Abstract: An optical device. In some embodiments, the device comprises: an input waveguide, configured to receive light; a first electro-absorption modulator, coupled to receive light from the input waveguide, and operable to produce a first output or a second output, wherein the second output has a lower amplitude than the first output; a second electro-absorption modulator, coupled to receive light from the input waveguide, and operable to produce a third output or a fourth output, wherein the fourth output has a lower amplitude than the third output; and an output waveguide, coupled to receive light from the first electro-absorption modulator and the second electro-absorption modulator, and output a combined signal comprising an output of the first electro-absorption modulator and an output of the second electro-absorption modulator.

Abstract: An object of the present invention is to provide a polyester resin that has a high degree of freedom in design and that can have excellent biodegradability even with an increased molecular weight. A polyester of the present invention contains a hydroxy group-containing dicarboxylic acid component and a diol component (excluding a hydroxy group-containing dicarboxylic acid component) as copolymerization components, wherein more than 50 mol % of an aliphatic diol component is contained in 100 mol % of the diol component, the polyester has a number average molecular weight of 3000 or higher, and the polyester has a total hydroxyl value of 1000 eq/ton or higher.

Abstract: Described herein are methods for transporting and/or harvesting gas from bubbles, as well as associated articles and systems. In some embodiments, transporting and/or harvesting the gas from the bubbles can reduce or prevent the amount of foam that is present within a system. According to certain embodiments, a conduit comprising a porous wall portion can be at least partially submerged into a foam and/or a bubble-containing liquid. The porous wall portion of the conduit can be configured and/or arranged, according to certain embodiments, such that the porous wall portion provides a fluidic pathway through which gas from the bubbles within the liquid may be channeled to a gaseous environment in the interior portion of the conduit. The gas may be transported, according to certain embodiments, along the interior portion of the conduit into an external gaseous environment and/or harvested from the interior portion of the conduit.

Abstract: This disclosure relates to modified tryptophan synthase and more particularly to modified beta-subunits of tryptophan synthase. The disclosure further relates to cells expressing such modified subunits and methods of producing non-canonical amino acids.

Abstract: The invention encompasses hydrogels, monomer precursors of the hydrogels, methods for the preparation thereof, and methods of use therefor. The linking of monomers can take place using non-radical, bioorthogonal reactions such as copper-free click-chemistry.

Abstract: Preparation of phosphorus fine chemicals from phosphate sources is described.

Abstract: Disclosed here is a generally applicable framework that utilizes massively-parallel single-cell RNA-seq to compare cell types/states found in vivo to those of in vitro models. Furthermore, Applicants leverage identified discrepancies to improve model fidelity. Applicants uncover fundamental gene expression differences in lineage-defining genes between in vivo systems and in vitro systems. Using this information, molecular interventions are identified for rationally improving the physiological fidelity of the in vitro system. Applicants demonstrated functional (antimicrobial activity, niche support) improvements in Paneth cell physiology using the methods.

Abstract: Knit textile structures are formed of a yarn made of composite fibers, which is an active material within the knit structure that transforms in response to a change in temperature. In combination with non-active fibers and performative knit structure, this contraction can enable changes in the fabric that are adaptive to changes in environmental conditions during wear.

Abstract: A physiological feature of a subject is monitored by implanting a plurality of targets, such as magnets, and detecting at least one change in a physical property of the targets, followed by modifying a physiological feature of the subject in response to a change of state detected by the change in physical property detected in the targets. Cutaneous sensory feedback and proprioceptive feedback in a subject, as well as selective stimulation of axons or nerve fascicles of a neuron of a subject are provided.

Abstract: The present invention relates to genomic informatics and gene-expression profiling. Gene-expression profiles provide complex molecular fingerprints regarding the relative state of a cell or tissue. Similarities in gene-expression profiles between organic states provide molecular taxonomies, classification, and diagnostics. Similarities in gene-expression profiles resulting from various external perturbations reveal functional similarities between these perturbagens, of value in pathway and mechanism-of-action elucidation. Similarities in gene-expression profiles between organic and induced states may identify clinically-effective therapies. Systems and methods herein provide for the measurement of relative gene abundances, including unbiased selection of and construction of probes and targets designed and methods for using known properties of sparsity of measurements to reach gene abundances.

Abstract: A membrane for water collection may include a sheet having a top surface and a bottom surface, and a plurality of conical structures disposed on the top surface of the sheet, the conical structures comprising a hydrogel material. Each conical structure of the plurality of conical structures may have a height of 1 mm to 50 mm, wherein height is measured from the top surface of the sheet to an apex of a conical structure. Each conical structure of the plurality of conical structures may have an apex angle of 10 to 60 degrees.

Abstract: Compositions and methods related to straining defect doped materials as well as their methods of use in electrical circuits are generally described.

Abstract: A hydride ion conductor is represented by: MAMBH4-xFx??Formula (1), where MA is selected from the group consisting of Ca, Sr, and Ba, MB is selected from the group consisting of Mg and Ca, and is different from MA, and x is 0<x<4.

Abstract: Fabry-Pérot filters having different cavity thicknesses are formed in arrays on a substrate for spectral sensing. The filter array can be coupled to a detector array to make a compact, low size, weight and power spectral sensor that detects spectral information in a scene viewed by the detector array. The spectral sensor can be used in a compact spectrometer to detect the presence of harmful chemical vapors.

Abstract: FRET-based analytes detection and related methods and systems are described where a pair of FRET labeled primers and/or oligonucleotides are used that are specific for target sequences located at a distance up to four time the Forster distance of the FRET chromophores presented on the FRET labeled primers and/or oligonucleotides one with respect to the other in one or more polynucleotide analyte; in particular the pair of FRET labeled primers and/or oligonucleotides is combined with a sample and subjected to one or more polynucleotide amplification reactions before measuring FRET signals from at least one FRET chromophore.

Abstract: Systems and methods for optical nanostructures that use the interference of high order Mie resonances to locally control wavefront with high quality factor in two dimensions are described. The high-order Mie-resonant metasurfaces can be used to create band-stop filters, beam deflectors, lenses, beam splitters and holograms with high quality factor.

Abstract: Compositions configured to interact with organic molecules, and related articles and methods, are generally described.

Abstract: Embodiments disclosed herein provide a general, scalable, high-throughput, and high-resolution approach for experimental dissection of regulatory regions and driver nucleotides in the context of human biology and disease. Applicants present HiDRA, a novel high-resolution global screen for transcriptional regulatory activity in accessible chromatin regions, enabling high-efficiency, high-throughput, and high-resolution inference of regulatory activity.

Abstract: Devices and methods for fabrication of a multiscale porous high-temperature heat exchanger for high-temperature and high-pressure applications are disclosed. The heat exchanger can include a core with macrochannels formed in a checkerboard pattern to facilitate alternative flow of working fluid having hot and cold temperatures between adjacent macrochannels. Each macrochannel can include a two-dimensional microchannel array that further distributes flow throughout the heat exchanger to enhance heat transfer and mechanical strength without significant pressure drop penalty. The heat exchanger can further include a header integrated therewith to distribute working fluid flowing through the heat exchanger through the outlets such that it flows evenly therethrough. Methods of fabricating heat exchangers of this nature are also disclosed.

Abstract: An optical modulator is disclosed that includes an optical resonator structure. The optical resonator structure includes at least one non-linear portion, the at least one non-linear portion comprising at least one radial junction region. The at least one radial junction region is formed between at least first and second materials, respectively, having different electronic conductivity characteristics. A principal axis of the at least one radial junction region is oriented along a radius of curvature of the at least one non-linear portion. The optical modulator includes an optical waveguide that is coupled to the at least one non-linear portion of the optical resonator structure.