Abstract: A method is provided for modifying yeast to express mutant avian farnesyl disphospate synthase and the resulting modified yeast. The yeast advantageously includes additional mutants including but not limited to having ergosterol dependent growth and being erg-. The modified yeast are beneficial for the production of various terpenes including diterpenes.

Abstract: This application provides fluidic devices, such as microfluidic devices, which can be used for the creation and/or manipulation of droplets in droplet-based microfluidic systems, as well as systems and methods for using the same. The microfluidic devices can be used to generate droplets, extract or inject volume to droplets, and/or split droplets. Also provided are methods for generating nucleosomes, and isolated DNA from nucleosomes (or from non-nucleosomes), for example using the disclosed devices.

Abstract: A hybrid Cascaded H-Bridge (CHB) converter can include a selective harmonic current mitigation pulse width modulation (SHCM-PWM) unit coupled to an input current and providing an output signal SWSHCM, a phase shift pulse width modulation (PSPWM) unit coupled to the input current and providing an output signal SWPS, a modulation selector coupled to the output signal SWSHCM of the SHCM-PWM unit and the output signal SWPS of the PSPWM unit and providing an output signal SW, and a CHB converter coupled to the output signal SW of the modulation selector. The modulation selector can select one of the output signals (SWSHCM and SWPS) as the output signal SW based on the input current.

Abstract: Substituted hydroquinones and quinones and methods of synthesizing such compounds are disclosed herein. The substituted hydroquinones have the formula: while the substituted quinones have the corresponding oxidized structure (1,4-benzoquinones). One, two, three, or all four of R1, R2, R3 and R4 comprise a thioether moiety and a sulfonate moiety, and wherein each R1, R2, R3 and R4 that does not comprise a thioether and a sulfonate moiety sulfonate moiety is independently a hydrogen, an alkyl or an electron withdrawing group. The substituted hydroquinones and quinones are soluble in water, stable in aqueous acid solutions, and have a high reduction potential in the oxidized form. Accordingly, they can be used as redox mediators in emerging technologies, such as in mediated fuel cells or organic-mediator flow batteries.

Abstract: The present disclosure relates to a method for producing a coating film having high heat resistance, high hardness and wear resistance, a coating film having high heat-resistance, high hardness and wear resistance produced using the method, and a cutting tool including the same. The method includes forming a metal nitride layer on a metal base; forming a carbon layer on the metal nitride layer; and irradiating a laser into the carbon layer to add carbons into a portion of the metal nitride layer, thereby to form a carburized layer.

Abstract: Described herein are compositions of antibodies and carrier proteins and methods of making and using the same, in particular, as a cancer therapeutic. Also described are lyophilized compositions of antibodies and carrier proteins and methods of making and using the same, in particular, as a cancer therapeutic.

Abstract: One embodiment of the present invention is directed to compositions and methods for enhancing attachment of soft tissues to a metal prosthetic device. In one embodiment a construct is provided comprising a metal implant having a porous metal region, wherein said porous region exhibits a nano-textured surface.

Abstract: The present invention relates a vertex optimization method and system using a depth image in workspace modeling, the method including generating a workspace model by scanning a workspace and modeling the workspace; generating a vertex image by projecting vertices in the workspace model generated in the scanning of the workspace; generating a depth image by expanding the vertices in the vertex image generated in the generating of the vertex image; and resampling the workspace model generated in the generating of the workspace model using the depth image generated in the generating of the depth image. Accordingly, the depth image can be generated from a vertex image obtained by projecting spatial data scanned through a 3D scanner onto a virtual wall, thereby uniformly aligning non-uniform vertices and filling gaps in which no vertices are generated.

Abstract: The present invention relates to a surgical apparatus for dissecting a part of cornea during lamellar keratoplasty, which provides a surgical apparatus comprising: an injector unit including a hollow injection needle having a bevel structure at one end; a laser unit for emitting a laser for OCT imaging; an OCT detection unit for photographing a tomographic image of the cornea using the laser; a laser light sensor located on an inner surface of the bevel structure of the injection needle and connected to the laser unit and the OCT detection unit through an optical fiber; and a depth adjusting unit for adjusting a depth of the injection needle in the cornea according to an operation of a user.

Abstract: Compounds that regulate quorum sensing in Staphylococcal bacteria and in particular in Staphylococcus aureus are provided. Compounds are described in formulas I, II, III, IV, V and VI herein. One or more compounds herein can be employed to inhibit QS and to thus inhibit virulence in Staphylococcus bacteria and in particular in Staphylococcus aureus. Compounds herein and pharmaceutical compositions containing one or more of these compounds are useful, for example, in treating infections of Staphylococcus bacteria and in particular of Staphylococcus aureus. Methods for treating such bacterial infections are provided.

Abstract: A mechanism is disclosed for reconstructing trimmed surfaces whose underlying spline surfaces intersect in model space, so that the reconstructed version of each original trimmed surface is geometrically close to the original trimmed surface, and so that the boundary of each respective reconstructed version includes a model space trim curve that approximates the geometric intersection of the underlying spline surfaces. Thus, the reconstructed versions will meet in a continuous fashion along the model space curve. The mechanism may operate on already trimmed surfaces such as may be available in a boundary representation object model, or, on spline surfaces that are to be trimmed, e.g., as part of a Boolean operation in a computer-aided design system.

Abstract: Disclosed herein is a composite comprising a metal alloy matrix; where the metal alloy matrix comprises aluminum in an amount greater than 50 atomic percent; a first metal and a second metal; where the first metal is different from the second metal; and where the metal alloy matrix comprises a low temperature melting phase and a high temperature melting phase; where the low temperature melting phase melts at a temperature that is lower than the high temperature melting phase; and a contracting constituent; where the contracting constituent exerts a compressive force on the metal alloy matrix at a temperature between a melting point of the low temperature melting phase and a melting point of the high temperature melting phase or below the melting points of the high and low temperature melting phases.

Abstract: Disclosed is a projection image generating method for a 3D space. An exemplary embodiment of the present disclosure provides a projection image generating method, including: estimating a plurality of image obtaining poses and a plurality of depth obtaining poses including obtaining positions and obtaining angles of a plurality of obtained images and a plurality of obtained depth values obtained in an actual 3D space, respectively, with respect to a reference coordinate system; obtaining a user pose including a location and an angle of the user in a virtual 3D space corresponding to the actual 3D space with respect to the reference coordinate system; and generating a projection image obtained by projecting the plurality of obtained depth values into at least one of the plurality of obtained images, based on the corresponding image obtaining pose corresponding to the user pose and at least one corresponding depth obtaining pose.

Abstract: A rice cultivar designated Calaroma-201 is disclosed. The invention relates to the seeds of rice cultivar Calaroma-201, to the plants of rice Calaroma-201 and to methods for producing a rice plant produced by crossing the cultivar Calaroma-201 with itself or another rice variety. The invention further relates to methods for producing a rice plant containing in its genetic material one or more transgenes and to the transgenic rice plants and plant parts produced by those methods. This invention also relates to rice cultivars or breeding cultivars and plant parts derived from rice cultivar Calaroma-201, to methods for producing other rice cultivars, lines or plant parts derived from rice cultivar Calaroma-201 and to the rice plants, varieties, and their parts derived from the use of those methods. The invention further relates to hybrid rice seeds and plants produced by crossing the cultivar Calaroma-201 with another rice cultivar.

Abstract: An electromagnetic brake actuator for a vehicle. The actuator includes a motor, a casing defining an inner space containing the motor, and an electric connector leading to outside of the actuator. The actuator includes a duct in which an electric conductor is placed, which electrically connects the motor to the electric connector. The duct is configured to allow fluid to pass between the electric connector and the inner space, through the electric connector.

Abstract: The invention provides enrichment platform devices for size-based capture of particles in solution. The enrichment platform device is useful for label-free capture of any particle. The invention relates to enrichment platform devices using nanowires and vertically aligned carbon nanotubes. The invention provides methods for making the enrichment platform devices. The invention provides methods for using the enrichment platform devices for filtering particles, capturing particles, concentrating particles, and releasing viable particles.

Abstract: A tunable amplifier includes continuous tunability for both frequency and power levels. The tunable amplifier includes a combination of a tunable series resonator and a multi-stage LC network as the output matching network. The tunable amplifier incorporates a variable diode varactor with high breakdown voltage and high tuning range into a tunable resonator. The tunable resonator is connected to a fixed output matching network to enable a wide range of operating frequencies. The tunable amplifier enables high power, high efficiency, broadband and load-modulated power amplification, which is greatly desired for next-generation wireless communication systems and other high-frequency applications.

Abstract: A method of delivering exosomes and other micro vesicles to a biological target includes the steps of 1) providing blood, (2) separating plasma from the provided blood, and (3) separating the solution with the exosomes therefrom, (4) encapsulating the exosomes, and (5) delivering the exosomes. The step of encapsulation may be accomplished by water bead process, alginate bead process, spray drying bead formation, or plating. The biological target may be a human or animal heart, bone/joint, wound or skin. A method of encapsulating an exosome, a method of using an encapsulated exosome, compositions including encapsulated exosomes, and an encapsulated exosome per se are also disclosed.

Abstract: This document provides methods and materials related to treating rotator cuff conditions (e.g., rotator cuff tendonitis or rotator cuff injuries such as partial rotator cuff tears). For example, methods and materials for using zinc or a zinc chelator to treat rotator cuff conditions are provided.

Abstract: An acellular soft tissue-derived matrix includes a collagenous tissue that has been delipidated and decellularized. Adipose tissue is among the soft tissues suitable for manufacturing an acellular soft tissue-derived matrix. Exogenous tissuegenic cells and other biologically-active factors may be added to the acellular matrix. The acellular matrix may be provided as particles, a slurry, a paste, a gel, or in some other form. The acellular matrix may be provided as a three-dimensional scaffold that has been reconstituted from particles of the three-dimensional tissue. The three-dimensional scaffold may have the shape of an anatomical feature and serve as a template for tissue repair or replacement. A method of making an acellular soft tissue-derived matrix includes steps of removing lipid from the soft tissue by solvent extraction and chemical decellularization of the soft tissue.