Patents Assigned to Arkray
  • Glucose dehydrogenase
    Patent number: 9410184
    Abstract: A modified pyrroloquinoline quinone glucose dehydrogenase that exhibits a high selectivity for glucose is provided. A modified pyrroloquinoline quinone glucose dehydrogenase is disclosed in which the amino acid residue G at Position 99 of a pyrroloquinoline quinone glucose dehydrogenase (PQQGDH) represented by SEQ ID NO: 1, or the amino acid residue G at Position 100 of the pyrroloquinoline quinone glucose dehydrogenase (PQQGDH) represented by SEQ ID NO: 3, is substituted by the amino acid sequence TGZN (where Z is SX, S, or N and X is any amino acid residue). The modified PQQGDH of the present invention may additionally comprise one or more mutations selected from the group consisting of Q192G, Q192A, or Q192S; L193X; E277X; A318X; Y367A, Y367F, or Y367W; G451C; and N452X (where X is any amino acid residue).
    Type: Grant
    Filed: October 22, 2014
    Date of Patent: August 9, 2016
    Assignees: ARKRAY, Inc., Ultizyme International Ltd.
    Inventor: Koji Sode
  • Mixing apparatus
    Patent number: 9409175
    Abstract: A mixing apparatus includes: a mixing container with a discharge port for discharging mixed liquid; a filter paper covering the discharge port to temporarily retain the liquid; a receiving unit with a waste liquid collecting portion for receiving a first liquid discharged from the discharge port through the filter paper, and a measuring portion for receiving a second liquid subjected to treatment different from treatment for the first liquid; and an operation portion for enabling selection between a first receiving state in which the waste liquid collecting portion receives the first liquid and a second receiving state in which the measuring portion receives the second liquid, and also for controlling the movement of the first liquid or the second liquid.
    Type: Grant
    Filed: February 20, 2013
    Date of Patent: August 9, 2016
    Assignee: ARKRAY, Inc.
    Inventors: Takashige Tanaka, Junichi Oka, Daisuke Matsumoto, Hitoshi Okai
  • Cell culture device, cell culture system, and cell culture method
    Patent number: 9410119
    Abstract: To provide a cell culture device, a cell culture system and a cell culture method capable of suppressing fluctuations in pressure in a culture fluid, and suppressing gas bubbles from flowing into a cell culture section. A cell culture device including: a cell culture section that cultures cells; a storage section that stores a culture fluid; flow paths that connect the cell culture section and the storage section; a fluid delivery device that is provided at the flow paths and that delivers the culture fluid from the storage section to the cell culture section; a pressure equalizing unit that is provided at the flow paths and that suppresses fluctuations in pressure imparted to the culture fluid delivered to the cell culture section; and a pressurization unit that is provided at the flow path at a flow outlet side of the cell culture section and that applies a specific pressure to the culture fluid.
    Type: Grant
    Filed: March 26, 2014
    Date of Patent: August 9, 2016
    Assignee: ARKRAY, Inc.
    Inventors: Naoyuki Nakanishi, Yuichiro Noda
  • Plasma Spectrochemical Analysis Method and Plasma Spectrochemical Analyzer
    Publication number: 20160202187
    Abstract: The present invention provides a plasma spectrochemical analysis method that can be carried out easily and achieves high analytical sensitivity, and includes: a step of concentrating an analyte in a sample in the vicinity of at least one of a pair of electrodes by applying a voltage to the pair of electrodes in the presence of the sample; and a step of generating plasma by applying a voltage to the pair of electrodes and detecting light emitted from the analyte excited by the plasma.
    Type: Application
    Filed: January 13, 2016
    Publication date: July 14, 2016
    Applicant: ARKRAY, Inc.
    Inventors: Yasunori Shiraki, Hitoshi Okai
  • Enzyme Electrode
    Publication number: 20160186230
    Abstract: The present invention provides an enzyme electrode comprising: an electrode; and a detection layer which is in contact with the electrode, where the detection layer includes an enzyme, a crosslinking agent, an electrically conductive polymer and a sugar, wherein electrons are transferred between the enzyme in the detection layer and the electrode.
    Type: Application
    Filed: December 21, 2015
    Publication date: June 30, 2016
    Applicant: ARKRAY, Inc.
    Inventor: Hisashi Kaneda
  • MIXING CONTAINER USED FOR REAGENTS
    Publication number: 20160175841
    Abstract: A mixing container includes a first container that stores two or more reagents and a second container for mixing two or more reagents. The first container includes reagent storage chambers that are respectively provided for the two or more reagents and have openings formed at portions thereof, and a sealing member that seals the respective openings of the reagent storage chambers. The second container includes an opening portion formed such that the first container can be connected thereto, and protruding portions disposed so as to pierce the sealing member when the first container is connected to the opening portion.
    Type: Application
    Filed: December 14, 2015
    Publication date: June 23, 2016
    Applicants: ARKRAY, Inc., BODITECH MED INC.
    Inventors: Fumito HIRAMURA, Hironori HASEGAWA, Park Ki TAE, Kim Cheol MIN
  • Substance Measurement Method and Measurement Device Employing Electrochemical Biosensor
    Publication number: 20160177365
    Abstract: A method is provided for measuring a substance using a biosensor, the method comprising: introducing a sample containing the substance into an electrochemical measurement cell which comprises an insulating base plate; at least two electrodes formed on the insulating base plate; and a reagent layer that is disposed on at least one of the electrodes and comprises an oxidoreductase; applying a voltage to the electrodes; detecting a charge transfer limiting current which is generated due to the transfer of electrons from the substance in the sample to the electrode; and determining the concentration of the substance contained in the sample based on the charge transfer limiting current.
    Type: Application
    Filed: August 7, 2014
    Publication date: June 23, 2016
    Applicants: ARKRAY, Inc., BioEngineering Laboratories, LLC
    Inventor: Koji Katsuki
  • Terahertz Wave Measuring Device, Measuring Method, and Measuring Rig
    Publication number: 20160169735
    Abstract: There is provided a terahertz wave measuring device including (1) a terahertz wave generation element that generates a terahertz wave by difference frequency generation based on excitation light that is incident to the terahertz wave generation element, the excitation light including a plurality of different wavelength components and being condensed so as to have a beam diameter of a predetermined size, (2) a structural body through which the terahertz wave is transmitted; and (3) a detector that detects an intensity of the terahertz wave that has been transmitted through the structural body, wherein the structural body includes a sample holder of a predetermined width that holds a sample, and the structural body is in close contact with or is joined to the terahertz wave generation element.
    Type: Application
    Filed: December 11, 2015
    Publication date: June 16, 2016
    Applicant: ARKRAY, Inc.
    Inventor: Hirohisa Uchida
  • Analyzing Device, Sensor Testing Device, Testing Method and Computer-Readable Storage Medium
    Publication number: 20160161440
    Abstract: There is provided a sensor testing method including: applying at least one of a first voltage that obtains a response caused by a substance and a second voltage that either obtains no response or substantially no response caused by the substance across a first electrode and a second electrode of a sensor; measuring current flowing between the first electrode and the second electrode; and determining whether or not there is a defect present in the sensor based on a quantity related to an amount of change per specific period of time of a current measured when the first voltage and/or the second voltage have been applied.
    Type: Application
    Filed: February 18, 2016
    Publication date: June 9, 2016
    Applicant: ARKRAY, Inc.
    Inventor: Shinjiro Sekimoto
  • Analyzing Device, Sensor Testing Device, Testing Method and Computer-Readable Storage Medium
    Publication number: 20160161439
    Abstract: There is provided a sensor testing method including: applying at least one of a first voltage that obtains a response caused by a substance and a second voltage that either obtains no response or substantially no response caused by the substance across a first electrode and a second electrode of a sensor; measuring current flowing between the first electrode and the second electrode; and determining whether or not there is a defect present in the sensor based on a quantity related to an amount of change per specific period of time of a current measured when the first voltage and/or the second voltage have been applied.
    Type: Application
    Filed: February 18, 2016
    Publication date: June 9, 2016
    Applicant: ARKRAY, Inc.
    Inventor: Shinjiro Sekimoto
  • Measuring apparatus, measuring system, electric power supply apparatus, and electric power supply method
    Patent number: 9357957
    Abstract: A technique is provided, which makes it possible to continuously supply the driving electric power stably to a sensor even when the continuous monitoring period ranges over a long period of time when the numerical information is measured in relation to a test substance contained in a sample.
    Type: Grant
    Filed: January 17, 2011
    Date of Patent: June 7, 2016
    Assignee: ARKRAY, Inc.
    Inventors: Koji Katsuki, Yasunori Shiraki
  • Monitoring device and monitoring method
    Patent number: 9357960
    Abstract: A monitoring device which measures numerical value information on a subject substance in a body fluid has an electrochemical sensor including a sensor unit for detecting the subject substance which is used in the way of being embedded subcutaneously and generating an electric signal correlating to the numerical value information on the subject substance, and a temperature control unit which adjusts the detected ambient temperature as a temperature ambient to a sensor unit when detecting the subject substance so as to reach a target setting temperature when measuring the subject substance.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: June 7, 2016
    Assignee: ARKRAY, INC.
    Inventor: Koji Katsuki
  • Probe for detection of polymorphism in EGFR gene, amplification primer, and use thereof
    Patent number: 9359647
    Abstract: A polymorphism-detecting probe, an amplification primer and the use thereof are provided to enable simple and highly reliable determination of different polymorphisms in an EGFR gene.
    Type: Grant
    Filed: January 27, 2014
    Date of Patent: June 7, 2016
    Assignee: ARKRAY, Inc.
    Inventors: Aki Iguchi, Moeko Ijuin
  • Electrochemical sensor, lancet, and bodily fluid measuring apparatus
    Patent number: 9351676
    Abstract: An electrochemical sensor includes a base plate provided with a concave part formed on one of surfaces thereof, a fluid channel formed so that a bottom part of the concave part and the other one of the surfaces of the base plate are communicated with each other, a plurality of electrodes formed on the concave part; a reagent fixed on the electrodes, a cover which covers the concave part, and an air channel which causes the inside and outside of the concave part to be communicated with each other.
    Type: Grant
    Filed: October 28, 2011
    Date of Patent: May 31, 2016
    Assignee: ARKRAY, Inc.
    Inventors: Yoshiharu Sato, Tadao Yamaguchi, Shinichi Watanabe, Yoshimitsu Matsuura
  • Glucose dehydrogenase/cytochrome fusion protein
    Patent number: 9353395
    Abstract: A fusion protein of pyrroloquinoline quinone glucose dehydrogenase (PQQGDH) and a cytochrome is disclosed. PQQGDH is, for example, a water-soluble PQQGDH derived from Acinetobacter calcoaceticus. The cytochrome is, for example, an electron transfer domain of quinohemoprotein ethanol dehydrogenase from Comamonas testosteroni. The fusion protein of the present invention shows intramolecular electron transfer from PQQ, a redox center, to the cytochrome, which allow construction of a direct electron transfer-type glucose sensor which requires no electron mediators.
    Type: Grant
    Filed: October 19, 2012
    Date of Patent: May 31, 2016
    Assignees: ARKRAY, Inc., Ultizyme International Ltd.
    Inventor: Koji Sode
  • Method for adjusting amplification efficiency of target polynucleotide
    Patent number: 9340833
    Abstract: Disclosed is a method for adjusting the amplification efficiency of a target polynucleotide in the amplification of the target polynucleotide by PCR using primers (i) to (iii) below, the method comprising adjusting the amplification efficiency of the target polynucleotide by changing the quantity ratio of the primers (i) to (iii) below: (i) a first primer which is able to be base-paired with the target polynucleotide; (ii) a second primer which is able to be base-paired with the target polynucleotide in competition with the first primer and from which extension reaction by PCR less occurs as compared to the first primer; and (iii) a third primer designed to allow for the amplification of the target polynucleotide in pairs with the first primer.
    Type: Grant
    Filed: April 30, 2011
    Date of Patent: May 17, 2016
    Assignee: ARKRAY, Inc.
    Inventor: Mariko Komori
  • SENSOR INSERTION METHOD, ANALYSIS METHOD, AND SENSOR INSERTION DEVICE
    Publication number: 20160120447
    Abstract: A sensor insertion method for inserting a sensor into a user's body is provided. The method includes a unit fixing step of regulating a relative position between a sensor control unit and an inserting unit, where the sensor control unit is in a sensor insertion allowing state, and the inserting unit contains the sensor. In this step, the sensor control unit and the inserting unit are fixed to an insertion target portion of the user. Then, in a sensor inserting step, the inserting unit is caused to insert the sensor into the insertion target portion. In a sensor connecting step, the sensor control unit is shifted from the sensor insertion allowing state to a sensor connecting state, whereby electrical conduction is established between the sensor in the insertion target portion and the sensor control unit.
    Type: Application
    Filed: October 22, 2015
    Publication date: May 5, 2016
    Applicant: ARKRAY, INC.
    Inventors: Gai GO, Akihiro YAMAMOTO
  • Method of pre-treating sample for measuring saccharified amine and method of measuring saccharified amine
    Patent number: RE46073
    Abstract: The present invention provides a method of pretreating a sample containing a glycated amine as an analyte, thereby enabling highly reliable measurement of a glycated amine. A glycated amino acid in the sample is degraded by causing a fructosyl amino acid oxidase (FAOD) to act thereon, and thereafter, a FAOD further is caused to act on the glycated amine as the analyte in the sample to cause a redox reaction. The amount of the glycated amine is determined by measuring the redox reaction. The substrate specificity of the FAOD caused to act on the glycated amino acid may be either the same as or different from that of the FAOD caused to act on the glycated amine. When using the same FAOD, a FAOD is caused to act on the glycated amino acid to degrade it, and thereafter, the sample is treated with a protease to inactivate the FAOD and also to degrade the glycated amine.
    Type: Grant
    Filed: June 26, 2015
    Date of Patent: July 19, 2016
    Assignee: ARKRAY, Inc.
    Inventors: Satoshi Yonehara, Tsuguki Komori
  • Portion of a display screen of a handheld device with transitional icon
    Patent number: D763315
    Type: Grant
    Filed: February 28, 2014
    Date of Patent: August 9, 2016
    Assignee: ARKRAY, Inc.
    Inventors: Hisashi Nishiyama, Yeongkyu Yoo, Sungmin Kim
  • Method of selectively determining glycated hemoglobin
    Patent number: RE46105
    Abstract: A method of determining glycated hemoglobin is provided, by which a ratio of the glycated hemoglobin in a sample can be determined accurately and easily. The ratio of glycated hemoglobin can be determined by degrading a glycated hemoglobin in a whole blood sample selectively with a protease to give a glycated hemoglobin degradation product; causing a redox reaction between a glycation site of the glycated hemoglobin degradation product and a fructosyl amino acid oxidoreductase; and determining this redox reaction. Further, as shown in FIG. 1, in a whole blood sample, there is a correlation between the ratio of the glycated hemoglobin determined by this method and an HbA1c concentration. Thus, without determining the glycated ?-amino group as a characteristic structure of HbA1c, an amount of HbA1c can be determined accurately and easily from the determined ratio of the glycated hemoglobin.
    Type: Grant
    Filed: October 23, 2014
    Date of Patent: August 16, 2016
    Assignee: ARKRAY, Inc.
    Inventor: Satoshi Yonehara