Patents Assigned to Corixa
  • Methods, compositions and kits for the detection and monitoring of breast cancer
    Publication number: 20030170631
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as breast cancer, are disclosed. Compositions may comprise one or more breast tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a breast tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as breast cancer. Diagnostic methods based on detecting a breast tumor protein, or mRNA encoding such a protein, in a sample are also provided.
    Type: Application
    Filed: December 27, 2001
    Publication date: September 11, 2003
    Applicant: Corixa Corporation
    Inventors: Raymond L. Houghton, Davin C. Dillon, David A. Molesh, Jiangchun Xu, Barbara Zehentner, David H. Persing
  • Compositions and methods for the therapy and diagnosis of lung cancer
    Publication number: 20030170255
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
    Type: Application
    Filed: March 28, 2002
    Publication date: September 11, 2003
    Applicant: Corixa Corporation
    Inventors: Yoshihiro Watanabe, Robert A. Henderson, Michael D. Kalos, Paul R. Sleath, Thomas S. Vedvick, Darrick Carter, Gary R. Fanger
  • Lipophilin complexes for use in cancer diagnosis and therapy
    Publication number: 20030170246
    Abstract: Compositions and methods for the therapy and diagnosis of breast, ovarian and prostate cancer are disclosed. Compositions may comprise one or more lipophilin fusion proteins, which comprise at least two different lipophilin-like polypeptides linked by a peptide bond. Such compositions may be used for the prevention and treatment of breast, ovarian and prostate cancer. Diagnostic methods based on detecting the presence of lipophilin complexes, or antibodies thereto, in a patient are also provided.
    Type: Application
    Filed: March 12, 2002
    Publication date: September 11, 2003
    Applicant: Corixa Corporation
    Inventors: Gary R. Fanger, Margarita Durham, Raymond L. Houghton, Davin C. Dillon, Darrick Carter, David H. Persing
  • Compositions and methods for the therapy and diagnosis of ovarian cancer
    Patent number: 6617109
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly ovarian cancer.
    Type: Grant
    Filed: November 14, 2000
    Date of Patent: September 9, 2003
    Assignee: Corixa Corporation
    Inventors: Jiangchun Xu, John A. Stolk
  • Compositions and methods for the diagnosis and treatment of herpes simplex virus infection
    Publication number: 20030165820
    Abstract: Compounds and methods for the diagnosis and treatment of HSV infection are provided. The compounds comprise polypeptides that contain at least one antigenic portion of an HSV polypeptide and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits are also provided comprising such polypeptides and/or DNA sequences and a suitable detection reagent for the detection of HSV infection in patients and in biological samples.
    Type: Application
    Filed: September 6, 2002
    Publication date: September 4, 2003
    Applicant: Corixa Corporation
    Inventors: Craig H. Day, Nancy A. Hosken, Joseph M. Parsons
  • Compositions and methods for the diagnosis and treatment of herpes simplex virus infection
    Publication number: 20030165819
    Abstract: Compounds and methods for the diagnosis and treatment of HSV infection are provided. The compounds comprise polypeptides that contain at least one antigenic portion of an HSV polypeptide and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits are also provided comprising such polypeptides and/or DNA sequences and a suitable detection reagent for the detection of HSV infection in patients and in biological samples.
    Type: Application
    Filed: July 19, 2002
    Publication date: September 4, 2003
    Applicant: Corixa Corporation
    Inventors: Patrick McGowan, Nancy A. Hosken
  • Compositions and methods for the therapy and diagnosis of colon cancer
    Publication number: 20030166064
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly colon cancer, are disclosed. Illustrative compositions comprise one or more colon tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly colon cancer.
    Type: Application
    Filed: March 14, 2002
    Publication date: September 4, 2003
    Applicant: Corixa Corporation
    Inventors: Gordon E. King, Madeleine Joy Meagher, Jiangchun Xu, Heather Secrist, Yuqiu Jiang
  • Compositions and methods for the therapy and diagnosis of breast cancer
    Publication number: 20030166022
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
    Type: Application
    Filed: April 15, 2002
    Publication date: September 4, 2003
    Applicant: Corixa Corporation
    Inventors: Raymond L. Houghton, Paul R. Sleath, David H. Persing
  • Compounds for immunotherapy and diagnosis of tuberculosis and methods of their use
    Patent number: 6613881
    Abstract: Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more M. tuberculosis proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against M. tuberculosis infection, or may be used for the diagnosis of tuberculosis.
    Type: Grant
    Filed: May 5, 1998
    Date of Patent: September 2, 2003
    Assignee: Corixa Corporation
    Inventors: Mark Raymond Alderson, Davin C. Dillon, Yasir A. W. Skeiky, Antonio Campos-Neto
  • Compounds for immunotherapy of prostate cancer and methods for their use
    Patent number: 6613872
    Abstract: Compounds and methods for treating prostate cancer are provided. The inventive compounds include polypeptides containing at least a portion of a prostate tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of prostate cancer comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided, together with DNA molecules for preparing the inventive polypeptides.
    Type: Grant
    Filed: September 23, 1998
    Date of Patent: September 2, 2003
    Assignee: Corixa Corporation
    Inventors: Jiangchun Xu, Davin C. Dillon
  • Ovarian tumor sequences and methods of use therefor
    Patent number: 6613515
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, portions thereof, polynucleotides that encode such portions or antibodies or immune system cells specific for such proteins. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian cancer. Polypeptides and polynucleotides as provided herein may further be used for the detection and monitoring of ovarian cancer.
    Type: Grant
    Filed: August 15, 2000
    Date of Patent: September 2, 2003
    Assignee: Corixa Corporation
    Inventors: Jiangchun Xu, John A. Stolk
  • Leishmania antigens for use in the therapy and diagnosis of leishmaniasis
    Patent number: 6613337
    Abstract: Compositions and methods for preventing, treating and detecting leishmaniasis and stimulating immune responses in patients are disclosed. The compounds provided include polypeptides that contain at least an immunogenic portion of one or more Leishmania antigens, or a variant thereof. Vaccines and pharmaceutical compositions comprising such polypeptides, or polynucleotides encoding such polypeptides, are also provided and may be used, for example, for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmania infection.
    Type: Grant
    Filed: August 14, 2000
    Date of Patent: September 2, 2003
    Assignee: Corixa Corporation
    Inventors: Steven G. Reed, Antonio Campos-Neto, John R. Webb, Davin C. Dillon, Yasir A. W. Skeiky, Ajay Bhatia, Rhea Coler, Peter Probst
  • Compositions and methods for the therapy and diagnosis of prostate cancer
    Publication number: 20030157089
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.
    Type: Application
    Filed: May 9, 2002
    Publication date: August 21, 2003
    Applicant: Corixa Corporation
    Inventors: Jiangchun Xu, Davin C. Dillon, Jennifer L. Mitcham, Susan L. Harlocker, Yuqiu Jiang, Robert A. Henderson, Michael D. Kalos, Gary R. Fanger, Marc W. Retter, John A. Stolk, Craig H. Day, Thomas S. Vedvick, Darrick Carter, Samuel X. Li, Aijun Wang, Yasir A.W. Skeiky, William T. Hepler, John Hural, Patricia D. McNeill, Raymond L. Houghton, Carlota Vinals y de Bassols, Teresa M. Foy, Yoshihiro Watanabe, Madeleine Joy Meagher, Ta Deng
  • Methods for diagnosis and therapy of hematological and virus-associated malignancies
    Publication number: 20030157119
    Abstract: The present invention is directed to methods for detecting and treating hematological and virus-associated malignancies using Her2/neu sequences. The Her2/neu sequences may be polypeptides or polynucleotides.
    Type: Application
    Filed: December 4, 2002
    Publication date: August 21, 2003
    Applicant: Corixa Corporation
    Inventors: Alexander Gaiger, Martin A. Cheever, Susan Hand-Zimmermann
  • Compounds and methods for the diagnosis and treatment of ehrlichia infection
    Patent number: 6607728
    Abstract: Compounds and methods for the diagnosis and treatment of Ehrlichia infection, in particular human granulocytic ehrlichiosis, are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of an Ehrlichia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Ehrlichia infection in patients and biological samples. Antibodies directed against such polypeptides are also provided.
    Type: Grant
    Filed: September 23, 1998
    Date of Patent: August 19, 2003
    Assignee: Corixa Corporation
    Inventors: Steven G. Reed, Michael J. Lodes, Raymond L. Houghton, Patricia D. McNeill
  • Leishmania antigens for use in the therapy and diagnosis of leishmaniasis
    Patent number: 6607731
    Abstract: Compositions and methods for preventing, treating and detecting leishmaniasis and stimulating immune responses in patients are disclosed. The compounds provided include polypeptides that contain at least an immunogenic portion of one or more Leishmania antigens, or a variant thereof. Vaccines and pharmaceutical compositions comprising such polypeptides, or polynucleotides encoding such polypeptides, are also provided and may be used, for example, for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmania infection.
    Type: Grant
    Filed: May 5, 2000
    Date of Patent: August 19, 2003
    Assignee: Corixa Corporation
    Inventors: Steven G. Reed, Antonio Campos-Neto, John R. Webb, Davin C. Dillon, Yasir A. Skeiky, Ajay Bhatia, Rhea Coler, Peter Probst
  • Fusion proteins of mycobacterium tuberculosis antigens and their uses
    Publication number: 20030147911
    Abstract: The present invention relates to fusion proteins containing at least two Mycobacterium tuberculosis antigens. In particular, it relates to bi-fusion proteins which contain two individual M. tuberculosis antigens, tri-fusion proteins which contain three M. tuberculosis antigens, tetra-fusion proteins which contain four M. tuberculosis antigens, and penta-fusion proteins which contain five M. tuberculosis antigens, and methods for their use in the diagnosis, treatment and prevention of tuberculosis infection.
    Type: Application
    Filed: February 5, 2003
    Publication date: August 7, 2003
    Applicant: Corixa Corporation
    Inventors: Steven G. Reed, Yasir A. Skeiky, Davin C. Dillon, Mark Alderson, Antonio Campos-Neto
  • Prophylactic and therapeutic treatment of infectious and other diseases with immunoeffector compounds
    Publication number: 20030148993
    Abstract: Methods and compositions for treating or ameliorating diseases and other conditions, such as infectious diseases, autoimmune diseases and allergies are provided. The methods employ cyclic AGPs for selectively stimulating immune responses in animals and plants.
    Type: Application
    Filed: February 4, 2002
    Publication date: August 7, 2003
    Applicant: Corixa Corporation
    Inventors: Jory R. Baldridge, David A. Johnson, Christopher W. Cluff
  • Immunostimulant compositions comprising an aminoalkyl glucosaminide phosphate and QS-21
    Publication number: 20030147920
    Abstract: The invention provides pharmaceutical compositions, particularly vaccine compositions, employing an adjuvant system comprising RC-529 (an aminoalkyl glucosaminide phosphate compound) and QS-21 (a saponin). Such compositions synergistically enhance the immune response in a mammal to a co-administered antigen. Also provided are methods of using the compositions in the treatment of various human diseases, including cancer, microbial infections and autoimmune disorders.
    Type: Application
    Filed: June 21, 2002
    Publication date: August 7, 2003
    Applicant: Corixa Corporation
    Inventors: Sally Mossman, Lawrence Evans
  • Compounds and methods for immunotherapy and diagnosis of tuberculosis
    Publication number: 20030143243
    Abstract: Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more M. tuberculosis proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against M. tuberculosis infection, or may be used for the diagnosis of tuberculosis.
    Type: Application
    Filed: February 25, 2002
    Publication date: July 31, 2003
    Applicant: Corixa Corporation
    Inventors: Steven G. Reed, Yasir A.W. Skeiky, Davin C. Dillon, Antonio Campos-Neto, Raymond Houghton, Thomas S. Vedvick, Daniel R. Twardzik, Michael J. Lodes, Ronald C. Hendrickson