Abstract: A pin replicator is disclosed for dispensing minute volumes of liquid onto a substrate surface in an array in connection with drug discovery, diagnostic analysis, and other applications. The pin replicator comprises a base plate, a plurality of pins reciprocable through corresponding holes in the base plate, and a free floating weight plate resting on top of the upper ends of the pins. The weight plate biases the pins toward their fully extended lowered positions. A cover attaches to the base plate, encloses the pins and weight plate and guides the weight plate during vertical movement thereof. The pin replicator can be moved downwardly toward a first micro titer plate so that a lower end of each of the pins contacts the sample liquid in the corresponding well a sufficient amount to pick up and retain a small quantity of the sample liquid due to surface tension.

Abstract: In this invention we describe a magnet or magnetic material that is attached to a pipette to hang it on a ferrous or magnetic material. The magnet can be attached to any place on the pipette in such a way that the pipette can be hung as desired on the magnetic or ferrous surface such as ferrous clips, iron or steel sheets (refrigerator, lab bench, hood etc.). This will help to organize the laboratories. Furthermore this will reduce the contamination from pipette to pipette and sample to sample.

Abstract: The sampling pipette comprises an endpiece (4); a. piston (8) slidably movable in the endpiece; and a gasket (36) in contact with the endpiece and with the piston to provide sealing between them. The endpiece comprises two portions (4a, 4b) fixed to each other in releasable manner with the gasket (36) being interposed between them.

Abstract: A dual-manifold assembly is provided for the rapid, parallel transfer of liquid reagents from a microtiter plate to a solid state microelectronic device having biological sensors integrated thereon. The assembly includes aspiration and dispense manifolds connected by a plurality of conduits. In operation, the aspiration manifold is actuated such that the aspiration manifold is seated onto an array of reagent-filled wells of the microtiter plate. The wells are pressurized to force reagent through conduits toward the dispense manifold. A pressure pulse provided by a standard ink-jet printhead ejects nanoliter-to-picoliter droplets of reagent through an array of printhead orifices and onto test sites on the surface of the microelectronic device.

Abstract: The present invention is a disposable apparatus for the rapid, low-volume solid phase extraction of analytes from a variety of sources. The apparatus of the present invention is configured as a pipette tip and contains a loosely confined stationary phase. The mobility of the stationary phase particles enables rapid mixing and equilibration with a sample solution during agitation. The analyte may thereby be extracted in less time with less solvent, removing the need for a separate concentration step.

Abstract: A microarrayer for spotting solution onto slides in an automated microarray dispensing device. Elements of the present invention include: at least one dispense head for spotting the slides, at least one light source capable of illuminating the slides, at least one camera operating in conjunction with the at least one light source. The at least one camera is capable of acquiring and transmitting slide image data to a computer. The computer is programmed to receive the slide image data and analyze it. The computer will then generate post analysis data based on the analysis of the slide image data. The post analysis data is available for improving the spotting of the solution onto the slides. In a preferred embodiment, the slide image data includes information relating to slide alignment, information relating to spot quality, and slide identification information.

Abstract: A pipette tip and mounting shaft combination in an air displacement pipette, the combination comprising a pipette tip mounting shaft having a radially stepped exterior comprising adjacent substantially cylindrical portions of different diameter and an annular sealing zone including an annular edge seal at an outermost edge of a radially extending shaft transition, a pipette tip including an annular sealing region having an inner sealing surface on a sidewall of the tip which in the sealing region is sufficiently thin as to expand slightly and form an interference fit and air tight seal between the sealing surface and the sealing zone when the sealing zone penetrates the sealing region, and axial penetration limiting means for limiting penetration of the shaft into the tip to limit axial contact between the sealing region and the sealing zone to a narrow annular band comprising the annular edge seal.

Abstract: The invention concerns a liquid transfer device for an analysis apparatus with a liquid transfer cannula (5) and a capacitive liquid level detector to detect the immersion of the liquid transfer cannula (5) in an analysis liquid contained in a vessel. To reliably check if the liquid transfer cannula (5) is submerged in the analysis liquid or immersed for example in foam it is proposed additionally that resistance is measured by a measurement section (16) in the liquid transfer cannula (5).

Abstract: The present invention relates to a ceramic tip and a random access print head for the transfer of microfluidic quantities of fluid. The print head can randomly collect and deposit fluid samples to transfer the samples from a source plate to a target. The print head can also be programmed to create a direct map of the fluid samples from the source plate on the target or to create any desired pattern or print on the target. The tip and print head can be used for a wide variety of applications such as DNA microarraying and compound reformatting. In one preferred embodiment, the tip is used as a capillary or “gravity” pin to draw or collect source fluid and “spot” or deposit the fluid onto the target via physical contact (touch-off). In another preferred embodiment, the tip is used in conjunction with an aspirate-dispense system to actively aspirate source fluid and deposit the fluid via a contact or non-contact approach.

Abstract: A device and related method for dispensing liquid. The device includes a housing configured to contain a plurality of liquid dispensing members containing a liquid and configured to contain a receiving member in a receiving position to receive the liquid from the plurality of liquid dispensing members. The housing defines a first pressure chamber and a second pressure chamber. The first pressure chamber is capable of being sealed relative to the second pressure chamber. The device also includes a differential pressure generator operably connected to one of the first and second pressure chambers. The generator is capable of generating a pressure differential between the first and second pressure chambers to cause the plurality of liquid dispensing members to dispense liquid onto the receiving member.

Abstract: In a preferred embodiment, a small volume pipettor, including: a plurality of pistons; a plurality of liquid delivery needles; motive means to cause one of the pistons to move axially within one of the needles to cause a liquid to be selectively drawn into and discharged from the needle; sealing apparatus disposed around the pistons to effect sealing of upper ends of the needles; assembly apparatus in which the needles and the sealing apparatus are disposed; and apparatus to permit the assembly apparatus to be removed from the pipettor as a one-piece unit. Further provided are novel apparatus to seal upper ends of the needles around the pistons.

Abstract: A pipette for the handling of a syringe. The pipette has jaw chucks which are adjustably arranged with respect to the plunger receptacle, being pivotably mounted on a plunger-gripping device. The syringe is insertable with opened jaw chucks with the plunger head only partially contacting the jaw chucks. The jaw chucks are laterally engageable on the plunger head upon insertion of the syringe. The engaging movement of the jaw chucks on the plunger head is regulated according to the invention so that the engaging movement has a substantially tangential component with respect to the surface of the plunger head. As a result, a desired and form-locking connection to the plunger head of the syringe results that requires a small amount of force.

Abstract: Apparatus and methods for aspirating and dispensing reagents are provided. Aspirating of reagents is accomplished by a probe, a vial insert and reagent vial according to the present invention wherein a seal is formed between the probe and the vial insert when the probe engages the vial insert. Dispensing of reagents is accomplished by a probe and a probe dispense and wash station according to the present invention wherein a seal is formed between the probe and the vial insert when the probe engages the probe dispense and wash station.

Abstract: A pipette for repeatedly aspirating and dispensing a predetermined quantity of liquid. The pipette includes a hollow body having first and second extremities. The second extremity is adapted to removably receive the pipette tip. An ejector is carried by the body and has a first extremity disposed within the first extremity of the housing and a second extremity movable vertically about the second extremity of the housing. The ejector is movable from a first position for permitting the pipette tip to be securely mounted on the second extremity of the housing and a second position for pushing the pipette tip off of the second extremity of the housing. A spring is carried by the housing and is compressed so as to store energy in the spring. A locking mechanism is additionally carried by the housing for retaining the spring in the compressed position.

Abstract: A multiple pipette X according to the present invention includes a first pipette 1 and a second pipette 2. The first pipette 1 is capable of dispensing a liquid stored in a liquid storing section 17a divisionally a plurality of times each by a constant amount. The second pipette 2 is capable of dispensing a liquid sucked from the outside all at a time. The first pipette utilizes, for example, a ratchet mechanism 12d, 13a for dispensing the liquid divisionally a plurality of times each by a constant amount. Preferably, the first pipette 1 is provided with a cap 19 removably attached to the tip end thereof.

Abstract: A fluid dispensing system and method includes a pump to aspirate and expel sample fluid, a fluid dispensing tip, and a metering station. The fluid dispensing tip includes a working fluid and an air gap where the air gap separates the working fluid from the sample fluid. The metering station receives a drop of sample fluid that is at least twice as large as the predetermined volume to ultimately be dispensed. The fluid dispensing tip then withdraws the predetermined volume of fluid from the sample fluid. Precise volumes are ascertained by prior knowledge of the geometry of the fluid dispensing tip and by using an imaging device to monitor an interface of either the sample fluid or working fluid with the air gap within the fluid dispensing tip. The system and method are capable of accurately dispensing very small volumes of sample fluid on the order of 10 picoliters. In addition, the system and method do not require large volumes of sample fluid to prime a pump mechanism.

Abstract: A hand-held, single-channel dispenser/aspirator is disclosed. The present dispenser/aspirator comprises a body portion for gripping the dispenser and a head portion. In some embodiments, the head portion includes a valve, a liquid conduit and a removable liquid reservoir. The liquid conduit places the liquid reservoir and the dispensing valve in fluid communication. A gas conduit received by the body portion of the dispenser is operable to pressurize the fluid reservoir, or draw a partial vacuum therein. Controls located on the body portion operate the dispenser. The liquid reservoir is advantageously disposed near the valve, so that a relatively short length of liquid conduit is required to operatively connect the reservoir and the dispensing valve, thereby improving the accuracy of the dispensing operation.

Abstract: The device serves for the transfer of microobjects, in particular of biological objects, from a current substrate (9) to a target substrate. In this case, use is made of a displaceable pipette system which is connected to a pressure generating device for aspirating in and flushing out the biological objects. The pipette system is disposed in a micromanipulator (3) and consists mainly of a substantially vertically disposed microcapillary (1) having a clear width of 1 &mgr;m to 50 &mgr;m.

Abstract: The present invention provides an improved apparatus and method for loading tips onto a pipettor. A means for applying removal force on the pipette tip box is provided so as to ensure that the box is dislodged from the pipette tips after the pipette tips have been forced onto the dispense head mandrels. In the preferred embodiment, the shuck arms are modified to incorporate springs such that when the engagement force is removed from the pipette tip box, the shuck arms are forced by the springs against the pipette tip box thereby displacing the pipette tip box from the pipette tips.

Abstract: The invention provides pipette tips having high affinity for target biomolecules and methods of using the pipette tips for separating, filtering, and purifying samples, preparing samples, culturing cells, and running assays.

Abstract: A nozzle 33 is formed on a distal end side of a cylinder 3. The nozzle 33 has an intermediate portion 3b formed such that a tip 7 is freely attachable thereto and detachable therefrom. The intermediate portion 3b of the nozzle 33 is formed with an annular projection 3e for retaining the tip 7. The tip 7 has a thick portion 7a provided in a root portion thereof and formed larger in diameter than a root portion 3a of the nozzle 33 to be abuttable against a tip releasing member 11. Along an inner periphery of the root portion of the tip 7, an annular projection 7b is formed to contact with the annular projection 3e of the nozzle 33 thereby providing a seal with the nozzle 33. Both the annular projections 3e and 7b of the nozzle 33 and the tip 7 are arranged to reach a position where a sound of abutment is produced between the root end surface of the tip 7 and the shoulder of the nozzle 33 at the completion of fitting of the tip 7 onto the nozzle 33.

Abstract: Disclosed is an automated staining apparatus including an arm (30) moveable in three dimensions, and a hollow tip head (70) located on the arm including integral reagent tip head (40), wash tip (41) and blow tip (42) for selectively dispensing gas and liquid onto microscope slides. Also disclosed are various sub-components of the apparatus that are specifically adapted to the processing of specimens on slides.

Abstract: The invention relates to a device in which at least two liquid or semi-liquid reagents can be stored separately. When used, the inventive device enables precise, chronologically defined, sequential reagent discharge in a reaction chamber by means of a linear movement without any prior mixing of said reagents.

Abstract: A gas analyzer having an analysis or sensor unit and having an electronic processing unit, and a method for operating such a gas analyzer. In order to achieve substantially improved safety both in handling corrosive and/or combustible and/or toxic gases in a not potentially explosive atmosphere (ex-free atmosphere), and in the operation of such an analyzer in an exatmosphere, the analysis or sensor unit as such is of non-explosive configuration and is arranged in a gas tight chamber through which a toxic and/or corrosive and/or combustible gas flows and around which a second chamber is arranged.

Abstract: The present invention provides for techniques for transporting materials using electrokinetic forces through the channels of a microfluidic system. The subject materials are transported in regions of high ionic concentration, next to spacer material regions of high ionic concentration, which are separated by spacer material regions of low ionic concentration. Such arrangements allow the materials to remain localized for the transport transit time to avoid mixing of the materials. Using these techniques, an electropipettor which is compatible with the microfluidic system is created so that materials can be easily introduced into the microfluidic system. The present invention also compensates for electrophoretic bias as materials are transported through the channels of the microfluidic system by splitting a channel into portions with positive and negative surface charges and a third electrode between the two portions, or by diffusion of the electrophoresing materials after transport along a channel.

Abstract: A method and apparatus therefor for depositing a flattened droplet on a partially absorbent surface comprising the steps of providing a narrow bore transfer tube having a proximal end and a distal end and containing a microvolume of liquid, the proximal end connected to a pneumatic system adapted for issuing an outgoing flow of displacement gas into the tube and drawing an incoming flow of displacement gas therefrom; and issuing an outgoing flow of displacement gas for slowly discharging substantially the entire microvolume of liquid as a droplet on the surface and controllably blowing one or more bubbles into the droplet towards the end of its discharge for flattening the droplet on the surface.

Abstract: The present invention provides a method, and an apparatus, for forming a prescribed concentration of a substance in a mixture with a fluid, from a comparatively dilute mixture. The mixture is most preferably a solution of a solute in a solvent. The following summary and description generally discuss the invention in terms of a particularly preferred solution and a preferred use for that solution; however, in its broadest embodiments, the invention encompasses both the use for other solutions, and the use for a suspension of a solid substance in a fluid to form a mixture (which can also be referred to as a slurry). The invention provides for significant economic, safety and quality benefits over conventional evaporative systems.

Abstract: An improved pre-filled disposable pipette (10) consisting of a hollow tube (12) dimensioned to enclose a medicinal product and having attached a medication transfer tube (22) from where the pipette is filled and the medicinal product released. The improvement consists in having a primary grasping tab (32) attached to an upper end (14) of the bulb (12); a secondary grasping tab (38) attached to each side of the tube (22); and a support tab (52) also attached to each side of the tube (22) near the lower end (26) of the tube (22). The primary and secondary grasping tabs (32, 38) allow the pipette (10) to be conveniently and easily handled without having to grasp the sensitive bulb (12) or to directly grasp the tube (22). The support tab (52) functions to allow the pipette (10) to be placed on a conveyor rack apparatus (88) from where the pipette (10) can be automatically filled and sealed by a cap (72) or heat applied foil (82).

Abstract: It has been hard to suck the high viscosity sample by using the syringe and to stop the suction of the sample. A sample sucking-discharging device in the invention comprises an injector provided with a cylinder and a piston installed in the cylinder so as to move up and down; a main body for holding the cylinder of the injector; a gear or a pair of gears held in the main body so as to rotate on an axis right-angled to the moving direction of the piston; a first rack, of which one end is connected with the piston, for moving with meshing to the gear or the pair of gears; and, a second rack held in the main body so as to move in the direction opposite to or crossing with the moving direction of the first rack.

Abstract: An exchangeable oscillating pipette needle for an automatic analyzer for examining biological body fluids is provided, in which the analyzer has a holder provided with a tension spring, and with which the oscillating arm, carrying the pipette needle and resting on a knife-edge bearing, is fixed in a stationary position and is releasably connected.

Abstract: Methods, apparatus and systems are provided for introducing large numbers of different materials into a microfluidic analytical device rapidly, efficiently and reproducibly. In particular, improved integrated pipettor chip configurations, e.g. sippers or electropipettors, are described which are capable of sampling extremely small amounts of material for which analysis is desired, transporting material into a microfluidic analytical channel network, and performing the desired analysis on the material.

Abstract: A pipetting system including a syringe (2), a working piston (5) connectable with the syringe piston (24) and extending into a working chamber (3), an actuating piston (7) extending into the working chamber, and a storage chamber (4) connected with the working chamber (3) by a valve (12) that provides for flow of the hydraulic liquid, which fills both chambers, from the working chamber (3) into the storage chamber when the working piston (5) is displaced into the working chamber (3), for flow of the hydraulic fluid from the storage chamber (4) into the working chamber (3) when the actuating piston is displaced out of the working chamber, and that separates the storage and working chambers (3, 4) when the actuating piston (7) is advanced into the working chamber.

Abstract: A delivery apparatus has, in a housing (13), a cannula (8) whose rear end is connected to a diluter (17) via a connecting tube (16). A piezoelectric actuator (10) increases in length under the action of a control signal and acts on a membrane (6) pierced by the cannula tip (9) and belonging to an interchangeable polypropylene pipette tip mounted on the delivery apparatus and adhering to the housing (13) by means of a collar (7) resting against said housing, and causing said membrane to sag, with the result that a drop of a sample liquid which was previously sucked in by means of the diluter (17) and whose accurately adjustable volume is between 1 nl and 1 &mgr;l is ejected from an outlet orifice (4). After a pipetting process the pipette tip is ejected by means of a slide (15). If the level of the sample liquid in the pipette tip always remains below the cannula tip (9), virtually no carry-over occurs.

Abstract: An automated sample-on-solid-support processing system includes a treatment solution supply subsystem which feeds solvent to a dispenser to dispense a measured amount of treatment solution to each well of a multi-well plate. The dispenser measures the solution within a fill container having a plurality of reservoir wells corresponding to the number of wells in the multi-well plate. The fill container is contained within a reservoir chamber that is filled with an excess of solution. Each reservoir well is surrounded by a plurality of bores which drains excess solution from the top of the fill container so that a precise amount of solution is left in the reservoir wells when solution is drained out of the reservoir chamber. Gas pressure is introduced into the reservoir chamber to force the solution out of the reservoir well through a bundle of tubes, with one tube per well, and into the wells of the multi-well plate.

Abstract: A method and apparatus for preventing or limiting damage to capillaries used to dispense microdrops measures the voltage produced by a piezoelectric transducer when the capillary contacts a solid surface or the phase shift occurring when the piezoelectric transducer is operated at its resonant frequency. After distinguishing the voltage created from such contact from the voltage produced from unrelated random sources, corrective action is taken, in one aspect by stopping the relative movement of the capillary and the surface being contacted. The method and apparatus may also be employed to determine the position of a solid or liquid surface.

Abstract: A volume adjustable manual pipette having a hand-holdable housing supporting (i) an electronic digital display and associated position sensing and control circuitry, (ii) a plunger unit and (iii) a quick set volume adjustment mechanism for simultaneously controlling the volume setting of the pipette and the electronic display, the quick set volume adjustment mechanism comprising a pipette volume setting member for limiting upward movement of the plunger unit within the housing to define the volume setting for the pipette and the volume setting member being supported for axial movement on the plunger unit and releasably secured relative to the housing by a pipette user operable locking mechanism. When released from the housing, the volume setting member is axially moveable on and with the plunger unit to quickly set the volume for the pipette.

Abstract: A liquid dispenser includes an elongated tube formed with a first opening, and a closed shell connected to the tube and formed with a second opening aligned axially with and in fluid communication with the first opening. The shell has a portion that is resilient and that is compressible so as to generate a suction force when the portion is pressed and is subsequently released.

Abstract: A pipette tip member having an elongated tubular receptacle with a protrusion on an inner surface of the receptacle, and a recess on the inner surface adjacent the protrusion. The tip member has a generally conical shape and the protrusion extends around the inner surface to form an annular sealing ring. The protrusion has a V-shaped axial cross section with edges that intersect at an angle between about 30° and about 120°. The recess has a generally circular axial cross section and the recess is disposed proximal to the protrusion in the axial direction. The recess depth is about as great as the protrusion height. A method of forming a pipette tip member is also disclosed.

Abstract: A method and apparatus is provided for depositing a flattened droplet on a surface. The method includes the steps of providing a tube with a distal end that contains a microvolume of liquid, issuing an outgoing flow of displacement gas for slowly discharging substantially the entire microvolume of liquid as a droplet on the surface, and controllably blowing one or more bubbles into the droplet for flattening the droplet on the surface.

Abstract: A pipetting station having a bottom sensing device is provided in conjunction with one of any known liquid level sensing devices. The bottom sensing device includes a pipetting probe spring mounted to a pipetting arm of the pipetting station. The bottom sensing device also includes a sensor for determining when a pipetting tip of the pipetting probe is in contact with a bottom of a tube. The bottom sensing device permits the pipetting probe to measure an exact volume of fluid in the tube by allowing the pipetting tip to be lowered to the bottom of the tube beyond the sensed fluid level.

Abstract: Apparatus and methods for aspirating and dispensing reagents are provided. Aspirating of reagents is accomplished by a probe, a vial insert and reagent vial according to the present invention wherein a seal is formed between the probe and the vial insert when the probe engages the vial insert. Dispensing of reagents is accomplished by a probe and a probe dispense and wash station according to the present invention wherein a seal is formed between the probe and the vial insert when the probe engages the probe dispense and wash station.

Abstract: The invention provides multichannel pipette heads and autopipettors for loading, measuring, transporting and dispensing, particularly from one micro-plate to another. An exemplary multichannel pipette head comprises a pump housing, pistons, a drive plate, an aspiration drive and bearing rails, wherein the pump housing comprises chambers adapted to receive the pistons, the pistons each comprise a shaft, the drive plate retains the pistons and translocates the piston shafts through chambers, the aspiration drive translocates the drive plate along the bearing rails which pass through the drive plate and attach to the pump housing.

Abstract: A method and device for storing and dispensing specified subsets from a collection of tens, hundreds or thousands of different reagents to specified locations within microtitre trays or microarray substrates or the like. The reagents of interest are stored in racks of syringe-like dispensers. These dispensers and/or substrates and/or actuators are controllably moved by automated means to a dispensing position where a single action, vibration and weighing system transfers a controlled quantity to a specified location in a microtitre tray or the like. Deficits of the prior art, such as evaporation, cross-contamination, oxidation, waste of reagents and lab-ware, and human operator non-reliability are overcome.

Abstract: An automatic measuring apparatus comprising an annular conveyor for conveying specimen receptacles each having a top opening and reaction receptacles each having a top opening in an intermixed manner, conveyance means for imparting a drive to the conveyor, dispensing means for acquiring a certain amount of specimen from the specimen receptacles and for discharging it into the reaction receptacles, and transfer means for transferring the dispensing means in both the horizontal and vertical directions, wherein a horizontally extending track of the dispensing means defined by the transfer means coincides with part of a receptacle conveyance track provided by the conveyance means.

Abstract: A pre-filled disposable pipette for pharmaceutical and cosmetic products which has a hollow, round pipette body (40). The body consists of a hollow, rigid bulb section (44) forming a reservoir for storage and dispersion of the liquid pharmaceutical or cosmetic product which is pre-filled within the body. The body (40) further includes a hollow tubular section (46) that is smaller in diameter and contiguous with the bulb section, for ease of handling the pipette. The preferred embodiment has a hollow, frangible upper tube (42) with a distal end that is sealed for introducing air into the body (40) when the seal is broken, thus releasing the liquid from the tubular section. The liquid is dispensed from the body by breaking the upper tube allowing air to enter the pipette with the liquid flowing by gravity. The second embodiment has a resilient bulb section and omits the upper tube. A tapered section (90) is added to the tubular section, with a hollow tip (86) on the end.

Abstract: A pipette tip having at least two separate dispensing channels for dispensing liquid simultaneously into a corresponding number of micro titration wells or other container. The tip has a tubular body with one open end for mounting on a pipette. At the other end of the body, at least two spaced legs extend away from the body, each having a central channel communicating with the tip interior and an end opening. The tips are stored in a rack having an alignment arrangement, such as a ridge on each tip cooperating with a notch in the rack, to assure that all tips are aligned the same. The leg channels can be configured so that different amounts of liquid are dispensed into different micro titration wells in a predetermined pattern. The tip may also be used to transfer liquid from one micro titration plate to another, or any suitable container.

Abstract: A fixed volume liquid transfer device defined by a small bore tube having an open end for collection of liquids and a plunger in the tube is disclosed. A piston is mounted around the open end and an air plug is mounted in the piston adjacent the open end. Liquid in a test tube is transferred to a testing site by inserting the transfer device into the test tube. As the piston contacts the liquid, the liquid is pumped into the tube. As the transfer device is inserted further, the air plug is actuated to balance air pressure across the piston. The device may then be withdrawn from the test tube and transported to a test site. At the test site, the plunger is depressed to expel the liquid into a testing device.

Abstract: A membrane actuated fluid dispensing head apparatus and method for dispensing fluids. The dispenser housing has a top plate, a bottom plate, and a fluid distribution plate disposed between the top and bottom plates. The top plate has fluid inlet means therethrough for admitting pressurized fluid over the distribution plate, the bottom plate having a plurality of elongated hollow pipettes thereon extending away from the top plate and in fluid communication with the fluid distribution plate. A first resilient membrane is disposed between the fluid distribution plate and the bottom plate, the bottom plate having a plurality of spaced cavities thereon having outer peripheries and in fluid communication with the pipettes. A second resilient membrane is disposed between the top plate and the distribution plate having an opening therethrough.

Abstract: The invention provides printing systems and methods for depositing small volumes of liquid on solid substrates. These systems and methods are useful with a wide variety of liquids and substrates and offer a wide variety of applications, including the deposition of arrays of analytes. In particular embodiments, the systems comprise a preservation device, a detachable ganged plurality of printing devices, and/or a wire bonding capillary.

Abstract: A bilaterally symmetrical lightweight hand holdable battery powered microprocessor controlled electronic pipette including an axially elongated hollow housing having a vertically extending longitudinal axis. An upper portion of the housing includes a forward compartment containing a forwardly facing alpha-numeric display, a plurality of columns of forwardly facing control keys and plurality of forwardly facing trigger switches arranged in a vertically spaced pattern such that a user in gripping a lower handle portion of the housing in either his or her right or left hand can easily reach with his thumb the control keys, trigger switches as well as a push button of a pipette tip ejector.