Patents Assigned to SANDOZ
  • Patent number: 4623720
    Abstract: 1:1 and 1:2 metal complexes comprising the unit of the formula ##STR1## wherein A and B, independently, are radicals of diazo or coupling components, with the proviso that when one of A and B is a radical of a diazo component, the other is a radical of a coupling component,T is --SO.sub.2 N(R.sub.1)-- or --N(R.sub.1)SO.sub.2 --, wherein R.sub.1 is hydrogen, C.sub.1-4 alkyl, C.sub.1-4 alkyl substituted by phenyl or carboxy or C.sub.2-4 alkyl substituted in the .beta.--, .gamma.-- or .delta.--position by phenoxy, C.sub.1-4 alkyl, chloro or hydroxy, with the proviso that T is --N(R.sub.1)SO.sub.2 -- when A is the radical of a diazo component and T is --SO.sub.2 N(R.sub.
    Type: Grant
    Filed: June 4, 1981
    Date of Patent: November 18, 1986
    Assignee: Sandoz Ltd.
    Inventor: Herbert Holliger
  • Patent number: 4623397
    Abstract: Compounds of the formula I ##STR1## in which each R.sub.1, independently, is hydrogen, C.sub.1-8 alkyl, C.sub.2-3 alkyl substituted by one or two substituents selected from the group consisting of halo, hydroxy, cyano, methoxy, ethoxy and (C.sub.1-2 alkoxy)carbonyl or cyclohexyl, and each R.sub.2 and R.sub.3, independently, is hydrogen, chlorine, bromine, methyl, methoxy or ethoxy, their production and use as pigments for the mass pigmentation of, for example, viscose, surface coatings such as oil and water base paints and lacquers and inks, pigment printing, textile coating and pigmenting paper in the mass.
    Type: Grant
    Filed: October 10, 1984
    Date of Patent: November 18, 1986
    Assignee: Sandoz Ltd.
    Inventor: Bansi L. Kaul
  • Patent number: 4622336
    Abstract: 3,3-Dialkyl- or 3,3-alkylene-indolines which are unsubstituted at the 1- and 2-positions and which are substituted at the 4- or 6-position by an optionally etherified hydroxy group or substituted at the 5- or 7-position by an etherified hydroxy group, as well as their physiologically-hydrolyzable and -acceptable esters. The said indolines and esters as well as their pharmaceutically acceptable acid addition salts possess analgesic activity.
    Type: Grant
    Filed: January 17, 1985
    Date of Patent: November 11, 1986
    Assignee: Sandoz Ltd.
    Inventor: Roland Achini
  • Patent number: 4622045
    Abstract: The invention provides a process for dyeing a textile substrate comprising wool fibres, which process comprises bringing the substrate into contact with an aqueous dyebath containing an acid dyestuff or a mixture of acid dyestuffs having(a) a build-up power on wool of from 90 to 98% at pH 4.5; together with(b) a migrating ability on wool of from 25 to 40%, at pH 4.5;(a) and (b) being determined under specific conditions, in the presence of a levelling agent which is the alkoxylation product of an amine substituted by a fatty saturated or unsaturated residue, the aqueous dyebath containing a mixture of acid dyestuffs when the substrate is a wool/synthetic polyamide fibre blend.These dyestuffs give level, fast and reproducible dyeings of a high quality.
    Type: Grant
    Filed: September 28, 1984
    Date of Patent: November 11, 1986
    Assignee: Sandoz Ltd.
    Inventors: Josef Frauenknecht, Karl Zeller
  • Patent number: 4619703
    Abstract: Aqueous wax dispersions containing a non-oxidized paraffin wax, a cationic surfactant of formula I ##STR1## in which the significances of the symbols are given in the text, and optionally a cold stabilizer such as ethylene glycol, have excellent stability when used for textile finishing under high-shear conditions, for example in jet dyeing machines.
    Type: Grant
    Filed: November 30, 1984
    Date of Patent: October 28, 1986
    Assignee: Sandoz Ltd.
    Inventors: Hans Gerber, Eckart Schleusener
  • Patent number: 4619991
    Abstract: Process for the production of triazoles of the formula ##STR1## in which R.sub.1 is hydrogen or an aliphatic or aromatic substituent conventional for diazo components of disperse dyes, which substituent is bound to the N-atom in the 1- or 2-position of the triazole nucleus through a carbon atom, andK is a coupling component radicalcomprising treating a compound of the formula ##STR2## with a dehydrating agent.
    Type: Grant
    Filed: August 18, 1982
    Date of Patent: October 28, 1986
    Assignee: Sandoz Ltd.
    Inventor: Peter Matzinger
  • Patent number: 4619917
    Abstract: The invention discloses certain substituted 2-furanyl- or 5-oxo-2-furanyl methoxy phosphoryl alkyl cyclimmonium salts useful as PAF inhibitors, pharmaceutical compositions containing said compounds as an active ingredient thereof and a method of using such compositions for inhibiting PAF-induced blood platelet aggregation, PAF-mediated bronchoconstriction and extravasation, PAF-induced hypotension and PAF-induced ischemic bowel disease.
    Type: Grant
    Filed: October 31, 1985
    Date of Patent: October 28, 1986
    Assignee: Sandoz Pharm. Corp.
    Inventors: Mark L. Lee, Christian Jaeggi
  • Patent number: 4619993
    Abstract: Compounds of the formula ##STR1## wherein K is a coupling component radical, are useful for dyeing textile materials comprising a synthetic or semisynthetic, hydrophobic, high molecular weight material, e.g., linear aromatic polyesters, cellulose 21/2 acetate, cellulose triacetate and synthetic polyamides.
    Type: Grant
    Filed: July 18, 1984
    Date of Patent: October 28, 1986
    Assignee: Sandoz Ltd.
    Inventor: Werner Baumann
  • Patent number: 4618673
    Abstract: Asymmetric 1:2 chromium complexes of the formula, ##STR1## in which A is a group of the formula ##STR2## in which X is halogen, nitro or methyl,Y is hydrogen or nitro,* designates the carbon atom bound to the azo group,each Z is halogen or nitro, both substituents being the same,each of R.sub.1 and R.sub.2, independently, is phenyl or phenyl substituted by a total of up to three substituents selected from halogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, nitro and cyano (maximum of two nitro and/or cyano), andM.sup..sym. is hydrogen or an equivalent of a non-chromophoric cation,with the proviso that the sulpho group is in salt form, and mixtures of two or more of such 1:2 asymmetric complexes, which complexes and mixtures are useful for dyeing nitrogen-containing organic substrates e.g., natural and synthetic polyamides such as wool, silk and nylon, polyurethanes and leather.
    Type: Grant
    Filed: September 22, 1981
    Date of Patent: October 21, 1986
    Assignee: Sandoz Ltd.
    Inventor: Jacky Dore
  • Patent number: 4618359
    Abstract: New herbicidal chemical compounds of the formula: ##STR1## wherein X is trifluoromethyl; Y is selected from the group consisting of hydrogen, halogen, nitro and cyano and R is selected from the group consisting of nitro, alkylthio, halogen and cyano; herbicidal compositions thereof and methods of controlling weeds therewith. The compound, 3-tetrahydrofuryl 2-nitro-5-(2-chloro-4-trifluoromethylphenoxy) benzoate, is particularly useful for the control of the weed, velvetleaf, and safe to corn and soybean. Velvetleaf is found in corn and soybean crops and its presence will lower the yield of these crops.
    Type: Grant
    Filed: March 25, 1985
    Date of Patent: October 21, 1986
    Assignee: Sandoz Ltd.
    Inventor: Frank Wu
  • Patent number: 4617306
    Abstract: Pharmaceutical preparations comprising (a) co-dergocrine or a pharmaceutically acceptable acid addition salt thereof and (b) a calcium antagonist or a pharmaceutically acceptable salt thereof, as well as the treatment of hypertension/migraine by co-administration of components (a) and (b), e.g. in the form of a composition as defined.
    Type: Grant
    Filed: September 13, 1985
    Date of Patent: October 14, 1986
    Assignee: Sandoz Ltd.
    Inventors: Dieter Welzel, Hans Buhlmann
  • Patent number: 4615728
    Abstract: This invention relates to a propionamides of the following structural formula: ##STR1## wherein X is chlorine or trifluoromethyl and Y is hydrogen or chlorine. The compounds of this invention are useful as sugarcane ripeners.
    Type: Grant
    Filed: August 19, 1985
    Date of Patent: October 7, 1986
    Assignee: Sandoz Ltd.
    Inventors: Louis G. Nickell, Leonard J. Stach, Takeo Hokama
  • Patent number: 4615707
    Abstract: A process for improving the fastness properties of a sulphur dyestuff on a substrate comprising hydroxy group-containing fibres by applying to the dyed or printed substrate the reaction product (R) of(A) the product of reacting a mono- or polyfunctional primary or secondary amine with cyanamide, dicyanodiamide, guanidine or bi-guanidine; said product containing reactive hydrogen atoms bound to nitrogen, and(B) an N-methylol derivative of a urea, melamine, guanamine, triazinone, urone, carbamate or acid amidein the presence of (C) a catalyst for the crosslinking of N-methylol compounds of the type (B) above, and subsequently carrying out a heat-curing step.These compounds are useful for the aftertreatment of textile material.
    Type: Grant
    Filed: September 30, 1985
    Date of Patent: October 7, 1986
    Assignee: Sandoz Ltd.
    Inventor: Tibor Robinson
  • Patent number: 4615881
    Abstract: Polymers formed by incomplete esterification of the hydroxy groups of a water-soluble polymer such as polyvinyl alcohol, amylose or dextran with a pharmacologically acceptable mono- or di-carboxylic acid to an extent sufficient to render the polymer water-insoluble although still water-swellable, are biodegradable. They are useful for the formulation of pharmaceutical compositions for parenteral administration, particularly in the form of injectable fine particles in which a drug is intimately mixed with or encapsulated by the polymer.
    Type: Grant
    Filed: March 12, 1984
    Date of Patent: October 7, 1986
    Assignee: Sandoz Ltd.
    Inventors: Heinrich Deibig, Roland Reiner, Hendricus B. A. Welle
  • Patent number: 4613675
    Abstract: Substituted 1-cyclohexene-1,2-dicarboxamides, synthesis thereof, intermediates therefor, and the use of said compounds for the control of weeds.
    Type: Grant
    Filed: November 30, 1984
    Date of Patent: September 23, 1986
    Assignee: Sandoz Ltd.
    Inventor: Shy-Fuh Lee
  • Patent number: 4613610
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is C.sub.1-6 alkyl not containing an asymmetric carbon atom,each of R.sub.2 and R.sub.5 is independently hydrogen, C.sub.1-3 alkyl, n-butyl, i-butyl, t-butyl, C.sub.1-3 alkoxy, n-butoxy, i-butoxy, trifluoromethyl, fluoro, chloro, phenyl, phenoxy or benzyloxy,each of R.sub.3 and R.sub.6 is independently hydrogen, C.sub.1-3 alkyl, C.sub.1-3 alkoxy, trifluoromethyl, fluoro, chloro, phenoxy or benzyloxy,each of R.sub.4 and R.sub.7 is independently hydrogen, C.sub.1-2 alkyl, C.sub.1-2 alkoxy, fluoro or chloro, with the provisos that not more than one of R.sub.2 and R.sub.3 is trifluoromethyl, not more than one of R.sub.2 and R.sub.3 is phenoxy, not more than one of R.sub.2 and R.sub.3 is benzyloxy, not more than one of R.sub.5 and R.sub.6 is trifluoromethyl, not more than one of R.sub.5 and R.sub.6 is phenoxy, and not more than one of R.sub.5 and R.sub.6 is benzyloxy,X is --(CH.sub.2).sub.m --, --CH.dbd.CH--, --CH.dbd.CH--CH.sub.2 -- or --CH.sub.2 --CH.dbd.
    Type: Grant
    Filed: June 6, 1985
    Date of Patent: September 23, 1986
    Assignee: Sandoz Pharmaceuticals Corp.
    Inventor: James R. Wareing
  • Patent number: 4611063
    Abstract: Compounds of the formula I: ##STR1## wherein each of R.sup.1, R.sup.2 and R.sup.3 is, independently, (a) alkyl having from 1 to 22 carbon atoms; or(b) of the formula ##STR2## in which m is 0, 1 or 2, and each of R' and R" is independently a hydrogen atom, alkyl having from 1 to 3 carbon atoms, alkoxy having from 1 to 3 carbon atoms, or halo having an atomic weight of from about 19 to 127; and R is of an aralkyl-, phenyl- tryptophanyl- or benzocycloalkyl-type, are obtained by hydrogenating corresponding .alpha.-.beta. ethylenically-unsaturated analogs (II), which in turn are obtained by hydrogenating corresponding .alpha.-.beta. acetylenically-unsaturated analogs. Compounds I and II are useful as anti-atheroslerotic agents.
    Type: Grant
    Filed: August 25, 1983
    Date of Patent: September 9, 1986
    Assignee: Sandoz Corp.
    Inventor: Robert E. Damon, II
  • Patent number: 4609731
    Abstract: The present invention provides an improved process for the production of a compound of formula I ##STR1## wherein R.sub.1 is carboxyl, alkoxy(C.sub.1-5)carbonyl, amido, alkyl(C.sub.1-5)amido, di(alkyl(C.sub.1-5)amido or an amido radical of formula II ##STR2## wherein R.sub.a is alkyl(C.sub.1-4),R.sub.b is alkyl(C.sub.1-4) or benzyl, andR.sub.2 is hydrogen or alkyl(C.sub.1-4), andeitherR.sub.3 is hydrogen and R.sub.4 is hydrogen or alkoxy(C.sub.1-4)orR.sub.3 and R.sub.4 together are a single bond,characterized in that a compound of formula III ##STR3## wherein R.sub.1 to R.sub.4 are as defined above,is brominated with a bromine complex of 3-bromo-6-chloro-2-methyl-imidazo[1,2-b]pyridazine.
    Type: Grant
    Filed: April 18, 1980
    Date of Patent: September 2, 1986
    Assignee: Sandoz Ltd.
    Inventors: Milan Jurgec, Rudolf Rucman, Branko Stanovnik, Miha Tisler
  • Patent number: 4609664
    Abstract: Piperidylidene derivatives of formula ##STR1## wherein n is 2 or 3, R.sub.1 comprises a tricyclic nucleus and R.sub.2 is hydrogen or an acid residue, useful in the treatment and prophylaxis of asthmatic conditions.
    Type: Grant
    Filed: July 16, 1984
    Date of Patent: September 2, 1986
    Assignee: Sandoz Ltd.
    Inventor: Klaus Hasspacher
  • Patent number: 4609657
    Abstract: This invention provides compounds of ##STR1## wherein R.sub.1 is benzyl or benzyl substituted by hydroxy, chlorine, fluorine, amino, amido, (C.sub.2-5) alkanoylamino, (C.sub.1-4) alkyl, (C.sub.1-4) alkylamino, (C.sub.1-4) alkoxy, (C.sub.1-4) alkylamido, di[(C.sub.1-4) alkyl]amino, or di[(C.sub.1-4) alkyl]amino,R.sub.2, R.sub.4 and R.sub.5 are each (C.sub.1-4) alkyl, andR.sub.3 is (C.sub.2-4) alkylare prolactin secretion promoters.
    Type: Grant
    Filed: July 14, 1980
    Date of Patent: September 2, 1986
    Assignee: Sandoz Ltd.
    Inventors: Paul Stadler, Franz Troxler