Abstract: The present disclosure generally relates to sugar reduction in foods and, in some aspects, to enzyme-polymer conjugated particles for food and other applications. Certain aspects of the disclosure are directed to compositions for reducing sugar content and/or producing dietary fiber within food products during or after consumption (e.g., in a subject's gastrointestinal (GI) tract), while maintaining the sweetness and flavor of the sugar in food products upon consumption (e.g., in a subject's mouth). For example, in one set of embodiments, a composition may comprise a particle comprising an enzyme capable of converting a sugar into a relatively non-digestible form (e.g., a polymer), optionally an inhibitor that reversibly inhibits the enzyme from converting the sugar, and optionally an additive capable of associating with the inhibitor. The composition may be used for in situ conversion of sugars upon exposure to an environment condition (e.g., pH and/or temperature) in the GI tract.

Abstract: Chemical-shift nuclear magnetic resonance (NMR) spectroscopy involves measuring the effects of chemical bonds in a sample on the resonance frequencies of nuclear spins in the sample. Applying a magnetic field to the sample causes the sample nuclei to emit alternating current magnetic fields that can be detected with color centers, which can act as very sensitive magnetometers. Cryogenically cooling the sample increases the sample's polarization, which in turn enhances the NMR signal strength, making it possible to detect net nuclear spins for very small samples. Flash-heating the sample or subjecting it to a magic-angle-spinning magnetic field (instead of a static magnetic field) eliminates built-in magnetic field inhomogeneities, improving measurement sensitivity without degrading the sample polarization.

Abstract: Systems and methods for thermal management using separable heat pipes and methods of manufacture thereof. Various embodiments provide a porous insert that can be used to join or connect heat pipes. Further embodiments provide thermal management systems that are modular, expandable, reparable, by allowing for joining of evaporators, condensers, and adiabatic sections via porous inserts. Various embodiments allow for two-phase thermal management systems, where liquid and gaseous phases can be transported simultaneously. Certain embodiments incorporate heat generating components with embedded evaporators and/or condensers. Many embodiments are additively manufactured, including via 3D printing.

Abstract: Provided are methods and compositions for treating cancer in a subject in need thereof. One of the top gene products in glioblastoma multiforme (GBM) is KLRB1 (also known as CD161), a C-type lectin protein that binds to CLEC2D. Binding of CLEC2D to the KLRB1 receptor inhibits the cytotoxic function of NK cells as well as cytokine secretion. KLRB1 is only expressed by small subpopulations of human blood T cells, and consequently little is known about the function of this receptor in T cells. However, preliminary data demonstrate that KLRB1 expression is induced in T cells within the GBM microenvironment. In an exemplary embodiment, a method is provided comprising administering an agent capable of blocking the interaction of KLRB1 with its ligand. The agent may comprise an antibody or fragment thereof, which may bind KLRB1 or CLEC2D.

Abstract: The present disclosure relates to a device, comprising a base and a plurality of microneedles attached to the base, wherein each microneedle has an outer surface; the outer surface of at least one microneedle being coated with a composition comprising at least one polymer and least one Peptide Nucleic Acid (PNA). The present disclosure additionally relates to a method of detecting an analyte in interstitial fluid (ISF), comprising contacting the device to a subject, for example, to human skin.

Abstract: The present disclosure provides compositions, methods, and kits that enable the in situ growth of polymers on or within a subject. In some aspects, the monomer, dopamine, polymerizes in vivo to form a polymer on a tissue. In additional aspects, the compositions, methods, and kits are useful for treating or preventing a disease or disorder.

Abstract: Systems and methods in accordance with various embodiments of the invention provide a photovoltaic concentrator tile for a space-based solar power (SBSP) system including constituent components thereof. In a number of embodiments, the photovoltaic concentrator tile include a one photovoltaic cell, a reflector, a power transmitter and circuitry configured to perform a variety of control functions. Embodiments also provide compactible structures, materials for improving thermal emissivity, and methods and mechanisms for manufacturing and using these components.

Abstract: Disclosed are system (100) and method (300) for optimizing data transmission in communication network. System comprises Internet of Thing (IoT) device node (102) having sensors for capturing sensor data and controller (106) configured at the IoT device node for constructing set of attributes from the sensor data, such that each set of attribute comprises sensor data based on correlation. Support Vector Regression (SVR) models for pruning the sensor data at IoT device node (102) is defined. Values for each attribute in set of attributes predicted based on predicting run-time errors in values according to the SVR models defined for each of base attribute and the non-base attribute. The run-time errors for each of base attributes and non-base attributes gets compared with threshold error values. The IoT device node (102) transmits either model parameters for attributes or training data along with the set of attributes by transceiver (108) to the data collector node (104).

Abstract: Disclosed herein is a phased antenna array which is configured to provide a signal through multiple antennas. The phased antenna array may include a plurality of sub-arrays. Each sub-array may include a complete and functional optically synchronized integrated circuit including an integrated photo diode. Advantageously, integrating the photo diode into the integrated circuit may reduce the size of the sub-array and decrease the length the high frequency timing signal is passed.

Abstract: On-chip generation of coherent radiation, i.e. laser-like radiation, can be tuned over broad and/or hard-to-access wavelength regions in an integrated platform. Target spectral coverage is beyond what could be achieved with existing integrated laser systems.

Abstract: Disclosed are a method, an apparatus and a non-transitory storage medium. The method includes: dividing satellites of the mega-constellation into satellite topology groups, so as to construct corresponding space-time grids, obtaining a dynamic matching relationship in time domain between the space-time grids and the satellite topology groups, setting a path weight for each space-time grid, acquiring a static grid path for forwarding a mission, where the static grid path is determined by an order of the space-time grids that need to be passed sequentially to forward the mission, adjusting the static grid path according to the satellite node currently receiving the mission and the dynamic matching relationship, so as to acquire the next satellite node to which the mission is forwarded from the satellite node currently receiving the mission.

Abstract: This disclosure describes improvements to both hardware and enzymatic reactions used in single cell analyses such as but not limited to Seq-well that enable significant increases in the yield of transcripts per cell, improved portability and case of use, increased scalability of the assay, and linkage of transcript information to other measurements made in the picowell arrays.

Abstract: Described herein are concepts, system and techniques which provide a means to construct robust high-field superconducting magnets using simple fabrication techniques and modular components that scale well toward commercialization. The resulting magnet assembly—which utilizes non-insulated, high temperature superconducting tapes (HTS) and provides for optimized coolant pathways—is inherently strong structurally, which enables maximum utilization of the high magnetic fields available with HTS technology. In addition, the concepts described herein provide for control of quench-induced current distributions within the tape stack and surrounding superstructure to safely dissipate quench energy, while at the same time obtaining acceptable magnet charge time. The net result is a structurally and thermally robust, high-field magnet assembly that is passively protected against quench fault conditions.

Abstract: A method for dynamic output force distribution of a multi-degree-of-freedom over-actuated motion stage includes: establishing a mathematical model G(s) of a motion stage based on a modal representation; setting a time delay interval parameter ?? and an instruction shaper order nCS, and calculating each pulse time delay parameter ?i; calculating matrices Tb and Vb; initializing q=1; defining Hq; calculating intermediate variable {tilde over (T)}jq, {tilde over (V)}, ?Hq, YHq, T?Hq, V?Hq, and ?q; calculating an estimated value ?q of Hq; obtaining an amplitude Aikq of an instruction shaper; q=q+1, until calculation is completed for all logical axis channels; calculating ?(s) by using Aikq; and obtaining a dynamic output force distribution matrix Tf(s). Zero-residue vibration suppression in all controllable flexible modalities can be realized with finite actuator redundancies.

Abstract: Provided is a temperature calibration method that makes it possible to efficiently calibrate temperature in a short time and enhance temperature calibration accuracy. This temperature calibration method uses a temperature calibration device (10) comprising a temperature calibration block (2) having formed therein a placement part (25) for a reference temperature sensor (5) and a temperature sensor (T) to be calibrated. In this temperature calibration method, a temperature state in a gradual temperature variation transition process of the temperature calibration block (2) is taken to be a calibration temperature. The temperature calibration device (10) comprises: a vacuum-insulated container (1) comprising a vacuum region (Va) surrounding the temperature calibration block (2) and an accommodation part for accommodating the temperature calibration block (2); and a Peltier module (3) that is thermally coupled to the temperature calibration block (2).

Abstract: A method and device for electrostatically controlling charges in an electrostatic field effect optoelectronic device by modulating charges in at least one layer of the electrostatic field effect optoelectronic device by providing either a positive bias or a negative bias to a capacitively coupled plate of the electrostatic field effect optoelectronic device thereby adjusting the charge utilization efficiency of the device.

Abstract: Embodiments disclosed herein provide methods of using somatic mutations in mitochondrial genomes to retrospectively infer cell lineages in native contexts and to serve as genetic barcodes to measure clonal dynamics in complex cellular populations. Further, somatic mutations in mitochondrial DNA (mtDNA) are tracked by single cell genomic approaches for simultaneous analysis of single cell lineage and state. Applicants further show that mitochondrial mutations can be readily detected with contemporary single cell transcriptomic and epigenomic technologies to concomitantly capture gene expression profiles and chromatin accessibility, respectively.

Abstract: A construction system for mechanical metamaterials based on discrete assembly of a finite set of modular, mass-produced parts. A modular construction scheme enables a range of mechanical metamaterial properties to be achieved, including rigid, compliant, auxetic and chiral, all of which are assembled with a consistent process across part types, thereby expanding the functionality and accessibility of this approach. The incremental nature of discrete assembly enables mechanical metamaterials to be produced efficiently and at low cost, beyond the scale of the 3D printer. Additionally, a lattice structure constructed of two or more rigid, compliant, auxetic and chiral part types enable the creation of heterogenous macroscopic metamaterial structures.

Abstract: This disclosure provides systems, methods, and compositions for RNA-guided RNA-targeting CRISPR effectors for the treatment of diseases as well as diagnostics. In some embodiments, nucleotide deaminase functionalized CRISPR systems for RNA editing RNA knockdown, viral resistance, splicing modulation, RNA tracking, translation modulation, and epi-transcriptomic modifications are disclosed.

Abstract: The present invention relates to an article of clothing that is worn by a person for preventing an infant from accidental falling while the person nurses the infant. The article may be a garment that includes an item of clothing to be worn by a person and a support garment panel attached to the item of clothing. The support garment panel is attached to the perimeter of the armholes of the item of clothing and defines a pocket between the support garment panel and the item of clothing. The pocket includes an opening for receiving an infant and a base for supporting the infant.