Patents Assigned to SANDOZ
  • Cholesterol ester-reducing amides of hexahydroindolinols
    Patent number: 4194002
    Abstract: Long chain fatty acid amides of styryl hexahydroindolinols in which the amido portions have ethyleneically unsaturated positions or cyclopropanyl rings, eg 1-(1-oxo-9-cis-octadecenyl)-(3aRS, 4RS, 7aRS)-4-(Z)-(3,4-dimethoxy)-styryl-hexahydro-4-indolinol, are useful as cholesterol ester-reducing agents and are obtainable by reacting corresponding long chain carboxylic acids (or derivatives thereof) with appropriate 4-styryl-4-hexahydroindolinols.
    Type: Grant
    Filed: March 29, 1978
    Date of Patent: March 18, 1980
    Assignee: Sandoz, Inc.
    Inventor: Faizulla G. Kathawala
  • 4-Hydroxy-3-nitro-quinoline-2(1H)-ones
    Patent number: 4192876
    Abstract: Anti-allergic 4-hydroxy-3-nitro-quinoline-2(1H)-ones are prepared by reacting an isatoic anhydride with the carbanion resulting from the treatment of nitro acetic acid alkyl esters with a proton abstracting agent.
    Type: Grant
    Filed: June 20, 1977
    Date of Patent: March 11, 1980
    Assignee: Sandoz, Inc.
    Inventor: Goetz E. Hardtmann
  • Halogenated phosphonitrilic esters
    Patent number: 4192830
    Abstract: Alkaline earth metal oxides are used as acid binding agents in the production of halogenated phosphonitrilic esters from phosphonitrilic halides and halogenated aliphatic alcohols and/or halogenated aliphatic diols. The products are useful as flameproofing agents for textiles, plastics and synthetic resins.
    Type: Grant
    Filed: July 3, 1978
    Date of Patent: March 11, 1980
    Assignee: Sandoz Ltd.
    Inventor: Rainer Wolf
  • Substituted 4-hydroxy pyridones
    Patent number: 4191827
    Abstract: This disclosure describes novel compounds of the formula: ##STR1## where R.sub.1 is straight chain lower alkyl or ##STR2## where R.sub.4 is hydrogen or halo having an atomic weight of about 19 to 36, andR.sub.2 is straight chain lower alkyl, andR.sub.3 is hydrogen or halo as defined above,which are useful as minor tranquilizers and muscle relaxants.
    Type: Grant
    Filed: September 18, 1978
    Date of Patent: March 4, 1980
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Organic compounds
    Patent number: 4191532
    Abstract: Disclosed is a liquid dye concentrate for dilution down to form a dyebath for the dyeing of blend substrates comprising acid and cationic dyeable fibres, which concentrate comprises at least one acid dye, at least one cationic dye and, as auxiliary agents, a nonionic or anionic polyglycol ether, or a mixture thereof, and a cationic, amino group containing polyglycol ether, other preferred optional additives being a low molecular weight carboxylic acid, such as acetic or formic, and one or more aliphatic C.sub.6-16 alcohols, particularly for viscosity stabilization and/or foam inhibition. Also disclosed is a dyeing process employing such a concentrate in dilute form.
    Type: Grant
    Filed: January 26, 1978
    Date of Patent: March 4, 1980
    Assignee: Sandoz Ltd.
    Inventors: Rolf Gross, Rene Fricker
  • Tricyclo[2.2.1.0.sup.2,6 ]heptan-3-ones
    Patent number: 4190603
    Abstract: The present invention concerns a novel process for preparing derivatives useful in the production of prostaglandins.The present invention provides a process for the production of a compound of formula I ##STR1## wherein R.sub.1 is a protecting group which comprises hydrolysing a compound of formula II ##STR2## wherein R.sub.1 is as defined above andR.sub.2 is a leaving group,under acidic conditions.
    Type: Grant
    Filed: November 20, 1978
    Date of Patent: February 26, 1980
    Assignee: Sandoz Ltd.
    Inventor: Peter Funfschilling
  • Pharmaceutical preparation and use of 4-hydroxy-2-quinolinone-3-carboxylic acid esters
    Patent number: 4190659
    Abstract: Disclosed are compounds which are 4-hydroxy-2-quinolinone-3-carboxylic acid esters, e.g., 1-methyl-4-hydroxy-2-quinolinone-3-carboxylic acid ethyl ester, useful as anti-allergic agents and intermediates for 1-alkyl-4-alkoxy-quinolin-2(1H)-ones, and prepared by reacting an isatoic anhydride with an alkali metal salt of a malonic ester.
    Type: Grant
    Filed: June 20, 1977
    Date of Patent: February 26, 1980
    Assignee: Sandoz, Inc.
    Inventor: Goetz E. Hardtmann
  • Di-(cyanoalkyl)-.beta.-haloethanephosphonates and dithiophosphonates and use as plant growth regulators
    Patent number: 4190430
    Abstract: .beta.-Haloethanephosphonates and thio derivatives thereof of formula, ##STR1## where X signifies chlorine or bromine,Y signifies oxygen or sulphur,andZ signifies a carboxylic acid ester or carbamoyl group, or an optionally further substituted methyl or ethyl group substituted by such a group, or signifies an acylmethyl, optionally aryl-substituted alkenyl or alkynyl, cyclic ether, e.g. tetrahydropyranyl, or optionally mono-substituted cyanomethyl group, or signifies an alkyl-, cycyloalkyl- or aryl-thio, -sulphinyl or -sulphonyl group, or an optionally further substituted methyl or ethyl group substituted by such a group, or signifies a sulphonic acid ester group, or an optionally further substituted methyl or ethyl group substituted by such a group,are useful as regulators of plant growth or plant secretion, especially as stimulators of latex flow in latex-forming plants.
    Type: Grant
    Filed: November 9, 1978
    Date of Patent: February 26, 1980
    Assignee: Sandoz Ltd.
    Inventor: Werner Trueb
  • Reducing free fatty acid of the blood and suppressing appetite
    Patent number: 4189494
    Abstract: The present invention provides a new use of the compounds of formula I, ##STR1## wherein R.sub.1 is lower alkyl, cycloalkyl having 3 to 4 carbon atoms, phenylalkyl of 8 to 10 carbon atoms or 1-adamantyl, andR.sub.2 is hydroxymethyl, carboxyl or lower alkoxycarbonyl,as agents for the treatment or prevention of myocardism or as appetite suppressants.
    Type: Grant
    Filed: February 21, 1978
    Date of Patent: February 19, 1980
    Assignee: Sandoz Ltd.
    Inventors: Gunter Engel, Heribert Wagner
  • Dyeing of polyamide textiles and anthraquinone dyestuffs therefor
    Patent number: 4188187
    Abstract: A process for dyeing or printing natural or synthetic polyamide textile substrates comprising employing, as dyestuff, a compound of formula I, ##STR1## in which R is hydrogen, methyl or ethyl,R.sub.1 is hydrogen, methyl or ethyl, andthe ring A is unsubstituted or monosubstituted by halogen, (C.sub.1-2)alkyl, (C.sub.1-2)alkoxy or alkyl(C.sub.1-2)carbonylamino or disubstituted by methyl groups,in free acid or salt form.
    Type: Grant
    Filed: April 5, 1978
    Date of Patent: February 12, 1980
    Assignee: Sandoz Ltd.
    Inventors: Roland Mislin, Karl-Ulrich Steiner
  • Treating spastic conditions or relaxing muscles
    Patent number: 4188393
    Abstract: This invention provides a new myotonolytic use of thiazoline, oxazoline and imidazoline derivatives and novel pharmaceutical compositions for such use.
    Type: Grant
    Filed: December 18, 1978
    Date of Patent: February 12, 1980
    Assignee: Sandoz Ltd.
    Inventor: Peter Neumann
  • 4-Hydroxy-2-quinolinone-3-carboxylic acids and salts thereof
    Patent number: 4187309
    Abstract: Disclosed are compounds which are 4-hydroxy-2-quinolinone-3-carboxylic acids and salts thereof, e.g., 1-allyl-6,7-dimethoxy-4-hydroxy-2-quinolinone-3-carboxylic acid, useful as anti-allergic agents, and prepared by hydrolysis of the corresponding carboxylic acid esters.
    Type: Grant
    Filed: June 20, 1977
    Date of Patent: February 5, 1980
    Assignee: Sandoz, Inc.
    Inventor: Goetz E. Hardtmann
  • Organic compounds
    Patent number: 4187295
    Abstract: The invention provides polypeptides useful, for example, as soporifics, a process for the preparation thereof and compositions containing these compounds.
    Type: Grant
    Filed: September 6, 1978
    Date of Patent: February 5, 1980
    Assignee: Sandoz Ltd.
    Inventors: Janos Pless, Edmond Sandrin
  • Pressure indicators for inflatable cuff-type catheters
    Patent number: 4185638
    Abstract: Inflatable cuff-type catheters, e.g., endotracheal and tracheotomy tubes, with cuff pressure indicators are provided. One indicator comprises an expandable chamber with an open-ended spring about the mid-section of the chamber. As the chamber expands, the spring also expands to indicate the gas pressure in the cuff.
    Type: Grant
    Filed: January 10, 1977
    Date of Patent: January 29, 1980
    Assignee: Sandoz, Inc.
    Inventor: James D. Bruner
  • Virus insecticide composition
    Patent number: 4186195
    Abstract: Improved insecticides are provided by compositions comprising a Heliothis virus in combination with chlordimeform.
    Type: Grant
    Filed: July 10, 1978
    Date of Patent: January 29, 1980
    Assignee: Sandoz, Inc.
    Inventor: William C. Yearian
  • Polyurethanes prepared from alcohols and hydrocarbon polyisocyanates used in textile wet treatment processes
    Patent number: 4186119
    Abstract: Disclosed is a textile wet treatment process wherein, to increase the lubricity of the substrate, certain specified polyurethanes are employed in the treatment liquor.
    Type: Grant
    Filed: November 28, 1978
    Date of Patent: January 29, 1980
    Assignee: Sandoz Ltd.
    Inventors: Jose Canela, Hans Gerber
  • Dyeing with organic dyestuffs dispersed in an organic liquid
    Patent number: 4185962
    Abstract: A dyeing or printing process for substrates consisting of synthetic or semi-synthetic, high molecular organic substances of hydrophobic character, performed with an organic dyestuff which is dispersed in a liquid organic compound containing a dissolved alkyd resin acting as a dispersing agent.
    Type: Grant
    Filed: January 30, 1975
    Date of Patent: January 29, 1980
    Assignee: Sandoz Ltd.
    Inventors: Hans Gerber, Erwin Grueninger, Werner Koch, Franz Somm
  • Process for thiophosphoric acid derivatives
    Patent number: 4185052
    Abstract: The present invention relates to a novel process for the production of thiophosphoric acid derivatives of the formula ##STR1## wherein R.sub.1 is C.sub.1 -C.sub.5 alkylX is H, Cl or BrY.sub.1 is C.sub.1 -C.sub.5 alkoxy, Cl or Br andY.sub.2 is Cl or Br andthe --CH.sub.3 and --COOR.sub.1 radicals are Cis one to another in the crotonic acid moiety.The compounds of formula I are useful intermediates in the production of known insecticides.
    Type: Grant
    Filed: June 12, 1978
    Date of Patent: January 22, 1980
    Assignee: Sandoz Ltd.
    Inventor: Jean-Pierre Leber
  • Anionic azo dyes having a 3-dibenzofuranyl diazo component radical optionally having a 2- or 8-sulfo group
    Patent number: 4185013
    Abstract: Disclosed are azo dyes containing, a diazo component radical of the formula ##STR1## wherein each of Z and Z.sub.1 is independently hydrogen or sulfo, with the proviso that at least one of Z and Z.sub.1 is hydrogen, for example monoazo and disazo dyes of the formula ##STR2## and salts thereof, wherein K is a coupling component radical of the aromatic carbocyclic, active methylene group-containing aliphatic or aromatic heterocyclic series, andZ and Z.sub.1 are as defined above, with the proviso that the dyes contain one or two sulfo groups, and the use thereof for the dyeing and printing of anionic dyeable substrates, particularly polyamide substrates.
    Type: Grant
    Filed: November 8, 1976
    Date of Patent: January 22, 1980
    Assignee: Sandoz Ltd.
    Inventors: Francois Benguerel, Jean-Jacques Salzmann
  • Benzocycloalkylamides
    Patent number: 4185118
    Abstract: Unsaturated fatty acid amides of benzocycloalkylamines, eg. N-(1-indanyl)-cis,cis-9,12-octadecadienylamide, are useful as pharmaceutical agents and are obtainable by reacting a mixed anhydride of a long chain unsaturated carboxylic acid with an appropriate benzocycloalkylamine.
    Type: Grant
    Filed: January 12, 1979
    Date of Patent: January 22, 1980
    Assignee: Sandoz, Inc.
    Inventor: Faizulla G. Kathawala