Abstract: The present disclosure includes methods for manipulation of the genome, to products obtained or obtainable from such methods, and uses of these products.

Abstract: Disclosed are methods for generating oxygen via an electrolysis reaction. One places an anode and a cathode in aqueous solution, and uses an external source of electricity to drive the electrolysis reaction from the anode and cathode. The anode has at least three metal oxides, preferably with nickel oxide or cobalt oxide as at least one of the oxides. Also disclosed are electrodes designed for catalyzing oxygen consumption or formation reactions, where the electrodes have a mix of such three metal oxides.

Abstract: Methods and devices for receiving reflectance-based input are provided. In some embodiments, the electronic device includes a plurality of electromagnetic radiation emitting devices and one or more electromagnetic radiation receiving devices for receiving reflected light from the electromagnetic radiation emitting devices. In one aspect, a method includes: repeatedly performing a reflectance measuring routine, the reflectance measuring routine including: alternatingly outputting light at each of the plurality of electromagnetic radiation emitting devices; and monitoring light received at one or more of the electromagnetic radiation receiving devices as a result of the alternating output; determining, based on the light received at the one or more electromagnetic radiation receiving devices, whether a predetermined gesture has been performed; and performing a function associated with the predetermined gesture when the predetermined gesture has been performed.

Abstract: Provided are a mobile communication system comprising a femto base station for transmitting system information, and a terminal for receiving the system information from the femto base station. The terminal receives the system information from the femto base station, and during other times, receives data from a serving macro base station.

Abstract: Electrodes and methods for making electrodes including modified carbon nanotube sheets are provided. The carbon nanotube sheets can be modified with metal particles or at least one mediator titrant. The electrodes can be disposed on a glassy carbon electrode to modify the glassy carbon electrode. Methods are provided that include forming a suspension of carbon nanotubes and metal particles or at least one mediator titrant, and filtering the suspension to form a modified carbon nanotube sheet.

Abstract: A device for collecting material from a solid surface, and optionally concentrating the collected material, for subsequent analysis includes a nebulizer that generates and discharges a fluid stream, and a collector positioned to intercept material caused by the fluid stream after it is deflected from the solid surface. The device is usable in a sample collection process having steps of spraying a fluid stream of gas containing nebulized solvent as the solid surface, positioning a collector to intercept material carried by the fluid. The process may be repeated to concentrate the material being sampled.

Abstract: Disclosed herein is an apparatus and method for providing an indoor navigation service. An apparatus includes a communication module for, when an indoor navigation service is executed, accessing a service server for providing the indoor navigation service. An image control module acquires indoor images in real time and displays the indoor images on an indoor navigation screen. An indoor location recognition module extracts indoor marker from the indoor images, obtains information about the extracted indoor marker, and recognizes a current location in the indoor space based on the indoor marker information. An indoor navigation module requests indoor navigation information to the service server based on information about the current location and destination information, and displays the indoor navigation information.

Abstract: A method of generating pluripotent stem cells is described. The method comprises: (a) expanding human pancreatic beta cells; and subsequently (b) generating induced pluripotent stem (iPS) cells from the human pancreatic beta cells. Methods of redifferentiating the iPS cells into particular cell types are also disclosed. Uses of the cell populations are also described.

Abstract: A solar cell production method involves printing longer central gridlines and one or more pairs of shorter “side” gridlines such that end points of the two gridline sets form step patterns on octagonal (pseudo-square) substrates. A special printhead is used that includes a set of central nozzles which receive ink from a first valve by way of a first flow channel to print the longer central gridlines, and additional sets of side nozzles that receive ink from additional valves by way of additional flow channels to print the shorter “side” gridlines. The central nozzles have outlet orifices that offset in the process direction from side outlet orifices of the side nozzles. A start signal is simultaneously sent to the valves such that ink is substantially simultaneously extruded through both the central and side orifices, whereby the extruded ink produces gridline endpoints having the desired step pattern.

Abstract: Disclosed herein are an autonomous driving apparatus and method for a vehicle. The autonomous driving apparatus includes an autonomous driving context data processing unit, a simulator unit, a section determination unit, a path planning unit, and a context determination main control unit. The autonomous driving context data processing unit gathers autonomous driving context data. The simulator unit simulates autonomous driving based on the gathered autonomous driving context data. The section determination unit determines a reliable section or an unreliable section based on results of the simulation. The path planning unit searches for at least one global path to a set destination based on results of the determination, and searches the at least one global path for a local path along which the autonomous driving is possible. The context determination main control unit controls the autonomous driving of the vehicle along the local path.

Abstract: A cleaning system is disclosed that includes a vehicle that has a cooling system for circulating a coolant, a diverter coupled with the cooling system that is configured to divert the coolant through a heat exchanger, a pump configured to pump a cleaning solution through the heat exchanger so that the heat exchanger heats the cleaning solution without mixing the coolant and the cleaning solution, and a rotary head cleaner in fluid communication with the heat exchanger for receiving the cleaning solution and applying the cleaning solution to a floor.

Abstract: N-type voltage-gated calcium channels (CaV2.2) are critical mediators of neurotransmitter release and are thought to be involved with transmission of nociception. The use of conventional CaV2.2 blockers in pain therapeutics is limited by side effects. Reported herein is a means to suppress both inflammatory and neuropathic pain without directly blocking CaV2.2, but rather by inhibiting the binding of the axonal collapsin response mediator protein 2 (CRMP-2), a protein known to enhance CaV2.2 function. A 15 amino acid peptide of CRMP-2 fused to the protein transduction domain of the HIV tat protein (TAT CBD3) reduced meningeal blood flow induced by activation of the trigeminovascular system, prevented inflammation-induced tactile hypernociception induced by intraplantar formalin and nocifensive behavior following corneal capsaicin application, and reversed neuropathic hypernociception produced by the antiretroviral drug 2?,3?-dideoxycytidine. Preventing CRMP-2—mediated enhancement of CaV2.

Abstract: We describe the use of an exosome for the preparation of a pharmaceutical composition to promote or enhance would healing or hair growth, or both, in an individual. The exosome may be derived from a stem cell such as a mesenchymal stem cell (MSC).

Abstract: Disclosed is a dual mode function pixel that operates either in a first mode or in a second mode according to the intensity of a projected light to have a high visibility regardless of the intensity of projected light. The dual mode function pixel includes: a first membrane on which a self-luminescent element is formed; one or more membranes formed to surround the first membrane; and a lower layer formed below the first membrane and the one or more membranes to be spaced apart from the first membrane and the one or more membranes. The dual mode function pixel is controlled such that the self-luminescent element is driven either to emit light in a first mode operation or to selectively reflect a projected light by utilizing an interference of light generated between the first to one or more membranes and the lower layer in a second mode operation.

Abstract: The present invention relates to nucleic acid sequences and amino acid sequences which influence bone deposition, the Wnt pathway, ocular development, tooth development, and may bind to LRP. The nucleic acid sequence and polypeptides include Wise and Sost as well as a family of molecules which express a cysteine knot polypeptide. Additionally, the present invention relates to various molecular tools derived from the nucleic acids and polypeptides including vectors, transfected host cells, monochronal antibodies, Fab fragments, and methods for impacting the pathways.

Abstract: The present invention concerns glutathione-lanthionine compounds, the process of preparing such compounds, and their use. The invention also concerns methods of using the compounds and derivatives and combinations of these compounds in the treatment and/or prevention diseases, including diseases affecting the central nervous system.

Abstract: A polypeptide is provided that comprises an actinohivin variant polypeptide having an amino acid sequence selected from SEQ ID NOS: 4-12. The polypeptide can be provided as part of a fusion protein that includes the actinohivin variant polypeptide and either a fragment crystallizable domain of an antibody (Fc), a fragment antigen-binding domain of an antibody (Fab), or a single chain variable fragment of an antibody (scFv). Isolated nucleic acid molecules encoding the polypeptides are also provided along with vectors and plant cells capable of expressing the polypeptides. Methods of treating an infection of a subject by an enveloped virus are further provided and include administering an effective amount of the polypeptides to a subject.

Abstract: In a method of determining insulin sensitivity in a patient, glucose level is sensed continuously. A first area under the curve representing the glucose level over time is calculated. An amount of insulin that has been administered to the patient is sensed. An estimation of insulin on board the patient is calculated based on the glucose level and the amount of insulin administered to the patient. A second area under the curve representing the insulin on board over time is calculated. Patient data indicative of at least one patient physical parameter is received. Information indicative of amount of glucose ingested by the patient during a meal is received. An insulin sensitivity output indicative of ability of insulin to stimulate glucose utilization and inhibit glucose production in the patient based on the first and second area under the curve, the patient data and the meal information is generated.

Abstract: A method of generating an antibody which inhibits a metalloenzyme is disclosed. The method comprises immunizing a subject with: (i) a synthetic zinc mimicry compound having structural and electronic properties similar to a catalytic domain of the metalloenzyme; and (ii) the metalloenzyme, Antibodies generated by this method are also disclosed as well as uses thereof.

Abstract: Described are various embodiments of surgical procedures, systems, implants, devices, tools, and methods, useful for treating pelvic conditions in a male or female, the pelvic conditions including incontinence (various forms such as fecal incontinence, stress urinary incontinence, urge incontinence, mixed incontinence, etc.), vaginal prolapse (including various forms such as enterocele, cystocele, rectocele, apical or vault prolapse, uterine descent, etc.), and other conditions caused by muscle and ligament weakness, the devices and tools including devices and tools for anchoring an implant to tissue.