Abstract: Disclosed are compounds that possess inhibitory activity against FAK. Also disclosed are pharmaceutical compositions containing the compounds and methods of using the compounds to treat cancer mediated by aberrant FAK activity.

Abstract: A trust reality service brokering apparatus located on an edge cloud receives a context rule, analyzes event data of at least one physical entity connected to the edge cloud based on the context rule, and transmits an action command to a physical entity or virtual entity corresponding to the event when it is determined that an event has occurred according to an analysis result.

Abstract: A regeneration method of a nitrogen-containing carbon catalyst includes the following steps: roasting the nitrogen-containing carbon catalyst in a nitrogen-containing atmosphere to obtain a regenerated nitrogen-containing carbon catalyst. The method is a universal method, which is suitable for nitrogen-doped carbon catalysts and can be used to regenerate a nitrogen-containing carbon catalyst for producing vinyl chloride (VC) through 1,2-dichloroethane cracking. The method can greatly reduce the production cost of the catalyst and increase the service life of the catalyst, and a regeneration process thereof is fast, simple, and controllable, and does not require high temperatures.

Abstract: The present disclosure discloses a storage method, a data processing method, a device and an apparatus based on a non-volatile memory, the method comprising: acquiring a weight value that needs to be stored in the non-volatile memory; determining a conductivity value corresponding to the weight value according to a first conversion method if the non-volatile memory is a high-resistance storage device; determining a conductivity value corresponding to the weight value according to a second conversion method which is different from the first conversion method if the non-volatile memory is a low-resistance memory device; and setting the non-volatile memory according to the conductivity value to store the weight value.

Abstract: A biological desulfurization processing system is provided. The biological desulfurization processing system includes a desulfurization reaction tank and a culture tank of desulfurization bacteria. The culture tank of desulfurization bacteria is used for cultivating desulfurization bacteria and is connected to the desulfurization reaction tank. The desulfurization reaction tank includes a desulfurization reaction zone. The desulfurization reaction zone includes at least one desulfurization layer and at least one supporting layer, and the desulfurization layer and the supporting layer are stacked in a staggered manner. A biological desulfurization processing method is also provided.

Abstract: The present disclosure relates to, inter alia, a modified surface comprising an optically active monomer, a polymeric material having a surface onto which the optically active monomer is covalently bound. In one aspect, a membrane comprising an optically active monomer, a poly(aryl sulfone) membrane having a surface onto which the optically active monomer is covalently bound. The present disclosure also relates to a method of modifying a surface, the method comprising applying sufficient energy to a surface to induce covalent bonding with an optically active monomer, and contacting the optically active monomer with the surface. In one aspect, a method of modifying a surface of a poly(aryl sulfone) membrane is disclosed. In another aspect, a method of synthesizing an optically active monomer is disclosed. In one aspect, a method of filtration of chiral compounds is disclosed.

Abstract: A method for semantic keypoint detection is described. The method includes linking, using a keypoint graph neural network (KGNN), semantic keypoints of an object within a first image of a video stream into a 2D graph structure corresponding to a category of the object. The method also includes embedding descriptors within the semantic keypoints of the 2D graph structure corresponding to the category of the object. The method further includes tracking the object within subsequent images of the video stream using the embedded descriptors within the semantic keypoints of the 2D graph structure corresponding to the category of the object.

Abstract: SAR ADC and sampling method based on single-channel TIS. The SAR ADC comprises: a capacitor array comprising a weight capacitor and a compensation capacitor, a first switch array, a second switch array, a channel switch group and a sampling switch; when in a sampling state: a lower plate of the weight capacitor is connected to an input voltage by means of the first switch array, and an upper plate of the capacitor array is connected to a common mode voltage by the sampling switch and the channel switch group; when in a successive approximation state: the lower plate of the weight capacitor is connected to a reference voltage by the second switch array. Input signals are sampled by using a unified to sampling switch, which solves the problem in the traditional technology that sampling moments are mismatched due to different sampling signals in each time-interleaved channel.

Abstract: The present disclosure provides an oscillating circuit and an electronic device; the oscillating circuit includes a capacitor charging and discharging circuit unit, a voltage comparison circuit unit and a threshold voltage generation circuit unit; the oscillating circuit uses the capacitor charging and discharging and the hysteresis effect of the capacitor charging and discharging circuit unit to achieve oscillation based on the negative feedback regulation constituted by the voltage comparison circuit unit and the threshold voltage generation circuit unit, which is different from the traditional oscillating circuit based on capacitance and inductance; the oscillating circuit does not adopts inductors, has relatively low power consumption, and outputs oscillation signals with frequencies that vary with currents.

Abstract: The present disclosure provides combined adjuvants nanoparticles prepared by self-assembly with amphiphilic monomer molecules as the building blocks, wherein the amphiphilic monomer molecules are generated from the reaction between hydrophobic adjuvants molecules and hydrophilic adjuvants molecules.

Abstract: One embodiment provides a method of making an oxidation and corrosion resistant nuclear fuel. The method includes refining, by high energy ball milling (HEBM), a nuclear fuel powder comprising at least one nuclear fuel component and sintering the refined powder to form a nuclear fuel pellet. The method may further include adding a powdered dopant to the nuclear fuel powder. The refined powder includes the nuclear fuel powder and the powdered dopant.

Abstract: Provided herein are compounds of Formulae (I) and (II), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. The compounds described herein bind an E3 ubiquitin ligase (e.g., Cereblon) and induce degradation of a transcription factor (e.g., IKZF1, IKZF3). Also provided are pharmaceutical compositions comprising the compounds, and methods of treating and/or preventing diseases (e.g., proliferative diseases (e.g., cancers (e.g., carcinoma); leukemia, lung cancer, breast cancer, liver cancer, pancreatic cancer, gastric cancer, ovarian cancer, colon cancer, colorectal cancer, multiple myeloma, and acute myeloid leukemia (AML))). Further provided are methods of inducing the degradation of a transcription factor (e.g., IKZF1, IKZF3) by administering a compound or composition described herein to a subject and/or to a biological sample (e.g., cell or tissue).

Abstract: Provided is a compound semiconductor device. The compound semiconductor device according to embodiments of the inventive concept includes a first semiconductor layer having a fin extending in a first direction on a substrate, an upper gate electrode extending in a second direction perpendicular to the first direction on the first semiconductor layer, a second semiconductor layer disposed between a sidewall of the fin and the upper gate electrode, a dielectric layer disposed between a top surface of the fin and the upper gate electrode, and a lower gate structure connected to a bottom surface of the first semiconductor layer by passing through the substrate.

Abstract: A zeolite membrane composite including a porous support and a zeolite membrane formed on a surface of the porous support. The zeolite membrane has an LTA-type crystal structure. The first atomic ratio: Si/Al of silicon element (Si) to aluminum element (Al) in the zeolite membrane is 1.29 or greater and 1.60 or less.

Abstract: A deep-sea ore hydraulic lifting system with a deep-sea single high-pressure silo feeding device, which comprises a water injection pump, a water injection riser, a deep-sea single high-pressure silo feeding device, a lifting riser, a dewatering device and a pipeline. The water injection pump and the dewatering device are fixed on a mining ship. The water injection pump is connected to the deep-sea single high-pressure silo feeding device through the water injection riser. The deep-sea single high-pressure silo feeding device is connected to the dewatering device through the lifting riser. The water injection pump is connected to the dewatering device through the pipeline. Seawater is pumped into the water injection riser by the water injection pump, then ore is fed into a high-pressure hydraulic pipeline by the deep-sea single high-pressure silo feeding device to be mixed with the seawater, and an obtained ore and seawater mixture is lifted.

Abstract: Disclosed are bispecific compounds (degraders) that target EP300/CBP for degradation. Also disclosed are pharmaceutical compositions containing the degraders and methods of using the compounds to treat disease.

Abstract: The present invention relates to a composition for preventing or treating a degenerative brain disease, comprising 2-pentylfuran or a solvate thereof, a stereoisomer thereof or a pharmaceutically acceptable salt thereof as an active ingredient.

Abstract: An operation method of a receiving apparatus may comprise: receiving an N-th data block belonging to a frame including a plurality of data blocks from a transmitting apparatus, each of the plurality of data blocks including a data period and a UW period; storing a first UW received in a UW period of the N-th data block in a buffer; receiving an (N+1)-th data block belonging to the frame from the transmitting apparatus; estimating a phase noise in a time domain by combining the first UW with a second UW received in a UW period of the (N+1)-th data block; and applying time-domain compensation according to the estimated phase noise to the (N+1)-th data block, and demodulating data of the (N+1)-th data block, wherein the first UW and the second UW are configured with a same sequence.

Abstract: Disclosed herein are an apparatus and method for converting a neural network. The method includes separating neural network data of a source framework to form a tree structure by analyzing the same, converting the neural network data in a tree structure to a neural network optimized for a target framework, classifying training data based on the result of analysis of the neural network data of the source framework, converting the classified training data to the training data structure of the target framework, and creating a neural network and training data of the target framework by combining the converted neural network and the converted training data.

Abstract: An image encoding/decoding method and apparatus of the present invention may divide one picture into a plurality of division units, determine whether to perform filtering on a boundary of a current division unit based on a predetermined flag, and perform filtering on the boundary of the current division unit in response to the determination.