Abstract: Provided is a lung cancer biomarker containing a DDR2 protein or a DDR2 gene, or a mutant thereof, i.e., the following (a), (b) and (c): (a) overexpressed DDR2 protein or DDR2 gene; (b) overexpressed DDR2 protein or DDR2 gene mutant; and (c) DDR2 protein or DDR2 gene mutant.

Abstract: A method of determining the condition of the oral cavity in a subject is provided by using an analytical tool comprising the following (A), (B), and (C): (A) a reagent for measuring one or more parameters that reflect the dental caries risk for a test sample obtained from the oral cavity, (B) a reagent for measuring one or more parameters that reflect the periodontal disease risk for the test sample obtained from the oral cavity, and (C) a reagent for measuring one or more parameters that reflect the degree of oral cleanliness for the test sample obtained from the oral cavity.

Abstract: An analytical tool for use in analysis of a sample is provided. The analytical tool includes a first unit and a second unit. The first unit has an analysis portion where analysis is performed. The second unit, configured to be coupled with the first unit, has a liquid reservoir for confining a particular liquid used for the analysis of the sample. When the first unit and the second unit are coupled, a fluid passage for conducting the particular liquid from the liquid reservoir into the first unit is formed by only a part of the first unit, or only a part of the second unit, or a combination of respective parts of the first unit and the second unit.

Abstract: An electrophoresis chip that can be small and simple and that can analyze a sample with high accuracy is provided. The electrophoresis chip includes an upper substrate 4, a lower substrate 1, an introduction reservoir 2a, a recovery reservoir 2b and a capillary channel for sample analysis 3x. The introduction reservoir 2a and the recovery reservoir 2b are formed in the lower substrate 1. The introduction reservoir 2a and the recovery reservoir 2b are in communication with each other via the capillary channel for sample analysis 3x. The introduction reservoir 2a receives a sample to be measured. The sample is electrophoretically introduced directly into the capillary channel for sample analysis 3x by creating a potential difference between the introduction reservoir 2a and the recovery reservoir 2b, and is also analyzed in the capillary channel for sample analysis 3x during the separation of the sample while the sample is being continuously supplied.

Abstract: Provided is a stilbazolium derivative represented by the general formula (I): wherein R1, R2, R3, and R4 independently represent hydrogen, halogen, alkyl, hydroxyl, carboxyl, or amino; R5 represents hydrogen or alkyl; X represents oxygen or NR6 (R6 is hydrogen or alkyl); and Y? represents an anion. In the general formula (I), some or all of hydrogens maybe deuterium.

Abstract: Provided is a measurement system for performing qualitative measurement and quantitative measurement of a measurement item of a biological sample, the measurement system including a quantitative sample adjustment criterion storage section that stores a quantitative sample adjustment criterion corresponding to a qualitative measurement result in the qualitative measurement, a determination section that determines a proper quantitative sample adjustment condition by referring to the quantitative sample adjustment criterion to determine necessity to change the quantitative sample adjustment condition based on the qualitative measurement result, and an adjustment section that adjusts the biological sample based on the quantitative sample adjustment condition determined by the determination section.

Abstract: An object of the present invention is to provide a biological sample measurement device having a high throughput obtained by being capable of early determining whether or not change of a washing condition is necessary. Provided is a biological sample measurement device including a measurement section that performs measurement of a biological sample, and a washing section that washes a biological sample contact portion, the biological sample contact portion contacting the biological sample during the measurement, the biological sample measurement device further including a characteristic judgment portion that judges a characteristic of the biological sample before the measurement by the measurement section is completed, and a washing control section that determines a washing method by the washing section based on the characteristic judged by the characteristic judgment section.

Abstract: Provided is a method for measuring the concentration of a substance in a blood sample, the method comprising the steps of: supplying the blood sample to a biosensor comprising a hematocrit electrode for measuring a hematocrit value on the surface of which electrode an electrically conductive polymer is coated by physical adsorption in the absence of a crosslinking agent; and calculating the concentration of the substance from the measured value of a first current resulting from application of a first voltage; and correcting the concentration of the substance with the value of a second current resulting from application of a second voltage or the hematocrit value calculated from the value of the second current.

Abstract: Provided is a method for measuring the concentration of a substance in a blood sample, comprising: supplying the blood sample to a biosensor comprising a hematocrit electrode for measuring a hematocrit value on the surface of which electrode an electrically conductive polymer is covalently immobilized; and calculating the concentration of the substance from the measured value of a first current resulting from application of a first voltage; and correcting the concentration of the substance with the value of a second current resulting from application of a second voltage or the hematocrit value calculated from the value of the second current.

Abstract: In a measurement situation information storage unit, a plurality of sets of measurement situation information for identifying a measurement situation in which predetermined measurement is performed on a measurement target are stored in association with time periods. A measurement processing unit executes measurement on the measurement target. A display unit selects, from among the plurality of sets of measurement situation information, a set of measurement situation information corresponding to the measurement operation timing based on the time of the measurement operation timing or based on processing results obtained as a result of execution of measurement by the measurement processing unit, and causes a display to show the selected set of measurement situation information in a manner distinguishable from other measurement situation information.

Abstract: A specimen supplying tool in which structure is simple, and a liquid specimen and air bubbles do not remain within a through-bore for introduction of a specimen, is provided. The specimen supplying tool includes a substrate 11 and a through-bore 13 provided in the substrate 11. One opening of the through-bore 13 is a specimen inflow port, and the other opening of the through-bore 13 is a specimen outflow port. The specimen supplying tool further includes a projection portion 14 projecting from a part p of a marginal part of the specimen outflow port. A liquid specimen is introduced from the specimen inflow port to the through-bore 13. When the introduced liquid specimen is discharged from the specimen outflow port, and supplied to a specimen analyzing instrument, the liquid specimen is drawn to the projection portion 14, led by the projection portion 14, and supplied to the specimen analyzing instrument.

Abstract: Provided is a treatment method for damaging an erythrocyte and a leukocyte while suppressing damage to cells other than blood cells present in blood. In an embodiment, the disclosure relates to a method for treating a sample containing blood components, the method including mixing a sample containing blood components with a surfactant A, where the surfactant A is a nonionic surfactant represented by General formula R1—O-(EO)n-R2 (I).

Abstract: A method for assaying bilirubin in which a dry reagent is used, which is capable of accelerating the reaction of bilirubin oxidase, and an assay instrument to be used in the method for assaying bilirubin, are provided. The method for assaying bilirubin is characterized in that a biological sample and a bilirubin oxidase-containing dry reagent are mixed first, and then the mixture obtained and a surfactant-containing dry reagent are mixed. An assay instrument (1) to be used in bilirubin assay is characterized in that a bilirubin oxidase and a surfactant are arranged in any of a sample supply part (11), passages (12, 13, 14), and a detection part (15) in a manner such that the bilirubin oxidase is positioned closer to the sample supply part (11) than the surfactant is.

Abstract: Provided is a treatment method for damaging an erythrocyte and a leukocyte while suppressing damage to cells other than blood cells present in blood. In an embodiment, the disclosure relates to a method for treating a sample containing blood components, the method including mixing a sample containing blood components with a surfactant A, where the surfactant A is a nonionic surfactant represented by General formula R1—O-(EO)n-R2 (I).

Abstract: The present invention relates to a blood analysis apparatus X for measuring concentrations of glucose and glycohemoglobin in blood. The blood analysis apparatus X is configured to perform the concentration measurement of the glucose and the glycohemoglobin by one sampling of blood 13. The blood analysis apparatus X is preferably configured to simultaneously carry out sample preparations for concentration measurement of the glucose and the glycohemoglobin by one sample preparation. The blood analysis apparatus X may be configured to perform dilution of a blood sample for measuring the glycohemoglobin and dilution of a blood sample for measuring the glucose using the same diluent.

Abstract: An object is to provide an optical measurement apparatus for performing an efficient test by optical measurement without incurring incorrect measurements. To this end, the measurement apparatus utilizes a test instrument mounted thereto and including a carrier with a reagent retaining portion for application of a sample. The measurement apparatus includes a reader for color development at the reagent retaining portion, and a controller for driving control of the reader and for required determination. The controller performs the determination by utilizing the data obtained by reading the color development of the reagent after a reaction completion period Tr1-Tr6 depending on the reagent and starting from the mounting of the test instrument. When detecting that the color development at the reagent retaining portion is completed before the lapse of the reaction completion period Tr1-Tr6 after the mounting of the test instrument, the controller stops the test for the test instrument.

Abstract: A method of determining glycated hemoglobin is provided, by which a ratio of the glycated hemoglobin in a sample can be determined accurately and easily. The ratio of glycated hemoglobin can be determined by degrading a glycated hemoglobin in a whole blood sample selectively with a protease to give a glycated hemoglobin degradation product; causing a redox reaction between a glycation site of the glycated hemoglobin degradation product and a fructosyl amino acid oxidoreductase; and determining this redox reaction. Further, as shown in FIG. 1, in a whole blood sample, there is a correlation between the ratio of the glycated hemoglobin determined by this method and an HbA1c concentration. Thus, without determining the glycated ?-amino group as a characteristic structure of HbA1c, an amount of Hba1c can be determined accurately and easily from the determined ratio of the glycated hemoglobin.

Abstract: A method of determining glycated hemoglobin is provided, by which a ratio of the glycated hemoglobin in a sample can be determined accurately and easily. The ratio of glycated hemoglobin can be determined by degrading a glycated hemoglobin in a whole blood sample selectively with a protease to give a glycated hemoglobin degradation product; causing a redox reaction between a glycation site of the glycated hemoglobin degradation product and a fructosyl amino acid oxidoreductase; and determining this redox reaction. Further, as shown in FIG. 1, in a whole blood sample, there is a correlation between the ratio of the glycated hemoglobin determined by this method and an HbA1c concentration. Thus, without determining the glycated ?-amino group as a characteristic structure of HbA1c, an amount of HbA1c can be determined accurately and easily from the determined ratio of the glycated hemoglobin.