Abstract: Compounds of formula (I) ##STR1## or a pharmaceutically acceptable salt thereof, wherein R.sup.1 is hydrogen, halogen or alkyl and R.sup.2 is hydrogen or alkyl are useful to reduce serum lipids in animals, including humans.
Abstract: A plastic toothpaste dispenser containing an aqueous toothpaste that includes a flavoring oil and a non-toxic oil in an amount effective to reduce the loss of the flavoring oil escaping through the plastic dispenser.
Abstract: The invention involves polyclonal antibodies reactive with a complex of a hapten and its binding protein, wherein the antibodies are unreactive with the free hapten or free binding protein. The antibodies are useful in assays of the hapten or the binding protein.
Abstract: A compound of formula (I): ##STR1## or a salt or solvate thereof in which R.CO is an acyl group in which R is of formula (II) ##STR2## in which R.sub.3 is Br, NO.sub.2 or CF.sub.3 ; and, R.sub.1 and R.sub.2 are independently C.sub.1-6 alkyl or together form a C.sub.3-6 polymethylene or alkylene group, is useful for treating pain.
Type:
Grant
Filed:
August 31, 1987
Date of Patent:
May 2, 1989
Assignee:
Dr. Lo Zambeletti S.p.A.
Inventors:
Vittorio Vecchietti, Massimo Signorini, Antonio Giordani
Abstract: The present invention provides a quinoline base compound represented by the following general formula (1) of: ##STR1## wherein X is CH.sub.2, O or S. Further provided are the process for the preparation of the aforementioned quinoline base compound and an anticancer agent including the same as a pharmacologically efficacious component.
Abstract: Antibacterially active 6-carbamate erythromycin derivatives of formula I and their pharmaceutically acceptable esters and acid addition salts; ##STR1## wherein: R.sup.1 or R.sup.2 is optionally substituted amino, or R.sup.1 or R.sup.2 +R.sup.5 is --O--C(R.sup.A)(R.sup.B)--O--, and R.sup.2 or R.sup.1 is H, or R.sup.1 +R.sup.2 is oxo, oxime, substituted oxime, or imino;R.sup.3 is carbamoyl or N-substituted carbamoyl;R.sup.4 is H or OH, and R.sup.5 is OH, or etherified hydroxy, or R.sup.4 +R.sup.5 is --O--CO--O-- or --O--C(R.sup.A) (R.sup.B)--O--;R.sup.6 is H, F or OH;R.sup.7 is H or CH.sub.3 ;R.sup.8 or R.sup.9 is H, OH, alkoxy, optionally substituted NH.sub.2, alkanoyloxy, or R.sup.C --SO.sub.2 O--, and R.sup.9 or R.sup.8 is H, or R.sup.8 +R.sup.9 is oxo or optionally substituted oxime;R.sup.A, R.sup.B are H or hydrocarbon; andR.sup.C is organic.
Abstract: A sealant tape, which comprises a deformable, tacky butyl rubber strip having top and bottom surfaces, a layer of an elastic abrasion-resistant rubber laminated to said top surface, and a strippable release member covering said bottom surface.
Abstract: Novel solid antibacterial compositions suitable for use in an oil or gas well comprise at least 50% by weight of a solid antibacterial nitroalkanol compound active against sulphate-reducing bacteria and a carrier, the composition having a density of at least 1.2 g/cm.sup.3 and being adapted to dissolve, disintegrate or disperse in water but not in oil. A preferred antimicrobial compound is 2-bromo-2-nitropropane-1,3-diol. The antibacterial compositions are introduced into the aqueous layer in the sump at the bottom of the collecting system of the oil or gas well. This inhibits corrosion in the metal work of the oil or gas well, for example the pipe lines of the collecting system.
Type:
Grant
Filed:
November 21, 1986
Date of Patent:
April 11, 1989
Assignees:
Oilfield Speciality Products Manufacturing Ltd., of Canada, The Boots Company, plc, of England
Inventors:
John M. McLennan, Keith D. Brunt, Walter G. Guthrie
Abstract: Antibacterial agents have the formula (I) or are pharmaceutically acceptable salts or in vivo hydrolysable esters thereof: ##STR1## wherein R.sup.3 is phenyl, substituted phenyl, cyclohexenyl, cyclohexadienyl or an optionally substituted 5- or 6-membered heterocyclic ring containing up to three hetero atoms selected from oxygen, sulphur or nitrogen, R.sup.4 is hydrogen or formamido, R.sup.5 is hydrogen, C.sub.1-6 alkyl, substituted alkyl, aryl or aralkyl, R.sup.6 and R.sup.7 are the same or different and represent hydrogen, C.sub.1-6 alkyl, substituted alkyl, halogen, amino, phenyl, substituted phenyl, hydroxyl or C.sub.1-6 alkoxy or R.sup.6 and R.sup.7 form the residue of an optionally substituted 5- or 6-membered carbocyclic ring or a 5- or 6- membered heterocyclic ring containing up to three hetero atoms selected from oxygen, sulphr or nitrogen, and X represents ##STR2## or tautomers thereof wherein R.sup.8 and R.sup.9 are the same or different and each represents hydroxy, or protected hydroxy.
Abstract: This invention concerns a liquid distribution system consisting of modular elements fitted with two or more outlets. Each modular element (1) has an external jacket (2) through which one or more tubular ducts (3) pass, each receiving two opposed stopcocks or control valves (15) connecting or shutting off the branch pipes (4) from the internal ports (9, 10) through which the liquid flows, these inner ports (9, 10) being fitted with a projection (12) and recess (11) fitting for assembly of the various elements so as to form the distribution system, the branch pipes (4) being fitted with a spike base (27) to be inserted into the flower pot or into the flower bed, the system permitting the obtaining of a perfect and homogeneous distribution of the liquid at a minimum pressure, low costs, limited space requirements and easy installation.
Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt or in-vivo hydrolysable ester thereof: ##STR1## wherein R.sup.1 is hydrogen or an amino protecting group and R is substituted methyl; optionally substituted C.sub.2-12 alkyl, alkenyl or alkynyl; carbocyclyl; aryl or heterocyclyl. These compounds have antibacterial properties, and therefore are of use in the treatment of bacterial infections in humans and animals caused by a wide range of organisms.
Abstract: Compounds of formula I ##STR1## in which R.sub.1 is C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.3-7 cycloalkyl, cycloalkylalkyl or optionally substituted phenyl; R.sub.2 is H or C.sub.1-3 alkyl; R.sub.3 and/or R.sub.4 are H, formyl, C.sub.1-3 alkyl, C.sub.3-6 alkenyl, C.sub.3-6 alkynyl, C.sub.3-7 cycloalkyl or R.sub.3 and R.sub.4 together with the nitrogen atom form a heterocyclic ring system; R.sub.5 and/or R.sub.6 are H, halo, CF.sub.3, C.sub.1-3 alkyl, C.sub.1-3 alkoxy, C.sub.1-3 alkylthio or R.sub.5 and R.sub.6 together with the carbon atoms to which they are attached form a second benzene ring show therapeutic activity in the treatment of depression. Pharmaceutical compositions and processes for preparing compounds of formula I are disclosed.
Type:
Grant
Filed:
May 1, 1987
Date of Patent:
March 21, 1989
Assignee:
The Boots Company PLC
Inventors:
James E. Jeffery, Antonin Kozlik, Eric C. Wilmshurst
Abstract: A laser generator with a catalyst for the laser gas is provided comprising a cavity which communicates with a housing receiving a catalytic cartridge, which communicates also with a laser gas reserve, and which is subjected to the action of the heat released by the laser effect. The cartridge contains, inside a mechanical filter, granules of zeolite on which a manganese dioxide catalyst has been fixed. The generator, whose output power is stabilized, has a long lifespan.
Abstract: A compound of the formula (I) ##STR1## wherein R is a group ##STR2## R.sup.1 is hydrogen, phenyl, C.sub.1-20 alkyl, C.sub.2-8 alkenyl or C.sub.2-8 alkynyl each of which may optionally be substituted; or C.sub.3-7 cycloalkyl,X is a divalent group --Y--C.dbd.C--, andY is oxygen or sulphur,have antibacterial and/or antimycoplasmal activity.
Type:
Grant
Filed:
February 25, 1983
Date of Patent:
March 14, 1989
Assignee:
Beecham Group p.l.c.
Inventors:
Norman H. Rogers, Peter J. O'Hanlon, Graham Walker, Michael J. Crimmin
Abstract: Apparatus for shielding an area of an aircraft from the adverse effects of a fire, which comprises a wall for enclosing at lease a portion of the area of the aircraft to be shielded, a highly water-absorbent polymer operatively associated with the wall, a reservoir for storing water, conduits for establishing liquid communication between the reservoir and the polymer, and a device for delivering water from the reservoir to the polymer via the conduits.
Abstract: A compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein all the symbols are defined in the specification; having pharmacological activity, including blood pressure lowering activity, a process and intermediates for their preparation and their use as pharmaceuticals.
Type:
Grant
Filed:
June 6, 1986
Date of Patent:
March 14, 1989
Assignee:
Beecham Group p.l.c.
Inventors:
John M. Evans, Geoffrey Stemp, Frederick Cassidy
Abstract: A binary complex between streptokinase and plasminogen is prepared in which the catalytic site essential for fibrinolytic activity is blocked by a group which is removable by hydrolysis such that the pseudo-first order rate constant for hydrolysis of the complex is in the range 10.sup.-6 sec.sup.-1 to 10.sup.-3 sec.sup.-1 in isotonic aqueous media at pH 7.4 at 37.degree. C. The complex is preferably a p-anisoyl streptokinase/plasminogen complex without internal peptide bond cleavage. The complex is useful in the treatment of venous thrombosis.
Type:
Grant
Filed:
August 29, 1986
Date of Patent:
February 28, 1989
Assignee:
Beecham Group p.l.c.
Inventors:
Richard A. G. Smith, John G. Winchester
Abstract: Compounds of the formula ##STR1## as defined in the specification, and processes for their preparation and methods of using the compounds for the treatment of hypertension in mammals, such as humans and for the treatment and/or prophylaxis of cerebrovascular disorders and/or disorders associated with cerebral senility in mammals, such as humans.
Type:
Grant
Filed:
July 30, 1986
Date of Patent:
February 28, 1989
Assignee:
Beecham Group p.l.c.
Inventors:
John M. Evans, Geoffrey Stemp, Charles D. Nicholson, Dieter Angersbach