Abstract: The present invention includes compositions and methods for treating arthritic joints found in patients with autoinflammation, e.g., systemic onset juvenile idiopathic arthritis, by administering at the site of inflammation a therapeutically effective amount of at least one agent that reduces or blocks the bioavailability of interleukin-1?.
Type:
Grant
Filed:
July 20, 2020
Date of Patent:
August 9, 2022
Assignee:
BAYLOR RESEARCH INSTITUTE
Inventors:
Jacques F. Banchereau, Maria Virginia Pascual
Abstract: Smart membranes (14) are integrated into a small, unmanned surface vessel (20) to enable the efficient, automated cleanup of oil spills. Such a vessel (20) has the potential to provide a low-cost, modular solution for day-to-day oil-spill cleanup operations, especially in confined aquatic areas, such as under piers and in the small spaces between marine vessels and piers. The smart membranes (14) are provided on the surface of a conveyor belt (34) that circulates the membranes (14) through the surrounding body of water (10) for oil collection, as well as through an internal reduction chamber (22) of the vessel (20) for oil release. The smart membranes (14) are adapted to attract and repel oil (12) in response to low-voltage commands applied across the conveyor belt (34), using a process that is repeatable for a number of cycles, offering high efficiency and long durability (FIG. 5).
Type:
Grant
Filed:
December 4, 2018
Date of Patent:
August 9, 2022
Assignee:
THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY
Abstract: A ladder-structural gravity-assisted-heat-pipe geothermal energy recovery system without liquid-accumulation effect, comprises a ladder-structural gravity-assisted heat pipe, a condenser, and a liquid tank. The ladder-structural gravity-assisted heat pipe comprises a return pipe, an outer pipe and an inner pipe. The return pipe is provided in a space between the outer pipe and the inner pipe and communicated with the liquid tank, and the space between the outer pipe and the inner pipe is divided to form a ladder structure. A liquid working medium flows from the liquid tank through the return pipe into each section sequentially, absorbs heat from a high-temperature rock through a wall of the outer pipe, vaporizes into a gaseous working medium, gets into the inner pipe, and rises to the condenser to condense and flows to the liquid tank to circulate. Such design greatly improves the heat transfer efficiency in geothermal energy recovery using ultra-long heat pipes.
Type:
Grant
Filed:
June 25, 2019
Date of Patent:
August 9, 2022
Assignee:
GUANGZHOU INSTITUTE OF ENERGY CONVERSION, CHINESE ACADEMY OF SCIENCES
Inventors:
Fangming Jiang, Wenbo Huang, Wenjiong Cao, Yiwei Wang
Abstract: The present invention relates to biomarkers of lung cancer, particularly to markers that enable distinguishing between subtypes of non-small cell lung cancer (NSCLC), particularly between adenocarcinoma (AC) and squamous cell carcinoma (SCC). In particular, the present invention relates to means and methods for diagnosing, assessing the level of severity and selecting methods of treating NSCLC.
Type:
Grant
Filed:
May 22, 2018
Date of Patent:
August 9, 2022
Assignee:
THE NATIONAL INSTITUTE FOR BIOTECHNOLOGY IN THE NEGEV LTD.
Abstract: Compositions and methods to reduce the risk of graft versus host disease (GVHD) in a subject receiving hematopoietic stem cell transplantation (HSCT). Also disclosed are methods for identifying patients receiving HSCT who are at risk for developing GVHD, methods for prognosing the severity of GVHD in a subject receiving HSCT, and methods for monitoring efficacy of a therapeutic for treatment of GVHD in a subject HSCT.
Type:
Grant
Filed:
February 10, 2015
Date of Patent:
August 9, 2022
Assignee:
H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
Abstract: Disclosed is an optimization decision-making method of an industrial process fusing domain knowledge and multi-source data. The method comprises the steps of: acquiring the domain knowledge of the industrial process by using probability soft logic, and building an domain rule knowledge base of the industrial process; fusing multi-source data semantics and multi-source data features to form a new semantic knowledge representation of the industrial process, and constructing a semantic knowledge base of the industrial process; under a posteriori regularization framework, utilizing the domain rule knowledge base of the industrial process and the semantic knowledge base of the industrial process to obtain an optimization decision-making model embedded with the domain rule knowledge and obtain a posteriori distribution model; and migrating knowledge in the optimization decision-making model embedded with the domain rule knowledge into the posteriori distribution model through the knowledge distillation technology.
Type:
Grant
Filed:
December 23, 2021
Date of Patent:
August 9, 2022
Assignee:
INSTITUTE OF AUTOMATION, CHINESE ACADEMY OF SCIENCES
Abstract: Disclosed is an image data encoding/decoding method and apparatus. A method for decoding a 360-degree image comprises the steps of: receiving a bitstream obtained by encoding a 360-degree image; generating a prediction image by making reference to syntax information obtained from the received bitstream; combining the generated prediction image with a residual image obtained by dequantizing and inverse-transforming the bitstream, so as to obtain a decoded image; and reconstructing the decoded image into a 360-degree image according to a projection format.
Abstract: A bidirectional optical transceiver module includes an optical Tx block including a light source configured to output an optical Tx signal; an optical Rx block provided in parallel to the optical Tx block and including a PD configured to receive an optical Rx signal; a wavelength distributor configured to change a travel path of the optical Tx signal; an optical filter provided on a predetermined area of a first surface of the wavelength distributor adjacent to the optical Tx or Rx block and configured to transmit the optical Rx signal and reflect the optical Tx signal; a first lens provided between the optical Tx block and the wavelength distributor; a second lens provided between the optical Rx block and the wavelength distributor; and a third lens configured to output the optical Tx signal to outside and output the optical Rx signal from the outside to the wavelength distributor.
Type:
Grant
Filed:
March 17, 2021
Date of Patent:
August 9, 2022
Assignee:
ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
Inventors:
Joon Young Huh, Sae-Kyoung Kang, Sanghwa Yoo
Abstract: A high voltage logic circuit for high voltage system application comprises a first device layer formed from a first semiconductor material and comprises a low voltage logic circuit; and a second device layer formed from a second different semiconductor material and comprising one or more components of an additional circuit for generating a high voltage logic output from a low voltage logic input from the low voltage logic circuit; wherein the first and second device layers are integrally formed.
Type:
Grant
Filed:
January 4, 2021
Date of Patent:
August 9, 2022
Assignees:
MASSACHUSETTS INSTITUTE OF TECHNOLOGY, NANYANG TECHNOLOGICAL UNIVERSITY
Abstract: Provided is a method of manufacturing a high efficiency flexible thin film solar cell module including a see-thru pattern. The method of manufacturing a flexible thin film solar cell module includes: sequentially forming a light-absorbing layer, a first buffer layer, and a first transparent electrode layer on the release layer; forming a second buffer layer on the exposed bottom surface of the light-absorbing layer; forming a P2 scribing pattern by removing at least one portion of each of the first buffer layer, the light-absorbing layer, and the second buffer layer; forming a second transparent electrode layer on the second buffer layer and the first transparent electrode layer exposed by the P2 scribing pattern; and forming a P4 see-thru pattern by selectively removing at least one portion of the first buffer layer, the light-absorbing layer, the second buffer layer, and the second transparent electrode layer.
Type:
Grant
Filed:
October 14, 2020
Date of Patent:
August 9, 2022
Assignee:
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventors:
Hyeonggeun Yu, Jeung-hyun Jeong, Won Mok Kim, Jong-Keuk Park, Eunpyung Choi
Abstract: Devices, systems, and methods for adjusting the high flex point of a deformable sensor are disclosed herein. A deformable sensor may include an enclosure comprising a housing and a deformable membrane coupled to an upper portion of the housing, where the enclosure is configured to be filled with a medium, a contact mechanism coupled to the housing and selectively adjustable such that adjusting a position of the contact mechanism causes a change in a location of a high flex point of the deformable membrane, and an internal sensor, disposed within the enclosure, having a field of view configured to be directed through the medium and toward a bottom surface of the deformable membrane, where the internal sensor is configured to output a deformation region within the deformable membrane when placed in contact an object.
Type:
Grant
Filed:
March 31, 2020
Date of Patent:
August 9, 2022
Assignee:
TOYOTA RESEARCH INSTITUTE, INC.
Inventors:
Alexander Alspach, Naveen Suresh Kuppuswamy, Avinash Uttamchandani
Abstract: Provided is a movement robot configured so that various types of operation can be executed according to motion of other objects or a movement body and a utilization area can be expanded accordingly. The movement robot includes a robot body 1, a control unit 2, a traveling unit 3, and a detection unit 4.
Abstract: Devices, systems and methods are described for non-invasively monitoring and/or measuring or estimating intraocular pressure. Medical or diagnostic methods embodiments described herein include high resolution imaging of the sclera of one or both of a patient's eyes using digital photography or videography. The hardware employed may be for two-dimensional (2D) or three-dimensional (3D) imaging.
Abstract: The invention provides for recombinant AAV vectors comprising a polynucleotide sequence comprising the guide strand of miR-29c and methods of using the recombinant vectors to reduce or prevent fibrosis in subjects suffering from dystrophinopathy or muscular dystrophy. The invention also provides for combination therapies comprising expressing both miR-29 and micro-dystrophin to reduce and prevent fibrosis in patients suffering from dystrophinopathy or muscular dystrophy.
Type:
Grant
Filed:
April 14, 2017
Date of Patent:
August 9, 2022
Assignee:
RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL
Inventors:
Louise Rodino-Klapac, Jerry R. Mendell, Kristin N. Heller
Abstract: The present invention relates to a method for continuous removal of carbon dioxide, the method comprising the steps of: a) preparing an aqueous solution containing an amine-based compound and an acidic calcium compound; b) bringing a gas containing carbon dioxide to be treated into contact with the aqueous solution to prepare a calcium carbonate precipitate; and c) recovering the calcium carbonate and then adding a basic calcium compound to the residual aqueous solution, wherein after step c), step b) and step c) are repeatedly performed. The removal of carbon dioxide by the method of the present invention has advantages of requiring low energy and being capable of mineralizing and removing carbon dioxide at a fast rate without a separate time for induction.
Type:
Grant
Filed:
November 8, 2017
Date of Patent:
August 9, 2022
Assignee:
KOREA INSTITUTE OF ENERGY RESEARCH
Inventors:
Soon Kwan Jeong, Min Hye Youn, Ki Tae Park, Seong-Pil Kang, Wonhee Lee, Hak Joo Kim, Young Eun Kim, Ji Min Kang, Arti Murnandari
Abstract: The purpose of the present invention is to provide a novel compound which has antibacterial activity against Mycobacterium avium and Mycobacterium intracellulare that are causative bacteria of MAC infection and which is different in backbone structure from known drugs for treatment of MAC infection. One aspect of the present invention relates to a compound of Formula (I) [where R1 has the same meaning as described in the specification and claims] or a salt thereof, or a solvate thereof. Another aspect of the present invention relates to a method for producing the compound of Formula (I) or a salt thereof, or a solvate thereof, and a therapeutic agent for Mycobacterium avium complex infection (MAC infection), which comprises the compound or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof as an active ingredient.
Type:
Grant
Filed:
August 30, 2018
Date of Patent:
August 9, 2022
Assignees:
THE KITASATO INSTITUTE, OP BIO FACTORY CO., LTD.
Abstract: The present disclosure in some embodiments provides a security system using both key management service (KMS) and a hardware security module (HSM), and a method of operating the security system. At least one embodiment provides a security system including an HSM, a bootstrapping enclave, and one or more KMS enclaves. The HSM is configured to generate, replace or remove a root key, the HSM being physically independent. The bootstrapping enclave is configured to receive the root key from the HSM. The one or more KMSs are configured to perform an attestation procedure with the bootstrapping enclave, to receive the root key from the bootstrapping enclave, and to utilize the root key for establishing a secure channel with the HSM.
Type:
Grant
Filed:
August 5, 2020
Date of Patent:
August 9, 2022
Assignee:
KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
Abstract: The method includes configuring a first CLI-RS configuration at a first UE (200a). Further, the method includes configuring a second CLI-RS configuration at a second UE (200b). Further, the method includes generating a CLI-RS sequence using a common CLI-RS reference point known to the first UE (200a) and the second UE (200b). Further, the method includes filling the CLI-RS sequence in the first set of CLI-RS resources indicated in the first CLI-RS configuration. Further, the method includes transmitting the CLI-RS sequence filled in the first set of CLI-RS resources indicated in the first CLI-RS configuration to the second UE (200b). Further, the method includes receiving the CLI-RS sequence transmitted by the first UE (200a). Further, the method includes processing the received CLI-RS sequence based on the second CLI-RS configuration.
Type:
Grant
Filed:
January 10, 2020
Date of Patent:
August 9, 2022
Assignees:
CENTRE OF EXCELLENCE IN WIRELESS TECHNOLOGY, INDIAN INSTITUTE OF TECHNOLOGY MADRAS (IIT MADRAS)