Abstract: A method and system are disclosed for detecting microbial pathogens in a sample suspected of containing the pathogens. The method includes combining loop-mediated isothermal amplification (LAMP) reagents and a polymer gel, such as a hydrogel, together with the sample to form a mixture. The gel polymerizes over a short time to immobilize the viral particles within the mixture. If target DNA/RNA are present in the sample, amplicons are produced. The target microorganisms are detected by visually detecting the presence or absence of the amplicons. The target microorganism concentrations may be determined based on the number of fluorescent amplicon dots after the reaction using a smartphone or a fluorescent microscope. The method may be employed for rapidly and inexpensively quantifying microbial pathogens in environmental water samples with high sensitivity.
Abstract: A self-restoring polyurethane-based polymer obtained by polymerization of a composition containing an aromatic disulfide diol represented by Chemical Formula, HO—Ar1—S—S—Ar2—OH, an alicyclic polyisocyanate, and a polyol. Ar1 and Ar2 each are independently a substituted or unsubstituted C6-C30 arylene group. The composition satisfies Equation, 0.1?M[disulfide]/M[OH]. M[disulfide] is a total mole number of the aromatic disulfide diol in the composition, and M[OH] is a total mole number of the aromatic disulfide diol and the polyol in the composition.
Type:
Grant
Filed:
July 11, 2018
Date of Patent:
April 12, 2022
Assignee:
Korea Research Institute of Chemical Technology
Inventors:
Sung Yeon Hwang, Jeyoung Park, Dong Yeop Oh, Jong Geon Jegal, Seon Mi Kim, Hyeon Yeol Jeon
Abstract: The flame retardant foam is a molded form of a mixture containing at least a cellulose containing powder, a hydrophilic polymer, a foamable thermoplastic resin, a flame retardant, and water. The mixture contains at least one of tricalcium phosphate or silica as a dispersant.
Abstract: The invention provides for recombinant AAV vectors comprising a polynucleotide sequence comprising the guide strand of miR-29c and methods of using the recombinant vectors to reduce or prevent fibrosis in subjects suffering from muscular dystrophy.
Type:
Grant
Filed:
April 14, 2017
Date of Patent:
April 12, 2022
Assignee:
RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL
Inventors:
Louise Rodino-Klapac, Jerry R. Mendell, Kristin N. Heller
Abstract: A method for information display, a processing device, and a display system are disclosed. The display system includes a light transmissive display screen, at least one first information extraction device, at least one second information extraction device, and a processing device. The processing device is connected to a display screen, the first information extraction device, and the second information extraction device. The first information extraction device extracts position information of a user. The second information extraction device extracts position information of a target object. The processing device constructs a fixed reference coordinate system, locates initial positions of the user, the target object, and the display screen, accordingly displays a fused image on the display screen, and updates the fused image displayed on the display screen according to at least one of a movement amount of the display screen and a movement amount of the user.
Type:
Grant
Filed:
March 16, 2020
Date of Patent:
April 12, 2022
Assignee:
Industrial Technology Research Institute
Abstract: The current subject matter relates to rehabilitation using a content guide for viewing video, for example as a vision rehabilitation aid for individuals with hemianopia or as a rehabilitation aid for individuals with attention disorders. The current subject matter includes providing video in which a region of interest of the image is specified with a marker, referred to herein as a content guide. The content guide can include a circle surrounding the region of interest. By providing video with a content guide to direct viewers to a region of interest in the video, information acquisition by the viewers is improved. Such an approach can aid individuals with vision deficits or attention disorders. The current subject matter can also be used as a therapy for spatial neglect. Related apparatus, systems, techniques and articles are also described.
Type:
Grant
Filed:
February 17, 2018
Date of Patent:
April 12, 2022
Assignee:
The Schepens Eye Research Institute, Inc.
Inventors:
Dylan J. Rose, Daniel R. Saunders, Russell L. Woods
Abstract: A supercapacitor consisting of a tight protective housing, first and second electrodes, which are electrically insulated from each other. One or both electrodes are also insulated from the housing. Free volume of the cell and the space between the electrodes are filled with electrolyte fluid. On the surface of the first electrode there are applied carbonaceous materials comprising C-14 isotope. Method of supercapacitor construction lies in the preparation of the first and second electrodes with application of the surface layer made of carbonaceous materials, allocation of the first and second electrodes inside the tight housing and their electric insulation from each other, filling of the housing with electrolyte fluid. Into the layer of carbonaceous materials onto the surface of the first electrode the C-14 isotope is introduced.
Type:
Grant
Filed:
August 31, 2016
Date of Patent:
April 12, 2022
Assignees:
JOINT STOCK COMPANY “SCIENCE AND INNOVATIONS”, JOINT STOCK COMPANY “INSTITUTE OF NUCLEAR MATERIALS”
Inventors:
Vladimir Dmitrievich Risovanyy, Sergey Viktorovich Bulyarskiy, Dmitriy Vladimirovich Markov, Leonid Prokop'evich Sinel'nikov, Viktor Nikolaevich Nikolkin, Sergey Borisovich Zlokazov, Aleksandr Aleksandrovich Dzhanelidze, Vyacheslav Viktorovich Svetukhin
Abstract: An apparatus and method for wireless communication, and a method of fabricating the apparatus. The apparatus comprises two or more transceiver array groups, each transceiver array group comprising one or more radio frequency, RF, circuits, and one or more RF front end, RF FE, circuits; wherein the transceiver array groups are configured to operate at different frequencies; wherein the transceiver array groups are configured to be connected to one corresponding digital baseband processor; and wherein the transceiver array groups comprise at least one first transceiver array group configured to operate at cm wavelength or larger. Preferably, the transceiver array groups comprise at least one second transceiver array group configured to operate at mm wavelength.
Type:
Grant
Filed:
May 10, 2019
Date of Patent:
April 12, 2022
Assignees:
Nanyang Technological University, Massachusetts Institute of Technology
Abstract: The present invention generally relates to methods and systems for capturing a Lewis acid gas (e.g., CO2). In some embodiments, the methods and systems utilize an ionic liquid incorporated into one or more electrochemical cells.
Type:
Grant
Filed:
April 2, 2019
Date of Patent:
April 12, 2022
Assignee:
Massachusetts Institute of Technology
Inventors:
Trevor Alan Hatton, Paul Brown, Sahag Voskian
Abstract: A frequency stabilizer includes: a delay line interferometer that receives an optical signal corresponding to one frequency mode of a pulsed laser, divides and transmits the received optical signal to a reference arm and a delay arm including an optical fiber delay line, and then outputs an interference signal between signals passing through the reference arm and the delay arm; a photoelectric converter that converts the interference signal into an electrical signal; a mixer that generates a baseband signal of the electrical signal by mixing a carrier frequency signal; and a feedback controller that transmits a control signal generated based on the baseband signal to the pulsed laser. The optical signal passing through the delay arm is weighted with a delay time caused by the optical fiber delay line compared to the optical signal passing through the reference arm, and the optical signal passing through the delay arm is frequency shifted to a carrier frequency of an oscillator.
Type:
Grant
Filed:
September 29, 2020
Date of Patent:
April 12, 2022
Assignee:
KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
Abstract: Chromatography systems and methods for using carbon dioxide to separate one or more cannabis-derived compounds from other components of a mixture are generally described. Some of the methods described herein comprise transporting a mixture comprising a first cannabis-derived compound and one or more other components through a chromatography column containing a stationary phase comprising a packing material. In some embodiments, the mixture is transported through the column within a mobile phase that comprises carbon dioxide (e.g., supercritical CO2, liquid CO2). The mobile phase may be substantially free of a co-solvent that is in liquid phase at standard room temperature and pressure. In some embodiments, the mobile phase is free of any co-solvent and comprises 100 vol % carbon dioxide.
Type:
Grant
Filed:
August 7, 2018
Date of Patent:
April 12, 2022
Assignee:
Massachusetts Institute of Technology
Inventors:
Clark K. Colton, John M. Moses, Veronica M. Wilson, William H. Dalzell, Mariya Layurova, Tony J. Elian, Truong H. Cai, John MacKay
Abstract: The present disclosure provides a composite material comprising an electrically conductive polymer, such as poly(3,4-ethylenedioxythiophene) (PEDOT) and an ionically conductive polymer, such as poly(ethylene oxide) (PEO). This composite forms a dual conductor for three-dimensional electrodes in electrochemical applications including lithium ion batteries.
Abstract: A method and system for updates an occupancy map based on a first ray determined from a plurality of rays, as known as a super ray. The method of updating an occupancy map based on grids and octrees includes the step of generating a mapping line based on point clouds obtained from a sensor, determining a super ray by identifying a cell belonging to a plurality of cells forming the occupancy map and traversing an identical cell based on the generated mapping line, and updating the occupancy map by updating a cell through which the super ray corresponding to some of rays related to the plurality of cells forming the occupancy map passes.
Type:
Grant
Filed:
November 20, 2017
Date of Patent:
April 12, 2022
Assignee:
KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventors:
Sung-Eui Yoon, Youngsun Kwon, Donghyuk Kim
Abstract: Provided herein are CRISPR/Cas methods and compositions for targeting RNA molecules, which can be used to detect, edit, or modify a target RNA.
Abstract: Provided herein is an apparatus for assessing a fluorescence characteristic of a gemstone. The apparatus comprises an optically opaque platform for supporting a gemstone to be assessed, one or more light source to provide uniform UV and non-UV illumination, an image capturing component, and a telecentric lens positioned to provide fluorescent images of the illuminated gemstone to the image capturing component. Also provided are methods of fluorescence analysis based on images collected using such an apparatus.
Type:
Grant
Filed:
December 8, 2020
Date of Patent:
April 12, 2022
Assignee:
Gemological Institute of America, Inc. (GIA)
Abstract: A reactor cooling and power generation system according to the present disclosure includes a reactor vessel, a heat exchange section formed to receive heat generated from a core inside the reactor vessel, from a feedwater system through a fluid, and an electric power production section. A Stirling engine is provided to produce electric energy using the energy of the fluid whose temperature has increased while receiving the heat of the reactor. The system is formed to circulate the fluid that has received heat from the core in the heat exchange section through the electric power production section. The system operates even during a normal operation and during an accident of the nuclear power plant. The reactor cooling and power generation system accompanies a nuclear reactor vessel which includes a reactor coolant system, a feedwater system and a steam generator. A turbine produces electric power from the feed water system.
Type:
Grant
Filed:
June 11, 2018
Date of Patent:
April 12, 2022
Assignees:
KOREA ATOMIC ENERGY RESEARCH INSTITUTE, KING ABDULLAH CITY FOR ATOMIC AND RENEWABLE ENERGY
Inventors:
Youngin Kim, Youngmin Bae, Hunsik Han, Cheongbong Chang, Junewoo Kee, Minkyu Lee, Kisun Park, Bonghyun Cho
Abstract: The disclosure relates to pharmaceutical combinations comprising an HDAC6 selective inhibitor and a BET inhibitor for the treatment of cancer in a subject in need thereof. Also provided herein are methods for treating cancer in a subject in need thereof, comprising administering to the subject an effective amount of an HDAC6 selective inhibitor and a BET inhibitor.
Type:
Grant
Filed:
June 9, 2017
Date of Patent:
April 12, 2022
Assignees:
DANA-FARBER CANCER INSTITUTE, INC., ACETYLON PHARMACEUTICALS, INC.
Inventors:
Kwok-kin Wong, Yan Liu, Dennis O. Adeegbe, Steven Norman Quayle
Abstract: Disclosed herein are a Bluetooth connection device and method based on estimation of a relative angle. The Bluetooth connection method based on estimation of a relative angle is performed by a Bluetooth connection device based on estimation of a relative angle, and includes estimating relative angles using relative angle estimation information included in packets received from one or more communication target devices that are scanned for a Bluetooth connection, determining a communication target device with which a communication link is to be established based on the estimated relative angles, and establishing a communication link through a Bluetooth connection to the determined communication target device, and reestablishing the communication link to any one of additional communication target devices, relative angles of which have been estimated, depending on a change in a relative angle to the communication target device with which the communication link has been established.
Type:
Grant
Filed:
August 14, 2020
Date of Patent:
April 12, 2022
Assignee:
ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
Inventors:
Jae-Ho Lee, Do-Hyung Kim, Jin-Kyeong Kim, Cheol Ryu, Hyung-Seok Lee
Abstract: A platform door system is disclosed. The platform door system has: a platform data transmitting element positioned on a platform for transmitting a platform signal; a vehicle information integrating element, positioned on a vehicle adjacent to the platform, for receiving the platform signal and a vehicle signal corresponding to a door opening or closing status of the vehicle door from the vehicle, and for transmitting a platform-vehicle integration signal; and a platform door controlling element, positioned on the platform, for receiving the platform-vehicle integration signal and for opening or closing a platform door in response to the platform-vehicle integration signal to correspond to the opening-or-closing status of the vehicle door.
Type:
Grant
Filed:
December 27, 2018
Date of Patent:
April 12, 2022
Assignees:
KAOHSIUNG RAPID TRANSIT CORPORATION, INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Inventors:
Shih-Hsiang Chien, Wen-Tsuen Chen, Hsin-I Chiang, Chien-Liang Liu