Patents Assigned to SANDOZ
  • Patent number: 4510137
    Abstract: A method of combatting insects, particularly in a cotton locus, using quinalphos and thiometon, as well as insecticidal compositions for use in such method.
    Type: Grant
    Filed: September 18, 1981
    Date of Patent: April 9, 1985
    Assignee: Sandoz Ltd.
    Inventor: Peter Meyes
  • Patent number: 4510150
    Abstract: Pharmaceutical composition containing as active agents (A) a calcium antagonist of a 4-(2,1,3-benz-oxa- or thiadiazoly)-1,4-dihydro pyridine type and (B) a .beta.-blocker and/or a vasodilating nitrate, effective against coronary heart disease and hypertension.
    Type: Grant
    Filed: August 1, 1983
    Date of Patent: April 9, 1985
    Assignee: Sandoz Ltd.
    Inventor: Richard Berthold
  • Patent number: 4507310
    Abstract: The present invention relates to the use of a compound (a), an oomycetes controlling fungicide having the structure element of formula I ##STR1## in which X is CH or N, in association with a compound (b), selected from CYMOXANIL and Phosetyl-Al in combatting or preventing fungal diseases, and fungicidal composition comprising such compounds.
    Type: Grant
    Filed: January 21, 1983
    Date of Patent: March 26, 1985
    Assignee: Sandoz Ltd.
    Inventors: Andre Devoise-Lambert, Ulrich Gisi
  • Patent number: 4505857
    Abstract: Compounds of the formula ##STR1## in which K is the radical of a coupling component of the aniline, .alpha.-naphthylamine, pyrazolone, aminopyrazole, indole, tetrahydroquinoline, thiazole, phenol, naphthol, pyridine or pyridone series.R is --CHO, --CH.dbd.C(CN)--R.sub.1, --CH.dbd.CH--R.sub.2, --CH.dbd.C(NO.sub.2)--R.sub.3, --CH.dbd.NOH or --CN,wherein R.sub.1 is (C.sub.1-10 alkoxycarbonyl; (C.sub.1-10 alkoxy)carbonyl monosubstituted by chloro, bromo, cyano, hydroxy, C.sub.1-2 alkoxy, (C.sub.1-2 alkyl)carbonyloxy or (C.sub.1-2 alkoxy)carbonyl; (C.sub.1-10 alkoxy)carbonyl disubstituted by hydroxy and by chloro or bromo; (C.sub.3-8 alkenyl)oxycarbonyl; (C.sub.3-8 chloroalkenyl)oxycarbonyl; (C.sub.3-8 bromoalkenyl)oxycarbonyl; propynyloxycarbonyl; benzyloxycarbonyl; chlorobenzyloxycarbonyl; nitrobenzyloxycarbonyl; C.sub.1-4 alkylsulfonyl; phenylsulfonyl; tolylsulfonyl; carbamoyl; (C.sub.1-2 alkyl)carbamoyl; di(C.sub.
    Type: Grant
    Filed: March 10, 1981
    Date of Patent: March 19, 1985
    Assignee: Sandoz Ltd.
    Inventor: Robert Egli
  • Patent number: 4503221
    Abstract: The process for preparing cephalosporanic acid derivatives ##STR1## and salts thereof with bases as well as solvates thereof, comprising reacting a compound of the formula II: ##STR2## wherein R.sub.3 represents hydrogen or an amino protecting group and R.sub.2 represents hydrogen, an easily removable ester group or other carboxyl protecting group, with a compound of formula IIIa, ##STR3## wherein R.sub.1 represents hydrogen, an easily removable ester group or other carboxyl protecting group, and R.sub.4 is a 2-benzothiazol group and salts thereof with bases, and if required removing any ester group or protecting group.
    Type: Grant
    Filed: June 20, 1983
    Date of Patent: March 5, 1985
    Assignee: Sandoz Ltd.
    Inventors: Hans Fliri, Helmut Hamberger
  • Patent number: 4502866
    Abstract: Symmetrical compounds of the formula, ##STR1## in which R.sub.1 is hydrogen, C.sub.1-4 alkyl or C.sub.1-4 alkoxy,R.sub.2 is hydrogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or --NHCOR.sub.6,R.sub.3 is hydrogen or C.sub.1-4 alkyl,each of R.sub.4 and R.sub.5, independently, is hydrogen, C.sub.1-4 alkyl or hydroxy C.sub.2-4 alkyl,R.sub.6 is C.sub.1-4 alkyl, --NH.sub.2, --NC(C.sub.1-4 alkyl) or --N(C.sub.1-4 alkyl).sub.2,Hal is fluorine, chlorine or bromine, andX is either C.sub.2-10 alkylene, C.sub.3-10 alkenylene, mono- or dihydroxy C.sub.3-10 alkylene optionally containing one or two hetero atom linkages C.sub.5-7 cycloalkylene optionally substituted by 1 or 3 C.sub.1-4 alkyl groups,or X together with ##STR2## form a piperazine ring, with the proviso that X is other than unsubstituted C.sub.2-10 alkylene when R.sub.2 is --NHCOR.sub.
    Type: Grant
    Filed: November 28, 1980
    Date of Patent: March 5, 1985
    Assignee: Sandoz Ltd.
    Inventors: Kurt Brenneisen, Werner Koch
  • Patent number: 4503191
    Abstract: Textile materials, preferably carpets, are backsized with a composition comprising(a) a natural or synthetic polymeric latex(b) a filler, and(c) a fixing agent for anionic dyestuffs.The resulting textile materials are fast to water spotting.
    Type: Grant
    Filed: November 7, 1983
    Date of Patent: March 5, 1985
    Assignee: Sandoz Ltd.
    Inventor: Hans-Peter Stakelbeck
  • Patent number: 4503046
    Abstract: Hydroxymethylated aminoglycoside derivatives which are useful, in particular as anti-bacterially active antibiotics.
    Type: Grant
    Filed: August 3, 1982
    Date of Patent: March 5, 1985
    Assignee: Sandoz Ltd.
    Inventors: Hans Loibner, Wolfgang Streicher, Peter St/u/ tz
  • Patent number: 4501672
    Abstract: A fluid loss reducing additive for an oil-based well working fluid is the product of mixing together, in an oil or oil-based fluid, lignite or humic acid with an aliphatic amide or hydroxyamide, or a cyclic derivative thereof, containing no primary or secondary amine or amine salt groups.
    Type: Grant
    Filed: March 25, 1983
    Date of Patent: February 26, 1985
    Assignee: Sandoz Ltd.
    Inventors: David L. Connell, Jacqueline A. Coates
  • Patent number: 4501589
    Abstract: A process for dyeing or printing sized textiles comprising applying to the sized substrate a dyeing liquor or a printing paste which contains, in addition to the dyestuffs(i) a compound or a mixture of compounds selected from compounds having solubilizing, washing, emulsifying, dispersing or dye fixation accelerating properties, and(ii) a textile size or a mixture of textile sizes.
    Type: Grant
    Filed: June 10, 1983
    Date of Patent: February 26, 1985
    Assignee: Sandoz Ltd.
    Inventor: Christian Oschatz
  • Patent number: 4499280
    Abstract: The invention provides a method of reducing the feeding activity of insects on plants with the aid of 1,2,3-triazoles being unsubstituted in the 4- and 5-positions and bearing a phenyl moiety in the 1-position, fungicidal compositions comprising such triazoles and novel 1,2,3-triazoles.
    Type: Grant
    Filed: July 15, 1982
    Date of Patent: February 12, 1985
    Assignee: Sandoz Ltd.
    Inventor: Fritz Reisser
  • Patent number: 4499018
    Abstract: A phthalocyanine product in which at least two phthalocyanine groups which may be metallized or unmetallized are joined by a bridging group, the bridging group being attached to the phthalocyanine groups through --CH.sub.2 --X.sub.o -- linkages where X.sub.o is a basic group and the phthalocyanine groups are attached to the methylene group of the linkages. The phthalocyanine product is useful as a dyestuff.
    Type: Grant
    Filed: October 15, 1982
    Date of Patent: February 12, 1985
    Assignee: Sandoz Ltd.
    Inventors: Jacky Dore, Helmut Moser
  • Patent number: 4499279
    Abstract: This disclosure describes compounds of the formula ##STR1## where R.sub.1 represents hydrogen, fluoro, chloro, lower alkyl having 1 to 4 carbon atoms or lower alkoxy having 1 to 4 carbon atoms, andR.sub.2 represents hydroxy, andR.sub.3 and R.sub.4 each independently represent lower alkyl as defined above, orR.sub.3 and R.sub.4 together with N represent ##STR2## wherein n is 1, 2 or 3, andR.sub.5 and R.sub.6 each independently represent hydrogen or lower alkyl as defined above,or a pharmaceutically acceptable acid addition salt thereof, which are useful as anti-diabetic agents, in particular as hypoglycemic agents and inhibiting or impeding post-prandial hyperglycemia.
    Type: Grant
    Filed: August 22, 1983
    Date of Patent: February 12, 1985
    Assignee: Sandoz, Inc.
    Inventors: Leonard J. Brand, Jeffrey Nadelson
  • Patent number: 4496543
    Abstract: Straight-chain or mono-cyclicpolypeptides comprising a heptapeptide moiety, said moiety having in the 1-position (N-terminal) an .alpha.-N-phenylalkylated, optionally ring-substituted phenylalanine residue, in the 2-position a cysteine residue, in the 3-position an optionally ring-substituted phenylalanine residue, in the 4-position an optionally benzene-ring-substituted tryptophan residue, in the 5-position an optionally .epsilon.-N-alkylated lysine residue and in the 7-position (C-terminal) a cysteine or cysteinol residue the S-atoms of the cysteine residue at the 2-position and the cysteine or cysteinol residue at the 7-position being linked together in the case of the mono-cyclic polypeptides to form an -S-S-bridge, whereby the residues at the 1-, 2-, 4-, 6-, and 7-positions of said heptapeptide moiety may each be in the (L)- or (D)-configuration and the residues at the 4-, 5- and 6-positions of said heptapeptide moiety may each be optionally .alpha.
    Type: Grant
    Filed: August 18, 1983
    Date of Patent: January 29, 1985
    Assignee: Sandoz Ltd.
    Inventors: Wilfried Bauer, Janos Pless
  • Patent number: 4496364
    Abstract: A process for dyeing a voluminous flat form polyamide substrate with anionic dyestuffs according to the cold pad-batch method, which process comprises the step of selecting the initial pH of the dyeing liquor within a range depending on the affinity of the substrate for anionic dyestuffs and the molecular weight of the anionic dyestuffs so as to give a substantial linear exhaustion of the dyeing liquor, the dyeing liquor being free from a thickening, swelling or foaming agent.
    Type: Grant
    Filed: April 25, 1983
    Date of Patent: January 29, 1985
    Assignee: Sandoz Ltd.
    Inventor: Hans-Peter Stakelbeck
  • Patent number: 4494955
    Abstract: Disclosed is mass-dyed polyester comprising, as dyestuff, a compound or mixture of compounds of formula I ##STR1## wherein R.sub.1 is a direct bond, --CONH-- or --NHCO--, R.sub.2 is alkyl, phenyl or naphthyl, optionally substituted or cyano, provided that R.sub.1 is a direct bond when R.sub.2 is cyano, and R.sub.3 is hydrogen, methyl, ethyl, alkoxy-C.sub.1-3 -carbonyl or --CH.dbd.CH--CH.dbd.CH-- bound in the 1,2-position.
    Type: Grant
    Filed: November 7, 1983
    Date of Patent: January 22, 1985
    Assignee: Sandoz Ltd.
    Inventors: Peter Bitterli, Bansi L. Kaul
  • Patent number: 4491581
    Abstract: Novel 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydropyridazines, particularly compounds of the formula I, ##STR1## wherein COOR.sub.1 and COOR.sub.2 are the same or different carboxylic acid ester groups,R.sub.3 is H or (C.sub.1-6)alkyl andR.sub.4 is H, (C.sub.1-6)alkyl, (C.sub.3-6)alkenyl or -alkynyl, (C.sub.3-7)cycloalkyl, (C.sub.4-8)cycloalkylalkyl, (C.sub.7-9)phenylalkyl or (C.sub.9-12) phenylalkenyl, the phenyl ring being unsubstituted or mono-, di- or trisubstituted independently by halogen, OH, (C.sub.1-4)alkyl or -alkoxy,for the treatment of coronary insufficiency, spasms in smooth muscles, hypertension or cerebrovascular insufficiency.
    Type: Grant
    Filed: October 28, 1982
    Date of Patent: January 1, 1985
    Assignee: Sandoz Ltd.
    Inventor: Arnold Vogel
  • Patent number: 4491664
    Abstract: A process for the production of an ergot alkaloid comprising intramolecularly cyclizing a 3-iminoethyl-4-trans-buta-1',3'-dienylindole to produce an 8-ergolene and as necessary converting the resultant ergolene into the desired ergot alkaloid.
    Type: Grant
    Filed: March 12, 1982
    Date of Patent: January 1, 1985
    Assignee: Sandoz Ltd.
    Inventor: Wolfgang Oppolzer
  • Patent number: 4490150
    Abstract: A process for shifting the equilibrium of disperse dyestuffs between an aqueous liquor and a textile substrate comprising adding to the aqueous liquor a compound of formula I ##STR1## wherein R.sub.1 and R.sub.2, independently, are hydrogen or C.sub.4-12 -alkyl, provided that R.sub.1 and R.sub.2 are not both hydrogen;R is a mixed chain containing from 7 to 31 ethyleneoxy and 3 to 27 propyleneoxy units,with the proviso that R contains at most a total of 34 units.
    Type: Grant
    Filed: February 3, 1983
    Date of Patent: December 25, 1984
    Assignee: Sandoz Ltd.
    Inventor: Juerg Heller
  • Patent number: 4484927
    Abstract: The wet fastness properties of direct or reactive dyeings on cellulosic substrates are improved by aftertreatment with an agent comprising(A) a linear or crosslinked polymer comprising repeating units containing at least two quaternary nitrogen atoms linked by bridging groups connected to the quaternary nitrogen atoms by alkylene or arylene groups; optionally(B) an N-methylol derivative of a urea, melamine, guanamine, triazinone, urone, carbamate or acid amide;and, as an essential component,(C) a catalyst for the cross-linking of N-methylol compounds of the type (B) above,and subsequently carrying out a heat-curing step.Certain of the quaternary polymers (A), containing melamine groups, are novel.
    Type: Grant
    Filed: January 25, 1984
    Date of Patent: November 27, 1984
    Assignee: Sandoz Ltd.
    Inventor: Salvatore Valenti