Abstract: High refractive index and optically clear copoly(carbosilane and siloxane) elastomers and ophthalmic lenses made therefrom are provided. The elastomers are comprised of copolymers having carbosilane repeat units and siloxane repeat units. The copolymers and ophthalmic lenses of the present invention have a high refractive index and excellent folding recoverability.

Abstract: An intraocular lens suitable for implantation into an eye has an optically clear, deformable lens body composed of a silicone polymer and a silica reinforcer that structurally reinforces the polymer. The silica reinforcer is chemically modified with aryl groups effective to increase the refractive index of the silica reinforcer, preferably so as to substantially match the refractive index of the silicone polymer.

Abstract: The present invention is concerned with biomedical device comprising (a) a biocompatible organic or inorganic bulk material and (b) a coating comprising polymerizable carbon-carbon double bonds covalently attached to at least part of the bulk surface. The biomedical devices of the invention are radiation sensitive and may be used, for example, as ready-to-use corneal onlay in ophthalmic surgery.

Abstract: Polymerizable compositions for making transparent polymeric substrates, resulting transparent polymeric substrates and the applications thereof in optics. The composition comprises: from 35 to 70 parts by weight of one or more monomers (I) of formula: ?wherein R1 and R2 represent H or CH3, A is a divalent moiety of formula: ?m1 and m2 each are an integer in the range of 4 to 20, from 5 to 50 parts by weight of a monomer (II) comprising at least a urethane unit and at least two (meth)acrylate functions, and from 5 to 40 parts by weight of a monomer (III) with a high Abbe number and comprising one or more methacrylate functions, the total of the monomers (I), (II) and (III) representing 100 parts by weight.

Abstract: A method of deriving a prediction model and calculating a predicted lens power to provide a desired post-operative spherical equivalent to correct myopia in a phakic eye of a patient using an intraocular lens includes measuring and determining the predictive significance of certain pre-operative characteristics of the eye, including cycloplegic and manifest spherical equivalent, vertex distance, anterior chamber depth, axial length, and keratometry. The prediction model is derived using multiple regression analysis on the pre-operative and post operative data. Measured data corresponding to a particular patient is used in the lens power prediction model to calculate the predicted lens power for implantation in the patient.

Abstract: The present invention provides an ophthalmic lens capable of correcting or minimizing presbyopia, or of functioning used as an anti-myopic lens. The ophthalmic lens can be a contact lens, a phakic intraocular lens or an aphakic intraocular lens. The ophthalmic lens comprises an optical zone, the optical zone having a first surface and an opposite second surface and including a coma-like wavefront aberration oriented vertically from the top to the bottom of the ophthalmic lens. In addition, the present invention provides a method for minimizing/correcting presbyopia or for preventing children's eyes from becoming severely myopic.

Abstract: The present invention is directed to a coated biomedical device said micelle having a hydrophilic outer shell and a hydrophobic inner core, or a hydrophobic outer shell and a hydrophilic inner core said micelle comprised of a block copolymer having a HLB value ranging from about 1 to about 40. The medical device may have one coating thereon or multiple coatings. The present invention is also directed to the use of the micelle as a drug carrier.

Abstract: A process for producing silicone-containing prepolymers capable of absorbing blue light for use in the production of relatively high refractive index polymeric compositions is described herein. Polymeric compositions so produced are useful in the production of ophthalmic devices such as for example intraocular lenses and corneal inlays.

Abstract: In an insertion device for deforming a deformable intraocular lens to a smaller size and inserting the intraocular lens into an eye via an insertion tube, a slit is formed in an insertion end portion of the insertion tube, and cut surfaces of the slit and at least the inner wall surface of the insertion end portion are connected by curved surfaces.

Abstract: An artificial vision system including a sealed capsule adapted for intraocular placement upstream of a retina, an electronic display located within the sealed capsule and focusing optics located within the sealed capsule and arranged for focusing an image on the electronic display onto the retina.

Abstract: Optically transparent, relatively high refractive index polymeric compositions and ophthalmic devices such as intraocular lenses, corneal inlays and contact lenses made therefrom are described herein. The preferred polymeric compositions are produced through the polymerization of one or more aromatic-based siloxane macromonomers or the copolymerization of one or more aromatic-based siloxane macromonomers with one or more non-siloxy aromatic-based monomers, non-aromatic-based hydrophobic monomers or non-aromatic-based hydrophilic monomers.

Abstract: Relatively high refractive index polymeric compositions and ophthalmic devices such as for example intraocular lenses and corneal inlays made therefrom are described herein. The preferred polymeric compositions are produced through the copolymerization of one or more aromatic-substituted polysiloxane prepolymers with one or more aromatic monomers, alkylated monomers or hydrophilic monomers.

Abstract: An intraocular lens assembly and method. The assembly comprises an optic disc and an annulus surrounding the optic disc. Hinges connect the optic disc to the annulus to permit anterior and posterior movement of the optic disc relative to the annulus in response to contraction and relaxation of the ciliary muscle so that the eye accommodates to focus on a near object. The method comprises the steps of placing in the posterior chamber an optic disc and an annulus. The annulus surrounds the optic disc and is connected to it by hinges that permit anterior and posterior movement of the optic disc relative to annulus in response to contraction and relaxation of the ciliary muscle whereby said eye accommodates to focus on a near object.

Abstract: The present invention relates to a process for the manufacture of a porous polymer; wherein a composition comprising a polymerizable component, a porogen having an inverse temperature dependent solubility and a solvent are polymerized at a temperature around the cloud point temperature of the composition. The porous polymers obtainable according to the process of the invention are useful, for example, as materials for the manufacture of biomedical devices and prostheses, including ophthalmic devices such as contact lenses or artificial corneas.

Abstract: Optically transparent, relatively high refractive index polymeric compositions and ophthalmic devices such as intraocular lenses, contact lenses and corneal inlays made therefrom are described herein. The preferred polymeric compositions are produced through the polymerization of one or more aromatic-based silyl monomers or the copolymerization of one or more aromatic-based silyl monomers with one or more aromatic or non-aromatic non-siloxy-based monomers, hydrophobic monomers or hydrophilic monomers.

Abstract: An insertion system for an intraocular lens having a deformable optical portion and loop-shaped support portions for supporting the optical portion within an eye includes a holding member for holding the intraocular lens at a standby position in a state in which no stress acts on the optical portion of the lens; a deforming member for deforming the lens to a reduced size; an insertion tube through which the deformed lens is inserted into the eye; a pusher mechanism having a push rod for pushing and inserting the lens into the eye; and a lens moving mechanism for moving the lens from the standby position to an insertion position at which the pusher mechanism can push and insert the lens into the eye. When the lens is moved to the insertion position, the optical portion and the support portions of the lens are placed in different spaces in order to fix the positional relationship between the optical portion and the support portions of the lens.

Abstract: Solid rigid acrylic copolymer materials, useful for forming ophthalmic devices, are processed into the shape of an ophthalmic device, such as an intraocular lens and are then processed into a foldable form. The acrylic copolymer material has polymer units derived from an ?,?-ethylenically unsaturated carboxylic acid monomer, such as, (meth)acrylic acid, 1-butenoic acid, and the like, and an aryl(meth)acrylate monomer, such as, phenyl(meth)acrylate, 2-ethyloxy(meth)acrylate, and the like. The processing into a foldable shape may be accomplished by contacting the rigid material, having a Tg of 25° C. or higher, with an alcohol, preferably in the presence of acid catalyst, to lower the Tg to 20° C. or less.

Abstract: Optically transparent, relatively high refractive index polymeric compositions and ophthalmic devices such as intraocular lenses and corneal inlays made therefrom are described herein. The preferred polymeric compositions are produced through the polymerization of one or more copolymers with one or more hydrophilic monomers and optionally one or more aromatic-based monomers, hydrophobic monomers or a combination thereof.

Abstract: A compound favored with low viscosity, capable of providing a cured product having high refractive index, and suitable for application to optical materials, including plastic lens material, radical polymerizable flame retardant and the like, as well as a process for producing the compound, a plastic lens composition using the compound, a plastic lens obtained by curing the composition and a process for producing the plastic lens. A novel aromatic ring-containing polyvalent (meth)allyl ester derived from a polyvalent carboxylic acid of trivalent or greater valent is employed.

Abstract: Optically transparent, relatively high refractive index polymeric compositions and ophthalmic devices such as intraocular lenses, contact lenses and corneal inlays made therefrom are described herein. The preferred polymeric compositions are produced through the polymerization of one or more aromatic-based silyl monomers or the copolymerization of one or more aromatic-based silyl monomers with one or more aromatic or non-aromatic non-siloxy-based monomers, hydrophobic monomers or hydrophilic monomers.

Abstract: Apparatus, and methods of making and using apparatus, for inserting intraocular lenses (IOLs) are disclosed. The apparatus includes a hollow tube having an interior wall defining a hollow space through which an intraocular lens may be passed from the open space into an eye. A lubricity enhancing component is covalently bonded to the hollow tube at the interior wall in an amount effective to facilitate the passage of the intraocular lens through the hollow space. The lubricity enhancing component includes a substituent component effective to reduce hydrolysis of said lubricity enhancing component relative to an identical lubricity enhancing component without the substituent component.

Abstract: Methods, apparatus and systems for measuring pressure and/or for quantitative or qualitative measurement of analytes within the eye or elsewhere in the body. Optical pressure sensors and/or optical analyte sensors are implanted in the body and light is cast from an extracorporeal light source, though the cornea, conjunctiva or dermis, and onto a reflective element located within each pressure sensor or analyte sensor. The position or configuration of each sensor's reflective element varies with pressure or analyte concentration. Thus, the reflectance spectra of light reflected by the sensors' reflective elements will vary with changes in pressure or changes in analyte concentration. A spectrometer or other suitable instrument is used to process and analyze the reflectance spectra of the reflected light, thereby obtaining an indication of pressure or analyte concentration adjacent to the sensor(s).

Abstract: The present invention relates to lenses that are capable of post-fabrication power modifications. In general, the inventive lenses comprise (i) a first polymer matrix and (ii) a refraction modulating composition that is capable of stimulus-induced polymerization dispersed therein. When at least a portion of the lens is exposed to an appropriate stimulus, the refraction modulating composition forms a second polymer matrix. The amount and location of the second polymer matrix may modify a lens characteristic such as lens power by changing its refractive index and/or by altering its shape. The inventive lenses have a number of applications in the electronics and medical fields as data storage means and as medical lenses, particularly intraocular lenses, respectively.

Abstract: An intraocular implant for implantation into the interior of a human eye, the eye having a retina, the implant comprising a body member and an optical arrangement. The body member has an anterior surface, a posterior surface and optical properties. The optical arrangement is configured for forming a first image on the retina. The first image is an image of at least part of the central visual field. The body member and/or the optical arrangement are configured for forming a second image on the retina. The second image is an image of at least part of the peripheral visual field.

Abstract: This invention includes a wettable biomedical device containing a high molecular weight hydrophilic polymer and a hydroxyl-functionalized silicone-containing monomer.

Abstract: The present invention provides monofocal ophthalmic lenses that exhibit extended depth of field while providing sufficient contrast for resolution of an image over a selected range of defocus distances. In some embodiments, a lens of the invention can include a refractive surface having controlled surface modulations relative to a base profile. The surface modulations are designed to extend a depth of field of the lens such that a single image can be resolved, albeit with somewhat less contrast, over a range of distances greater than the focal region of a conventional lens. The ophthalmic lenses of the invention can be employed in various vision correction applications, including, but not limited to, intraocular lenses, contact lenses, instrastromal implants and other refractive devices.

Abstract: A high gain lens system for implant into the capsular bag after removal of the natural crystalline lens. A preferred embodiment of the invention comprises a combination of a positive or convex lens and a negative or concave lens. These two lenses are spaced from one another and their relative spacing and respective focal lengths determine their combined focal length. When the lens system is inserted into the capsular bag, two opposed haptic flanges on each side, extend toward the inner radial edge of the bag adjacent the ciliary muscles. When the muscles contract, the bag is stretched thereby compressing the haptic flanges together or at least toward one another. This action cause the two lenses to separate further from each other and the increased spacing between the positive and negative lenses shortens the focal length to permit focusing of objects at near distances. On the other hand, when the muscles relax, the bag relaxes also, the haptic flanges separate and the lenses come closer together.

Abstract: Disclosed are soft, high refractive index, acrylic device materials having improved strength. The materials contain cross-linked acrylate or methacrylate microspheres.

Abstract: Methods for the creation of microspheres treat the clear, intact crystalline lens of the eye with energy pulses, such as from lasers, for the purpose of correcting presbyopia, other refractive errors, and for the retardation and prevention of cataracts. Microsphere formation in non-contiguous patterns or in contiguous volumes works to change the flexure, mass, or shape of the crystalline lens in order to maintain or reestablish the focus of light passing through the ocular lens onto the macular area, and to maintain or reestablish fluid transport within the ocular lens.

Abstract: An intraocular lens for use in a mammalian eye having a natural lens, the intraocular lens including a lens body sized and adapted for placement in the eye, and having a baseline optical power and at least one optical add power. The at least one optical add power is reduced relative to the corresponding optical power of a similar intraocular lens adapted for placement in a similar eye in which the natural lens has been removed.

Abstract: An adjustable ocular insert to be implanted during refractive cataract surgery and clear (human) crystalline lens refractive surgery and adjusted post-surgically. The implant comprises relatively soft but compressible and resilient base annulus designed to fit in the lens capsule and keep the lens capsule open. Alternatively the annulus may be placed in the anterior or posterior chamber. The annulus can include a pair of opposed haptics for secure positioning within the appropriate chamber. A rotatable annular lens member having external threads is threadedly engaged in the annulus. The lens member is rotated to move the lens forward or backward so to adjust and fine-tune the refractive power and focusing for hyperopia, myopia and astigmatism. The intraocular implant has a power range of approximately +3 {square root}0 &pgr; −3 diopters.

Abstract: Macromolecular photocrosslinkers have polymeric backbones of substituted siloxane groups carrying photoactive groups. When exposed to light of wavelength above 305 nm, the photocrosslinkers are adapted to generate radicals which are retained on the macromolecular photocrosslinker and react to form a crosslinked network structure. The photocrosslinkers may be used in the production of medical devices, including ophthalmic lenses.

Abstract: An artificial vision system including a sealed capsule adapted for intraocular placement upstream of a retina, an electronic display located within the sealed capsule and focusing optics located within the sealed capsule and arranged for focusing an image on the electronic display onto the retina.

Abstract: The invention related to a hydrogel forming aqueous composition of water soluble polymers having a sufficiently high coherency that it substantially not is dispersed when being injected into an aqueous environment of a body site such as the capsular bag of the eye to undergo a photoinitiated crosslinking reaction. The water soluble polymers either can be a water-soluble polymer bearing free acrylic, or other vinylic groups capable of facile free radical reaction with a polymeric water-soluble photoinitiator also present in the composition, or a water-soluble polymer bearing both free acrylic, or other vinylic groups capable of facile free radical reaction and photoinitiator, wherein both polymers are capable of being crosslinked when irradiated with light of wavelengths greater than about 305 nm to form the hydrogel.

Abstract: The present invention discloses methods of obtaining ophthalmic lens capable of reducing the aberrations of the eye comprising the steps of characterizing at least one corneal surface as a mathematical model, calculating the resulting aberrations of said corneal surface(s) by employing said mathematical model, selecting the optical power of the intraocular lens. From this information, an ophthalmic lens is modeled so a wavefront arriving from an optical system comprising said lens and corneal model obtains reduced aberrations in the eye. Also disclosed are ophthalmic lenses as obtained by the methods which are capable reducing aberrations of the eye.

Abstract: Covalently-bound, hydrophilic copolymer coatings for implants are disclosed. The copolymer coatings comprise a hydrophobic aryl acrylic monomer, a hydrophilic monomer selected from the group consisting of hydroxyalkyl (meth)acrylates, n-vinyl pyrrolidone and acrylamides, and a reactive plasticizer.

Abstract: Ophthalmic lenses, such as intraocular lenses, include cross-linked polymeric materials having a first constituent derived from a first monomeric component selected from the group consisting of acrylates, methacrylates and mixtures thereof, and a second constituent derived from a second component in an amount effective as a cross linker in the cross-linked polymeric material. The cross-linked polymeric material has branched chain alkyl groups, preferably included with at least a portion of the first monomeric component, in an amount effective to reduce the tackiness of the cross-linked polymeric material relative to a substantially identical cross-linked polymeric material without the branched chain alkyl groups.

Abstract: A photocurable resin composition comprising: (A) a urethane (meth)acrylate produced by reacting at least a polyether polyol with a number average molecular weight of 500 or more having an alkyleneoxy structure in the molecule, an organic polyisocyanate compound, and a (meth)acrylate containing a hydroxyl group; (B) a monofunctional (meth)acrylate shown by the following formula (1), wherein R1 represents a hydrogen atom or a methyl group, R2 represents —(CH2CH2O)p—, —(CH(CH3)CH2O)q—, or —CH2CH(OH)CH2O—, Y1, Y2, and Y3 individually represent a hydrogen atom, bromine atom, alkyl group having 1-10 carbon atoms, phenyl group, or —C(CH3)2C6H5—, and p and q represent integers from 0 to 10; and (C) a photoinitiator; its use and optical parts prepared from the photocurable resin composition.

Abstract: Foldable intraocular lenses having a reduced risk of posterior capsule opacification are disclosed. The foldable intraocular lenses have optics that are prepared such that their surface is glassy and their bulk is rubbery.

Abstract: Optically transparent, high refractive index hydrogels and intraocular lenses fabricated therefrom. The preferred hydrogels have a refractive index of 1.45 or above and a water content of approximately 5 to 30 percent by weight.

Abstract: Optically transparent, relatively high refractive index polymeric compositions and ophthalmic devices such as intraocular lenses and corneal inlays made therefrom are described herein. The preferred polymeric compositions are produced through the polymerization of one or more copolymers with one or more hydrophilic monomers and optionally one or more aromatic-based monomers, hydrophobic monomers or a combination thereof.

Abstract: A method of manufacturing an intraocular lens that has been customized to provide optimum vision for an eye with prior corneal refractive surgery. Such a custom manufactured IOL will address not only optical correction requirements as currently met by spherical or toric-shaped IOLs, but will correct higher order optical aberrations using needed optimum customized shapes.

Abstract: Collars are disposed on loops of intraocular lenses for improved fixation of loops in rims of capsular bags of eyes. A collar may preferably be positioned on an outer portion of a loop and retained on the loop by an enlarged end portion of the loop.

Abstract: The present invention provides extended depth of field to human eyes by modifying contact lenses, intraocular implants, and/or the surface of the eye itself. This may be accomplished by applying selected phase variations to these optical elements (e.g., by varying surface thickness of the cornea of the eye). The phase variations EDF-code the wavefront and cause the optical transfer function to remain essentially constant within a range of distances from the in-focus position. This provides a coded image on the retina. The human brain decodes this coded image, resulting in an in-focus image over an increased depth of field.

Abstract: Optically transparent, high refractive index hydrogels and intraocular lenses fabricated therefrom. The preferred hydrogels have a refractive index of 1.45 or above and a water content of approximately 5 to 30 percent by weight.

Abstract: Optically transparent, high refractive index hydrogels and intraocular lenses fabricated therefrom. The preferred hydrogels have a refractive index of 1.45 or above and a water content of approximately 5 to 30 percent by weight.

Abstract: Optically transparent, high refractive index hydrogels and intraocular lenses fabricated therefrom. The preferred hydrogels have a refractive index of 1.45 or above and a water content of approximately 5 to 30 percent by weight.

Abstract: Disclosed are soft, high refractive index, acrylic materials having an elongation of at least 150%. These materials, especially useful as intraocular lens materials, contain an aryl acrylic hydrophobic monomer as the single principal device-forming monomer. In addition to their use as intraocular lens materials, the present materials are also suitable for use in other ophthalmic or otorhinolaryngological devices, such as contact lenses, keratoprostheses, corneal inlays or rings; otological ventilation tubes and nasal implants.

Abstract: The present invention relates to a process for the manufacture of a porous polymer, wherein a composition comprising a polymerizable component, a porogen having an inverse temperature dependent solubility and a solvent are polymerized at a temperature around the cloud point temperature of the composition. The porous polymers obtainable according to the process of the invention are useful, for example, as materials for the manufacture of biomedical devices and prostheses, including ophthalmic devices such as contact lenses or artificial corneas.

Abstract: A composition for plastic lenses having a viscosity suitable for application to plastic lens materials and other optical materials and capable of giving a cured material having a relatively high refractive index and a low specific gravity, a plastic lens obtained by curing the composition, and a process for producing the plastic lens. A specific dicarboxylic acid component and a specific diol component are employed and the ratio of the components is adjusted to provide the composition for plastic lenses.