Patents Represented by Attorney Edward A. Conroy, Jr.

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  • Compositions and method of use to treat arthritic disease with m-fluorobenzimidoylacetonitrile
    Patent number: 4167580
    Abstract: This disclosure describes compositions of matter useful as anti-inflammatory agents and as inhibitors of the progressive joint deterioration characteristic of arthritic disease, and the methods of meliorating inflammation and of inhibiting joint deterioration in mammals therewith, the active ingredients of said compositions of matter being benzimidoylacetonitrile, meta-fluorobenzimidoylacetonitrile, para-fluorobenzimidoylacetonitrile, or mixtures thereof.
    Type: Grant
    Filed: September 13, 1978
    Date of Patent: September 11, 1979
    Assignee: American Cyanamid Company
    Inventor: Adolph E. Sloboda
  • 6- AND 7-Aryl-1,2,4-triazolo[4,3-b]-1,2,4-triazines
    Patent number: 4159375
    Abstract: This application discloses 6- or 7-(o-, m- or p-substituted-phenyl)-1,2,4-triazolo[4,3-b]-1,2,4-triazines useful as anxiolytic agents.
    Type: Grant
    Filed: August 24, 1978
    Date of Patent: June 26, 1979
    Assignee: American Cyanamid Company
    Inventors: Ronald I. Trust, Jay D. Albright
  • 3-Chromonecarboxamido derivatives of penicillins
    Patent number: 4159268
    Abstract: This disclosure describes compounds of the class of 6-[D-.alpha.-(substituted-chromone-3-carboxamido)phenylacetamido]-penicill anic acids which possess antimicrobial activity.
    Type: Grant
    Filed: March 24, 1978
    Date of Patent: June 26, 1979
    Assignee: American Cyanamid Company
    Inventors: William V. Curran, Adma S. Ross
  • 10-(Piperazinyl)thieno[3,4-b][1,5]benzoxazepines and 10-(piperazinyl)thieno[3,4-b][1,5]benzothiazepines
    Patent number: 4157444
    Abstract: This disclosure describes 10-[4-(substituted)-1-piperazinyl]thieno[3,4-b][1,5]benzoxazepines and 10-[4-(substituted-1-piperazinyl]thieno[3,4-b][1,5]benzothiazepines useful as anti-psychotic or neuroleptic agents.
    Type: Grant
    Filed: March 13, 1978
    Date of Patent: June 5, 1979
    Assignee: American Cyanamid Company
    Inventors: Jeffery B. Press, Sidney R. Safir
  • Alkylated derivatives of antibacterial agents cis-BM123.gamma..sub.1 and cis-BM123.gamma..sub.2
    Patent number: 4154925
    Abstract: This disclosure describes a novel series of potent antibacterial agents designated alkylated-cis-BM123.gamma..sub.1 and alkylated-cis-MB123.gamma..sub.2 produced by a novel photolytic process whereby alkylated-trans-BM123.gamma..sub.1 and alkylated-trans-BM123.gamma..sub.2 are transformed to their corresponding cis-isomers. The new antibacterial agents are active against a variety of microorganisms and thus are useful in inhibiting the growth of such bacteria wherever they may be found.
    Type: Grant
    Filed: January 19, 1977
    Date of Patent: May 15, 1979
    Assignee: American Cyanamid Company
    Inventor: Joseph J. Hlavka
  • Heterocyclic substituted benzylideneaminoguanidines
    Patent number: 4154947
    Abstract: This disclosure describes novel substituted benzylideneaminoguanidines useful as anti-hypertensive agents and as diuretics.
    Type: Grant
    Filed: March 13, 1978
    Date of Patent: May 15, 1979
    Assignee: American Cyanamid Company
    Inventors: Leon Goldman, Joseph W. Marsico, Jr.
  • 2-Substituted-4'-(monoalkylamino)-acetophenones
    Patent number: 4154756
    Abstract: This disclosure describes 2-substituted 4'-(monoalkylamino)-acetophenones useful as hypolipidemic and anti-atherosclerotic agents.
    Type: Grant
    Filed: December 15, 1977
    Date of Patent: May 15, 1979
    Assignee: American Cyanamid Company
    Inventor: Robert G. Shepherd
  • Cycloalkyl and cycloalkenyl prostaglandin congeners
    Patent number: 4152524
    Abstract: This disclosure describes novel 15-hydroxy prostanoic acids and derivatives thereof useful as bronchodilators and hypotensive agents.
    Type: Grant
    Filed: January 6, 1977
    Date of Patent: May 1, 1979
    Assignee: American Cyanamid Company
    Inventors: Robert E. Schaub, Martin J. Weiss
  • Polysubstituted-alkyl esters of 4-alkylaminobenzoic acids
    Patent number: 4146546
    Abstract: Compounds of the formula: ##STR1## or pharmaceutically acceptable salts thereof wherein R.sub.4 is an unbranched or branched alkyl group C.sub.n H.sub.2n+1 wherein n is 8 to 19, having the ability to arrest the development of atheromatous lesions as well as to lower serum sterols and triglycerides in warm-blooded animals, are disclosed.
    Type: Grant
    Filed: October 12, 1977
    Date of Patent: March 27, 1979
    Assignee: American Cyanamid Company
    Inventors: Robert G. Shepherd, Thomas G. Miner
  • Thieno[3,4-b][1,5]benzoxazepin-10-ones and thieno[3,4-b][1,5]benzothiazepin-10-ones
    Patent number: 4144235
    Abstract: This disclosure describes novel substituted thieno[3,4-b][1,5]benzoxazepin-10 (9H)-ones and thieno[3,4-b][1,5]benzothiazepin-10(9H)-ones which are useful as intermediates for the preparation of 10-[4-(substituted)-1-piperazinyl]thieno[3,4-b][1,5]benzoxazepines and 10-[4-(substituted)-1-piperazinyl]thieno[3,4-b][1,5]benzothiazepines which possess anti-psychotic or neuroleptic activity.
    Type: Grant
    Filed: March 13, 1978
    Date of Patent: March 13, 1979
    Assignee: American Cyanamid Company
    Inventors: Jeffery B. Press, Sidney R. Safir
  • Novel 11-deoxy-11-substituted prostaglandins of the E and F series
    Patent number: 4141914
    Abstract: This disclosure describes 11-deoxy-11-substituted members of the E.sub.2, F.sub.2, E.sub.1, F.sub.1, dihydro E.sub.1 and dihydro F.sub.1 prostaglandin series which are useful as hypotensive agents and as anti-ulcer agents.
    Type: Grant
    Filed: July 24, 1972
    Date of Patent: February 27, 1979
    Assignee: American Cyanamid Company
    Inventors: Charles V. Grudzinskas, Martin J. Weiss
  • Antibiotic BL580.DELTA. and method of use
    Patent number: 4138481
    Abstract: This disclosure describes a new antibiotic designated BL580.DELTA. produced in a microbiological fermentation under controlled conditions using a new strain of Streptomyces hygroscopicus and mutants thereof. This new antibiotic is an active anticoccidial agent.
    Type: Grant
    Filed: January 4, 1977
    Date of Patent: February 6, 1979
    Assignee: American Cyanamid Company
    Inventors: John H. E. J. Martin, Martin R. Hertz
  • 1,4-Bis(aminoalkylamino)-anthraquinones and leuco derivatives thereof
    Patent number: 4138415
    Abstract: This disclosure describes 1,4-bis(substituted-amino)-5,6-dihydroxyanthraquinones and 1,4,5-tris(substituted-amino)-8-hydroxyanthraquinones useful as chelating agents, as curing catalysts for epoxy resins, and for inhibiting the growth of transplanted mouse tumors.
    Type: Grant
    Filed: May 5, 1978
    Date of Patent: February 6, 1979
    Assignee: American Cyanamid Company
    Inventors: Keith C. Murdock, Ralph G. Child
  • 4-(Monoalkylamino)benzoic acid imidates
    Patent number: 4136256
    Abstract: This disclosure describes 4-(monoalkylamino)benzoic acid amides and imidates useful as hypolipidemic and antiatherosclerotic agents.
    Type: Grant
    Filed: September 27, 1977
    Date of Patent: January 23, 1979
    Assignee: American Cyanamid Company
    Inventor: Robert G. Shepherd
  • Compositions of matter and method of use to treat arthritic disease
    Patent number: 4134990
    Abstract: This disclosure describes compositions of matter useful as anti-inflammatory agents and as inhibitors of the progressive joint deterioration characteristic of arthritic disease, and the methods of meliorating inflammation and of inhibiting joint deterioration in mammals therewith, the active ingredients of said compositions of matter being benzimidoylacetonitrile, meta-fluorobenzimidoylacetonitrile, para-fluorobenzimidoylacetonitrile, or mixtures thereof.
    Type: Grant
    Filed: November 22, 1977
    Date of Patent: January 16, 1979
    Assignee: American Cyanamid Company
    Inventor: Adolph E. Sloboda
  • Antibiotic BL580 Zeta and use thereof as anticoccidial agent
    Patent number: 4132779
    Abstract: This disclosure describes a new antibiotic designated BL580 ZETA produced in a microbiological fermentation under controlled conditions using a new strain of Streptomyces hygroscopicus and mutants thereof. This new antibiotic is an active anticoccidial agent.
    Type: Grant
    Filed: June 20, 1977
    Date of Patent: January 2, 1979
    Assignee: American Cyanamid Company
    Inventors: Martin R. Hertz, John H. E. J. Martin
  • Method of stimulating leukemic immune response
    Patent number: 4132797
    Abstract: Various acylaminotetramisoles have been shown to be effective leukemic immunostimulant agents.
    Type: Grant
    Filed: June 20, 1977
    Date of Patent: January 2, 1979
    Assignee: American Cyanamid Company
    Inventors: Frederick E. Durr, Martin R. Damiani
  • 2-Aryloxy-2-(phenoxyalkoxy)phenyl acetic acid and esters
    Patent number: 4125732
    Abstract: This disclosure describes substituted 2-aryloxy-2-(para-phenoxyalkoxy)phenylacetic acids and esters and salts thereof useful as hypolipidemic agents.
    Type: Grant
    Filed: May 6, 1977
    Date of Patent: November 14, 1978
    Assignee: American Cyanamid Company
    Inventors: Francis J. McEvoy, Jay D. Albright
  • Alkylated derivatives of antibiotic BM123.gamma.
    Patent number: 4123607
    Abstract: This disclosure describes a novel series of potent antibacterial agents derived by reductive alkylation of antibiotic BM123.gamma. with certain classes of aldehydes and ketones.
    Type: Grant
    Filed: May 31, 1977
    Date of Patent: October 31, 1978
    Assignee: American Cyanamid Company
    Inventors: Joseph J. Hlavka, Panayota Bitha
  • Antibacterial antibiotics AM31.alpha., AM31.beta. and AM31.gamma.
    Patent number: RE29903
    Abstract: This disclosure describes a novel class of antibiotics, three of which have been designed AM31.alpha., AM31.beta., and AM31.gamma. and are produced in a microbiological fermentation under controlled conditions using a new strain of Streptoverticillium netropsis.
    Type: Grant
    Filed: February 22, 1977
    Date of Patent: February 6, 1979
    Assignee: American Cyanamid Company
    Inventors: Jane P. Kirby, Donald B. Borders