Abstract: The present invention relates to a dual-scale porous silica particle-based pharmaceutical composition for preventing or treating cancer, which includes porous silica nanoparticles and porous silica microparticles. The pharmaceutical composition of the present invention promotes the generation of a larger amount of antigen-specific, cytotoxic T cells against cancer than a mesoporous silica nanoparticle (MSN) vaccine, and exhibits increased anti-tumor efficacy compared with a mesoporous silica microrod (MSR) vaccine.

Abstract: The present invention relates to an enzyme-porous carbon composite, and more specifically, to an enzyme-porous material composite capable of realizing a much higher enzyme adsorption amount than porous silica and maintaining high stability of an immobilized enzyme.

Abstract: The present invention provides a biomarker for predicting effectiveness for autoimmune disease treatment, a diagnostic kit, and a use for treatment. More particularly, the present invention provides a biomarker for predicting the effectiveness of mesenchymal stem cells (MSC) comprising the chemokine receptor CXCR3 for autoimmune disease treatment; a biomarker comprising the chemokine CXCL10 for predicting the prognosis of autoimmune disease treatment; a diagnostic kit comprising an agent capable of measuring the expression of the biomarker; and a pharmaceutical composition for prevention or treatment of an autoimmune disease, which comprises mesenchymal stem cells having an upregulated expression level of the chemokine receptor CXCR3.

Abstract: An in-memory vector addition method for a dynamic random access memory (DRAM) is disclosed which includes consecutively transposing two numbers across a plurality of rows of the DRAM, each number transposed across a fixed number of rows associated with a corresponding number of bits, assigning a scratch-pad including two consecutive bits for each bit of each number being added, two consecutive bits for carry-in (Cin), and two consecutive bits for carry-out-bar (Cout), assigning a plurality of bits in a transposed orientation to hold results as a sum of the two numbers, for each bit position of the two numbers: computing the associated sum of the bit position; and placing the computed sum in the associated bit of the sum.

Abstract: The present disclosure relates to a neuron behavior-imitating electronic synapse device and a method of fabricating the same. According to one embodiment, the neuron behavior-imitating synapse device includes a first electrode having a lithium-doped surface, an active layer formed on the first electrode and including a polyelectrolyte and one or more metal nanoparticles, and a second electrode formed on the active layer.

Abstract: The present invention provides a method for detecting mycoplasma, which can directly confirm whether a cell is infected with mycoplasma, by simultaneously amplifying DNA extracted from lysing a host cell infected with mycoplasma, and mitochondrial DNA in the cytoplasm of the host cell. According to the method of the present invention, by directly using the DNA inside the host cell, the DNA of mycoplasma bound around the nucleus of the host cell can be used as an amplification target, thereby increasing detection sensitivity. In addition, since the mitochondrial DNA inside the host cell is used as an amplification target of an internal control sample, whether the sample has been sampled in an appropriate amount can be confirmed in a convenient manner, and furthermore, by comparing the band size between the internal control sample and the mycoplasma DNA, the degree of mycoplasma infection can be quantitatively confirmed.

Abstract: The invention provides a method and system for Dynamic Bandwidth Assignment (DBA) Virtualization in a Passive Optical Network, comprising an Optical Line Termination (OLT) point and a plurality of Optical Network Units (ONU) and a plurality of Virtual Network Units (VNO), wherein each VNO is configured with a virtual Dynamic Bandwidth Assignment module to schedule a bandwidth assignment independently of the other VNOs and using a merging engine to implement a detailed bandwidth scheduling allocation over the Passive Optical Network.

Abstract: Disclosed are a high-sensitivity temperature sensor and a method of manufacturing the same.

Abstract: A processor-implemented neural network method includes: generating a bit vector based on whether each of a plurality of input activations within a neural network is 0; merging the bit vector into the input activations such that bit values within the neural network included in the bit vector are most significant bits (MSBs) of multi bit expressions of the input activations; merging the bit vector into weights such that the bit values included in the bit vector are MSBs of multi bit expressions of the weights; sorting the input activations and the weights based on bits corresponding to the MSBs; and implementing the neural network, including performing operations between the sorted input activations and the sorted weights.

Abstract: Provided is a method and apparatus for predicting a posttraumatic behavior problem that may predict a posttraumatic violent behavior problem of an individual, in detail, that may determine a biological phenotype of an individual experiencing a traumatic event within a predetermined period after the individual is exposed to the traumatic event, predict a violent symptom presentation probability of the individual based on the biological phenotype of the individual, and suggest an objective basis for preventive intervention in a development of posttraumatic stress disorder (PTSD) of the individual based on a prediction result.

Abstract: Mechanisms for customizing a refractive index of an optical component are disclosed. In one example, sub-wavelength openings are formed in a top layer of anti-reflective (AR) material of an optical component to tailor transmission characteristics of the AR material over a range of angles of incidence and a range of wavelengths. In another example, sub-wavelength openings are formed at different filling fractions in the surface of the optical component.

Abstract: A computer-implemented method for determining the volume of activation of neural tissue. In one embodiment, the method uses one or more parametric equations that define a volume of activation, wherein the parameters for the one or more parametric equations are given as a function of an input vector that includes stimulation parameters. After receiving input data that includes values for the stimulation parameters and defining the input vector using the input data, the input vector is applied to the function to obtain the parameters for the one or more parametric equations. The parametric equation is solved to obtain a calculated volume of activation.

Abstract: The present invention relates to methods of using cell-free DNA analysis for guiding treatment of advanced prostate cancer. In particular, liquid biopsies are collected from urine and/or plasma of patients for measuring copy number variation in cell-free DNA associated with metastatic prostate cancer. In particular, urine genomic abnormality (UGA) and plasma genomic abnormality (PGA) values are contemplated for use in predicting treatment responses in advanced prostate cancer patients and for use in making decisions related to androgen deprivation therapy (ADT) treatment outcomes in hormone sensitive stage and for starting or changing chemotherapy treatments in castrate resistant advanced cancer stage.

Abstract: Mechanisms for customizing a refractive index of an optical component are disclosed. In one example, sub-wavelength openings are formed in a top layer of anti-reflective (AR) material of an optical component to tailor transmission characteristics of the AR material over a range of angles of incidence and a range of wavelengths. In another example, sub-wavelength openings are formed at different filling fractions in the surface of the optical component.

Abstract: Disclosed are a method of preparing a zeolite nanosheet and a zeolite nanosheet particle prepared thereby, and more particularly a method of preparing a zeolite nanosheet capable of preparing a monolayer zeolite nanosheet through a simple process of mixing a multilayer zeolite precursor with a swelling agent to swell the multilayer zeolite precursor and drying and calcining the multilayer zeolite precursor, wherein the monolayer zeolite nanosheet is useful to separate a catalyst or gas, and a zeolite nanosheet particle prepared thereby.

Abstract: Dual sequential defibrillation (DSD) systems and methods include the use of a timing device. The timing device can assist a user with DSD administration by providing notifications spaced apart by the inter-shock timing. The user can use these notifications to trigger the administration of defibrillation in a sequential manner. The timing device can also be coupled to two defibrillation devices and can output a signal to each of the defibrillation devices to cause the defibrillation device to administer a defibrillation. The output of the signals by the timing device can be spaced apart by the inter-shock timing. Additionally, the signals can be QRS-like in nature to cause the defibrillation devices to administer a defibrillation when in a sync mode.

Abstract: The present invention provides benzothiadiazine and chroman derivatives and particularly diazoxide and cromakalim derivatives for use in treating glaucoma, retinopathy, treating age related macular degeneration, treating, stabilizing and/or inhibiting blood and lymph vascularization, and reducing intraocular pressure by administering a pharmaceutically effective amount of a prodrug disposed in an ophthalmically acceptable carrier to the eye, wherein the prodrug specifically modulates a KATP channel to reduce an intraocular pressure.

Abstract: A test apparatus may include transceivers and a global de-skew circuit. In a training mode, the transceivers provide first timing information obtained by delaying a first data signal in the range of up to a preset unit interval based on a clock signal and receive second timing information corresponding to timing differences between a slowest transceiver and the remaining transceivers. In an operation mode, the transceivers provide compensation data to a plurality of DUTs (Devices Under Test) substantially simultaneously. The compensation data may be obtained by delaying a second data signal by multiples of the preset unit interval in response to the second timing information. In the training mode, the global de-skew circuit receives the first timing information, calculates, using the first timing information, the timing differences between the slowest transceiver and the remaining transceivers, and provides the second timing information corresponding to the timing differences to the transceivers.

Abstract: The present invention relates to devices and methods of use thereof for detection of biomolecules, in vitro, in vivo, or in situ. The invention relates to methods of diagnosing and/or treating a subject as having or being at risk of developing a disease or condition that is associated with abnormal levels of one or more biomolecules including, but not limited to, inter alia, epilepsy, diseases of the basal ganglia, athetoid, dystonic diseases, neoplasms, Parkinson's disease, brain injuries, spinal cord injuries, and cancer. The invention also provides methods of differentiating white matter from gray matter. In some embodiments, regions of the brain to be resected or targeted for pharmaceutical therapy are identified using sensors. The invention further provides methods of measuring the neurotoxicity of a material by comparing microvoltammograms of a neural tissue in the presence and absence of the material using the inventive sensors.

Abstract: Compositions and methods are provided for detection, diagnosis and prognosis of Lyme disease (LD), including a method for confirming Borrelia spp. infection by contacting, in vitro, whole blood samples from subjects suspected of having LD with synthetic peptides comprising T-cell epitope-containing regions derived from Borrelia proteins that are expressed at different stages of Lyme disease, and indirectly detecting LD-specific activated T-cells by determining production of a T-cell immune response indicator (e.g., interferon-Y) in response to stimulation by the peptides.