Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q5, R1, R2, R3, Z1 and Z2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
Type:
Grant
Filed:
April 6, 2012
Date of Patent:
July 9, 2013
Assignee:
Achaogen, Inc.
Inventors:
James Bradley Aggen, Paola Dozzo, Adam Aaron Goldblum, Darin James Hildebrandt, Timothy Robert Kane, Micah James Gliedt, Martin Sheringham Linsell
Abstract: Sulfanyl-tetrahydropyran-based compounds, pharmaceutical compositions comprising them, and methods of their use for the treatment of diseases and disorders such as diabetes and obesity are disclosed.
Type:
Grant
Filed:
August 18, 2010
Date of Patent:
July 2, 2013
Assignee:
Lexicon Pharmaceuticals, Inc.
Inventors:
Bryce Alden Harrison, Spencer David Kimball, Ross Mabon, David Brent Rawlins
Abstract: It has been found that a limulus-positive glycolipid is present in xanthan gum derived from Xanthomonas, which has been commercially available and eaten for many years, and this was purified, and it has been found that this limulus-positive glycolipid has an immunopotentiation effect. A method for safely and inexpensively producing the limulus-positive glycolipid containing an immunopotentiator at high concentrations is provided. The method for producing the limulus-positive glycolipid of the present invention comprises extracting the limulus-positive glycolipid from xanthan gum. A limulus-positive glycolipid composition containing the limulus-positive glycolipid can be used for various applications such as pharmaceuticals, pharmaceuticals for animals, quasi drugs, cosmetics, foods, functional foods, feedstuff and bath agents.
Type:
Grant
Filed:
November 2, 2011
Date of Patent:
June 25, 2013
Assignees:
BioMedical Research Group Inc., Macrophi, Inc.
Abstract: Glycolipids of branched chain alkyl oligosaccharides according to this patent comprise of a primary alcohol branched in the 2-position and an oligosaccharide, covalently bond to the alcohol in either ?- or ?-linkage (shown in Formula I and Formula II). These compounds show particularly interesting phase behavior not found for the corresponding straight chain counterparts. The properties involve an ambient temperature liquid crystalline appearance and thermotropic liquid crystal phase polymorphism. Upon the latter, the formation of cubic phases is considered most interesting with respect to life science applications, e.g. liposome for drug delivery. Depending on the choice of sugar head group and alkyl tail, various levels of water miscibility may be adjusted to meet applications requirements (complete solubility for emulsifier applications, e.g. cosmetic creams, to limited water swelling only, e.g. for the preparation of artificial membranes).
Type:
Application
Filed:
November 5, 2012
Publication date:
June 13, 2013
Inventors:
RAUZAH HASHIM, Thorsten HEIDELBERG, Hind HASSAN, Nasrul Zamani MOHD RODZI, Rusnah Syahila DAULI HUSSEN, Ahmad Sazali HAMZAH, Shahidan RADIMAN, Volkmar VILL, Matthias WULF, Seiji UJIIE
Abstract: An object of the present invention is to provide a 3,6-O-bridged pyranose-inverted compound useful for being easy to produce ?-O-pyranosides selectively. The 3,6-O-bridged pyranose-inverted compound according to the present invention is represented by General Formula (1): wherein RA and RB each represent hydrogen or are bonded to each other to form a benzene ring; one of RC and RD represents hydrogen and the other represents —OR2; R1 represents hydroxy or halogen; and R2 and R3 each represent a hydroxy-protecting group.
Abstract: The present disclosure describes tetrahydropyran nucleoside analogs, oligomeric compounds prepared therefrom and methods of using the oligomeric compounds. More particularly, tetrahydropyran nucleoside analogs are provided, having one or more chiral substituents, that are useful for enhancing properties of oligomeric compounds including nuclease resistance and binding affinity. In some embodiments, the oligomeric compounds provided herein hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.
Type:
Grant
Filed:
December 1, 2011
Date of Patent:
May 14, 2013
Assignee:
Isis Pharmaceuticals, Inc.
Inventors:
Eric E. Swayze, Andrew M. Siwkowski, Balkrishen Bhat, Thazha P. Prakash, Charles Allerson, Punit P. Seth
Abstract: Compositions and methods for reducing gas-cell surface interface damage include a protective composition having at least sugar moiety where the sugar moiety provides a hydrophilic component to the protective composition.
Type:
Grant
Filed:
August 27, 2007
Date of Patent:
May 14, 2013
Assignee:
The Ohio State University Research Foundation
Inventors:
Jeffrey J. Chalmers, James F. Rathman, Weiwei Hu
Abstract: The present invention relates to a composition for treatment of obesity using a wheat bran extract or a tachioside or 9,12,13-trihydroxy-10(E)-octadecenoic acid, an active ingredient isolated therefrom. The wheat bran extract or the active ingredients inhibit the expression of PPAR?, C/EBR? and ADD1/SREBP1c, transcription factors which inhibit the differentiation of adipocyte progenitor cells to adipocytes, promoted by insulin, inhibit the accumulation of fats, and are centrally involved in the differentiation of adipocytes.
Type:
Application
Filed:
December 30, 2010
Publication date:
April 25, 2013
Inventors:
Hai Soo Lee, Ok Pho Zee, Joa Sub Oh, Eun Kyung Ahn, Jung A. Lee, Seong Su Hong
Abstract: The present invention provides compounds characterized by the formula (I), where each of the substituent radicals is described in the specification. The invention also describes the use of said compounds in the treatment of various diseases, including: cancer or tumoral processes in general, Paget's disease, hypercalcaemia, hypercalciuria and neurological diseases (inter alia, Parkinson's, Alzheimer's, Huntington's).
Type:
Grant
Filed:
February 4, 2008
Date of Patent:
April 23, 2013
Assignees:
University of Kentucky Research Foundation, Universidad de Oviedo
Inventors:
Jürgen Rohr, Irfan Baig, José Antonio Salas Fernández, Alfredo Fernández Braña, Carmen Méndez Fernández, Mariá Pérez Solares
Abstract: The invention relates to novel fungicidally active compound combinations of 2?-cyano-3,4-dichloroisothiazole-5-carboxanilide of the formula and active compounds listed in the disclosure.
Abstract: The invention concerns novel polyunsaturated compounds of formula (I) wherein: R1 represents a R?1, -A-R?1 group, R?1 being selected from —COOH, —COOR3, —CONH2, —CONHR3, —CONR3 R4, —CHO, —CH2OH, —CH2OR5, and A represents a C2-C16 alkylene, alkenylene or alkynylene; R2 represents: an optionally substituted aryl group or an optionally substituted heteroaryl group; a sugar residue or, a fatty acid residue optionally branched and/or substituted preferably at the chain terminus and particularly by hydroxy, acetoxy radical or by an optionally protected amino radical; a —OC —(CH2)n CO-tocopheryl (alpha, beta or gamma or delta) group, with 2 $m(F) n $m(F) 10; a —R?2—O—R6 group, wherein R?2 is an optionally substituted arylene group or an optionally substituted heteroarylene group, and R6 represents a hydrogen atom, a straight or branched optionally substituted C 1-C 16 alkyl, a straight or branched optionally substituted C2-C16 alkenyl, or a straight or branched C2-C16 alkynyl group, an optionally substituted tocophe
Abstract: The present invention presents the isolation, characterization and synthesis of oligosaccharides of Bacillus anthracis. Also presented are antibodies that bind to such saccharide moieties and various methods of use for such saccharide moieties and antibodies.
Type:
Grant
Filed:
December 24, 2008
Date of Patent:
April 16, 2013
Assignees:
University of Georgia Research Foundation, Inc., The United States of America as represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention
Inventors:
Russell W. Carlson, Geert-Jan Boons, Conrad Quinn, Mahalakshmi Vasan, Margreet A. Wolfert, Biswa Choudhury, Elmar Kannenberg, Christine Leoff, Alok Mehta, Elke Saile, Jana Rauvolfova, Patricia Wilkins, Alex J. Harvey
Abstract: The invention provides nucleoside and nucleotide molecules containing cleavable linkers linking a label such as a dye. The invention also provides nucleosides and nucleotide molecules containing a blocking group, either removable or non-removable. The invention additionally provides methods of using the nucleoside and nucleotide molecules containing a cleavable linker and/or a blocking group.
Type:
Grant
Filed:
September 4, 2007
Date of Patent:
March 19, 2013
Assignee:
Illumina, Inc.
Inventors:
Chanfeng Zhao, Igor Kozlov, Melissa D. Shults
Abstract: The invention disclosed in this document is related to the field of pesticides and their use in controlling pests. A compound having the following structure is disclosed.
Type:
Grant
Filed:
February 11, 2010
Date of Patent:
March 12, 2013
Assignee:
Dow AgroSciences, LLC.
Inventors:
Gary D. Crouse, Thomas C. Sparks, CaSandra L. McLeod, Annette V. Brown, Thomas L. Siddall
Abstract: The protein CD1d binds self and foreign glycolipids for presentation to CD1-restricted T cells by means of TCR recognition, and activates TH1 and TH2 chemokines release. Accordingly, a variety of glycolipid ligands were attached to a microarray surface and their binding with CD1d investigated. An ?-galactosyl ceramide (?-GalCer) bearing a carbamate group at the 6?-OH position was tethered to the surface and the dissociation constant with CD1d determined. Competition assays were used to determine the dissociation constants (Ki) of the new and intact glycolipids. The para-fluoroheptaphenyl-modified ?-GalCer was found to bind most strongly with CD1d (Ki 0.14 ?M), two orders of magnitude stronger than ?-GalCer and more than three times more selective for IFN-? release.
Abstract: The invention disclosed in this document is related to the field of pesticides and their use in controlling pests. A compound having the following structure is disclosed.
Type:
Grant
Filed:
February 11, 2010
Date of Patent:
February 26, 2013
Assignee:
Dow AgroSciences, LLC.
Inventors:
Gary D. Crouse, Thomas C. Sparks, CaSandra Lee McLeod, David A. Demeter, Zoltan L. Benko, Debra L. Camper
Abstract: The present invention provides, for example, a labeling substance that allows the double helix structure of a nucleic acid to be detected effectively. The present invention provides a compound having a structure derived from mononucleoside or mononucleotide, with the structure being represented by the following formula (1), (1b), or (1c), a tautomer or stereoisomer thereof, or a salt thereof. In the above formulae, B is an atomic group having a nucleobase skeleton, E is an atomic group having a deoxyribose skeleton, a ribose skeleton, or a structure derived from either one of them, or an atomic group having a peptide structure or a peptoid structure, and Z11 and Z12 each are a hydrogen atom, a protecting group, or an atomic group that exhibits fluorescence and may be identical to or different from each other.
Abstract: Oligonucleotides with a novel sugar-phosphate backbone containing at least one 2?-arabino-fluoronucleoside and an internucleoside 3?-NH—P(?O)(OR)—O-5? linkage, where R is a positively charged counter ion or hydrogen, and methods of synthesizing and using the inventive oligonucleotides are provided. The inventive phosphoramidate 2?-aribino-fluorooligonucleotides have a high RNA binding affinity to complementary nucleic acids and are base and acid stable.
Abstract: [Object] An object of the present invention is to provide a human sweet taste receptor-acting sweet taste regulating substance to a sweet taste substance by which the advantageous effects such as improvement in a taste, saving of a sweetener, reduction in calorie, low caries etc. can be obtained by applying to various foods and beverages. [Solution] The sweet taste receptor-acting sweet taste regulating substance of the present invention is identified by measurement of a physiological response by a sweet taste substance, using a cultured cell strain which is allowed to express hT1R2 and hT1R3, and a G protein ? subunit, by transferring an expression construct obtained by inserting respective cDNAs encoding the hT1R2 and the hT1R3, and the G protein ? subunit into the same plasmid, into a 293 cell in which an FRT (Flippase Recognition Target) site has been incorporated into one place in a genome DNA.
Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
Type:
Grant
Filed:
April 7, 2011
Date of Patent:
February 12, 2013
Assignee:
Achaogen, Inc.
Inventors:
James Bradley Aggen, Martin Sheringham Linsell, Adam Aaron Goldblum, Darin James Hildebrandt, Timothy Robert Kane, Paola Dozzo, Micah James Gliedt, Heinz Ernst Moser
Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
Type:
Grant
Filed:
April 7, 2011
Date of Patent:
February 5, 2013
Assignee:
Achaogen, Inc.
Inventors:
James Bradley Aggen, Martin Sheringham Linsell, Adam Aaron Goldblum, Darin James Hildebrandt, Timothy Robert Kane, Paola Dozzo, Micah James Gliedt, Heinz Ernst Moser
Abstract: The present invention provides labeled phospholink nucleotides that can be used in place of naturally occurring nucleotide triphosphates or other analogs in template directed nucleic acid synthesis reactions and other nucleic acid reactions and various analyzes based thereon, including DNA sequencing, single base identification, hybridization assays, and others.
Abstract: The present invention relates to the use of a specific family of glycerolipid compounds of formula (I) described in the detailed description or the manufacture of a medicament for the prevention or for the treatment of cancer metastasis.
Type:
Application
Filed:
February 17, 2011
Publication date:
January 31, 2013
Applicants:
UNIVERSITE DE BRETAGNE OCCIDENTALE (U.B.O.), INSERM ( INSTITUT NATIONAL DE LA SANTA ET DE LA RECHERCHE MEDICALE), UNIVERSITE FRANCOIS-RABELAIS DE TOURS
Inventors:
Christophe Vandier, Philippe Bougnoux, Aurelie Chantome, Bernard Corbel, Alban Girault, Jean-Pierre Haelters, Virginie Joulin, Marie Potier-Cartereau, Gaelle Simon
Abstract: The subject invention provides a novel and advantageous method for preventing and treating viral infection. Specifically exemplified herein are therapeutic uses of forsythoside A and jacaranone, compounds isolated from traditional Chinese medicinal material such as Fructus forsythiae (Lian Qiao). Also provided is use of a Yin Qiao San composition for preventing and treating viral infection.
Type:
Application
Filed:
December 30, 2010
Publication date:
January 31, 2013
Inventors:
Allan Sik-Yin Lau, Lai Hung Cindy Yang, Anna Hing-Yee Law
Abstract: The present invention relates to branched polyethyleneglycol (PEG) derivatives consisting of a molecule with a quaternary carbon connected to three PEG chains, wherein all three PEG chains are of equal length and each comprises 1-30 —OCH2CH2— units, and one group with at least one carbon atom, wherein said at least one carbon atom is attached to the quaternary carbon. Also compositions containing such derivatives and use of such derivatives are disclosed.
Abstract: The present invention provides a novel form of 3-(3-{4-[3-(?-D-glucopyranosyloxy)-5-isopropyl-1H-pyrazol-4-ylmethyl]-3-methylphenoxy}propylamino)-2,2-dimethylpropionamide with improved storage stability. Since 3-(3-{4-[3-(?-D-glucopyranosyloxy)-5-isopropyl-1H-pyrazol-4-ylmethyl]-3-methylphenoxy}-propylamino)-2,2-dimethylpropionamide hemifumarate dihydrate has extremely excellent storage stability, it is useful as a drug substance. Furthermore, it shows an extremely good crystalline property and can be purified by a convenient method, and therefore is suitable for the industrial preparation.
Abstract: The present invention pertains to a process for producing three-dimensional, self-supporting and/or substrate-supported formed pieces or structures on surfaces by means of site-selective solidification of a liquid to pasty, organic or organically modified material within a bath consisting of this material by means of two- or multiphoton polymerization, whereby the material has at least one compound that has both an organic radical polymerizable via two-photon or multiphoton polymerization and a biocompatible, biodegradable or bioresorbable group, and/or wherein the bath material additionally contains groups or radicals, which are available for an inorganic crosslinking or which are already inorganically crosslinked, providing that both an organic radical polymerizable via two-photon or multiphoton polymerization and a biocompatible, biodegradable or bioresorbable group must be contained in the material.
Type:
Application
Filed:
February 8, 2011
Publication date:
January 10, 2013
Inventors:
Ruth Houbertz-Krauss, Matthias Beyer, Joern Probst, Thomas Stichel
Abstract: The invention provides amphiphiles for manipulating membrane proteins. The amphiphiles can feature carbohydrate-derived hydrophilic groups and branchpoints in the hydrophilic moiety and/or in a lipophilic moiety. Such amphiphiles are useful as detergents for solubilization and stabilization of membrane proteins, including photosynthetic protein superassemblies obtained from bacterial membranes.
Type:
Application
Filed:
September 10, 2012
Publication date:
January 3, 2013
Applicants:
UCHICAGO ARGONNE, LLC, WISCONSIN ALUMNI RESEARCH FOUNDATION
Inventors:
Samuel Helmer GELLMAN, Pil Seok CHAE, Phillip D. LAIBLE, Marc J. WANDER
Abstract: Compounds of general formula (I) for the treatment of inflammatory processes involved in numerous diseases such as intestinal inflammatory diseases. The invention moreover refers to compounds included within such general formula and to the procedure of the obtainment thereof.
Type:
Application
Filed:
December 14, 2010
Publication date:
December 6, 2012
Applicant:
Consejo Superior de Investigaciones Cientificas (CSIC)
Inventors:
Juan Carlos Espin De Gea, Juan Carlos Morales Sánchez, Isabel Medina Mendez
Abstract: The present invention relates to a method for preparation of the tetrasaccharide lacto-N-neotetraose (LNnt, formula (I)) especially in large scale, as well as intermediates in the synthesis, a new crystal form (polymorph) of LNnt, and the use thereof in pharmaceutical or nutritional compositions.
Type:
Application
Filed:
February 21, 2011
Publication date:
December 6, 2012
Applicant:
GLYCOM A/S
Inventors:
István Bajza, Gyula Dekany, Károly Ágoston, Ignacio Pérez Figueroa, Julien Boutet, Markus Hederos, Ferenc Horváth, Piroska Kovács-Pénzes, Lars Kröger, Christoph Röhrig, Andreas Schroven, Ioannis Vrasidas, Péter Trinka, László Kalmár, Irme Kovács, Sándor Demkó, Ágnes Ágoston, Christian Risinger
Abstract: Methods for treating or preventing cardiomyopathy in a subject by administering an ?1 adrenergic receptor agonist, wherein the treatment does not result in increased blood pressure are provided.
Type:
Grant
Filed:
November 2, 2009
Date of Patent:
December 4, 2012
Assignee:
The Regents of the University of California
Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein Q1 and Q2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
Type:
Grant
Filed:
November 14, 2011
Date of Patent:
November 27, 2012
Assignee:
Achaogen, Inc.
Inventors:
Adam Aaron Goldblum, Paola Dozzo, Timothy Robert Kane, James Bradley Aggen, Martin Sheringham Linsell, Darin James Hildebrandt, Micah James Gliedt
Abstract: A pheromonal compound produced by Caenorhabditis elegans has been identified as 5R-(3?-O-[?-D-glucosyl]-tetrahydro-3?R,5?R-dihydroxy-6?S-methyl-2H-pyran-2?R-yloxy)-2-hexanone. The novel compound, in combination with other ascarosides, elicit a synergistic signaling response from various adult male Caenorhabditis spp.
Type:
Grant
Filed:
January 30, 2009
Date of Patent:
November 27, 2012
Assignees:
The United States of America, as represented by the Secretary of Agriculture, California Institute of Technology
Inventors:
Peter E. A. Teal, Hans T. Alborn, Paul W. Sternberg, Jagan Srinivasan, Arthur S. Edison, Fatma Kaplan, Frank C. Schroeder
Abstract: A silver nanocomposite, a formation method for forming the silver nanocomposite, and an application method utilizing the silver nanocomposite. The silver nanocomposite includes a silver nanoparticle conjugated to a glycosaminoglycan (GAG) or glucose. The formation method includes chemically reacting silver nitrate with a reducing agent to form a silver nanoparticle conjugated to the reducing agent of a GAG or glucose. The application method may include topically applying the silver nanocomposite to a wound or burn as an anti-microbial with respect to an antibiotic-resistant genotype in the wound or burn, wherein the silver nanocomposite topically applied includes the silver nanoparticle conjugated to the GAG of 2,6-diaminopyridinyl heparin (DAPHP) or hyaluronan (HA). The application method may include applying the silver nanocomposite as a coating to plastic, a catheter, or a surgical tool, wherein the silver nanocomposite applied as the coating includes the silver nanoparticle conjugated to the GAG of DAPHP.
Abstract: Nucleotide triphosphate probes containing a molecular and/or atomic tag on a ? and/or ? phosphate group and/or a base moiety having a detectable property are disclosed, and kits and method for using the tagged nucleotides in sequencing reactions and various assay. Also, phosphate and polyphosphate molecular fidelity altering agents are disclosed.
Type:
Grant
Filed:
December 29, 2006
Date of Patent:
November 20, 2012
Assignee:
Life Technologies Corporation
Inventors:
Susan H. Hardin, Xiaolian Gao, James Briggs, Richard Willson, Shiao-Chun Tu
Abstract: Fire extinguishing compositions and methods of extinguishing a fire comprising compounds of formula (I) where Rf is a fluorocarbon group. The compounds and compositions described herein are useful as intermediates in the preparation of or as additives to AFFF (aqueous film forming foam) formulations used for the extinguishment of fuel and solvent fires.
Abstract: The present invention relates to a liquid crystal compound that can be used as a base for injection formulations. The present invention provides an amphipathic compound having the following general formula (I): wherein X and Y each denotes a hydrogen atom or together denote an oxygen atom, n denotes an integer from 0 to 2, m denotes the integer 1 or 2, and R denotes a hydrophilic group generated by removal of one hydroxyl group from any one selected from the group consisting of glycerol, erythritol, pentaerythritol, diglycerol, triglycerol, xylose, sorbitol, ascorbic acid, glucose, galactose, mannose, dipentaerythritol, maltose, mannitol, and xylitol; as well as a base for injection formulations and depot formulation comprising the same.
Abstract: The present invention describes novel compounds and methods for capping reactive groups on support and during multistep synthesis. These new capping reagents are also useful for high quality synthesis on solid supports and surfaces used as microarrays, biosensors, or in general as biochips. The compounds are also useful for controlling surface density of reactive groups on a support. The compounds may also be used to modify the hydrophilic/hydrophobic characteristics of a surface or a molecule. The compounds have functional utility in various applications in the fields of genomics, proteomics, diagnostics and medicine.
Abstract: A reactive cyclodextrin derivative or a reactive glucose derivative is used as a template derivative for forming an ultra-low dielectric layer. A layer is formed of the reactive cyclodextrin derivative or the reactive glucose derivative capped with Si—H and then cured in an atmosphere of hydrogen peroxide to form the ultra-low dielectric layer.
Type:
Application
Filed:
May 18, 2012
Publication date:
September 13, 2012
Applicant:
HYNIX SEMICONDUCTOR INC.
Inventors:
Sung Kyu MIN, Ja Chun KU, Sang Tae AHN, Chai O CHUNG, Hyeon Ju AN, Hyo Seok LEE, Eun Jeong KIM, Chan Bae KIM
Abstract: The invention provides amphiphiles for manipulating membrane proteins. The amphiphiles can feature carbohydrate-derived hydrophilic groups and branchpoints in the hydrophilic moiety and/or in a lipophilic moiety. Such amphiphiles are useful as detergents for solubilization and stabilization of membrane proteins, including photosynthetic protein superassemblies obtained from bacterial membranes.
Type:
Grant
Filed:
April 8, 2009
Date of Patent:
September 11, 2012
Assignees:
Wisconsin Alumni Research Foundation, UChicago Argonne, LLC
Inventors:
Samuel Helmer Gellman, Pil Seok Chae, Philip D. Laible, Marc J. Wander
Abstract: Nucleic acid compositions, methods of making and using such compositions that comprise modular functional groups that can be configured to provide desired functionality to different nucleotide types through a swappable and preferably non-covalent linkage component. Such compositions are useful in a variety of applications including nucleic acid analyses.
Abstract: There is disclosed nucleotides and nucleotide analogs having a protecting or “caging” group. There is further disclosed oligonucleotides and oligonucleotides analogs formed having a protecting or “caging” group. There is further disclosed a method for decaging the nucleotides and nucleotide analogs having a protecting or “caging” group and oligonucleotides and oligonucleotide analogs having a caging group.
Abstract: The present invention provides branched water-soluble polymers that allow two or more water-soluble polymers to be conjugated to another species. The branched polymers provide access to therapeutic agents that are conjugated at a single site to two or more water-soluble polymers. The branched polymers are based upon branch points that are simple branched alkyl structures, reactive side-chain amino acids and small peptides of reactive side-chain amino acids, and saccharides. Also provided is a method for preparing mono-disperse poly(ethylene glycol) of a well-defined and determinable molecular weight, and a method for the rational end-functionalization of poly(ethylene glycol). Conjugates of the branched water-soluble polymers with diverse species, e.g., peptides, lipids, glycolipids and small molecules are also provided.
Abstract: The present invention relates to the use of glycan-binding polypeptides and glycans as a medicament, in particular for treating and/or preventing helminthic infections or an immune disease. Moreover, the present invention is directed to corresponding pharmaceutical compositions, food products and animal feed comprising isolated glycans and/or glycan-binding polypeptides. In addition, the present invention teaches methods for identifying anti-helminthic carbohydrate-binding polypeptides, for identifying helminthic glycan and gene targets involved in glycan-mediated toxicity, for identifying helminths susceptible to glycan-mediated toxicity, and for identifying anti-helminthic and anti-allergic substances.
Type:
Application
Filed:
October 12, 2010
Publication date:
August 16, 2012
Applicants:
UNIVERSITY OF ZURICH, ETH ZURICH
Inventors:
Markus Kunzler, Martin Walti, Alex Butschi, Markus Aebi, Michael Hengartner
Abstract: A saponin or a sapogenin, or a saponin or sapogenin derivative, from a plant of the capsicum genus for use in the treatment of a disease other than eczema and dermatitis. A process for preparing a plant of the capsicum genus, extracts, or seeds thereof for use as a medicament suitable for the treatment of diseases other than skin conditions which process comprises storing the plant, extracts or seeds thereof at a temperature of 20° C. or below.
Abstract: This invention relates to compounds represented by formula (I): wherein the variables are defined as herein above, which are useful for treating diseases and conditions mediated by the sodium D-glucose co-transporter (SGLT), e.g. diabetes. The invention also provides methods of treating such diseases and conditions, and compositions etc. for their treatment.
Type:
Application
Filed:
October 20, 2010
Publication date:
August 2, 2012
Applicant:
NOVARTIS AG
Inventors:
Gregory Raymond Bebernitz, Mark Gary Bock, Debnath Bhuniya, Laxmikant Datrange, Suresh Eknath Kurhade, P. Venkata Palle, Dumbala Srinivas Reddy
Abstract: The present invention provides novel methods for determining the presence or amount of a hydrolytic enzyme in a sample, based on novel substrates for the enzymes, and also provides compositions and methods that provide highly sensitive assay methods for such hydrolytic enzymes.