Abstract: A monolithic, three-dimensional (3D) integrated circuit (IC) device includes a sensing layer, a memory layer, and a processing layer. The sensing layer includes a plurality of carbon nanotube field-effect transistors (CNFETs) that are functionalized with at least 50 functional materials to generate data in response to exposure to a gas. The memory layer stores the data generated by the plurality of CNFETs, and the processing layer identifies one or more components of the gas based on the data generated by the plurality of CNFETs.

Abstract: An apparatus and method for a pre-trained brain machine interface based on brain state data is disclosed. An initial session of determining brain state data during performance of a task by a subject at a first time is conducted. The brain state data correlated with task performance are recorded. A pre-training set of the brain state data is assembled. A decoder module of the brain machine interface system is pre-trained via the pre-training set of the recorded brain state data to decode intentions of the subject correlated with brain state. A current session is conducted at a second time subsequent to the first time. The current session includes the decoder module accepting a brain state data input of the brain of the subject, decoding a brain state output from the brain state data input, and generating a control signal to perform the task based on the determined brain state output.

Abstract: A position sensor with six degrees of freedom (DoF) measurement capability may be used for position sensing of the rotor in a bearingless slice motor to enable active control. The sensor is designed to fit entirely under the rotor and operates by accessing the rotor bottom surface only, enabling packaging of the pump on the top of the rotor. The sensor has two parts; both operate using eddy currents. One of these parts measures the two radial DoF of the rotor. The other part measures the axial, angular rotation and tip/tilt DoF. The sensor utilizes a conductive target fixed to the underside of the rotor. The design and fabrication of the sensor along with the signal processing methods are described.

Abstract: Provided herein are chimeric antigen receptor (CAR) viral libraries and methods of making the same. In some embodiments, the CAR comprises an intracellular domain (ICD) with at least one immune activation signaling domain, one co-stimulatory domain, and one or more inhibitory signaling domain or signaling domain from non-T cell lineages. In some embodiments, the signaling domains of the ICD are joined by distinct linkers of 10 amino acids. In some embodiments, the CARs contain a 18-nucleotide barcode in the 3? untranslated region. Also provided herein, are CAR cell libraries and methods of making the same.

Abstract: An integrated photonic platform for a transceiver aperture. New functions that can only be realized in the integrated platform are further described.

Abstract: A bearingless split tooth flux-reversal motor (FRM) for use with a pump, such as a centrifugal blood pump. In some embodiments, the motor has a magnet-free rotor and a magnetic configuration wherein the force generation is independent of the rotor angle, allowing for simple radial force generation using stator-fixed currents. The motor torque can be generated using commutated two-phase currents.

Abstract: Methods and apparatus for determining a contractile reserve of a heart of a patient are provided. The method includes controlling a heart pump to operate at a first speed, determining based on a motor current signal received from a motor when the heart pump is operating at the first speed, a first value for a cardiac contractility metric, controlling the heart pump to operate at a second speed, determining based, at least in part, on the motor current signal received from the motor when the heart pump is operating at the second speed, a second value for the cardiac contractility metric, determining a contractile reserve metric based, at least in part, on the first value and the second value of the cardiac contractility metric, and outputting an indication of the contractile reserve metric on a user interface associated with the heart pump.

Abstract: A replacement heart valve device is disclosed. In some embodiments, the device includes a frame coupled to one or more leaflets that are moveable between open and closed configurations. In some embodiments, the frame comprises at least two frame sections that join at a pair of commissural posts. In some embodiments, the device may be geometrically accommodating to adapt to different vasculature shapes and sizes and/or to be able to change size while implanted within a growing patient.

Abstract: The invention discloses methods for simultaneously measuring various properties of a fluid using a waveguide. The method includes transmitting a plurality of wave modes into the fluid using an ultrasonic shear wave transducer from one end of a waveguide. Further, the wave modes are reflected from the other end of the waveguide. The reflected wave modes are processed simultaneously. The time of flight and the amplitude of the received wave modes are determined. Further, one or more properties of the fluid are measured using determined time of flight and amplitude of the received wave modes. The disclosed method is used to accurately measure the properties of fluid such as level, density, viscosity or flow rate in a short period of time.

Abstract: A dc-dc converter can include a plurality of switches, a piezoelectric resonator (PR) for power stage energy storage, and a means for controlling one or more switching sequences. The switches operate in accordance with the switching sequences to transfer energy from the input to the output via the PR while providing low-loss resonant soft-charging of the PR's capacitance. The switching sequences include: connected stages in which a first and second PR terminals are both connected to one of the input, the output, or the other PR terminal; and open stages in which at least one of the first or second PR terminal is not connected by a closed switch to one of the input, the output, or the other PR terminal.

Abstract: The present disclosure generally relates to apparatuses, systems, and methods for separating a target species (e.g., CO2) from a gas mixture (e.g., gas stream) via an electrochemical process.

Abstract: An auto-powered biosensor capable detecting a target molecule, and a method of powering the same, wherein the biosensor is fabricated with a microfluidics layer, a multimodal sensing layer comprising a biofuel cell and an electrode, and a logic circuit that may include a processor and non-transitory memory with computer executable instructions embedded thereon.

Abstract: Embodiments described herein include systems and techniques for converting (i.e., transducing) a quantum-level (e.g., single photon) signal between the three wave forms (i.e., optical, acoustic, and microwave). A suspended crystalline structure is used at the nanometer scale to accomplish the desired behavior of the system as described in detail herein. Transducers that use a common acoustic intermediary transform optical signals to acoustic signals and vice versa as well as microwave signals to acoustic signals and vice versa. Other embodiments described herein include systems and techniques for storing a qubit in phonon memory having an extended coherence time. A suspended crystalline structure with specific geometric design is used at the nanometer scale to accomplish the desired behavior of the system.

Abstract: A process includes means for depositing an anti-corrosion coating filled with liquid oil on an aluminum substrate. Aluminum is anodized and then treated with a thin hydrophobic sub-coating. The pores created through anodization are then impregnated with liquid oil. Oil penetration is maximized and residual air is minimized by first filling the pores with a filling solution, replacing the filling solution with an exchange fluid, and then replacing the exchange fluid with perfluorinated oil. The oil gives the surface coating anti-wetting properties and self-healing properties, thereby protecting the aluminum substrate underneath from corrosion.

Abstract: Described herein are medical devices and medical implements with high lubricity to flesh (or biological fluid) and/or inhibited nucleation on its surface. The device has a surface comprising an impregnating liquid and a plurality of micro-scale and/or nano-scale solid features spaced sufficiently close to stably contain the impregnating liquid therebetween. The impregnating liquid fills spaces between said solid features, the surface stably contains the impregnating liquid between the solid features, and the impregnating liquid is substantially held in place between the plurality of solid features regardless of orientation of the surface.

Abstract: In an aspect, provided herein are low density materials, including shell-based materials, with three-dimensional architectures formed, in part, via self-assembly processes. Shell-based materials of some embodiments exhibit a combination of ultralow density (e.g., ?100 mg cm?3 and optionally ?10 100 mg cm?3) and non-periodic architectures characterized by low defect densities and geometries avoiding stress concentrations. Low density shell based materials of some embodiments have architectures characterized by small curvatures and lack of straight edges providing enhance mechanical response. In some embodiments, for example, the present low density materials, including shell-based materials, providing a combination target mechanical properties including high stiffness-to-density ratios, mechanical resilience and tolerance for deformation.

Abstract: A microfluidic flow restrictor that uses micron-sized beads to impede flow is described. The flow rate can be adjusted by adding or removing the beads using injection needles through self-sealing ports, one injection needle injecting or aspirating beads and another injection needle pushing or pulling fluid from outside of a bead trap within the flow restrictor. In alternative embodiments, the beads or other filler material can be trapped in a manifold bead trap such that they block a subset of fluid channels of the flow restrictor, allowing fluid to flow freely through the rest of the fluid channels. The flow restrictor can be integrated with a contact lens or implantable medical device for use in dispensing liquid therapeutic agents at flow rates of microliters per minute or moving body fluids at a controlled rate from one part of the body to another.

Abstract: Methods and systems for the electrochemical conversion of halogenated compounds are provided. In some embodiments, a method comprises converting a halogenated compound (e.g., fluorinated gas) to relatively non-hazardous products via one or more electrochemical reactions. The electrochemical reaction(s) may occur under relatively mild conditions (e.g., low temperature) and/or without the aid of a catalyst. In some embodiments, the electrochemical reaction may produce a relatively large amount of energy. In some such cases, systems, described herein, may be designed to facilitate the conversion of the halogenated compound (e.g., SF6, NF3) while harnessing (e.g., storing, converting) the energy associated with the electrochemical reaction. System and methods described herein may be used in a wide variety of applications, including waste management (e.g., environmental remediation, greenhouse gas mitigation), energy recovery (e.g., industrial energy recovery), and primary batteries (e.g., metal-gas batteries).

Abstract: Flexible air-breathing microscale fuel cells are produced using ion exchange polymer membranes without silicon substrates or other rigid components. The microscale fuel cells provide long-life energy supply sources in portable electronics due to reduced volume, high energy density, and low cost. More particularly, the microscale fuel cell has a direct hydrogen flow-through porous anode electrode with a pair of air-breathing cathodes.

Abstract: A system configured to be at least partially implanted along an aorta includes an inelastic, static member and a pinching member. The pinching member is configured to receive an activation signal at an activation rate and in response to the activation signal, repeatedly compress the aorta at the second location at the activation rate to pump fluid within the aorta in a desired pumping direction. The system is configured to selectively control wave reflections in order to achieve both improved wave dynamics to reduce cardiac load and increased (or at least non-diminished) blood flow to targeted organs within the cardiovascular system.