Abstract: A top-pinned magnetic tunnel junction device with perpendicular magnetization, including a bottom electrode, a non-ferromagnetic spacer, a free layer, a tunneling barrier, a synthetic antiferromagnetic reference layer and a top electrode, is provided. The non-ferromagnetic spacer is located on the bottom electrode. The free layer is located on the non-ferromagnetic spacer. The tunnel insulator is located on the free layer. The synthetic antiferromagnetic reference layer is located on the tunneling barrier. The synthetic antiferromagnetic reference layer includes a top reference layer located on the tunneling barrier, a middle reference layer located on the bottom reference layer and a bottom reference layer located on the tunneling barrier. The magnetization of the top reference layer is larger than that of the bottom reference layer. The top electrode is located on the synthetic antiferromagnetic reference layer.

Abstract: The present invention uses the principles of electrochemical ion absorption (charging) and ion desorption (discharge), and relates to a continuous flow-electrode system, a high-capacity energy storage system, and a water treatment method using the same, in which high-capacity electric energy is stored as electrode materials of a slurry phase and electrolytes simultaneously flow in a successive manner within a fine flow channel structure formed on an electrode. More specifically, the present invention relates to a continuous flow-electrode system, an energy storage system, and a water treatment method, wherein electrode active materials consecutively flow in a slurry state whereby a high capacity is easily obtained without enlarging or stacking electrodes.

Abstract: Disclosed herein are systems and methods for using demethylation of genomic DNA for diagnosing, predicting, and/or monitoring the status or outcome of a neoplasm or a cancer in a subject.

Abstract: The invention relates to a mixture containing an alkali-activated aluminosilicate binder, said mixture, after hardening, containing at least 25% by weight of glass beads, based on the total mass. The hardened product has a surface which has very little tendency to soil and is easy to clean. A process for the preparation of the mixture according to the invention and the use thereof as joint filler are disclosed.

Abstract: The present disclosure relates generally to the field of epigenetics and in particular epigenetic profiles associated with a pathological condition. The present specification teaches screening of individuals and populations for epigenetic profiles associated with a pathological condition. The epigenetic profiles can be from an intron, an intron/exon boundary or a splicing region. Epigenetic profiles are disclosed from the following sites in the FMR locus: FREES, intron 2 of FMR1, the genomic FREE2 region as a whole or specific FREE2 fragments including FREE2 (D) or FREE2 (E). Kits and diagnostic assays are also taught herein as are computer programs to monitor changes in epigenetic patterns and profiles. Further enabled herein is a method for screening for agents which can reduce or mask the adverse effects of epigenetic modification and the use of these agents in therapy and prophylaxis.

Abstract: A method for inserting characteristic extractor is provided. The method includes parsing a transaction level model (TLM) of an electronic device of a target system to find out at least one target point of an operation status of the electronic device; and inserting at least one characteristic extractor into the at least one target point.

Abstract: The invention provides methods of treating Friedreich's ataxia using histone deacetylase inhibitors.

Abstract: The present invention discloses compositions of liquid and gel formulation containing aripiprazole in the form of a patch for transdermal delivery.

Abstract: In a method of determining insulin sensitivity in a patient, glucose level is sensed continuously. A first area under the curve representing the glucose level over time is calculated. An amount of insulin that has been administered to the patient is sensed. An estimation of insulin on board the patient is calculated based on the glucose level and the amount of insulin administered to the patient. A second area under the curve representing the insulin on board over time is calculated. Patient data indicative of at least one patient physical parameter is received. Information indicative of amount of glucose ingested by the patient during a meal is received. An insulin sensitivity output indicative of ability of insulin to stimulate glucose utilization and inhibit glucose production in the patient based on the first and second area under the curve, the patient data and the meal information is generated.

Abstract: According to embodiments of the present invention, a probe device is provided. The probe device includes a flexible probe that is implantable into a biological tissue, a rigid carrier, and a biodegradable material received in a recess defined between the flexible probe and the rigid carrier, the biodegradable material bonding the flexible probe and the rigid carrier to each other, wherein the biodegradable material is dissolvable in the biological tissue such that the flexible probe and the rigid carrier are separable and the rigid carrier is removable from the biological tissue, and wherein the biodegradable material is capable of drug delivery upon dissolution. According to further embodiments of the present invention, a method of fabricating a probe device is also provided.

Abstract: A system, method, electronic device and server are provided for metering electronic messages and for managing message traffic within an organization. An electronic message resistance value is stored for recipients within an organization. When a message is composed and addressed at a sending terminal, the electronic message resistance value may be retrieved and displayed at the sending terminal. The message server receiving the composed message for transmission to the recipient sends the message to the recipient in accordance with a priority determined based on the recipient's electronic message resistance; for example, the message may be sent with a low priority attribute, or the transmission of the message to the recipient may be delayed for a set period of time.

Abstract: A method for measuring the temperature of an electrical conductor, the method comprising (a) providing a clamp comprising a flexible, thermally conductive material in thermal contact with the electrical conductor, wherein the clamp has an outer surface of a known emissivity value, or a coating of a known emissivity value is disposed on the outer surface of the clamp and (b) measuring the infrared (IR) temperature of the clamp to determine the temperature of the electrical conductor.

Abstract: This application discloses phosphoramidate and phosphonoamidate prodrugs of alcohol-based therapeutic agents, such as nucleosides, nucleotides, acyclonucleosides, C-nucleosides, and C-nucleotides, and use of these prodrugs for treatment of diseases or disorders, including infectious diseases and cancers. This application also discloses a general method for enhancing bioavailability and/or liver-targeting property of alcohol drugs through converting the alcohol drugs to phosphoramidate or phosphonoamidate prodrugs, and methods of preparation of these prodrugs.

Abstract: Disclosed herein are an autonomous driving apparatus and method for a vehicle. The autonomous driving apparatus includes an autonomous driving context data processing unit, a simulator unit, a section determination unit, a path planning unit, and a context determination main control unit. The autonomous driving context data processing unit gathers autonomous driving context data. The simulator unit simulates autonomous driving based on the gathered autonomous driving context data. The section determination unit determines a reliable section or an unreliable section based on results of the simulation. The path planning unit searches for at least one global path to a set destination based on results of the determination, and searches the at least one global path for a local path along which the autonomous driving is possible. The context determination main control unit controls the autonomous driving of the vehicle along the local path.

Abstract: A radiation sensor is provided. The radiation sensor includes a substrate; a diaphragm positioned over the substrate; an absorbing layer which is configured to absorb infrared radiation; a supporting element arranged between the absorbing layer and the diaphragm such that a spacing gap is formed between the absorbing layer and the diaphragm; wherein the size of the spacing gap is in a range of about 3.6 micrometer to about 100 micrometer.

Abstract: Disclosed are methods for generating oxygen via an electrolysis reaction. One places an anode and a cathode in aqueous solution, and uses an external source of electricity to drive the electrolysis reaction from the anode and cathode. The anode has at least three metal oxides, preferably with nickel oxide or cobalt oxide as at least one of the oxides. Also disclosed are electrodes designed for catalyzing oxygen consumption or formation reactions, where the electrodes have a mix of such three metal oxides.

Abstract: A hybrid direction apparatus and method that rapidly and accurately detects a direction of a radio signal source based on a direction detecting scheme by comparing an amplitude or signal strength, a virtual Doppler scheme, a phase difference comparison scheme while removing an ambiguity based on an amplitude or signal strength scheme, and identify a direction relatively precisely based on a phase difference scheme using only two antennas. Also, an arrival direction of a relative radio wave when an arrival direction of a radio wave is vertical to a single rotating axis may be precisely identified by mounting a directional antenna and a phase comparison antenna on the single rotating axis, and rotating the two antennas.

Abstract: The present invention concerns glutathione-lanthionine compounds, the process of preparing such compounds, and their use. The invention also concerns methods of using the compounds and derivatives and combinations of these compounds in the treatment and/or prevention diseases, including diseases affecting the central nervous system.

Abstract: A method of generating pluripotent stem cells is described. The method comprises: (a) expanding human pancreatic beta cells; and subsequently (b) generating induced pluripotent stem (iPS) cells from the human pancreatic beta cells. Methods of redifferentiating the iPS cells into particular cell types are also disclosed. Uses of the cell populations are also described.

Abstract: It relates to a device comprising (a) a core comprising polyurethane; (b) a sheath comprising ethylene vinyl acetate copolymer, said sheath substantially or completely surrounding said core; and (c) one or more active pharmaceutical ingredients dissolved or dispersed in said core and/or said sheath; and to a process for its preparation.