Patents Assigned to Advanced Cardiovascular Systems
  • Rapid-exchange delivery systems for self-expanding stents
    Patent number: 7867271
    Abstract: A catheter assembly is provided having an inner member and an outer member extending along a longitudinal axis, the inner member and the outer member having a coaxial configuration and dimensioned for relative axial movement. The outer member may include an anti rotation member adapted to engage with a longitudinal slot formed on the inner member so as to maintain rotational alignment between inner member and outer member. The inner member can be made with a proximal portion made from a tubing such as hypotubing or a coil tubing. The inner member also may be made with a proximal portion made with a support mandrel. A coil tubing can be utilized to form the guide wire receiving member which is attached to the inner member.
    Type: Grant
    Filed: November 20, 2003
    Date of Patent: January 11, 2011
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Timothy A. Geiser, Charles R. Peterson, Andy Denison, Stephanie Klocke, Samir Patel, Joanna Lubas, Joanne Lumauig, Kathy Lind, Keif Fitzgerald
  • Radiation or drug delivery source with activity gradient to minimize edge effects
    Patent number: 7862495
    Abstract: A radiation delivery source, such as a stent, and method for making radioactive a delivery source are disclosed. A drug delivery source and method for making a drug delivery region on the drug delivery source are also disclosed.
    Type: Grant
    Filed: May 31, 2001
    Date of Patent: January 4, 2011
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Brandon James Yoe, Arthur Au
  • Method and apparatus for spray processing of porous medical devices
    Patent number: 7854958
    Abstract: Thermal spray processing and cold spray processing are utilized to manufacture porous starting materials (such as tube stock, wire and substrate sheets) from biocompatible metals, metal alloys, ceramics and polymers that may be further processed into porous medical devices, such as stents. The spray processes are also used to form porous coatings on consolidated biocompatible medical devices. The porous substrates and coatings may be used as a reservoir to hold a drug or therapeutic agent for elution in the body. The spray-formed porous substrates and coatings may be functionally graded to allow direct control of drug elution without an additional polymer topcoat. The spray processes are also used to apply the drug or agent to the porous substrate or coating when drug or agent is robust enough to withstand the temperatures and velocities of the spray process with minimal degradation.
    Type: Grant
    Filed: March 18, 2009
    Date of Patent: December 21, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventor: Pamela A. Kramer
  • Tissue regeneration
    Patent number: 7854944
    Abstract: A method including positioning a delivery device at a location in a vessel within a mammalian body, introducing a first treatment agent including a cellular component through the delivery device, and introducing a different second treatment agent disposed in a carrier through the delivery device. A method including identifying an infarct region within myocardial tissue and a border region of perfused tissue adjacent the infarct region, introducing a treatment agent including a cellular component to the border region, and introducing a plurality of microparticles to the infarct region. A kit including a treatment agent including a cellular component in a form suitable for percutaneous delivery, and a separate amount of a plurality of microparticles in a form suitable for percutaneous delivery.
    Type: Grant
    Filed: December 17, 2004
    Date of Patent: December 21, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Evgenia Mandrusov, Charles Claude, Eugene T. Michal
  • Drug diffusion barriers for a catheter assembly
    Patent number: 7850643
    Abstract: Materials having barrier characteristics are used with a balloon of a catheter assembly and a sheath for covering the balloon. The barrier materials prevent significant absorption of therapeutic substances used in association with the balloon, for example via a medicated prosthesis, into the balloon wall or the sheath. Accordingly the quantity and concentration of the therapeutic substances are preserved. Materials which can serve as a barrier include barrier polymers, polymers with additive fillers, polymers with a metallic coating, metallic films, polymers with a main group element oxide coating, and sulfonated or fluorinated polymers. For the sheath, materials such as glass and metals also function effectively.
    Type: Grant
    Filed: September 27, 1999
    Date of Patent: December 14, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventor: Stephen D. Pacetti
  • Vulnerable plaque treatment
    Patent number: 7846147
    Abstract: A method including introducing a treatment device via a transluminal route within a blood vessel to a treatment site including a vulnerable plaque; and dispensing a treatment agent including a compound having a property that tends to modify a property of a content of the vulnerable plaque. A kit including a first treatment agent including a property capable of modifying a property of a content of a vulnerable plaque; and a different second treatment agent. A composition including a treatment agent capable of modifying the mobility of a content of a vulnerable plaque in a form and concentration suitable for dispensing through a catheter into a blood vessel.
    Type: Grant
    Filed: November 18, 2004
    Date of Patent: December 7, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventor: Edwin Y. Wang
  • Guidewire with chemical sensing capabilities
    Patent number: 7842012
    Abstract: A guidewire with a sensor which can detect NO and/or superoxide levels is disclosed. This invention can be useful for in vivo analysis of vascular health.
    Type: Grant
    Filed: February 3, 2006
    Date of Patent: November 30, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Jeffrey T. Ellis, Robert D. Ainsworth, Deborah L. Kilpatrick, Alex Q. Tilson, Bridget A. Hurley
  • Hinged short cage for an embolic protection device
    Patent number: 7842064
    Abstract: A filtering device for capturing and removing embolic debris from a body vessel and a system for insertion and removal of the filtering device to facilitate an interventional procedure in a stenosed or occluded region of a body vessel. The filtering device is adapted to be expandable in the body vessel, allowing blood to pass therethrough while maintaining apposition with the body vessel wall and capturing embolic material released into the bloodstream during the interventional procedure, and to be collapsible to remove the captured embolic material from the body vessel. The filtering device includes a guidewire, an expandable cage assembly secured to the guide wire, filter material secured to the expandable cage assembly, and at least one hinge, the hinge allowing the expandable cage assembly to bend independent from the guide wire.
    Type: Grant
    Filed: August 1, 2006
    Date of Patent: November 30, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Benjamin C. Huter, Kevin M. Magrini, John E. Papp
  • Method and apparatus to prevent reperfusion injury
    Patent number: 7837650
    Abstract: Embodiments of a method and apparatus to prevent reperfusion injury. In one embodiment, blood flow proximal to a lesion is occluded. An infusion catheter is advanced to a region distal to the lesion and an anti-reperfusion injury drug is delivered. The lesion may then be treated with a dilating device to reintroduce blood flow to the region distal to the lesion.
    Type: Grant
    Filed: December 30, 2004
    Date of Patent: November 23, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Daniel L. Cox, Hongzhi Bai, Paul Consigny, Jessica G. Chiu
  • METHODS OF FABRICATING STENTS WITH ENHANCED FRACTURE TOUGHNESS
    Publication number: 20100289191
    Abstract: Stents and methods of manufacturing a stents with enhanced fracture toughness are disclosed.
    Type: Application
    Filed: July 28, 2010
    Publication date: November 18, 2010
    Applicant: Advanced Cardiovascular Systems, Inc.
    Inventors: DAVID C. GALE, Bin Huang, Timothy A. Limon, Vincent J. Gueriguian
  • Catheter shaft junction having a polymeric multilayered sleeve with a low processing temperature outer layer
    Patent number: 7833193
    Abstract: One aspect of the invention is directed to a balloon catheter with a multilayered polymeric sleeve at the rapid exchange intermediate section, having an outer layer formed of a polymer with a relatively low processing temperature (i.e., melting temperature for semi-crystalline polymers or glass transition temperature for amorphous polymers), and having an inner layer.
    Type: Grant
    Filed: January 14, 2010
    Date of Patent: November 16, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventor: Jeong S. Lee
  • Polymeric marker with high radiopacity for use in medical devices
    Patent number: 7833597
    Abstract: High radiopacity is achieved in a polymeric marker by combining a polymeric resin, a powdered radiopaque agent having uniformly shaped particles of a specific particle size distribution and a wetting agent. The method to produce the marker calls for the blending and pelletization of these materials followed by extrusion onto support beading. The resulting supported tubing is subsequently cut to length with the beading still in place. After ejection of the beading remnant the marker is slipped into place on the device to be marked and attached by melt bonding. Marking of a guidewire allows lesions to be measured while the marking of balloon catheters allow the balloon to be properly positioned relative to a lesion.
    Type: Grant
    Filed: October 24, 2007
    Date of Patent: November 16, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Vincent Peter Bavaro, John Arthur Simpson, Peter D'Aquanni, Aaron Baldwin
  • Stent mandrel fixture and method for reducing coating defects
    Patent number: 7833566
    Abstract: A stent mandrel fixture for supporting a stent during the application of a coating substance is provided.
    Type: Grant
    Filed: October 6, 2008
    Date of Patent: November 16, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Fuh-Wei Tang, Syed F. A. Hossainy, Dorrie Happ, Ty T. Hu
  • Severable support for a stent
    Patent number: 7833261
    Abstract: A stent with at least one severable supporting device and methods of coating using the same are disclosed. The severable supporting device can be an end tube or a tab attached to some portion of the stent by at least one “gate” or attachment. The end tube or tab may be part of the design of the stent when it is originally manufactured, or it may be attached to the stent in a secondary process by a biocompatible glue or solder. The end tube or tab can be used to support a stent during a coating process eliminating the need for a mandrel which would otherwise contact the stent during the coating process.
    Type: Grant
    Filed: December 12, 2005
    Date of Patent: November 16, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Yung-Ming Chen, Eric Aldenbrook
  • Cord locking mechanism for use in small systems
    Patent number: 7828819
    Abstract: A locking device that can be used to adjust a cord of a small system or a medical device. The locking device includes an outer housing having a first lumen. A cord is disposed within the first lumen where the cord is freely moveable through the first lumen. A locking mechanism is disposed within the first lumen and over the cord. The locking mechanism is configured to lock or unlock the cord relative to the outer housing. An actuator is configured to move the locking mechanism to lock or unlock the cord relative to the outer housing.
    Type: Grant
    Filed: December 17, 2003
    Date of Patent: November 9, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: William E. Webler, Dwight A. Ambat
  • Non-compliant multilayered balloon for a catheter
    Patent number: 7828766
    Abstract: A balloon catheter having a multi-layered balloon which has a first layer and at least a second layer, and which has noncompliant limited radial expansion beyond the nominal diameter of the balloon. By selecting the polymeric materials forming the balloon layers, and arranging and radially expanding the multiple layers of the balloon in accordance with the invention, a balloon is provided having an improved low compliance, preferably in combination with high flexibility and softness.
    Type: Grant
    Filed: December 20, 2005
    Date of Patent: November 9, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventor: Jonathan P. Durcan
  • COATING ABLUMINAL SURFACES OF STENTS AND OTHER IMPLANTABLE MEDICAL DEVICES
    Publication number: 20100276857
    Abstract: A sleeve is positioned over a radially-expandable rod assembly and a stent is positioned over the sleeve. A mandrel is inserted into the rod assembly to thereby press the sleeve against the inner surface of the stent and expand the stent. A coating (such as a solvent, a polymer and/or a therapeutic substance) is then applied to the outer (abluminal) surfaces of the stent, by spraying, for example. The sleeve advantageously prevents the coating material from being applied to inner (luminal) surfaces of the stent and also allows the coating material to be efficiently applied to the abluminal surfaces.
    Type: Application
    Filed: July 8, 2010
    Publication date: November 4, 2010
    Applicant: Advanced Cardiovascular Systems Inc.
    Inventors: Yung Ming Chen, Jeff H. Smith, Celenia Gutierrez
  • Stent with drug coating
    Patent number: 7824441
    Abstract: Coatings for stents that include a polymer and a drug are provided. A method of forming the coatings is also provided.
    Type: Grant
    Filed: November 8, 2006
    Date of Patent: November 2, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Veronica J. Santos, Santosh Prabhu
  • Stent fixture and method for reducing coating defects
    Patent number: 7823533
    Abstract: A stent fixture for supporting a stent during formation of a coating is provided.
    Type: Grant
    Filed: June 30, 2005
    Date of Patent: November 2, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Yung-Ming Chen, Allan Bradshaw, Philip C. Foreman, Greg Teaby
  • Stent with drug coating
    Patent number: 7824440
    Abstract: Coatings for stents that include a polymer and a drug are provided. A method of forming the coatings is also provided.
    Type: Grant
    Filed: October 12, 2006
    Date of Patent: November 2, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Veronica J. Santos, Santosh Prabhu