Abstract: Polymers formed by incomplete esterification of the hydroxy groups of a water-soluble polymer such as polyvinyl alcohol, amylose or dextran with a pharmacologically acceptable mono- or di-carboxylic acid to an extent sufficient to render the polymer water-insoluble although still water-swellable, are biodegradable. They are useful for the formulation of pharmaceutical compositions for parenteral administration, particularly in the form of injectable fine particles in which a drug is intimately mixed with or encapsulated by the polymer.
Type:
Grant
Filed:
November 23, 1981
Date of Patent:
May 29, 1984
Assignee:
Sandoz Ltd.
Inventors:
Heinrich Deibig, Roland Reiner, Hendricus B. A. Welle
Abstract: A pyrrolobenzotriazepine or a pharmaceutically acceptable acid addition salt thereof is useful as a neuroleptic, anti-depressant or soporific.
Type:
Grant
Filed:
December 17, 1980
Date of Patent:
May 22, 1984
Assignee:
Sandoz Ltd.
Inventors:
Rudolf Fischer, Franz M. Kunzle, Jean Schmutz
Abstract: Ethylenically unsaturated fatty acid amides of tryptophan derivatives e.g. .alpha.-[1-oxo-9-octadecenylamino)]-1H-indole-3-propanoic acid, ethyl ester, are useful as pharmaceutical agents and are obtainable by reacting a mixed anhydride of a long chain unsaturated carboxylic acid with an appropriate tryptophan ester.
Abstract: The fastness of direct dyes on cellulose substrates is improved by after-treatment with the reaction product of a quaternary polyalkylene polyamine with an N-methylol resin precursor, and heat curing in the presence of a catalyst. The unfixed portion of reactive dyes substantive to cellulose may also be given improved wet and light fastness by this treatment.
Type:
Grant
Filed:
August 30, 1982
Date of Patent:
April 17, 1984
Assignee:
Sandoz Ltd.
Inventors:
Bruno Kissling, Walter Knobel, Tibor Robinson
Abstract: Compositions having enhanced analgesic and myotonolytic activity comprising as active agents (a) an analeptically active quinazolinone and (b) a centrally acting myotonolytic.
Abstract: Additives, such as stabilizers, antioxidants, antistatic agents etc., are intimately blended with an irradiation-responsive substance, such as an optical brightener, and incorporated in a thermoplastic polymeric material which is then subjected to irradiation to determine the degree of uniformity of distribution of the additive-brightener blend.
Abstract: A pharmaceutical composition for treating or preventing vascular headaches, containing a 4-(2,1,3-benz-oxa- or thia-diazolyl)-1,4-dihydropyridine as an active compound.
Abstract: The present invention relates to a process for treating a polyamide textile substrate to increase the affinity thereof for anionic dyes or to reserve the same against cationic dyes comprising applying thereto, in a weakly alkaline medium, a compound of formula I, ##STR1## wherein R is phenyl; naphthyl; (C.sub.5-6)cycloalkyl; or phenyl or naphthyl substituted by a total of up to 3 substituents selected from the group consisting of (C.sub.1-4)alkyl, chlorine and bromine (maximum of two of each of these);each of R.sub.1 and R.sub.2, independently, is (C.sub.1-4)alkyl, and X.sup..crclbar. is a non-chromophoric anion.
Abstract: 7-[(Carboxymethoximino)-1H-pyrazol-3yl-acetyl]amino-3-desacetoxy-3-(1-methy l-1H-tetrazol-5yl-thio)cephalosporanic acid and salts and solvates thereof which possess chemotherapeutical in particular antibiotic activity.
Abstract: Compounds of formula I ##STR1## where R.sub.1, R.sub.2 and R.sub.3 are defined in the text, are useful as light stabilizers for polymeric materials, particularly for thermoplastic polymers and automotive finishes. Preferred compounds are those in which R.sub.1 is hydrogen and R.sub.2 and R.sub.3 are identical (C.sub.8-17 alkyl)carbonyl groups.
Type:
Grant
Filed:
January 22, 1982
Date of Patent:
April 3, 1984
Assignee:
Sandoz Ltd.
Inventors:
Hans Hinsken, Wolfgang Mueller, Hermann Schneider
Abstract: Disperse dye compositions comprising(a) 20 to 55% by weight of a dye of the formula ##STR1## wherein each R.sub.1 is independently halogen, (b) 5 to 40% by weight of at least one dye of the formula ##STR2## wherein R.sub.1 is halo, and R.sub.2 is hydrogen, (C.sub.1-4 alkyl)carbonyl or benzoyl; and(c) 30 to 60% by weight of one or more dispersing agents and any other additives that may be present.Components (a), (b) and (c) forming 100% dry weight of the composition.
Abstract: Compounds of the formula ##STR1## in which D is a diazo component radical,K is unsubstituted or substituted 1,4-phenylene or 1,4-naphthylene,R.sub.1 is, in the case where K is unsubstituted or substituted 1,4-phenylene, hydrogen, (C.sub.1-4)alkyl, C.sub.2-4 alkenyl, ##STR2## or (C.sub.2-4)alkyl or (C.sub.2-4)alkenyl monosubstituted by chlorine, bromine, hydroxy, cyano, (C.sub.1-4)alkoxy, phenoxy, phenyl, formyloxy, alkyl(C.sub.1-4)carbonyloxy, benzoyloxy, alkoxy(C.sub.1-4)carbonyl, alkoxy(C.sub.1-4 alkoxy)carbonyloxy, mono(C.sub.1,4 -alkyl)aminocarbonyloxy or dialkyl(C.sub.1-4)aminocarbonyloxy, or in the case where K is unsubstituted or substituted 1,4-naphthylene, R.sub.1 is hydrogen, C.sub.1-4 alkyl or (C.sub.2-4)alkenyl,R.sub.2 is (C.sub.1-4)alkylene or C.sub.2-4 alkylene-O-C.sub.2-4 alkylene, and where R.sub.1 is ##STR3## the R.sub.
Abstract: Disclosed is a mass-dyed polymeric material, e.g. polyester, comprising, as dyestuff, a compound or mixture of compounds of formula I ##STR1## herein the nuclei A, B and D may bear one or more substituents and Me is Ni or Cu. The mass-dyed polymeric material is preferably prepared by incorporating the compounds of formula I in form of a master-batch.
Abstract: The wet fastness properties of direct or reactive dyeings on cellulosic substrates are improved by aftertreatment with a precondensate of(A) the product of reacting a mono- or polyfunctional primary or secondary amine with cyanamide, dicyandiamide (DCDA), guanidine or biguanidine; or ammonia with cyanamide or DCDA; whereby up to 50 mole % of the cyanamide, DCDA, guanidine or biguanidine may be replaced with a dicarboxylic acid or a mono- or di-ester thereof, said product (A) containing reactive hydrogen atoms bound to nitrogen,and either (B) an epihalohydrin or a precursor thereofor (C) formaldehyde or a formaldehyde precursoror (D) a dihydroxyalkyleneurea or a methyl ether thereof, followed by formaldehyde or a formaldehyde precursoroptionally together with (E) an N-methylol derivative of a urea, melamine, guanamine, triazinone, urone, carbamate or acid amideand, if (A) is used with (C) or (D), or if (E) is present, together with (F) a catalyst for the cross-linking of N-methylol compounds of the type (E) ab
Abstract: The fastness properties of basic dyeings on cellulosic substrates are improved by treating the substrate with a fixing agent comprising a precondensate or mixture of(A) the reaction product of an amine with cyanamide, dicyandiamide, guanidine or biguanidine, or,(B) a quaternary polyalkylene polyamine with(C) formaldehyde and/or,(D) an N-methylol compound optionally together with(E) a catalyst, e.g. MgCl.sub.2.The fixing agents are normally applied as an aftertreatment, with a subsequent heat-curing step.
Abstract: The invention provides polypeptides of formula I,A--B--Gly--D--E IwhereinA is Tyr or substituted Tyr,B is --Gly-- or --(D)Ala--,D is, for example, Phe or MePheand E is, for example, --Met--X, --Leu--X,--Nle--X, --Nva--X, --Ile--X, methioninesulphoxide--X, methioninesulphone--X wherein X is --NR'R" or --OR'" and each of R', R" and R'" independently signifies hydrogen or alkyl of 1 to 5 carbon atoms,which compounds possess pharmacological activity, for example, analgesic activity.
Abstract: The invention provides fungicidal compostions comprising a N-amino-2-oxo-3-oxazolidine derivative (component a) such as 2-methoxy-N-(2,6-dimethylphenyl)-N-(2-oxo-3-oxazolidinyl)-acetamide and a component b) selected from a copper fungicide, folpet, captan, mancozeb or maneb. A further object of the invention are methods of combating phytopathogenic fungi in plants, seeds or soil with the aid of fungicidally effective amounts of a component (a) and a component (b).
Abstract: The wet fastness properties of direct or reactive dyeings on cellulosic substrates are improved by aftertreatment with an agent comprising(A) a linear or crosslinked polymer comprising repeating units containing at least two quaternary nitrogen atoms linked by bridging groups connected to the quaternary nitrogen atoms by alkylene or arylene groups;optionally(B) an N-methylol derivative of a urea, melamine, guanamine, triazinone, urone, carbamate or acid amide;and, as an essential component,(C) a catalyst for the cross-linking of N-methylol compounds of the type (B) above,and subsequently carrying out a heat-curing step.Certain of the quaternary polymers (A), containing melamine groups, are novel.
Abstract: The invention relates to a process for the production of anti-shrink treated wool dyeings in which wool is dyed with acid milling or metal complex dyes either before, after or between the steps of an anti-shrink treatment and, after the dyeing or the anti-shrink treatment or one of the steps of the anti-shrink treatment subsequent to the dyeing, is after-treated with a liquor containing a cationic fixing agent and a levelling/retarding agent having affinity for wool dyestuffs, and to a composition usable for such a process.
Type:
Grant
Filed:
May 27, 1982
Date of Patent:
March 13, 1984
Assignee:
Sandoz Ltd.
Inventors:
Oskar Annen, Hermann Egli, Karl Zesiger
Abstract: N-Acyl-polypeptides comprising the basic sequence ##STR1## wherein "Acyl" is the acyl residue of an organic or inorganic acid; A is H or alkyl; >N--CH(Z)--CO-- and E are the residues of natural .alpha.-amino acids or corresponding (D)-amino acids; C is --Trp-- or --(D)Trp--; F is a terminal grouping; and Y.sub.1 and Y.sub.2 are each H or together are a direct bond; as well as their salt forms and complexes.