Patents Assigned to Hitachi High-Technologies Corporation
  • Patent number: 10613108
    Abstract: One actuator (a gripper mechanism and reagent bottle lid opening mechanism drive unit 120) drives a gripper mechanism 106 that holds a reagent bottle 10 and a reagent bottle lid opening mechanism 104 that incises a lid of the reagent bottle 10. The gripper mechanism 106 operates to ascend when the reagent bottle lid opening mechanism 104 operates to descend in order to incise the reagent bottle lid 112, and the reagent bottle lid opening mechanism 104 operates to ascend when the gripper mechanism 106 operates to descend in order to hold the reagent bottle 10. The reagent bottle lid opening mechanism 104 and the gripper mechanism 106 operate without interfering with each other's functions.
    Type: Grant
    Filed: February 18, 2016
    Date of Patent: April 7, 2020
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Takamichi Mori, Hitoshi Tokieda
  • Patent number: 10613026
    Abstract: Provided are an imaging method and device for imaging using far infrared light that make it possible to quickly image a subject without producing damage or a non-linear phenomenon in the subject. A variable-frequency coherent light source is used, illumination light from the light source is irradiated onto a linear area on an imaging subject, transmitted or reflected light is used to form an image of the imaging subject, a non-linear optical crystal is used for wavelength conversion, and a one-dimensional or two-dimensional array sensor is used to image the imaging subject while the imaging subject is moved in at least one direction.
    Type: Grant
    Filed: January 11, 2019
    Date of Patent: April 7, 2020
    Assignee: Hitachi High-Technologies Corporation
    Inventor: Kei Shimura
  • Patent number: 10612073
    Abstract: The present invention provides a method for constructing a single-stranded nucleic acid molecule for nucleic acid sequencing by means of a nanopore sequencer, said method including: a step in which at least one hairpin primer including a single-stranded region on the 3? side and a pair of primers are used to synthesize a complementary strand of template DNA that includes the target sequence; and a step in which the synthesized complementary strand forms a hairpin structure inside a molecule and a template extension reaction is carried out. The obtained nucleic acid molecule includes both the target sequence and the complementary strand thereof in the sequence. Single strand construction enables analysis by nanopore sequencing, and the sequence of only the target nucleic acid, which does not include information of the complementary strand, is repeatedly analyzed, thus enabling analysis to be conducted with greater precision by addressing the problem of sequence errors.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: April 7, 2020
    Assignee: Hitachi High-Technologies Corporation
    Inventor: Michiru Fujioka
  • Patent number: 10613107
    Abstract: A connection unit connects one end of each of two processing systems and includes a processing unit for carrying out necessary processing on a specimen in a specimen container held by a specimen holding rack. The first and second processing systems each have an opening and closing part that can be opened and closed to expose an access surface for an operator. The connection unit is configured so as to connect the first and second processing systems in such a way that a distance along a horizontal plane from the access surface of the first processing system to the one end of the second processing system is longer than a distance by which the opening and closing part of the first processing system moves when opening and closing. Thus, various layouts resulting from the structure are possible within an inspection room without diminishing the ease of operation.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: April 7, 2020
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Toshiki Yamagata, Kenichi Takahashi, Hiroki Ihara
  • Patent number: 10605818
    Abstract: The purpose of the present invention is to stably hold the lid of a reagent container in an open state without being influenced by reagent container lid opening and closing operations. An automated analyzer is provided with reagent containers 116-118, a cassette 100, a reagent container lid opening and closing mechanism, and a lid holding mechanism 131. The reagent containers 116-118 accommodate the reagent and have lids 101a-101c that pivot about a pivot point. The reagent containers 116-118 are mounted on the cassette 100. The reagent container lid opening and closing mechanism opens and closes the lids 101a-101c. The lid holding mechanism 131 holds the lids 101a opened by the reagent container lid opening and closing mechanism.
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: March 31, 2020
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Kazuhiro Noda, Yukinori Sakashita, Takushi Miyakawa, Katsuhiro Kambara
  • Patent number: 10607825
    Abstract: Acceleration of decelerated ions and a reduction in the velocity dispersion width of decelerated ions are both achieved, whereby the sensitivity of detected ion sensitivity is improved and resolution is improved. The distance dx between at least one set of facing rod-shaped electrodes among rod-shaped electrodes (4-2-a) to (4-2-d) differs at the inlet part at which ions enter and the outlet part at which ions exit, and the distance dx between the at least one set of facing rod-shaped electrodes is gradually reduced or increased from the inlet part toward the outlet part.
    Type: Grant
    Filed: November 9, 2016
    Date of Patent: March 31, 2020
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Kiyomi Yoshinari, Yasushi Terui
  • Patent number: 10604393
    Abstract: A device for unstopping a stopped specimen vessel that contains a liquid specimen such as blood is equipped with a mechanism which sucks and captures particles floating around the opening of the specimen vessel and prevents contamination of the specimen. The unstopping device grips a vessel and the stopper of the opening of the vessel, and removes the stopper from the opening of the vessel by changing the relative distance between the vessel-gripping mechanism and the unstopping mechanism. The unstopping device is equipped with: suction holes for sucking therethrough the gas which is present around the opening and contains liquid or solid particles; a pipeline which is connected to the suction holes and through which the sucked gas and particles are led downstream; a suction device connected to the pipeline; and a spirally flexed pipeline part disposed between the pipeline and the suction device.
    Type: Grant
    Filed: June 29, 2015
    Date of Patent: March 31, 2020
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Hideo Enoki, Shigeki Yamaguchi, Takahiro Sasaki, Tooru Inaba
  • Patent number: 10603667
    Abstract: Provided are a device and a cleaning mechanism for a reaction container in the device that are characterized by being provided with: a reaction disk for holding a reaction container; a sample dispensing mechanism for dispensing a sample to the reaction container; a reagent dispensing mechanism for dispensing a reagent to the reaction container; an optical system comprising a light source for applying light to a mixture of the sample and the reagent dispensed to the reaction container, and a detector for detecting the light applied from the light source; and a cleaning mechanism for cleaning the reaction container, wherein the cleaning mechanism is provided with a cleaning liquid supply nozzle for supplying a cleaning liquid to the reaction container after an analysis, a cleaning liquid suction nozzle for suctioning the supplied cleaning liquid, and a cleaning tip provided on the lower end of the cleaning liquid suction nozzle, and the side surface of the cleaning tip is formed such that the width of the clean
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: March 31, 2020
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Kei Shioya, Masahiko Iijima
  • Patent number: 10605817
    Abstract: A reagent container transfer mechanism transfers a reagent container selected from among reagent containers stored in a second reagent container storage section to a first reagent container storage section. A controller controls the reagent container transfer mechanism to transfer a reagent container from a second reagent container storage section to the first reagent container storage section on the basis of a predetermined priority condition. The predetermined priority condition is one of a reagent provided with an effective calibration curve result, a number of remaining tests, and an expiration date of a reagent.
    Type: Grant
    Filed: November 7, 2018
    Date of Patent: March 31, 2020
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Masaki Shiba, Masaaki Hanawa, Masaharu Nishida, Hitoshi Otake
  • Patent number: 10600614
    Abstract: The present invention is to provide a stage device capable of improving field-of-view positioning accuracy of a stage having a Z-axis mechanism. The invention is directed to a sample stage device having a first table that moves a sample in a first direction, a second driving mechanism that moves the first table in a second direction different from the first direction, and a part having a function of moving a laser interferometer optical axis that measures the position of the first table, in the second direction.
    Type: Grant
    Filed: September 5, 2018
    Date of Patent: March 24, 2020
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Motohiro Takahashi, Masaki Mizuochi, Shuichi Nakagawa, Tomotaka Shibazaki, Hironori Ogawa, Naruo Watanabe, Takanori Kato
  • Patent number: 10600617
    Abstract: A plasma processing apparatus includes: a vacuum chamber in which plasma is formed; an inner chamber detachable from the vacuum chamber; a sample stage disposed in the inner chamber; a sample stage ring base disposed in the inner chamber; and a suspension beam coupled to the sample stage ring base in a space between the vacuum chamber and the inner chamber. With the inside of the vacuum chamber hermetically sealed, the inner chamber is placed on the sample stage ring base, and the inside is hermetically sealed. The upper part of the suspension beam is vertically movably held to a sample stage base plate configuring the upper part of the vacuum chamber to cover the inside. The plasma processing apparatus includes a conductive connector sandwiched between the suspension beam made of SUS and the upper part of the member and the sample stage base plate.
    Type: Grant
    Filed: September 12, 2019
    Date of Patent: March 24, 2020
    Assignee: HITACHI HIGH-TECHNOLOGIES CORPORATION
    Inventors: Masakazu Isozaki, Takahisa Hashimoto
  • Patent number: 10600619
    Abstract: A plasma processing method in which a stable process region can be ensured in a wide range, from low microwave power to high microwave power. The plasma processing method includes making production of plasma easy in a region in which production of plasma by continuous discharge is difficult, and plasma-processing an object to be processed, with the generated plasma, wherein the plasma is produced by pulsed discharge in which ON and OFF are repeated, radio-frequency power for producing the pulsed discharge, during an ON period, is a power to facilitate production of plasma by continuous discharge, and a duty ratio of the pulsed discharge is controlled so that an average power of the radio-frequency power per cycle is power in the region in which production of plasma by continuous discharge is difficult.
    Type: Grant
    Filed: April 6, 2016
    Date of Patent: March 24, 2020
    Assignee: HITACHI HIGH-TECHNOLOGIES CORPORATION
    Inventors: Yoshiharu Inoue, Tetsuo Ono, Michikazu Morimoto, Masaki Fujii, Masakazu Miyaji
  • Patent number: 10593512
    Abstract: The present invention provides a light guide capable of guiding light generated by a scintillator at high efficiency to a photoreceiving element, a detector, and a charged particle beam device. For attaining the purpose, the present invention proposes a light guide that guides light generated by a scintillator to a photoreceiving element, provided with a scintillator containment portion formed of a first surface facing a surface opposite to a charged particle incident surface of the scintillator and a second surface facing a surface different from the surface opposite to the charged particle incident surface of the scintillator, and a tilted surface reflecting light incident from the second surface to the inside of the light guide.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: March 17, 2020
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Yoshifumi Sekiguchi, Shin Imamura, Hajime Kawano, Shahedul Hoque
  • Patent number: 10591018
    Abstract: The vibration-suppressing mechanism includes: a first arcuate member that has an inner wall surface shaped along an outer wall of a column of a charged particle beam device; a second arcuate member that has an inner wall surface shaped along an outer wall of a column of the charged particle beam device and is connected to the first arcuate member to form an annular member surrounding the outer wall of the column of the charged particle beam device; a fastening member fastening both the first arcuate member and the second arcuate member together; a vibration sensor attached to the arcuate member; and an actuator that operates in response to an output of the vibration sensor, and can be detached by releasing connection obtained by a connecting member.
    Type: Grant
    Filed: June 14, 2017
    Date of Patent: March 17, 2020
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Hiroki Takahashi, Shuichi Nakagawa, Toshihiko Shimizu, Hironori Ogawa, Toshihiro Arisaka
  • Patent number: 10593062
    Abstract: A defect observation apparatus includes a storage unit configured to store defect information about defects detected by an external inspection apparatus; a first imaging unit configured to capture an image of a defect using a first imaging condition and a second imaging condition; a control unit configured to correct positional information on the defect using the image captured with the first imaging unit; and a second imaging unit configured to capture an image of the defect based on the corrected positional information.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: March 17, 2020
    Assignee: HITACHI HIGH-TECHNOLOGIES CORPORATION
    Inventors: Yuko Otani, Kazuo Aoki, Yohei Minekawa
  • Patent number: 10591442
    Abstract: The present invention addresses the problem of checking defects of a rail for a vehicle with a high SN ratio. A detection device (2) for generating check data related to the defects of a railway rail RR (rail for a vehicle) is provided with an oscillating coil C1 (211) and an oscillating coil C2 (211) that are disposed on the surface opposite the railway rail RR and generate AC magnetic fields whose directions are opposite to each other, and a receiving coil (212) that is positioned between or in the vicinity the oscillation coils and that outputs a magnetic field waveform based on the magnetic fields received from the oscillating coils as the check data.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: March 17, 2020
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Ryuzo Kawabata, Akihiko Kandori, Noritake Shizawa, Kenji Yamamoto, Hiroyuki Kanda
  • Patent number: 10591498
    Abstract: Provided is an automatic analyzer capable of replacing an insertion mechanism while suppressing occurrence of dispensing abnormality and analysis result abnormality accompanying deterioration of the insertion mechanism. Included are an insertion mechanism that is inserted into a closed container through a lid of the container; a storage unit that stores an insertion history count corresponding to a cumulative load of the insertion mechanism caused by inserting the insertion mechanism into a plurality of the containers, and an allowable insertion history count which is an allowable value of the insertion history count; and a control unit that compares the insertion history count with the allowable insertion history count and performs control to make a notification to an operator in a case where the insertion history count reaches the allowable insertion history count.
    Type: Grant
    Filed: February 1, 2016
    Date of Patent: March 17, 2020
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Koichi Nishimura, Hiroyuki Takayama
  • Patent number: 10586676
    Abstract: An object of the present invention is to provide a charged particle beam device capable of correcting an image drift caused by stage deformation or the like during imaging immediately after stage movement. In order to achieve the above object, proposed is a charged particle beam device including: a sample chamber; a sample stage arranged in the sample chamber; a charged particle beam source which releases a charged particle beam; a deflector which deflects the charged particle beam released from the charged particle beam source; a focusing lens which focuses the charged particle beam; and a control device that controls the sample stage and the deflector, in which the control device calculates a deflection signal to be supplied to the deflector based on a thrust information when driving of the sample stage and a coefficient assigned for each position of the sample stage.
    Type: Grant
    Filed: June 14, 2017
    Date of Patent: March 10, 2020
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Takanori Kato, Motohiro Takahashi, Shuichi Nakagawa, Hironori Ogawa
  • Patent number: 10586674
    Abstract: In order to provide a stable hexaboride single-crystal field emission electron source capable of heat-flashing, this field emission electron source is provided with a metal filament, a metal tube joined thereto, a hexaboride tip that emits electrons, and graphite sheets that are independent of the metal tube and the hexaboride tip. The hexaboride tip is arranged so as not to be in structural contact with the metal tube due to the graphite sheets. The hexaboride tip, the graphite sheets, and the metal tube are configured so as to be mechanically and electrically in contact with one another.
    Type: Grant
    Filed: November 24, 2016
    Date of Patent: March 10, 2020
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Toshiaki Kusunoki, Tomihiro Hashizume, Keigo Kasuya, Takashi Ohshima, Yusuke Sakai, Yoichi Ose, Noriaki Arai
  • Patent number: 10585089
    Abstract: When using an immunological analysis method wherein antigen-antibody reactions are used to form complexes of microparticles and a substance being measured, purifying, then measuring by spectroscopy, and a mass spectrometry method wherein antigen-antibody reactions are used to form complexes of microparticles and a substance being measured, purifying, then measuring with a mass spectrometer, the amount of the complex flowing in the flow path for immunological analysis and the amount of the complex flowing in the flow path for mass spectrometry are unknown, so the substance being measured cannot be accurately quantified even when merging information obtained from immunological analysis and information obtained from mass spectrometry. The invention provides a mechanism for quantifying the complexes after formation of the complexes, on the flow path for mass spectrometry and the flow path for immunological analysis.
    Type: Grant
    Filed: June 17, 2015
    Date of Patent: March 10, 2020
    Assignee: HITACHI HIGH-TECHNOLOGIES CORPORATION
    Inventors: Makoto Nogami, Shinya Ito, Tadao Yabuhara