Abstract: Described are concepts, systems, circuits and techniques directed toward methods and apparatus for generating one or more pulse width modulated (PWM) waveforms with the ability to dynamically control pulse width and phase with respect to a reference signal.

Abstract: Methods, systems, and compositions related to the recycling and/or recovery of activating materials from activated aluminum are disclosed. In one embodiment, an aqueous solution's composition may be controlled to maintain aluminum ions dissolved in solution during reaction of an activated aluminum. In another embodiment, aluminum hydroxide containing the activating materials may be dissolved into an aqueous solution to isolate the activating materials.

Abstract: Separator membranes for ion batteries and methods of producing such separator membranes are disclosed herein. The separator membranes have vertically-aligned pores that have as small as submicron diameters at one or both membrane surfaces. The separator membranes may be fabricated via a novel and innovative bidirectional freeze-casting process that produces a temperature gradient in two directions. The separator membranes disclosed herein and fabricated by this method can be used in ion batteries, such as sodium ion batteries.

Abstract: Semiconductor thin films and rapid methods of fabrication can include mixed cations created through recrystalization.

Abstract: A dual-pathway system for CO2 capture in both acidified and basified streams is provided. The system may be embodied in an off-shore stand-alone facility to allow for the operation of oceanic CO2 capture to be more efficient and cost effective. Systems maintain high environmental standards by containing all intermediate acidic and alkaline solutions in a closed system so that the effluent discharged back into the ocean is at the similar pH and salinity as the feed oceanwater, with only CO2 removed. Acid and base produced by an electrodialyzer unit is used to achieve oceanwater decarbonization via gaseous CO2 removal and solid CaCO3 precipitates removal. The system is configured to require the processing of a very small fraction of the total oceanwater intake for the acid-base generation process.

Abstract: The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas system.

Abstract: This disclosure provides a method and compositions for substantially increasing the concentration of DNA in macrophages of a patient. By administering to a patient one or more agents which prevent the activity of deoxyribonucleases within lysosomes of macrophages, degradation of DNA phagocytosed by macrophages is temporarily blocked, permitting its accumulation. This strategy has the potential to enhance the detection of genetic biomarkers from cells typically phagocytosed by macrophages, such as tumor cells, and thus has applications for early or residual detection of cancer.

Abstract: The retort pouch includes an inner cavity located within an outer seal and comprising a volume configured to receive a substance therein. A first tear strip is configured to generate an opening in the outer seal to expose the inner cavity. A drain element is located within and attached to a surface of the inner cavity. The drain element is positioned within the generated opening to allow a user to drain liquid from the inner cavity while retaining the substance in the inner cavity.

Abstract: A rigid non-isocyanate polyurethane foam and a preparation method therefor are provided. According to the present application, a rigid epoxide is firstly reacted with carbon dioxide to obtain rigid cyclic carbonate, then the product is reacted with diamine to obtain rigid non-isocyanate polyurethane, and the rigid non-isocyanate polyurethane is mixed with a foaming agent for foaming to obtain rigid non-isocyanate polyurethane foam. The present application improves the mechanical property of non-isocyanate polyurethane by optimizing the structures and groups of raw materials; according to the present application, mild reaction conditions such as atmospheric pressure and low temperature are used, and the amounts of reactants and foaming agents are adjusted, so that the reaction is significantly enhanced, and an excellent foaming effect is achieved.

Abstract: Methods of using sorbents to enhance the production of hydrogen from fuel, and related systems, are generally described. In some embodiments, the production of hydrogen from the fuel involves a reforming reaction and/or a gasification reaction combined with a water-gas shift reaction.

Abstract: A method for fabricating MAS NMR rotors and drive caps made of diamond to increase the maximum achievable spinning frequency and enhance MAS NMR sensitivity and resolution. Diamond is an excellent choice for making MAS NMR rotors due to its high tensile and flexural strength, however, micromachining diamond is difficult due to its hardness. Although laser cutting is often employed to cut diamond sheets, this process cannot be used to create the high aspect ratio and small features required for MAS NMR rotors. In the present invention, a laser micromachining process is used to create the desired high aspect ratio while maintaining the small lateral features. In this process, the laser is used to first convert the diamond into graphite followed by a conversion to carbon dioxide in the presence of oxygen. To create a rotor, a rectangular log has a center hole drilled by the laser, and is then micromachined into a hollow cylinder.

Abstract: Described is a spacecraft locker configured be deployed in outer space and configured to assemble satellites (e.g., CubeSats) within it and deploy them in outer space. In an embodiment, an unmanned spacecraft includes a housing configured to be deployed in a microgravity environment, the housing having an access point (e.g. a door), a storage area configured to store parts of a satellite, one or more robots movably positioned in the housing, and a controller configured to control at least one of the one or more robots to access parts from the storage area and to assemble the parts on an assembly platform of the housing. The controller may also control deployment of the assembled satellite through the door of the housing to a position in the microgravity environment.

Abstract: Disclosed herein are programmable, conditionally activated small interfering RNA constructs (Cond-siRNAs) and methods of making and using the same as therapeutic agents. The Cond-siRNA comprises a sensor strand, a core strand, and a guide strand, which crossover to form a sensor duplex and a RNAi duplex attached to each other to form a single structure. Upon binding an input strand to the sensor strand, the Cond-siRNA is activated and releases RNAi targeting a desired gene.

Abstract: The disclosure provides novel programmable targeting sequences and applications thereof. The targeting sequences can be engineered for binding to proteins, polypeptides, and other macromolecules.

Abstract: The present application discloses nanoparticles carrying therapeutic agents, including chemotherapeutic agents, and targeting ligands suitable for delivering these therapeutic agents through the blood brain barrier and methods of using these patients on those patients in need of such treatment.

Abstract: A method of making a food source or medicinal composition and a mycotecture construction unit includes (a) cultivating a mycelium/substrate composite and edible mushrooms, and (b) manufacturing the mycotecture construction unit. A mycelium inoculum is formed of a preselected fungus and used to inoculate a substrate. Mycelium are grown in the inoculated substrate in a growing column and edible mushrooms are harvested from the mycelium, leaving a mycelium-substrate composite. The manufacture of the mycotecture construction unit includes placing the mycelium-substrate composite into a modular, reconfigurable press having a cavity with a predetermined shape; pressing the mycelium-substrate composite at a predetermined pressure; and heating the mycelium-substrate composite in a heating chamber.

Abstract: An optically computed optical coherence tomography (OC-OCT) technology is disclosed. The OC-OCT system performs depth resolved imaging by computing the Fourier transform of the interferometric spectra optically. The OC-OCT system modulates the interferometric spectra with Fourier basis function projected to a spatial light modulator and detects the modulated signal without spectral discrimination. The optical computation strategy enables volumetric OCT imaging without performing mechanical scanning and without the need for Fourier transform in a computer. OC-OCT performs Fourier transform signal processing optically, without the need of mechanical scanning, and before data acquisition unlike traditional OCT methods and systems. The scan-less OCT imaging is achieved through the use of spatial light modulator (SLM) that precisely manipulates light wave to generate output with desired amplitude and phase.

Abstract: A polarization-separated, phase-shifted interferometer can generate interferograms without moving parts. It uses a phase shifter, such as an electro-optic phase modulator, to modulate the relative phase between sample and reference beams. These beams are transformed into orthogonal polarization states (e.g., horizontally and vertically polarized states) and coupled via a common path (e.g., polarization-maintaining fiber) to a polarizing beam splitter (PBS), which sends them into separate sample and reference arms. Quarter-wave plates in the sample and reference arms rotate the polarization states of the sample and reference beams so they are coupled out of the PBS to a detector via a 45° linear polarizer. The polarizer projects the aligned polarization components of the sample and reference beams onto the detector, where they interfere with known relative phase to produce an output that can be used to map surface topography of the test object.

Abstract: An enhanced stethoscope device and method for operating the enhanced stethoscope are provided. The enhanced stethoscope device generally operates by providing stethoscope sensors, ultrasonic sensors, and other sensors to obtain a series of measurements about a subject. The series of measurements may be correlated, such as by machine learning, to extract clinically relevant information. Also described are systems and methods for ultrasonic beamsteering by interference of an audio signal with an ultrasonic signal.

Abstract: Disclosed herein include circuits, compositions, nucleic acids, populations, systems, and methods enabling cells to sense, control, and/or respond to their own population size. In some embodiments, an orthogonal communication channel allows specific communication between engineered cells. Also described herein, in some embodiments, is an evolutionarily robust ‘paradoxical’ regulatory circuit architecture in which orthogonal signals both stimulate and inhibit net cell growth at different signal concentrations. In some embodiments, engineered cells autonomously reach designed densities and/or activate therapeutic or safety programs at specific density thresholds. Methods of treatment are also provided in some embodiments.