Patents Assigned to SANDOZ
  • Patent number: 4451452
    Abstract: Polymers formed by incomplete esterification of the hydroxy groups of a water-soluble polymer such as polyvinyl alcohol, amylose or dextran with a pharmacologically acceptable mono- or di-carboxylic acid to an extent sufficient to render the polymer water-insoluble although still water-swellable, are biodegradable. They are useful for the formulation of pharmaceutical compositions for parenteral administration, particularly in the form of injectable fine particles in which a drug is intimately mixed with or encapsulated by the polymer.
    Type: Grant
    Filed: November 23, 1981
    Date of Patent: May 29, 1984
    Assignee: Sandoz Ltd.
    Inventors: Heinrich Deibig, Roland Reiner, Hendricus B. A. Welle
  • Patent number: 4450108
    Abstract: A pyrrolobenzotriazepine or a pharmaceutically acceptable acid addition salt thereof is useful as a neuroleptic, anti-depressant or soporific.
    Type: Grant
    Filed: December 17, 1980
    Date of Patent: May 22, 1984
    Assignee: Sandoz Ltd.
    Inventors: Rudolf Fischer, Franz M. Kunzle, Jean Schmutz
  • Patent number: 4448785
    Abstract: Ethylenically unsaturated fatty acid amides of tryptophan derivatives e.g. .alpha.-[1-oxo-9-octadecenylamino)]-1H-indole-3-propanoic acid, ethyl ester, are useful as pharmaceutical agents and are obtainable by reacting a mixed anhydride of a long chain unsaturated carboxylic acid with an appropriate tryptophan ester.
    Type: Grant
    Filed: June 24, 1982
    Date of Patent: May 15, 1984
    Assignee: Sandoz, Inc.
    Inventors: Faizulla G. Kathawala, John G. Heider
  • Patent number: 4443223
    Abstract: The fastness of direct dyes on cellulose substrates is improved by after-treatment with the reaction product of a quaternary polyalkylene polyamine with an N-methylol resin precursor, and heat curing in the presence of a catalyst. The unfixed portion of reactive dyes substantive to cellulose may also be given improved wet and light fastness by this treatment.
    Type: Grant
    Filed: August 30, 1982
    Date of Patent: April 17, 1984
    Assignee: Sandoz Ltd.
    Inventors: Bruno Kissling, Walter Knobel, Tibor Robinson
  • Patent number: 4442084
    Abstract: Compositions having enhanced analgesic and myotonolytic activity comprising as active agents (a) an analeptically active quinazolinone and (b) a centrally acting myotonolytic.
    Type: Grant
    Filed: August 11, 1982
    Date of Patent: April 10, 1984
    Assignee: Sandoz Ltd.
    Inventor: Dietmar Romer
  • Patent number: 4442017
    Abstract: Additives, such as stabilizers, antioxidants, antistatic agents etc., are intimately blended with an irradiation-responsive substance, such as an optical brightener, and incorporated in a thermoplastic polymeric material which is then subjected to irradiation to determine the degree of uniformity of distribution of the additive-brightener blend.
    Type: Grant
    Filed: August 24, 1982
    Date of Patent: April 10, 1984
    Assignee: Sandoz, Inc.
    Inventors: Morris Blumberg, Chester C. Swasey
  • Patent number: 4442112
    Abstract: A pharmaceutical composition for treating or preventing vascular headaches, containing a 4-(2,1,3-benz-oxa- or thia-diazolyl)-1,4-dihydropyridine as an active compound.
    Type: Grant
    Filed: August 24, 1982
    Date of Patent: April 10, 1984
    Assignee: Sandoz Ltd.
    Inventor: Else Muller-Schweinitzer
  • Patent number: 4441884
    Abstract: The present invention relates to a process for treating a polyamide textile substrate to increase the affinity thereof for anionic dyes or to reserve the same against cationic dyes comprising applying thereto, in a weakly alkaline medium, a compound of formula I, ##STR1## wherein R is phenyl; naphthyl; (C.sub.5-6)cycloalkyl; or phenyl or naphthyl substituted by a total of up to 3 substituents selected from the group consisting of (C.sub.1-4)alkyl, chlorine and bromine (maximum of two of each of these);each of R.sub.1 and R.sub.2, independently, is (C.sub.1-4)alkyl, and X.sup..crclbar. is a non-chromophoric anion.
    Type: Grant
    Filed: November 9, 1978
    Date of Patent: April 10, 1984
    Assignee: Sandoz Ltd.
    Inventors: Hans-Peter Baumann, Urs Mosimann
  • Patent number: 4440767
    Abstract: 7-[(Carboxymethoximino)-1H-pyrazol-3yl-acetyl]amino-3-desacetoxy-3-(1-methy l-1H-tetrazol-5yl-thio)cephalosporanic acid and salts and solvates thereof which possess chemotherapeutical in particular antibiotic activity.
    Type: Grant
    Filed: January 18, 1982
    Date of Patent: April 3, 1984
    Assignee: Sandoz Ltd.
    Inventors: Hans Fliri, Helmut Hamberger
  • Patent number: 4440887
    Abstract: Compounds of formula I ##STR1## where R.sub.1, R.sub.2 and R.sub.3 are defined in the text, are useful as light stabilizers for polymeric materials, particularly for thermoplastic polymers and automotive finishes. Preferred compounds are those in which R.sub.1 is hydrogen and R.sub.2 and R.sub.3 are identical (C.sub.8-17 alkyl)carbonyl groups.
    Type: Grant
    Filed: January 22, 1982
    Date of Patent: April 3, 1984
    Assignee: Sandoz Ltd.
    Inventors: Hans Hinsken, Wolfgang Mueller, Hermann Schneider
  • Patent number: 4439207
    Abstract: Disperse dye compositions comprising(a) 20 to 55% by weight of a dye of the formula ##STR1## wherein each R.sub.1 is independently halogen, (b) 5 to 40% by weight of at least one dye of the formula ##STR2## wherein R.sub.1 is halo, and R.sub.2 is hydrogen, (C.sub.1-4 alkyl)carbonyl or benzoyl; and(c) 30 to 60% by weight of one or more dispersing agents and any other additives that may be present.Components (a), (b) and (c) forming 100% dry weight of the composition.
    Type: Grant
    Filed: August 5, 1982
    Date of Patent: March 27, 1984
    Assignee: Sandoz Ltd.
    Inventors: Ruedi Altermatt, Hans Jakob
  • Patent number: 4439362
    Abstract: Compounds of the formula ##STR1## in which D is a diazo component radical,K is unsubstituted or substituted 1,4-phenylene or 1,4-naphthylene,R.sub.1 is, in the case where K is unsubstituted or substituted 1,4-phenylene, hydrogen, (C.sub.1-4)alkyl, C.sub.2-4 alkenyl, ##STR2## or (C.sub.2-4)alkyl or (C.sub.2-4)alkenyl monosubstituted by chlorine, bromine, hydroxy, cyano, (C.sub.1-4)alkoxy, phenoxy, phenyl, formyloxy, alkyl(C.sub.1-4)carbonyloxy, benzoyloxy, alkoxy(C.sub.1-4)carbonyl, alkoxy(C.sub.1-4 alkoxy)carbonyloxy, mono(C.sub.1,4 -alkyl)aminocarbonyloxy or dialkyl(C.sub.1-4)aminocarbonyloxy, or in the case where K is unsubstituted or substituted 1,4-naphthylene, R.sub.1 is hydrogen, C.sub.1-4 alkyl or (C.sub.2-4)alkenyl,R.sub.2 is (C.sub.1-4)alkylene or C.sub.2-4 alkylene-O-C.sub.2-4 alkylene, and where R.sub.1 is ##STR3## the R.sub.
    Type: Grant
    Filed: July 7, 1977
    Date of Patent: March 27, 1984
    Assignee: Sandoz Ltd.
    Inventor: Klaus Koerte
  • Patent number: 4439562
    Abstract: Disclosed is a mass-dyed polymeric material, e.g. polyester, comprising, as dyestuff, a compound or mixture of compounds of formula I ##STR1## herein the nuclei A, B and D may bear one or more substituents and Me is Ni or Cu. The mass-dyed polymeric material is preferably prepared by incorporating the compounds of formula I in form of a master-batch.
    Type: Grant
    Filed: August 16, 1982
    Date of Patent: March 27, 1984
    Assignee: Sandoz Ltd.
    Inventor: Hans Bohler
  • Patent number: 4439203
    Abstract: The wet fastness properties of direct or reactive dyeings on cellulosic substrates are improved by aftertreatment with a precondensate of(A) the product of reacting a mono- or polyfunctional primary or secondary amine with cyanamide, dicyandiamide (DCDA), guanidine or biguanidine; or ammonia with cyanamide or DCDA; whereby up to 50 mole % of the cyanamide, DCDA, guanidine or biguanidine may be replaced with a dicarboxylic acid or a mono- or di-ester thereof, said product (A) containing reactive hydrogen atoms bound to nitrogen,and either (B) an epihalohydrin or a precursor thereofor (C) formaldehyde or a formaldehyde precursoror (D) a dihydroxyalkyleneurea or a methyl ether thereof, followed by formaldehyde or a formaldehyde precursoroptionally together with (E) an N-methylol derivative of a urea, melamine, guanamine, triazinone, urone, carbamate or acid amideand, if (A) is used with (C) or (D), or if (E) is present, together with (F) a catalyst for the cross-linking of N-methylol compounds of the type (E) ab
    Type: Grant
    Filed: May 10, 1982
    Date of Patent: March 27, 1984
    Assignee: Sandoz Ltd.
    Inventors: James R. Runyon, Salvatore Valenti
  • Patent number: 4439208
    Abstract: The fastness properties of basic dyeings on cellulosic substrates are improved by treating the substrate with a fixing agent comprising a precondensate or mixture of(A) the reaction product of an amine with cyanamide, dicyandiamide, guanidine or biguanidine, or,(B) a quaternary polyalkylene polyamine with(C) formaldehyde and/or,(D) an N-methylol compound optionally together with(E) a catalyst, e.g. MgCl.sub.2.The fixing agents are normally applied as an aftertreatment, with a subsequent heat-curing step.
    Type: Grant
    Filed: June 22, 1982
    Date of Patent: March 27, 1984
    Assignee: Sandoz Ltd.
    Inventors: Helmut Moser, Tibor Robinson
  • Patent number: 4438103
    Abstract: The invention provides polypeptides of formula I,A--B--Gly--D--E IwhereinA is Tyr or substituted Tyr,B is --Gly-- or --(D)Ala--,D is, for example, Phe or MePheand E is, for example, --Met--X, --Leu--X,--Nle--X, --Nva--X, --Ile--X, methioninesulphoxide--X, methioninesulphone--X wherein X is --NR'R" or --OR'" and each of R', R" and R'" independently signifies hydrogen or alkyl of 1 to 5 carbon atoms,which compounds possess pharmacological activity, for example, analgesic activity.
    Type: Grant
    Filed: December 2, 1977
    Date of Patent: March 20, 1984
    Assignee: Sandoz Ltd.
    Inventors: Wilfried Bauer, Francois Cardinaux, Rene Huguenin, Janos Pless, Edmond Sandrin
  • Patent number: 4436744
    Abstract: The invention provides fungicidal compostions comprising a N-amino-2-oxo-3-oxazolidine derivative (component a) such as 2-methoxy-N-(2,6-dimethylphenyl)-N-(2-oxo-3-oxazolidinyl)-acetamide and a component b) selected from a copper fungicide, folpet, captan, mancozeb or maneb. A further object of the invention are methods of combating phytopathogenic fungi in plants, seeds or soil with the aid of fungicidally effective amounts of a component (a) and a component (b).
    Type: Grant
    Filed: June 21, 1982
    Date of Patent: March 13, 1984
    Assignee: Sandoz Ltd.
    Inventor: Jost Harr
  • Patent number: 4436524
    Abstract: The wet fastness properties of direct or reactive dyeings on cellulosic substrates are improved by aftertreatment with an agent comprising(A) a linear or crosslinked polymer comprising repeating units containing at least two quaternary nitrogen atoms linked by bridging groups connected to the quaternary nitrogen atoms by alkylene or arylene groups;optionally(B) an N-methylol derivative of a urea, melamine, guanamine, triazinone, urone, carbamate or acid amide;and, as an essential component,(C) a catalyst for the cross-linking of N-methylol compounds of the type (B) above,and subsequently carrying out a heat-curing step.Certain of the quaternary polymers (A), containing melamine groups, are novel.
    Type: Grant
    Filed: May 10, 1982
    Date of Patent: March 13, 1984
    Assignee: Sandoz Ltd.
    Inventor: Salvatore Valenti
  • Patent number: 4436521
    Abstract: The invention relates to a process for the production of anti-shrink treated wool dyeings in which wool is dyed with acid milling or metal complex dyes either before, after or between the steps of an anti-shrink treatment and, after the dyeing or the anti-shrink treatment or one of the steps of the anti-shrink treatment subsequent to the dyeing, is after-treated with a liquor containing a cationic fixing agent and a levelling/retarding agent having affinity for wool dyestuffs, and to a composition usable for such a process.
    Type: Grant
    Filed: May 27, 1982
    Date of Patent: March 13, 1984
    Assignee: Sandoz Ltd.
    Inventors: Oskar Annen, Hermann Egli, Karl Zesiger
  • Patent number: 4435385
    Abstract: N-Acyl-polypeptides comprising the basic sequence ##STR1## wherein "Acyl" is the acyl residue of an organic or inorganic acid; A is H or alkyl; >N--CH(Z)--CO-- and E are the residues of natural .alpha.-amino acids or corresponding (D)-amino acids; C is --Trp-- or --(D)Trp--; F is a terminal grouping; and Y.sub.1 and Y.sub.2 are each H or together are a direct bond; as well as their salt forms and complexes.
    Type: Grant
    Filed: March 2, 1982
    Date of Patent: March 6, 1984
    Assignee: Sandoz Ltd.
    Inventors: Wilfried Bauer, Janos Pless