of a digit of a patient is treated using apparatus including an enclosure capable of housing at least a distal end of at least one digit of a patient having an infected nail. The apparatus also includes a heater and a nail infection agent-containing member housed within the enclosure and positionable against an infected nail at the distal end of a digit housed within the enclosure. The heater is in heat-transfer relationship with the nail infection agent. In this way heated nail infection agent can be maintained against an infected nail by the nail infection agent-containing member.

Abstract: The invention relates to a compress with a cooling effect, based on particles (6) of a polymer that has a high water absorption capacity, which comes enclosed with a reserve of water to activate it in an item (2) which comprises, inside a watertight outer sachet (3), on the one hand an inner pouch (4) filled with water and sealed in a watertight manner by a wall comprising a frangible region (10) and, on the other hand, the compress (1) produced in the form of a wrapper (5) at least partially permeable to water and containing the polymer particles (6) in the dry state. The sachet (3) is made of a material of a nature able to keep the pouch (4) and the compress (1) sterile.

Abstract: A therapeutic kit for providing heat to an area of the body is provided. The therapeutic kit may be used to treat a variety of injuries to muscles, ligaments, tendons, etc., including arm, leg, ankle, knee, shoulder, foot, neck, back, elbow, wrist, hand, chest, finger, toe injuries, and so forth. Regardless of its intended use, the therapeutic kit generally employs a pad that receives a thermal insert. The thermal insert includes a substrate containing an exothermic coating that is capable of generating heat in the presence of oxygen and moisture. One particular benefit of the thermal insert of the present invention is that it is disposable. Thus, when the thermal insert exhausts its heat-producing capacity, a new insert may simply be utilized. This allows for the continued use of the extensible material, resulting in substantial cost savings to the consumer.

Abstract: In accordance with the present invention, there is provided a system for treating a patient with local hypertension, comprising a hypertension treatment device adapted to have at least one surface of the device attached to the blood flow passageway, wherein said surface comprising a cooling surface able to cool said passageway to restrict said passageway thereby reducing the blood pressure distal to said restriction. In accordance with a another aspect of the present invention, there is provided a system for treating a patient with aneurysm, comprising a aneurysm treatment device adapted to have at least one surface of the device attached to the blood flow passageway, wherein said surface comprising a cooling surface able to cool said passageway to restrict said passageway thereby treating said aneurysm.

Abstract: An apparatus for determining a thermal property of tissue includes a base unit with one or more energy source and at least two, preferably detachable, leads. The distal end of each lead, which is introduced into the tissue to be treated, has at least two longitudinally spaced temperature measuring elements to measure surrounding tissue temperature and at least two longitudinally spaced electrode surfaces for applying current to the tissue. Each distal end is also provided with an element which uses energy emitted by the sources of energy to heat up the surrounding tissue. The base unit has computing elements, current generating elements for generating an alternating current, and conductance determining elements for determining the tissue conductance between pairs of electrode surfaces based on the alternating current applied by the current generating elements to the tissue. Methods for using the device and leads for use in the device are also described.

Abstract: Methods, apparatus and systems for personal care, such as treatment of a skin or hair treatment surface, are disclosed. In some embodiments, a base device is configured to thermally modify (heat or cool) an applicator on a hand piece that can then be used to cleanse, treat and/or otherwise rejuvenate the treatment surface. The applicator can be formulated with a smooth or abrasive material that can absorb, be coated with or otherwise take up a variety of materials, such as liquids, lotions, gels or creams, which are suitable for application to the treatment surface. The base device may thermally modify the material that is then coupled to the applicator and applied to the treatment surface during treatment.

Abstract: A therapeutic heating pad which is not hot to the touch provides substantial infrared radiation to a user. Accordingly it can be used for extended periods without feeling uncomfortable to the skin, while imparting deep therapeutic heat to the user. The heating pad is comprised of a radiant heat generating layer having a plane surface comprising means for radiating heat evenly from its surface, a pair of flexible electrically insulating and radiation permeable layers located adjacent and covering opposite sides of the layer, a thermal insulation layer disposed against and covering one of the electrically insulating layers, and a sealed radiation permeable envelope enclosing the entire heater. Preferably the flexible heat generating layer is comprised of a fiberglass material impregnated with a resistive material, which material provides a surface temperature, when current is conducted therethrough, which is no greater than about 54 degrees Celsius.

Abstract: The present invention encompasses a device for changing the temperature of the kidney during laparoscopic surgery or during organ transportation or transplantation.

Abstract: An electric warming blanket for warming patients during surgery and other medical procedures includes a flexible heater and a temperature sensor assembly coupled thereto; a first layer of water resistant material coupled to a second layer of water resistant material, about a perimeter of the heater, forms a substantially hermetically sealed space for the heater and the temperature sensor assembly. The blanket may further include a thermal insulation layer disposed between the temperature sensor assembly and the first layer of water resistant material. The temperature sensor assembly may provide input of an average temperature over a portion of a surface area of the heater to a temperature controller, when the heater and sensor assembly are coupled to the controller.

Abstract: Methods and apparatus for temperature modification of selected body regions including an induced state of local hypothermia of the brain region for neuroprotection. A heat exchange catheter is provided with heat transfer fins projecting or extending outward from the catheter which may be inserted into selected blood vessels or body regions to transfer heat with blood or fluid in the selected blood vessels or body regions. Another aspect of the invention further provides methods and apparatus for controlling the internal body temperature of a patient. By selectively heating or cooling a portion of the catheter lying within a blood vessel, heat may be transferred to or from blood flowing within the vessel to increase or decrease whole body temperature or the temperature of a target region. Feed back from temperature sensors located within the patient's body allow for control of the heat transfer from the catheter to automatically control the temperature of the patient or of the target region within the patient.

Abstract: A flexible drape useful for warming a patient during surgery includes a base film defining a target region, where the base film is attachable to a body surface of the patient, and an evacuation port in fluid communication with the target region. In this regard, the evacuation port is configured to negatively pressurize the target region and vasodilate the body surface of the patient adjacent the target region.

Abstract: Apparatus is provided including an assembly (22) and a control unit (36). The assembly (22) includes a housing (34) configured to be applied to a nerve (20) of a subject, and at least one cathode (30) and at least one Peltier cooler (32), which are fixed to the housing (34). The control unit (36) is configured to drive the cathode (30) to apply an activating current to the nerve (20) that generates action potentials traveling in first and second directions (38 and 40) in the nerve (20), and the Peltier cooler (32) to cool the nerve (20) sufficiently to block propagation of at least a portion of the cathode-generated action potentials traveling in the second direction (40). Other embodiments are also described.

Abstract: Different designs of hand-held devices for therapeutic skin treatment by application of heat are known. Inexpensive hand-held devices use heat radiation. In practice, however, there is no inexpensive hand-held device available that can be placed on the skin to be treated and that operates according to the principle of heat conduction and allows the skin to be treated within a defined temperature range without the use of a temperature sensor and control elements.

Abstract: The invention relates to a treatment probe for focused ultrasound including a probe body, which is mounted in rotation around an axis; an elongated treatment transducer with a focused ultrasound emission acoustic axis, which is more or less the same as the rotation axis of the probe body; and an imaging transducer, the imaging plane of which contains the acoustic axis of the treatment transducer. The inventive probe can be used to provide a simple treatment. The probe body can be rotated around the axis in order to vary the direction of the imaging plane without moving the focus, which always remains in the imaging plane. The treatment transducer can be extended in order to provide safer treatment in relation to the organs to be treated and without risk of damaging the fragile surrounding organs.

Abstract: Devices and methods for the treatment of skin conditions and lesions are disclosed herein. One aspect of the invention is a compact hand held device that can be safely used by those suffering from skin conditions, such as acne, warts, cold blisters, blemished skin, or fine wrinkles. The devices described herein employ the application of heat for the treatment of skin conditions and lesions. Typically, the peak temperatures employed are about 70° C. to about 400° C. by the devices, are achieved in less than about 1 second, and maintained for less than about 1 second. In some embodiments, the skin surface is heated with heat pulses. Thermal conduction transfers heat from the device to the skin and causes a biological response that accelerates acne clearing, treats blemished skin, itching, or fine wrinkles. The total heat transferred is low enough to prevent burns.

Abstract: A thermal treatment garment of the present invention includes an outer structure layer, an interior lining formed of a gel material that directly contacts a body portion of a user when the garment is worn by the user and a thermal treatment layer to thermally treat and control temperature of the garment. The thermal treatment layer heats and/or cools the gel material to a selected temperature or selected temperature range and is controlled by a controller. In an exemplary embodiment, the garment includes a cap to thermally treat the user's head, where the structure layer has a generally convex outer surface and the interior surface of the gel layer is generally concave and contoured to engage with and at least partially envelop at least one selected portion of the user's head.

Abstract: Apparatus and methods for the treatment of keratinized tissue infected with a pathogen are provided. In certain examples, electromagnetic energy, such as microwave energy, may be used in the treatment process to reduce the amount of or eliminate the pathogen from the keratinized tissue.

Abstract: Disclosed herein are devices and related methods for using those devices in the relieving and/or treating of pain, discomfort, and/or inflammation in the pelvic region using targeted pressure and temperature delivery. The devices and methods for using those devices to deliver targeted pressure and temperature therapy internally to patients through their rectal or vaginal cavities are disclosed.

Abstract: A method for treating the lung during an acute episode of reversible chronic obstructive pulmonary disease such as an asthma attack. The method comprises transferring energy to an airway wall of an airway such that a diameter of the airway is increased. The energy may be transferred to the airway wall prior to, during or after an asthma attack. The energy may be transferred in an amount sufficient to temporarily or permanently increase the diameter of the airway. The method may be performed while the airway is open, closed or partially closed.

Abstract: Embodiments of the invention provide devices and methods for the in situ or in transit adjustment of the core body temperature of a patient. Devices according to some embodiments include a control unit and pressure chamber adapted to apply a pulsating negative pressure to a limb of the patient. An adjustment temperature applied during the application of the pulsating pressure can heat or cool the patient as necessary. Devices and methods disclosed herein can provide for efficient heating and/or cooling of a patient. In addition, devices and methods provide such functionality in a portable device that can be manually carried by an individual.

Abstract: Methods include determining whether an infection is in proximity to an implanted rechargeable medical device. If an infection is determined to be present, the recharge process is allowed to sufficiently heat the device to facilitate clearing of the infection. Additional methods include monitoring temperature in proximity to an implantable rechargeable device in connection with recharging the device. If the monitored temperature falls outside a desired range, one or more parameters associated with recharge energy are modified to cause the temperature to reside within the desired range. The desired temperature range, may be a range that can facilitate treatment of a condition in proximity to the implanted device without causing undesired damage to the patient's tissue surrounding the implanted device.

Abstract: The invention relates to a cooling device, especially for cooling bodies or body parts of humans or animals, comprising at least one supporting material that contains superabsorber (SAP) which can absorb and re-dissipate moisture or liquid. The supporting material is wrapped in a covering fabric that has at least one moisture-permeable or air-permeable and steam-permeable zone. The invention is characterized in that at least one measuring instrument and/or sensor for measuring physical measuring values is provided on or in the device.

Abstract: Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues.

Abstract: Disclosed is a hypertension descending device capable of curing a hypertension disease by stimulating a patient's Acupuncture point Renying (or referred to as “carotid sinus”) by repeated cold pressure vibration. The hypertension descending device is designed to allow common users to use it easily, and provides a good hypertension descent effect by stimulating the patient's carotid sinus (Acupuncture point Renying) portion while maintaining a uniform cooling temperature of the contact tip, which is in contact with the patient's carotid sinus (Acupuncture point Renying) portion.

Abstract: Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.

Abstract: Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.

Abstract: Methods for treating a network of organs including generating a map of at least a portion of the network of organs using a rendering system; selecting at least one treatment location within the luminal passageway of the network of organs; and applying an energy therapy to the treatment location to treat the smooth muscle tissue, where the energy therapy applied to the respective treatment location is defined by a plurality of parameters that are associated with a map. Such a system allows for historical or ideal treatment parameters to be identified, visually or otherwise to actual treatment locations. Also, control systems and methods for delivery of energy that may include control algorithms that prevent energy delivery if a fault is detected and may provide energy delivery to produce a substantially constant temperature at a delivery site. In some embodiments, the control systems and methods may be used to control the delivery of energy, such as radio frequency energy, to body tissue, such as lung tissue.

Abstract: Methods are described for augmenting cerebral blood flow and altering sympathetic nerve firing and catecholamine release by cooling a part of the body. In particular localized cooling of the nose or mouth is used to augment cerebral blood flow and alter sympathetic nerve firing. By cooling a localized area such as nose or mouth, release of norepinephrine after an ischemic event is inhibited. The methods described may be applied to augment cerebral blood flow and alter catecholamine release, particularly in treatment of stroke, heart attack and transient ischemic event.

Abstract: A heatable cocoon including a body portion having an upper end and a pair of opposed side edges. The body portion is foldable to permit the pair of side edges to be folded over one another to form an enclosed interior. The body portion is formed of a first layer and second layer of supple material. A head covering portion having a concave opening extends from the upper end of the body portion. A securement device secures the opposed side edges of the body portion together. A plurality of enclosures is formed between the first and second layers. A plurality of heating devices is provided with one heating device of the plurality being disposed and sealed within each of the plurality of enclosures.

Abstract: Method, system and apparatus for monitoring target tissue temperatures wherein temperature sensors are configured as passive resonant circuits each with a unique resonating signature at monitoring temperatures extending below a select temperature setpoint. The resonant circuits are configured with an inductor component formed of windings about a ferrite core having a Curie temperature characteristic corresponding with a desired temperature setpoint. By selecting inductor winding turns and capacitance values, unique resonant center frequencies are detectable. Temperature monitoring can be carried out with implants at lower threshold and upper limit temperature responses. Additionally, the lower threshold sensors may be combined with auto-regulated heater implants having Curie transitions at upper temperature limits.

Abstract: Methods and apparatus for the prevention and treatment of shivering encountered during therapeutic temperature regulation are disclosed that utilize an active system of counterwarming such that the timing and intensity of warmth provided to selected body areas is regulated dynamically in response to such factors as the extent of cooling applied to the core, the degree of shivering encountered, and patient temperature. Additionally, methods and apparatus are disclosed for the measurement and quantification of shivering for use in this and other applications.

Abstract: A substrate that contains an exothermic coating is provided. More specifically, the exothermic coating includes one or more components (e.g., carbon, oxidizable metal, moisture-retaining particles, etc.) that are durably adhered to the substrate. To provide the desired durability, the exothermic coating includes the combination of a certain amount of a polymer latex and polysaccharide. When appropriately selected and incorporated into the exothermic coating, the present inventors have discovered that these components may interact synergistically to improve binding capacity.

Abstract: An apparatus (10) and a method for treating patients suffering from vascular disease with infra-, audible- and ultrasound waves. The apparatus (10) includes a treating head (15) for emitting sound waves with frequencies ranging from 1 Hz to 100 kHz and introducing the sound waves through a coupling medium (20) into a body portion (22) to be treated, an electronics (12) connected to the treating head (15) for energizing the treating head (15) to emit the sound waves, and a control panel (11) connected to the electronics (12) to choose the electronic waveform of the energizing.

Abstract: Method, system and apparatus for monitoring target tissue temperatures wherein temperature sensors are configured as passive resonant circuits each with a unique resonating signature at monitoring temperatures extending below a select temperature setpoint. The resonant circuits are configured with an inductor component formed of windings about a ferrite core having a Curie temperature characteristic corresponding with a desired temperature setpoint. By selecting inductor winding turns and capacitance values, unique resonant center frequencies are detectable. Temperature monitoring can be carried out with implants at lower threshold and upper limit temperature responses. Additionally, the lower threshold sensors may be combined with auto-regulated heater implants having Curie transitions at upper temperature limits.

Abstract: A microenvironment system for use with a heat transfer fluid includes a microenvironment structure and a fluid handling apparatus. The microenvironment structure defines a flow passage to receive a flow of the heat transfer fluid therethrough. The fluid handling apparatus is adapted to provide a flow of the heat transfer fluid through the flow passage. The fluid handling apparatus includes a gas driven pump and a supply of a phase change material (PCM). The gas driven pump is operable to force the flow of the heat transfer fluid through the flow passage. The supply of the PCM is convertible from a solid and/or liquid phase to a gas phase to provide a pressurized drive gas. The fluid handling apparatus is configured to drive the gas driven pump using the pressurized drive gas from the supply of the PCM.

Abstract: A medical and recreational devise comprises at least two laminas. The laminas comprises sources of magnetic field. The sources of the magnetic field located on one of the laminas faced to another one completely or partially by like and/or unlike magnetic poles, and at least one of said laminas are congruent to a treated part of body and attached to the treated part of body. A method of using said medical and recreational devise comprises the step: attached at least one of said laminas to the treated part of body, attached to lower or upper extremity to unload the affected extremity, and attached another set of said laminas to a bed parallel to the first one. The magnets embedded in said laminas attached to an affected part of the extremity faced to like poles to the magnets embedded to said laminas attached to the bed.

Abstract: A method wherein, following a therapeutic radiation treatment, a heat dose is administered to the treated cells to decrease the damage caused by radiation exposure or a therapeutic agent.

Abstract: The method and device of the present invention for pain relief using ultrasound waves in combination with cryogenic energy includes a generator and a transducer to produce ultrasonic waves and a cryogenic source to produce cryogenic energy. Ultrasound waves are delivered to the target in combination with cryogenic energy. Ultrasound waves and cryogenic energy can be delivered to the target from the radial side of the ultrasound horn and/or tip or can be delivered from the distal end of the ultrasound tip. Cryogenic energy can also be delivered directly to the target through a central orifice. Ultrasound energy can also be delivered through a cryogenic spray at the distal end. The use of ultrasound waves in combination with cryogenic energy can provide an analgesic effect.

Abstract: A heat exchange fluid supply system for supplying a heat exchange fluid to an intravascular heat exchange catheter includes a disposable cassette having a bulkhead and an external heat exchanger, and which is configured to operate in combination with a reusable master control unit. The bulkhead includes a reservoir section and a pump section. The reservoir section is provided with a means to monitor the amount of heat exchange fluid that is in the system. The bulkhead provides the mechanism for priming the system with heat exchange fluid from an external source and for circulating fluid to the catheter in a closed circuit. The pump section is configured to allow for pumping of heat exchange fluid at a constant pressure.

Abstract: A high viscosity composition which according to the invention comprises at least one polyoxyethylene-polyoxypropylene-block copolymer (poloxamer) having the structural formula HO(C2H4O)a (C3H6O)b (C2H4O)a H and having an average molecular weight of above 6000; at least one additional polymer having an average molecular weight of above 150000, and a dispersion medium, comprising at least one freezing point depressing dispersant and at least one freezing point non-depressing dispersant. The composition is heatable above the body temperature of a mammal and coolable below 0° C. within a predetermined temperature range.

Abstract: The present invention is directed to instruments and instrumental techniques for locating cancer cells in lymph nodes which utilize a radiation detector operatively connected to an ultrasound probe for locating the exact position of radiation tagged tissue, particularly in sentinel lymph nodes followed by placement of a biopsy device. Also described are unique new interoperative radiation detection probes for use in these techniques which include structure for placement of a biopsy device or biopsy needle into the located lymph node and procedures for removal of small portions of detected radiation emitting sentinel lymph nodes for evaluation in a pathology laboratory by measurement of expressed genes located in the removed tissue. The instruments and instrumental techniques also facilitate the subsequent delivery of materials to reverse the unfavorable immune response or environment conducive for metastasis in the sentinel lymph node once cancer cells are located therein.

Abstract: The present invention comprises methods and systems/devices for non-invasively measuring baseline collagen and collagen changes during treatment of tissue, e.g., denaturation by the application of RF energy, through linear dichroism, circular dichroism, or birefringence. The invention optionally uses polarization sensitive optical measurements to discriminate between denaturation of unidirectionally oriented strands of collagen, such as a ligament or tendon, and denaturation of planar collagen surfaces, such as the dermal layer of the skin or collagen in joint capsules.