Abstract: The present disclosure generally relates to local therapies for the eye and, more particularly, to shaped controlled-release ocular implant devices, including methods for making and using such devices, for delivery of therapeutic agents to the eye. A molded two-layer ocular implant comprises a therapeutic agent for treatment or prevention of a disorder of the eye. The implant comprises a polymer layer and a silicone adhesive layer with a therapeutic agent interspersed therein and joined to the polymer layer. This implant is for placement in the sub-Tenon's space of the eye and provides sustained release of the therapeutic agent during the treatment or prevention of the disorder of the eye.

Abstract: An implantable biocompatible expander suitable for implantation into a urinary duct, comprises an elongated sinusoidal ring comprising at least two proximal prongs and at least two distal prongs, wherein the expander is resiliently deformable from a relaxed radially expanded orientation to a radially contracted orientation suitable for transluminal delivery through the urinary duct. The expander is configured to exert an outward radial force against a wall of the urinary duct when in-situ within the urinary duct. In particular, the expander is suitable for treatment of benign prostatic hyperplasia and configured for implantation into the prostatic urethra between, and substantially spanning the prostatic urethra between, the bladder neck and external sphincter.

Abstract: The present disclosure relates to a technique for manufacturing a humidifying membrane including a hydrophobic thin film-coating layer having a nano-sized crack morphology pattern on the surface of an aromatic hydrocarbon-based polymer ion exchange membrane and applying the membrane to a reverse electrodialysis process. The humidifying membrane including a hydrophobic thin film-coating layer having a nano-sized crack morphology pattern on the surface of an aromatic hydrocarbon-based polymer ion exchange membrane, manufactured according to the present disclosure, embodies a low bulk resistance of the ion exchange membrane and significantly improves ion selectivity, thereby overcoming the trade-off relationship between membrane resistance and ion selectivity, and thus may be commercially available as an anion and cation exchange membrane of a reverse electrodialysis device.

Abstract: Herein provided is a new soybean variety designated ‘G13LL-44’ as well as the seeds, plants and derivatives of the new soybean variety ‘G13LL-44’. Also provided are tissue cultures of the new soybean variety ‘G13LL-44’ and the plants regenerated therefrom. Methods for producing soybean plants by crossing the new soybean variety ‘G13LL-44’ with itself or another soybean variety and plants produced by such methods are also provided. ‘G13LL-44’ is a MG VII line with glufosinate tolerance technology, and with resistance to race 3 of the soybean cyst nematode and frogeye leaf spot, and moderate resistance to southern root-knot nematode. ‘G13LL-44’ yielded 1.4 bu/ac (2.3%) greater than its recurrent parent ‘G00-3213’, across 11 environments and 0.5 bu/ac more than the high-yielding check cultivar ‘AG738 RR’. ‘G13LL-44’ provides a high yielding glufosinate tolerant soybean cultivar with superior nematode resistance.

Abstract: The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for incorporating the compounds as used for the targeted imaging of tumors. Conjugation of the amino acid linking groups increase specificity and detection of the compound. Methods and compositions for use thereof in diagnostic imaging are contemplated.

Abstract: The present disclosure relates to a hair implanter with an automatically retracting needle, and more specifically, to a hair implanter with an automatically retracting needle configured to automatically move a needle backward by a force of a spring when the needle is moved forward to a predetermined position to allow hair transplantation work to be smoothly performed.

Abstract: A magnetic device includes: a conductive layer into which current is injected in a first direction, the conductive layer causing spin Hall effect or Rashba effect; a ferromagnetic layer disposed in contact with the conductive layer such that the ferromagnetic layer and the conductive layer are stacked on each other, a magnetization direction of the ferromagnetic layer being switched; and a spin filter structure having a fixed magnetization direction, the spin filter structure being disposed on at least one of the opposite side surfaces of the first direction of the conductive layer to inject spin-polarized current into the conductive layer.

Abstract: A method of predicting the risk of a patient for developing phenytoin-induced adverse drug reactions (ADRs), including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), or drug reactions with eosinophilia and systemic symptoms (DRESS) is disclosed. Genetic polymorphisms of CYP2C genes (including rs1057910 (CYP2C9*3) and rs3758581 on CYP2C19), and HLA alleles (including HLA-B*1502, HLA-B*1301, and HLA-B*5101) can predict adverse reactions caused by phenytoin or fosphenytoin. Accordingly, the present invention provides a kit to assess the risk of a patient for developing adverse reactions in response to phenytoin-related drugs, which comprises the determination of the presence of a specific allele selected from the group consisting of rs1057910 (CYP2C9*3), rs3758581 on CYP2C19, HLA-B*1502, HLA-B*1301, and HLA-B*5101, wherein the presence of at least one allele is indicative of a risk for the adverse drug reactions.

Abstract: The present disclosure provides for an immunogenic composition against epizootic hemorrhagic disease virus (EHDV). The immunogenic composition has been shown to be efficacious in inducing serum neutralizing antibodies against EHDV and intended to be used to prevent or reduce clinical symptoms associated with EHDV infection in susceptible animals. The disclosure provides for composition and methods that represent an improvement over previous strategies for treating and preventing EHDV.

Abstract: Provided are a semiconductor memory device including a capacitor and a method of fabricating the same. The capacitor may include a plurality of contacts that are electrically connected to the switching device, exposed on the top surface of a substrate, and are arranged in a first direction and a second direction different from the first direction, and the first direction and the second direction are parallel to the substrate; mold insulators that are formed on the substrate between the contacts adjacent to one another in the first direction from among the plurality of contacts, are formed to have a predetermined thickness and have a predetermined width in the second direction, and extend in a direction vertical to the substrate; bottom electrodes that have a vertical plate-like structure, are provided on and supported by sidewalls of the mold insulators, and are electrically and respectively connected to the plurality of contacts.

Abstract: A method of producing a magnetic resonance (MR) image of a region of interest is provided. The method includes the steps of: acquiring an initial MR image of the region of interest, the initial MR image mapping values of an MR-sensitive, physical property at positions over the region; determining a corresponding map of the estimated uncertainties in the values of the MR-sensitive, physical property over the region; and calculating a weighted MR image of the region, the weighted MR image mapping values of a function which combines, at each position of the initial image, the respective value of the MR-sensitive, physical property and the respective estimated uncertainty, the function applying a higher weighting to positions with relatively low estimated uncertainties than to positions with relatively high estimated uncertainties.

Abstract: An electric machine includes a rotor, permanent magnets, a stator, and a stator winding wound about a plurality of teeth to form a number of stator magnetic poles. The rotor includes a rotor core and a plurality of walls that form openings in the rotor core. A permanent magnet is mounted in each of the openings formed in the rotor core. The plurality of permanent magnets are arranged to form a plurality of groups of permanent magnets that are equally circumferentially distributed around the rotor core with an interior polarity on a side of each permanent magnet facing other permanent magnets of the group of permanent magnets to which the permanent magnet is associated that is the same for all of the permanent magnets. Each permanent magnet is arranged to form a rotor pole, wherein a number of rotor poles is greater than the number of stator magnetic poles.

Abstract: Systems for detecting analytes in electrical double layer nanopore devices and methods of use are provided.

Abstract: Disclosed are compositions and methods for increasing influenza virus production.

Abstract: Devices and methods for treating penile aberrations include the use of traction devices. For example, this document describes devices and methods for applying longitudinal and/or contralateral penile traction forces to treat anatomical aberrations related to Peyronie's disease and other conditions.

Abstract: The present invention discloses a two-terminal vertical 1T-DRAM and a method of fabricating the same. According to one embodiment of the present invention, the two-terminal vertical 1T-DRAM includes a cathode layer formed of a first-type high-concentration semiconductor layer; a base region including a second-type low-concentration semiconductor layer formed on the cathode layer and a first-type low-concentration semiconductor layer formed on the second-type low-concentration semiconductor layer; and an anode layer formed of a second-type high-concentration semiconductor layer on the first-type low-concentration semiconductor layer.

Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as colorectal cancer.

Abstract: Circuits and methods for power conversion. In some examples, a modular multi-level converter (MMC) is configured for power conversion between an alternating current (AC) bus and a direct current (DC) bus. The MMC includes submodules arranged into a phase leg for at least one phase of the AC bus. Each submodule includes an energy storage component and a switch configured for bypassing the energy storage component or connecting the energy storage component into the phase leg. The MMC includes a pre-charger circuit configured to pre-charge the energy storage components of the submodules. The pre-charger circuit is configured for providing a first DC voltage that is lower than a second DC voltage on the DC bus, and the pre-charger circuit is coupled to an end submodule of the phase leg.

Abstract: Provided are a compound of chemical formula 1 or 2 and a use thereof. The compound can be advantageously used in the prevention or treatment of metabolic diseases including type 2 diabetes, insulin resistance, or obesity, on the basis of a mechanism of autophagy activation through the promotion of lysosome production.

Abstract: The new variety ‘TH-1334’ ripens around mid-April in southeastern Georgia. The fruit of the new variety ‘TH-1334’ are very large, firm, have good flavor and scar. The new variety ‘TH-1334’ is vigorous with an estimated chilling requirement of about 50 to 100 hours at or below approximately 7° C. The asexually reproduced variety is reliably propagated vegetatively.