Patents Assigned to Indena S.p.A.
  • Process for the glycosidation of colchicine and thiocolchicine
    Patent number: 8742080
    Abstract: A process for the preparation of compounds having formula (I) is disclosed, wherein: —R1 is a methoxy or methylthio group; —R2 is a O-glycosyloxy residue. Compounds having formula (I) are prepared by reacting the corresponding precursor having R2?OH and the suitably protected 1-acetyl-glycose.
    Type: Grant
    Filed: April 9, 2009
    Date of Patent: June 3, 2014
    Assignee: Indena S.p.A.
    Inventors: Stephen Beszant, Bruno Gabetta
  • SOLID FORMS OF ORTATAXEL
    Publication number: 20140128459
    Abstract: The present invention relates to solid forms of 13-(N-Boc-?-isobutylserinyl)-14-?hydroxybaccatin III 1, 14-carbonate (Ortataxel). Amorphous Form A, crystalline Form B, mixtures thereof and processes for preparing them are disclosed. Amorphous Form A is prepared by fast precipitation of Ortataxel from a mixture of acetone and water. Form A transforms in Form B when suspended and stirred in a mixture of ethanol and water for 4-8 hours. If the suspension is stirred for less than 4 hours, mixtures of Form B and Form A are obtained. Form B or mixtures of Forms A and B can also be obtained dissolving Ortataxel in a protic organic solvent, followed by addition of water.
    Type: Application
    Filed: December 10, 2013
    Publication date: May 8, 2014
    Applicant: Indena S.p.A.
    Inventors: Daniele Ciceri, Nicola Sardone, Bruno Gabetta, Maurizio Ricotti
  • Cosmetic wrinkle treatment method based on a zanthoxylum bungeanum extract
    Patent number: 8632826
    Abstract: The present invention relates to a cosmetic wrinkle treatment method which comprises the topical application of a Zanthoxylum bungeanum extract obtainable by extraction with carbon dioxide under hypercritical conditions. The present invention also relates to the use of such Zanthoxylum bungeanum extract for the preparation of topical compositions for the cosmetic treatment of skin wrinkles.
    Type: Grant
    Filed: February 18, 2010
    Date of Patent: January 21, 2014
    Assignee: Indena S.p.A.
    Inventors: Christian Artaria, Giada Maramaldi
  • Process for the preparation of isoserine derivatives
    Patent number: 8624051
    Abstract: This invention relates to a “one pot” process for the preparation of isoserine derivatives in high diastereoselective way. The process according to the invention includes the steps of reacting a protected glycidic acid with imines to yield isoserines protected both at the —OH and at the —COOH groups, deprotection of the obtained intermediates to isoserines or isoserine 1-4C— alkyl esters. Pure threo derivatives as the main isomer are obtained.
    Type: Grant
    Filed: April 13, 2011
    Date of Patent: January 7, 2014
    Assignee: Indena S.p.A.
    Inventors: Gabriele Fontana, Maria Luisa Gelmi, Federico Gassa
  • Use of a ginkgo complexes for the enhancement of cognitive functions and the alleviation of mental fatigue
    Patent number: 8591965
    Abstract: The use of Ginkgo complexed with phosphatidylserine for the manufacture of a medicament or a dietary supplement for the enhancement of cognitive function and alleviation of mental fatigue, i.e. to improve the speed of memory and memory quality, to increase accuracy and attention in activities in normal healthy subjects, to prevent deterioration of the speed and quality of memory in people with decreased cognitive functions, to counteract cognitive fatigue, and also having an influence on the mood, particularly in healthy children, young adults, middle-aged and/or old people. It is further provided the use of the Ginkgo-phosphatidylserine complex for the treatment and prevention of disease related with decreased cognitive function and increased mental fatigue such as Dementia, and Alzheimer's Disease.
    Type: Grant
    Filed: January 26, 2005
    Date of Patent: November 26, 2013
    Assignee: Indena S.p.A.
    Inventors: Paolo Morazzoni, Orlando Petrini, Andrew Scholey, David Kennedy
  • Cloning, yeast expression, purification and biological activity of the extension region of the soybean 7S globulin alfa' subunit involved in HEP G2 cell cholesterol homeostasis
    Patent number: 8569455
    Abstract: A truncated form of ?? chain (e??), the soybean 7S globulin, active in controlling the cholesterol and triglyceride homeostasis in in vitro and in vivo models, was cloned and expressed in the yeast Pichia pastoris. The recombinant polypeptide spanned 142 amino acid residues from the N-terminal side and included the N-terminal extension region of the soybean alpha? subunit. The e?? polypeptide was purified by conventional biochemical techniques and its potential to modulate the activity of the LDL-receptor was evaluated in a human hepatoma cell line (Hep G2) by monitoring the uptake and degradation of labeled LDL.
    Type: Grant
    Filed: June 16, 2010
    Date of Patent: October 29, 2013
    Assignee: Indena S.p.A.
    Inventors: Paolo Morazzoni, Antonella Riva, Cesare Ponzone, Davide Berlanda, Marcello Duranti, Alessandro Consonni
  • Stable and bioavailable compositions of isomers of lycopene for skin and hair
    Patent number: 8568806
    Abstract: The present invention relates to a method of manufacturing a stable composition enriched in cis-lycopene (z-isomers) by prolonged heating in solvents of tomatoes, parts of tomatoes, derivative thereof or tomato extracts in solvents.
    Type: Grant
    Filed: July 30, 2007
    Date of Patent: October 29, 2013
    Assignee: Indena, S.p.A.
    Inventors: Andrea Giori, Federico Franceschi
  • FORMULATIONS FOR THE TREATMENT OF DISORDERS OF THE UPPER RESPIRATORY TRACT
    Publication number: 20130280355
    Abstract: The present invention relates to formulations containing extracts of Vaccinium myrtillus or other species rich in anthocyanosides, Punica granatum, Echinacea, and optionally Krameria triandra. Said formulations are useful in the treatment of disorders of the mouth and its adnexa, the throat and respiratory tract, and in the treatment of influenza.
    Type: Application
    Filed: October 5, 2011
    Publication date: October 24, 2013
    Applicant: INDENA S.P.A.
    Inventors: Ezio Bombardelli, Massimo Ronchi, Paolo Morazzoni
  • FORMULATIONS CONTAINING EXTRACTS OF ECHINACEA ANGUSTIFOLIA AND ZINGIBER OFFICINALE WHICH ARE USEFUL IN REDUCING INFLAMMATION AND PERIPHERAL PAIN
    Publication number: 20130266672
    Abstract: Disclosed is a combination of lipophilic extracts of Zingiber officinale and Echinacea angustifolia for the treatment of itching, peripheral pain, superficial and deep inflammatory and painful states, pain associated with muscle spasms, herpes pain, and radiodermatitis caused by oncological radiotherapy, with or without fungal or bacterial infections.
    Type: Application
    Filed: July 20, 2011
    Publication date: October 10, 2013
    Applicant: INDENA S.P.A.
    Inventors: Ezio Bombardelli, Paolo Morazzoni
  • COMPOSITIONS FOR THE TREATMENT OF PERIPHERAL ULCERS OF VARIOUS ORIGINS
    Publication number: 20130236575
    Abstract: The present invention relates to compositions containing a combination of a cell proliferation-stimulating agent with vasokinetic properties and an antimicrobial, antifungal and antiviral agent with an anti-inflammatory/analgesic, which is useful in the treatment of peripheral ulcers of various origins, such as diabetic ulcers, ulcers caused by venous stasis of the limbs, bedsores and the associated skin infections. Said combination could be presented as formulations for topical or systemic use.
    Type: Application
    Filed: October 21, 2011
    Publication date: September 12, 2013
    Applicant: INDENA S.P.A.
    Inventors: Ezio Bombardelli, Paolo Morazzoni, Massimo Ronchi
  • Compositions for the treatment and prevention of infections of the oral cavity
    Patent number: 8496975
    Abstract: The present invention relates to compositions comprising benzophenanthridine alkaloids, benzofuran compounds and catechin polyphenols, which are useful in the treatment and prevention of infections of the oral cavity.
    Type: Grant
    Filed: April 6, 2009
    Date of Patent: July 30, 2013
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombardelli, Gabriele Fontana, Andrea Giori, Paolo Morazzoni, Antonella Riva, Massimo Ronchi
  • ANTIMICROBIAL COMPOSITIONS
    Publication number: 20130149257
    Abstract: The present invention relates to the use as an antimicrobial of tamarind seed polysaccharide (TSP) and to antimicrobial compositions which contain it as active ingredient. Antimicrobial compositions containing TSP are particularly useful for topical administration in the treatment and/or prevention of microbial infections of the skin and mucosa.
    Type: Application
    Filed: May 23, 2011
    Publication date: June 13, 2013
    Applicant: INDENA S.P.A.
    Inventors: Andrea Giori, Giacomo Mombelli, Stefano Togni
  • ANTI-INFLAMMATORY COMPOSITIONS
    Publication number: 20130136813
    Abstract: The present invention relates to the use as an anti-inflammatory of tamarind seed polysaccharide (TSP) and to anti-inflammatory compositions which contain it as active ingredient. Anti-inflammatory compositions containing TSP are particularly useful for topical administration in the treatment of inflammatory diseases of the skin and mucosa.
    Type: Application
    Filed: May 23, 2011
    Publication date: May 30, 2013
    Applicant: INDENA S.P.A.
    Inventors: Andrea Giori, Sabrina Arpini, Stefano Togni
  • COMPOSITIONS COMPRISING LIPOPHILIC EXTRACTS OF ZINGIBER OFFICINALE AND ECHINACEA ANGUSTIFOLIA FOR THE PREVENTION AND TREATMENT OF GASTRO-OESOPHAGEAL REFLUX AND CHEMOTHERAPY-INDUCED EMESIS
    Publication number: 20130108720
    Abstract: The present invention relates to compositions consisting of a combination of lipophilic extracts of Zingiber officinale and Echinacea angustifolia, obtained by extraction with carbon dioxide under supercritical conditions, which are useful for the prevention and treatment of oesophageal reflux and chemotherapy-induced emesis.
    Type: Application
    Filed: December 20, 2012
    Publication date: May 2, 2013
    Applicant: INDENA S.P.A.
    Inventor: INDENA S.P.A.
  • COMPOSITIONS FOR THE TREATMENT OF GYNAECOLOGICAL DISORDERS
    Publication number: 20130108717
    Abstract: The present invention relates to a combination of a rhatany extract, 18?-glycyrrhetic acid, in free form and in complexes with phospholipids, and Zanthoxylum bungeanum extract, for the topical treatment of gynaecological disorders, especially vulvovaginal infections.
    Type: Application
    Filed: May 3, 2011
    Publication date: May 2, 2013
    Applicant: INDENA S.P.A.
    Inventor: Stefano Togni
  • PROCESS FOR THE PREPARATION OF ISOSERINE DERIVATIVES
    Publication number: 20130090493
    Abstract: This invention relates to a “one pot” process for the preparation of isoserine derivatives in high diastereoselective way. The process according to the invention includes the steps of reacting a protected glycidic acid with imines to yield isoserines protected both at the —OH and at the —COOH groups, deprotection of the obtained intermediates to isoserines or isoserine 1-4C— alkyl esters. Pure threo derivatives as the main isomer are obtained.
    Type: Application
    Filed: April 13, 2011
    Publication date: April 11, 2013
    Applicant: INDENA S.P.A
    Inventors: Gabriele Fontana, Maria Luisa Gelmi, Federico Gassa
  • p185-encoding DNA and therapeutical uses thereof
    Patent number: 8389494
    Abstract: Methods for inhibiting the formation and growth of a p185neu positive tumor in a subject, and for treating a subject having a p185neu positive tumor, utilizing a DNA vector coding for a chimeric rat/human Her-2/neu/ErbB-2 protein are provided.
    Type: Grant
    Filed: May 17, 2011
    Date of Patent: March 5, 2013
    Assignee: Indena S.p.A.
    Inventors: Augusto Amici, Federica Cavallo, Guido Forni, Cristina Marchini
  • Grape seeds extracts obtainable by fractioning on a resin
    Patent number: 8372445
    Abstract: A process for the extraction of Vitis vinifera seeds which comprises: a) extraction of grape seeds with a solvent (total extract); b) removal of water-insoluble tannins; c) optional removal of water-soluble tannins; d separation of the products with different MW, through chromatographic purification on a column.
    Type: Grant
    Filed: July 13, 2006
    Date of Patent: February 12, 2013
    Assignee: Indena S.p.A.
    Inventors: Andrea Giori, Alessandro Anelli
  • Compositions comprising lipophilic extracts of and for the prevention and treatment of gastro-oesophageal reflux and chemotherapy-induced emesis
    Patent number: 8361521
    Abstract: The present invention relates to compositions consisting of a combination of lipophilic extracts of Zingiber officinale and Echinacea angustifolia, obtained by extraction with carbon dioxide under supercritical conditions, which are useful for the prevention and treatment of oesophageal reflux and chemotherapy-induced emesis.
    Type: Grant
    Filed: January 15, 2010
    Date of Patent: January 29, 2013
    Assignee: Indena, S.p.A.
    Inventor: Ezio Bombardelli
  • Formulations for the treatment of arthritis conditions
    Patent number: 8343554
    Abstract: The present invention relates to formulations comprising combinations of analgesic/anti-inflammatory, immunomodulating and cartilage-reconstructing agents in particular comprising saligenig, boswellic acid, procyanidins, N-acety-glucosamine and either glucoronic acid or glucoronolactone, for the treatment of rheumatoid arthritis and, more generally, of arthritis conditions.
    Type: Grant
    Filed: January 6, 2004
    Date of Patent: January 1, 2013
    Assignee: Indena S.p.A.
    Inventor: Ezio Bombardelli