Abstract: Hydroxamic acid derivatives of certain mercaptoacyl amino acids inhibit the conversion of angiotensin I to angiotensin II in mammals and are useful for the treatment of hypertension.
Type:
Grant
Filed:
November 20, 1980
Date of Patent:
December 29, 1981
Assignee:
E. R. Squibb & Sons, Inc.
Inventors:
Edward W. Petrillo, Jr., Miguel A. Ondetti
Abstract: 1-Mercaptoacyl proline or pipecolic acid having an azido group in the 4-position inhibits the conversion of angiotensin I to angiotensin II in mammals and is useful for the treatment of hypertension.
Type:
Grant
Filed:
October 29, 1980
Date of Patent:
December 29, 1981
Assignee:
E. R. Squibb & Sons, Inc.
Inventors:
Edward W. Petrillo, Jr., Frank L. Weisenborn
Abstract: An odometer i.e. a distance recorder, for a vehicle has a counting mechanism driven by a stepping mechanism which is in turn driven with rotation of a vehicle wheel. The stepping mechanism has a plurality of pawls which reciprocate with wheel rotation and which can advance respective ratchet wheels. For a given vehicle wheel size, one of the pawls is selected to operate its ratchet wheel by a cam means which then disables the or each other pawl from engagement with associated ratchet(s).
Type:
Grant
Filed:
November 16, 1979
Date of Patent:
December 29, 1981
Assignee:
E. Wehrle GmbH
Inventors:
Jorg G. Faller, Horst Kretz, Eberhard Steinhauser
Abstract: Addition to organosilicon compounds having at least one alkyl group attached to a silicon atom, at least one hydrogen atom being attached to the carbon atom adjacent the silicon atom, of a fluorocompound, which may be a fluoroolefin, a perfluoroketone, or a perfluoroether having a carbon-carbon double bond in .alpha.-position to the ether oxygen atom, give fluorine-containing organosilicon compounds. These adducts may be liquid or solid and are useful as (1) lubricants and sealants for automotive and aerospace industries (2) fire-resistant hydraulic fluids, and (3) siloxane elastomers having good oil and lubricant resistance.
Abstract: A method for purifying water-insoluble polyene antibiotics, such as amphotericin and nystatin, is provided which method includes the step of passing a mixture of the polyene antibiotic dispersed in methanol through an ion exchange column whereby gram positive and gram negative bacteria are removed from the antibiotic.
Abstract: A method for reading bar-coded labels by taking ratios of successive bars and spaces, then discriminating and categorizing the ratios of one of four possibilities. This output is combined and decoded into characters using a read-only-memory. The characters along with information on spacing between the characters is then passed to a microprocessor. The microprocessor decides which of the characters are valid and assembles a complete scans worth of information by making use of the data relating to the separation between characters. Handling the data in this fashion provides a means to assemble data from partial scans of the label into one complete scan.
Abstract: A cathodic electrocoating process using as the coating composition a polyhydroxyamine dispersant, a second polymer, and optionally a crosslinker polymer. The second polymer can be an epoxy reacted with an entity such as a fatty amine, or it can be acrylic or methacrylic polymers, butadiene, polyesters or alkyds.
Abstract: A toy vehicle only slightly longer than a "penlight" battery, and with chassis less than twice the width of such a battery, is able (traction permitting) to climb any grade on which it will not tip over backward--grades up to about 40.degree.--and to negotiate a vertical step taller than its tire radius. The AA-battery-powered four-wheel-drive vehicle has a small electric motor with a double-ended shaft, and a symmetrical gearing system consisting of, at each end of the motor, a pinion fixed on the shaft, a spur gear driven by the pinion and driving a worm, and a worm gear keyed to a corresponding axle. The motor, pinions, spur gears and worms, and the upper portions of the worm gears, are aligned along one side wall inside the vehicle chassis, with the battery alongside them occupying the rest of the chassis. Traction and climbing characteristics are enhanced by twice-overscale tires, preferably of open foam, with highly pronounced treads.
Abstract: A coating composition of an aliphatic polyurethane resin in an organic solvent; wherein the resin has terminal hydroxyl groups, a weight average molecular weight of about 3,000 to 30,000, and is the reaction product of a fatty acid ester of drying oil fatty acids, polyol, having at least three reactive hydroxyl groups, aromatic monobasic and an alkyl amino aromatic acid that provides ultraviolet light absorbing groups, and an aliphatic diisocyanate; the composition can contain conventional pigments, organo metallic driers, and light stabilizers and cures at ambient temperatures and is useful as primary finish for metals, plastics and reinforced plastics, and can be used as a refinish composition for automobiles and trucks.
Abstract: The antisticking and antiblocking properties of ethylene/methyl or ethyl acrylate/1,4-butenedioic acid monoalkyl ester terpolymers is improved by mixing with said terpolymer a small quantity of a C.sub.12 -C.sub.24 straight chain alkyl or alkenyl acid phosphate or a C.sub.12 -C.sub.24 straight chain alkyl- or alkenyloxypoly(ethyleneoxy) acid phosphate.
Abstract: A chamber block removably insertable into a centrifuge rotor of the type used for the preparation of cell dispersions on slides is characterized by a opening formed in the chamber block and sized to removably receive a supernatant collection vial therein. A deflection baffle is disposed within the chamber block so that supernatant withdrawn through a suction conduit from the vicinity of the slide is deflected into the collection vial. When the vial is received within the opening, a portion of the vial protrudes beyond the block, to facilitate manipulation by an operator.
Abstract: A control for selectively setting the operating depth of a ground working agricultural tool without changing the elevated height of the tool when in the transport position. The control includes a ground supported wheel frame pivotally mounting a tool frame. The tool frame is pivoted on the wheel frame between a raised inoperative position and a lowered operative position by operation of a cylinder assembly. The cylinder assembly is pivoted at one end to the tool frame. Its remaining end is connected to a bracket on the wheel frame. The bracket includes a slot, slidably mounting the remaining end of the cylinder. The slot is aligned along an arc centered on the pivot axis of the cylinder at its one end when the tool frame is elevated to the inoperative position. The slot is inclined upwardly toward this pivot axis as the tool frame is lowered to the operative position.
Abstract: Compounds of the following structure are provided ##STR1## wherein R.sup.1 is hydrogen or lower alkanoyl, R.sup.2 is hydrogen or lower alkyl, and R.sup.3 is hydrogen, lower alkyl or trifluoromethyl. The above compounds have useful hypotensive activity and anti-allergy activity.
Abstract: New mercaptoacyl derivatives of 3-substituted proline derivatives are provided which have the general formula ##STR1## and are useful as hypotensive agents.
Abstract: This invention relates to an insecticidal composition containing methomyl, an anticaking agent, a starch and optionally a wetting and/or dispersing agent and/or a diluent in specified amounts.
Abstract: Process for preparing the substituted phosphonoalkanoic acid of the formula ##STR1## wherein: R.sup.1 is alkyl of 1-8 carbon atoms, aralkyl of 7-10 carbon atoms, phenyl, or substituted phenyl of 6-10 carbon atoms;R.sup.2 is H, hydrocarbyl of 1-18 carbon atoms, or substituted hydrocarbyl of 1-18 carbon atoms, wherein in said hydrocarbyl groups the carbon atom attached to the ##STR2## moiety is substituted with two or three hydrogen atoms or is a carbon atom of an aromatic ring; andY is oxygen or sulfur,which process comprises contacting and reacting, at a temperature of about -70.degree. C. to about 125.degree. C., a pressure of about 1-100 atmospheres (0.1-10 MPa), and for a time sufficient to effect reaction, the phosphite ester of the formula ##STR3## wherein R.sup.1 and Y are as defined above, with the .alpha.-halocarboxylic acid of the formula R.sup.2 CHXCO.sub.2 H, wherein X is Cl, Br, or I and R.sup.
Abstract: An expandable composition of a solid synthetic vulcanizable elastomer of ethylene/higher alpha-olefin/nonconjugated diene copolymer or polychloroprene, a blowing agent, and a curing agent for the elastomer, said composition containing from about 5-25% based on the weight of total polymer of an ionomer resin which is an ethylene polymer containing at least about 50 mole percent ethylene and bearing from about 0.2-25 mole percent acid functional groups that are at least about 50% neutralized by metal ions.
Abstract: The production of an electrolytic alkali-metal cell can be temporarily curtailed by adding sodium-, calcium- or barium sulfate to the cell and reducing the current flow.
Abstract: New imidazolylethoxymethyl derivatives of thiazole are provided having the general formula ##STR1## wherein R.sup.1 is hydrogen, lower alkyl, lower alkoxy-lower alkyl, phenoxy-lower alkyl, phenyl-lower alkyl or substituted or unsubstituted phenyl;R.sup.2 is hydrogen or halogen;R.sup.3 and R.sup.4 are the same or different and are hydrogen, lower alkyl, lower alkoxy or halogen.The above compounds and their salts are useful as antifungal and antibacterial agents.
Abstract: A partially cutaway circular cylindrical tool for changing the master pins in an Almont lock is presented. The tool is fixedly coupled at one end along its axis to a handle which may be a key handle. At the opposite end, the tool comprises a plug stop which prevents the tool from going too far into the Almont lock. The partially cutaway circular cylindrical surface defines a master pin slot, two wire slots, a wire slot ridge, a stationary pin slot, and a pin holding cam ridge, which includes a cam adjacent to the master pin slot all parallel to the axis. Perpendicular to the axis and disposed about halfway between the end of the plug stop inserted into the lock and the point of coupling between the handle and the balance of the tool is a perpendicular stationary pin slot which entends between the master pin slot and the stationary pin slot. In operation, the tool is inserted into the Almont lock and rotated so that the master pins, which are wafer tumblers, slide up the master pin slot.