Patents Assigned to SANDOZ
  • Patent number: 4485034
    Abstract: Oxalanilides of formula I ##STR1## in which R is C.sub.6-22 alkyl or C.sub.6-22 alkoxyR.sub.1 and R.sub.2 are independently, hydrogen, C.sub.1-8 alkyl, C.sub.1-12 alkoxy, C.sub.1-12 alkylthio, phenoxy or phenylthio; provided that R.sub.1 and R.sub.2 may not both be selected from alkylthio, phenoxy and phenylthio;and R.sub.3 is hydrogen or C.sub.1-8 alkylcertain of which are novel, are useful as UV-stabilizers in organic polymers and organic polymer-containing coatings, particularly automotive finishes. The compounds have low volatility and excellent solubility in organic solvents such as are used in liquid finishes.
    Type: Grant
    Filed: September 6, 1983
    Date of Patent: November 27, 1984
    Assignee: Sandoz Ltd.
    Inventors: Lajos Avar, Evelyne Kalt, Hellmuth Reinshagen
  • Patent number: 4483796
    Abstract: Disazo and polyazo compounds of the formula ##STR1## wherein each A is independently ##STR2## and each R.sub.3 is independently C.sub.1-4 alkyl, oreach A, R.sub.3 and the ##STR3## radical to which they are attached, taken together, independently, are ##STR4## wherein each R.sub.21 is independently halo, C.sub.1-4 alkyl or C.sub.1-4 alkoxy,p is 0, 1 or 2,the * denotes the carbon atom attached to the --N.dbd.N-- radical, andthe ** denotes the carbon atom attached to X,each R.sub.1 and the ##STR5## radical to which it is attached taken together, independently, are the radical of an aromatic or heterocyclic coupling component,each A.sub.1 and A.sub.2 taken together are --O--Me--O--, wherein Me is copper, cobalt, iron, nickel, manganese or zinc, oreach A.sub.1 is hydroxy, andeach A.sub.2 is independently hydrogen, hydroxy or C.sub.1-4 alkoxy,X is a direct bond or a bridging radical,each Y is independently a direct bond, C.sub.1-4 alkylene, --CO--NH--(CH.sub.2).sub.m --, --NH--CO--(CH.sub.2).sub.m -- or --SO.sub.
    Type: Grant
    Filed: August 18, 1982
    Date of Patent: November 20, 1984
    Assignee: Sandoz Ltd.
    Inventors: Paul Doswald, Emil Moriconi, Helmut Moser, Horst Schmid
  • Patent number: 4481206
    Abstract: Spiro-(N'-methyl-piperidyl-4')-N-ethyl-succinimide for the treatment of Alzheimer's disease and senile dementia of the Alzheimer type.
    Type: Grant
    Filed: June 20, 1983
    Date of Patent: November 6, 1984
    Assignee: Sandoz Ltd.
    Inventors: Rene Spiegel, Hans Weidmann
  • Patent number: 4479911
    Abstract: This invention provides for the production of microspheres in an oil-in-water emulsion process using an emulsifier, whereby solvent removal from the oil phase allows for isolation of discrete microspheres, wherein the release rate of a core material is modified by the use of an alkaline agent, e.g. sodium hydroxide, during the preparation of the microspheres.
    Type: Grant
    Filed: March 8, 1983
    Date of Patent: October 30, 1984
    Assignee: Sandoz, Inc.
    Inventor: Jones W. Fong
  • Patent number: 4478750
    Abstract: A 1,2,3,4,5,6-hexahydro-6-phenyl-azepino[4,5-b]indole, or a pharmaceutically acceptable acid addition salt thereof is a useful neuroleptic, anti-depressant and anti-allergic agent.
    Type: Grant
    Filed: June 7, 1982
    Date of Patent: October 23, 1984
    Assignee: Sandoz Ltd.
    Inventor: Fulvio Gadient
  • Patent number: 4478837
    Abstract: Pharmaceutical compositions comprising as the active ingredient thereof an aminopyridazine derivative of the formula: ##STR1## wherein R.sub.1 is amino, or ##STR2## wherein each of R.sub.3 and R.sub.4 is alkyl of 1 to 4 carbon atoms, orR.sub.3 and R.sub.4 together with the carbon atom to which they are bound, form a cycloalkylidene radical of 5 to 12 carbon atoms,R.sub.2 is hydrogen or methyl,A is --(CH.sub.2).sub.n --, wherein n is 0 or an integer from 1 to 7, or >N--CO--R.sub.5, wherein R.sub.5 is alkyl of 1 to 16 carbon atoms, alkenyl of 3 to 6 carbon atoms, cycloalkyl of 3 to 8 carbon atoms, 1-adamantyl, or --(CH.sub.2).sub.m --R.sub.6, whereinm is 0 or an integer from 1 to 4, andR.sub.
    Type: Grant
    Filed: April 13, 1979
    Date of Patent: October 23, 1984
    Assignee: Sandoz Ltd.
    Inventor: Erhard Schenker
  • Patent number: 4478831
    Abstract: The antibiotics S 54832/A-I, S 54832/A-II, S 54832/A-III and S 54832/A-IV are obtained from a new Micromonospora globosa strain.
    Type: Grant
    Filed: May 10, 1982
    Date of Patent: October 23, 1984
    Assignee: Sandoz Ltd.
    Inventors: Camilla Keller-Juslen, Max Kuhn, Hamilton D. King
  • Patent number: 4477448
    Abstract: Novel compounds of formula I, ##STR1## in which R.sub.1 is hydrogen, alkyl, phenylalkyl, carbalkoxyalkyl, acyl, carboxyalkyl, alkoxyalkyl, hydroxyalkyl, cyanoalkyl, or carbamoylalkyl,R.sub.2 is hydrogen, pivaloyloxymethyl or the residue of an easily splittable ester grouping,R.sub.3 is a pyrazolyl radical, unsubstituted or mono- or di-substituted by alkyl, phenyl, alkoxy, alkylthio, carboxy, carboxyalkyl, carbamoyl, carbamoylalkyl, alkylsulphonyl, azido, acylamino, hydrazino, acylhydrazino alkylidenehydrazino, phenylidenehydrazino, in which the phenyl nucleus is unsubstituted or substituted by NH.sub.2, lower alkoxy or lower alkyl, furylidenehydrazino, carbalkoxy or a group R.sub.5 R.sub.6 N--, in which R.sub.5 and R.sub.6 are the same or different and are hydrogen or alkyl, provided that the nitrogen atoms and the 4-position of the pyrazole nucleus are either unsubstituted or substituted by alkyl, phenyl, or carbalkoxy, andR.sub.
    Type: Grant
    Filed: June 21, 1982
    Date of Patent: October 16, 1984
    Assignee: Sandoz Ltd.
    Inventors: Helmut Hamberger, Hans Fliri
  • Patent number: 4475920
    Abstract: The present invention relates to a textile treatment process which comprises applying to a textile substrate of natural or synthetic polyamide either before or after dyeing, a compound of formula I, ##STR1## in which R is an C.sub.6-20 alkyl radical, each ofR.sub.1 and R.sub.2, independently, is --CH.sub.2 --CHOHCH.sub.2 --X or C.sub.1-4 alkyl, with the proviso that the total number of carbon atoms in R+R.sub.1 +R.sub.2 is from 8 to 26;X is chlorine or bromine,Y is a non-chromophoric anion, andn is a whole number from 1 to 3,which treatment before dyeing increases the affinity of the substrate for anionic dyestuffs and after dyeing improves the wet-fastness of the dyed substrate.
    Type: Grant
    Filed: January 4, 1982
    Date of Patent: October 9, 1984
    Assignee: Sandoz Ltd.
    Inventor: Hans-Peter Baumann
  • Patent number: 4476135
    Abstract: The compounds of formula I ##STR1## wherein A is an optionally substituted 2,1,3-benzothiadiazole or 2,1,3-benzoxadiazole moiety,B is a trisubstituted amino group andC is an optionally 1-substituted 4,5-dihydro-1H-imidazol-2-yl or an optionally 3-substituted 3,4,5,6-tetrahydropyrimidin-2-yl moiety.are useful as bradycardiac agents, as anti-tremor, anti-rigor and myotonolytic agents, as tranquillizers and as antidepressants.
    Type: Grant
    Filed: February 16, 1982
    Date of Patent: October 9, 1984
    Assignee: Sandoz Ltd.
    Inventors: Peter Neumann, Gerhard Bormann
  • Patent number: 4475918
    Abstract: Aftertreatment of dyeings on cotton or nylon with (A) a polybasic compound which is the product of reacting a primary or secondary amine with cyanamide, dicyandiamide, guanidine or biguanidine and, sequentially or simultaneously (B) a precondensate formed by reacting a compound of type (A) with an N-methylol derivative gives wet fastness properties superior to those given by either (A) or (B) used alone.
    Type: Grant
    Filed: August 24, 1983
    Date of Patent: October 9, 1984
    Assignee: Sandoz Ltd.
    Inventors: Bruno Kissling, Tibor Robinson
  • Patent number: 4474971
    Abstract: Single enanitiomers of 6-(2-hydrocarbyl-substituted ethenyl)-bearing, 4-hydroxy tetrahydro-2H-pyran-2-ones, e.g., 6.alpha.-[2-(2-methyl-1-naphthyl)ethenyl]-3,4,5,6-tetrahydro-4.beta.-hydro xy-2H-pyran-2-one (4R,6S) are obtained by a multi-step process which includes protecting and deprotecting hydroxy groups at various stages.
    Type: Grant
    Filed: September 29, 1982
    Date of Patent: October 2, 1984
    Assignee: Sandoz, Inc.
    Inventor: James R. Wareing
  • Patent number: 4473574
    Abstract: A method for the prophylaxis of inflammatory, degenerative or proliferative arterial disease which method comprises administering an effective amount of endralazine.
    Type: Grant
    Filed: January 26, 1983
    Date of Patent: September 25, 1984
    Assignee: Sandoz Ltd.
    Inventor: Brian P. Richardson
  • Patent number: 4472313
    Abstract: The invention provides a method of converting ethylenically unsaturated units of an olefinic substrate to corresponding cyclopropanyl units, comprising treating the olefinic substrate, in an ether medium, with zinc and diiodomethane and a catalytic amount of a metallo-hydride reducing agent. Preferred substrates are olefinic fatty acids or their functional derivatives, e.g. oleic acid esters.
    Type: Grant
    Filed: September 20, 1982
    Date of Patent: September 18, 1984
    Assignee: Sandoz, Inc.
    Inventors: Urs Giger, Oljan Repic
  • Patent number: 4472425
    Abstract: The invention provides novel N-acylamino thiophene derivatives, e.g. N-(methoxyacetyl)-N-(5-bromo-4-methyl-2-methylthiothien-3-yl)alanine methyl ester, which are useful as fungicides. Other objects of the invention are fungicidal compositions comprising such novel compounds and methods of combatting phytopathogenic fungi with the acid of said novel compounds.
    Type: Grant
    Filed: September 6, 1983
    Date of Patent: September 18, 1984
    Assignee: Sandoz Ltd.
    Inventors: Rudolf Sandmeier, Karl Seckinger
  • Patent number: 4470315
    Abstract: An apparatus for introducing tubes automatically into a gas pathway between a gas source and a gas chromatograph when the apparatus is in use, the apparatus comprisinga gravity feed magazine for storing tubes,means for introducing a tube horizontally from the magazine to a gas pathway whereby, when the apparatus is in use, gas is introduced through a first pipe from a gas source to one end of the tube and is passed through the tube to a second pipe for introducing the gas into a gas chromatograph, one end of the tube and one end of the first pipe abutting opposite sides of a first resilient ring and the other end of the tube and one end of the second pipe abutting opposite sides of a second resilient ring the rings sealing the first pipe, tube and second pipe in the gas pathway while allowing gas to flow from the first pipe to the tube and from the tube to the second pipe.means for heating the tube when in the gas pathway andmeans for ejecting the tube from the pathway.
    Type: Grant
    Filed: June 7, 1982
    Date of Patent: September 11, 1984
    Assignee: Sandoz Ltd.
    Inventors: Dieter Ellgehausen, Urs V/o/ geli
  • Patent number: 4469485
    Abstract: Disclosed are the 1:2 chromium complex of the formula ##STR1## and the alkali metal salts thereof which are useful for the coloration of oxide layers produced on aluminum and alloys thereof and for dyeing natural and synthetic polyamides.
    Type: Grant
    Filed: August 22, 1983
    Date of Patent: September 4, 1984
    Assignee: Sandoz Ltd.
    Inventor: Hans Grossmann
  • Patent number: 4468348
    Abstract: Dyes of the formula ##STR1## and mixtures thereof, in which R signifies a radical of formula (a), (b), (c), (d), (e), (f), (g) or (h) ##STR2## in which R.sub.1 signifies an amino, anilino or toluidino radical, R.sub.2 signifies a hydroxy or amino radical, andeither R.sub.3 signifies hydrogen,or, where R.sub.1 and R.sub.2 signify amino, R.sub.3 signifies hydrogen, nitro, --SO.sub.3 M or C.sub.1-6 alkyl; ##STR3## in which R.sub.4 signifies a hydroxy, amino, anilino or toluidino radical, preferably a hydroxy or amino radical; ##STR4## in which R.sub.5 signifies a hydroxy radical, a C.sub.1-6 alkylsulphonyloxy radical, a phenylsulphonyloxy radical, an amino radical, a C.sub.1-6 alkylsulphonylamino radical or a phenysulphonylamino radical, preferably a hydroxy radical,R.sub.6 signifies a C.sub.1-6 alkyl, C.sub.1-6 alkoxy, acetyl, carboxyl or carbamoyl radical,R.sub.7 signifies hydrogen, an acyl radical or an unsubstituted or substituted C.sub.
    Type: Grant
    Filed: February 4, 1980
    Date of Patent: August 28, 1984
    Assignee: Sandoz Ltd.
    Inventor: Heinz Wicki
  • Patent number: 4468347
    Abstract: Disazo and polyazo compounds of the formula ##STR1## wherein each A is independently ##STR2## andeach R.sub.1 and the ##STR3## radical to which it is attached, taken together, independently, are ##STR4## wherein ring B may be substituted by one substituent selected from halogen, C.sub.1-4 alkyl and C.sub.1-4 alkoxy, and each R.sub.3 is independently C.sub.1-4 alkyl, orwherein the ** denotes the carbon atom attached to X, or each A, R.sub.3 and the ##STR5## radical to which they are attached, taken together, independently, are each R.sub.1 and the ##STR6## radical to which it is attached, taken together, independently, are the radical of an aromatic carbocyclic or heterocyclic coupling component, ##STR7## wherein each R.sub.21 is independently halo, C.sub.1-4 alkyl or C.sub.1-4 alkoxy,p is 0, 1 or 2,the * denotes the carbon atom attached to the --N.dbd.N-- radical, andthe ** denotes the carbon atom attached to X,eachA.sub.1 and A.sub.
    Type: Grant
    Filed: March 24, 1982
    Date of Patent: August 28, 1984
    Assignee: Sandoz Ltd.
    Inventors: Paul Doswald, Emil Moriconi, Helmut Moser, Horst Schmid
  • Patent number: D275298
    Type: Grant
    Filed: January 29, 1982
    Date of Patent: August 28, 1984
    Assignee: Sandoz, Inc.
    Inventor: Alfred H. Wimmershoff