Patents Assigned to Corixa
  • Compounds and methods for therapy and diagnosis of lung cancer
    Patent number: 6660838
    Abstract: Compounds and methods for the treatment and diagnosis of lung cancer are provided. The inventive compounds include polypeptides containing at least a portion of a lung tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of lung cancer comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided, together with DNA molecules for preparing the inventive polypeptides.
    Type: Grant
    Filed: December 22, 1998
    Date of Patent: December 9, 2003
    Assignee: Corixa Corporation
    Inventor: Tongtong Wang
  • Methods for enhancement of protective immune responses
    Patent number: 6660840
    Abstract: Methods for eliciting or enhancing immune responses to antigens, including tumor antigens, and/or DNA vaccines are provided. The methods employ polypeptides or nucleic acid compositions that contain at least a biologically active portion of a Leishmania braziliensis or Leishmania major homologue of the eukaryotic initiation factor 4A, or a variant thereof. Such polypeptides and compositions are useful for enhancing or eliciting a patient's cellular and/or humoral immune response, for instance within methods for treating tumors.
    Type: Grant
    Filed: September 17, 1999
    Date of Patent: December 9, 2003
    Assignee: Corixa Corporation
    Inventor: Steven G. Reed
  • Compositions and methods for the treatment and diagnosis of breast cancer
    Patent number: 6656480
    Abstract: Compositions and methods for the detection and therapy of breast cancer are disclosed. The compounds provided include nucleotide sequences that are preferentially expressed in breast tumor tissue, as well as polypeptides encoded by such nucleotide sequences. Vaccines and pharmaceutical compositions comprising such compounds are also provided and may be used, for example, for the prevention and treatment of breast cancer. The polypeptides may also be used for the production of antibodies, which are useful for diagnosing and monitoring the progression of breast cancer in a patient.
    Type: Grant
    Filed: October 28, 1999
    Date of Patent: December 2, 2003
    Assignee: Corixa Corporation
    Inventors: Marc W. Retter, Davin C. Dillon
  • Compounds for immunotherapy of prostate cancer and methods for their use
    Patent number: 6657056
    Abstract: Compounds and methods for treating prostate cancer are provided. The inventive compounds include polypeptides containing at least a portion of a prostate tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of prostate cancer comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided, together with DNA molecules for preparing the inventive polypeptides.
    Type: Grant
    Filed: July 14, 1998
    Date of Patent: December 2, 2003
    Assignee: Corixa Corporation
    Inventors: Jiangchun Xu, Davin C. Dillon
  • Compositions and methods for WT1 specific immunotherapy
    Publication number: 20030215458
    Abstract: Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that specifically binds to a WT1 polypeptide; or a T cell that specifically reacts with a WT1 polypeptide. Such compositions may be used, for example, for the prevention and treatment of metastatic diseases.
    Type: Application
    Filed: October 30, 2002
    Publication date: November 20, 2003
    Applicant: Corixa Corporation
    Inventors: Alexander Gaiger, Patricia D. McNeill, Nomalie Jaya
  • Amphipathic aldehydes and their uses as adjuvants and immunoeffectors
    Patent number: 6649172
    Abstract: This invention relates to novel aldehyde containing compounds and their uses as adjuvants and immunoeffectors.
    Type: Grant
    Filed: March 16, 2001
    Date of Patent: November 18, 2003
    Assignee: Corixa Corporation
    Inventor: David A. Johnson
  • Compositions and methods for the therapy and diagnosis of lung cancer
    Publication number: 20030211510
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
    Type: Application
    Filed: October 28, 2002
    Publication date: November 13, 2003
    Applicant: Corixa Corporation
    Inventors: Robert A. Henderson, Tongtong Wang, Yoshihiro Watanabe, Michael D. Kalos, Paul R. Sleath, Jeffrey C. Johnson, Marc W. Retter, Margarita Durham, Darrick Carter, Gary R. Fanger, Thomas S. Vedvick, Chaitanya S. Bangur, Andria McNabb
  • Compositions and methods for the therapy and diagnosis of ovarian cancer
    Publication number: 20030206918
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly ovarian cancer.
    Type: Application
    Filed: February 5, 2003
    Publication date: November 6, 2003
    Applicant: Corixa Corporation
    Inventors: Gary R. Fanger, Steven P. Fling
  • Leishmania antigens for use in the therapy and diagnosis of leishmaniasis
    Patent number: 6638517
    Abstract: Compositions and methods for preventing, treating and detecting leishmaniasis and stimulating immune responses in patients are disclosed. The compounds provided include polypeptides that contain at least an immunogenic portion of one or more Leishmania antigens, or a variant thereof. Vaccines and pharmaceutical compositions comprising such polypeptides, or polynucleotides encoding such polypeptides, are also provided and may be used, for example, for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmania infection.
    Type: Grant
    Filed: June 4, 2001
    Date of Patent: October 28, 2003
    Assignee: Corixa Corporation
    Inventors: Steven G. Reed, Antonio Campos-Neto, John R. Webb, Davin C. Dillon, Yasir A. W. Skeiky, Ajay Bhatia, Rhea N. Coler, Peter Probst, Mark Brannon
  • Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors
    Publication number: 20030199460
    Abstract: Aminoalkyl glucosaminide phosphate (AGP) compounds that are adjuvants and immunoeffectors are described and claimed. The compounds have a 2-deoxy-2-amino glucose in glycosidic linkage with an aminoalkyl (aglycon) group. Compounds are phosphorylated at the 4 or 6 carbon on the glucosaminide ring and comprise three 3-alkanoyloxyalkanoyl residues. The compounds augment antibody production in immunized animals as well as stimulate cytokine production and activate macrophages. Compositions and methods for using the compounds as adjuvants and immunoeffectors are also disclosed.
    Type: Application
    Filed: April 30, 2002
    Publication date: October 23, 2003
    Applicant: Corixa Corporation
    Inventors: David A. Johnson, C. Gregory Sowell
  • Compositions and methods for WT1 specific immunotherapy
    Publication number: 20030198622
    Abstract: Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that specifically binds to a WT1 polypeptide; or a T cell that specifically reacts with a WT1 polypeptide. Such compositions may be used, for example, for the prevention and treatment of metastatic diseases.
    Type: Application
    Filed: July 12, 2002
    Publication date: October 23, 2003
    Applicant: Corixa Corporation
    Inventors: Alexander Gaiger, Molly D. Smithgall, Darrick Carter, Martin A. Cheever, Patricia D. McNeill, R. Alec Sutherland, Sally P. Mossman, Lawrence S. Evans, Ryan M. Swanson
  • Compositions and methods for the therapy and diagnosis of lung cancer
    Publication number: 20030194764
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
    Type: Application
    Filed: April 4, 2002
    Publication date: October 16, 2003
    Applicant: Corixa Corporation
    Inventors: Chaitanya S. Bangur, Ann Switzer
  • Immunostimulant compositions comprising aminoalkyl glucosaminide phosphates and saponins
    Publication number: 20030190333
    Abstract: The invention provides pharmaceutical compositions, particularly vaccine compositions, employing an adjuvant system comprising at least one aminoalkyl glucosaminide phosphate compound and at least one saponin compound. Such compositions synergistically enhance the immune response in a mammal to a co-administered antigen. Also provided are methods of using the compositions in the treatment of various human diseases, including cancer, microbial infections and autoimmune disorders.
    Type: Application
    Filed: February 4, 2002
    Publication date: October 9, 2003
    Applicant: Corixa Corporation
    Inventors: Sally Mossman, Lawrence Evans, Jory R. Baldridge, Jay T. Evans
  • Compositions and methods for the therapy and diagnosis of prostate cancer
    Patent number: 6630305
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.
    Type: Grant
    Filed: October 10, 2000
    Date of Patent: October 7, 2003
    Assignee: Corixa Corporation
    Inventors: Jiangchun Xu, Davin C. Dillon, Jennifer L. Mitcham, Susan L. Harlocker, Yuqiu Jiang, Michael D. Kalos, Gary R. Fanger, Marc W. Retter, John A. Stolk, Craig H. Day, Thomas S. Vedvick, Darrick Carter, Samuel X. Li, Aijun Wang, Yasir A. W. Skeiky, William T. Hepler, Robert A. Henderson
  • Compositions and methods for the therapy and diagnosis of lung cancer
    Patent number: 6630574
    Abstract: Compositions comprising isolated cancer-associated L552S polypeptides are disclosed. Such compositions can comprise, for example, portions of said cancer-associated L552S polypeptides and/or the corresponding polynucleotides encoding such portions. Illustrative uses of the compositions, for example in cancer diagnostic methods, are also provided.
    Type: Grant
    Filed: July 11, 2000
    Date of Patent: October 7, 2003
    Assignee: Corixa Corporation
    Inventors: Tongtong Wang, Chaitanya S. Bangur, Michael J. Lodes, Gary R. Fanger, Thomas S. Vedvick, Darrick Carter, Marc W. Retter, Jane Mannion, Liqun Fan
  • Compositions and methods for the therapy and diagnosis of prostate cancer
    Publication number: 20030185830
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.
    Type: Application
    Filed: November 12, 2002
    Publication date: October 2, 2003
    Applicant: Corixa Corporation
    Inventors: Jiangchun Xu, John A. Stolk, Michael D. Kalos
  • Fusion proteins of Mycobacterium tuberculosis antigens and their uses
    Patent number: 6627198
    Abstract: The present invention relates to fusion proteins containing at least two Mycobacterium tuberculosis antigens. In particular, it relates to bi-fusion proteins which contain two individual M. tuberculosis antigens, tri-fusion proteins which contain three M. tuberculosis antigens, tetra-fusion proteins which contain four M. tuberculosis antigens, and penta-fusion proteins which contain five M. tuberculosis antigens, and methods for their use in the diagnosis, treatment and prevention of tuberculosis infection.
    Type: Grant
    Filed: April 7, 1999
    Date of Patent: September 30, 2003
    Assignee: Corixa Corporation
    Inventors: Steven G. Reed, Yasir A. Skeiky, Davin C. Dillon, Mark Alderson, Antonio Campos-Neto
  • Compounds for immunotherapy and diagnosis of colon cancer and methods for their use
    Patent number: 6623923
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as colon cancer, are disclosed. Compositions may comprise one or more colon tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a colon tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as colon cancer. Diagnostic methods based on detecting a colon tumor protein, or mRNA encoding such a protein, in a sample are also provided.
    Type: Grant
    Filed: September 22, 1999
    Date of Patent: September 23, 2003
    Assignee: Corixa Corporation
    Inventors: Jiangchun Xu, Michael J. Lodes, Heather Secrist, Madeleine Joy Meagher, John Stolk, Darin R. Benson, Tongtong Wang
  • Heterologous fusion protein constructs comprising a Leishmania antigen
    Publication number: 20030175294
    Abstract: The present invention provides a recombinant nucleic acid molecule encoding a fusion polypeptide, wherein the recombinant nucleic acid comprises a heterologous polynucleotide sequence encoding an antigen or an antigenic fragment, and a Leishmania polynucleotide sequence encoding a polypeptide or fragment thereof, wherein the Leishmania polynucleotide is selected from the group consisting of TSA polynucleotide, LeIF polynucleotide, M15 polynucleotide, and 6H polynucleotide. The invention also provides an expression cassette comprising the recombinant nucleic acid molecule, host cells comprising the expression cassette, compositions, fusion polypeptides, and methods of their use in diagnosis or in generating a protective immune response in hosts.
    Type: Application
    Filed: March 13, 2002
    Publication date: September 18, 2003
    Applicant: Corixa Corporation
    Inventors: Yasir Skeiky, Mark Brannon, Jeffrey Guderian
  • Compositions and methods for the therapy and diagnosis of prostate cancer
    Patent number: 6620922
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.
    Type: Grant
    Filed: August 9, 2000
    Date of Patent: September 16, 2003
    Assignee: Corixa Corporation
    Inventors: Jiangchun Xu, Davin C. Dillon, Jennifer L. Mitcham, Susan L. Harlocker, Yuqiu Jiang, Michael D. Kalos, Gary R. Fanger, Marc W. Retter, John A. Stolk, Craig H. Day, Thomas S. Vedvick, Darrick Carter, Samuel X. Li, Aijun Wang, Yasir A. W. Skeiky, William T. Hepler, Robert A. Henderson