Patents Assigned to SANDOZ
  • Process for producing a structurally modified interferon
    Patent number: 4184917
    Abstract: The invention provides structurally modified interferons, processes for producing such and a method of purification of interferons and structurally modified interferons. The modified interferons are useful as anti-viral agents.
    Type: Grant
    Filed: September 19, 1977
    Date of Patent: January 22, 1980
    Assignee: Sandoz Ltd.
    Inventors: Friedrich Dorner, Marianne Scriba, Rudolf Weil
  • Organic compounds
    Patent number: 4183943
    Abstract: The present invention provides compounds of formula, ##STR1## wherein n is from 0 to 4, m is from 0 to 4, whereby n+m is at least 1 and not more than 4, each of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may independently be, for example, hydrogen, alkyl or alkoxy, R.sub.5 may, for example, be nitrile or carbamoyl and R.sub.6 is hydrogen and, when n is 2 and m is 0, one of R.sub.6 can be alkyl of 1 to 4 carbon atoms, which compounds possess pharmaceutical, for example antiallergic, activity.
    Type: Grant
    Filed: February 3, 1978
    Date of Patent: January 15, 1980
    Assignee: Sandoz Ltd.
    Inventor: Jean-Michel Bastian
  • Fluorescent 1,2,3-triazole derivatives of 3-phenylcoumarin
    Patent number: 4182861
    Abstract: Polyester, cotton, polyamide and polyacrylonitrile fabrics and foils of polyvinylchloride are optically brightened by the addition of a compound of the formula ##STR1## in which each of R.sub.1 and R.sub.2 represents a hydrogen atom or an aliphatic, alicyclic, araliphatic, halogen- or alkyl-substituted araliphatic, aromatic, or halogen- or alkyl-substituted aromatic radical,R.sub.3 represents a hydrogen or halogen atom or a low molecular weight alkyl or alkoxy radical.
    Type: Grant
    Filed: December 30, 1976
    Date of Patent: January 8, 1980
    Assignee: Sandoz Ltd.
    Inventors: Fritz Fleck, Hans Balzer, Horst Aebli
  • 3-Hydrazino-5,6,7,8,9,10-hexahydro-cycloocta[c]pyridazines
    Patent number: 4181723
    Abstract: This invention provides new compounds of formula I, ##STR1## wherein R.sub.1 is amino, or ##STR2## wherein each of R.sub.3 and R.sub.4 is independently alkyl of 1 to 4 carbon atoms,R.sub.2 is alkyl of 1 to 4 carbon atoms or phenyl,R.sub.8 is hydrogen or alkyl of 1 to 4 carbon atoms, andA is --(CH.sub.2).sub.n --,wherein n is an integer from 1 to 3, with the proviso that when R.sub.1 is amino, R.sub.2 is methyl or phenyl and R.sub.8 is hydrogen, n is 2 or 3,or .dbd.N--CO--R.sub.5,wherein R.sub.5 is alkyl of 1 to 6 carbon atoms, alkenyl of 3 to 6 carbon atoms, a --(CH.sub.2).sub.m --R.sub.6 group, wherein m is an integer from 0 to 2, and R.sub.6 is phenyl, or phenyl monosubstituted by fluorine, chlorine, bromine, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or alkylmercapto of 1 to 4 carbon atoms,or an --OR.sub.7 group,wherein R.sub.
    Type: Grant
    Filed: November 23, 1977
    Date of Patent: January 1, 1980
    Assignee: Sandoz Ltd.
    Inventor: Erhard Schenker
  • Dyeing and printing with synthetic thickeners
    Patent number: 4181498
    Abstract: Disclosed is a process for dyeing or printing a textile substrate employing an aqueous paste comprising dyestuff and a synthetic thickener, which process comprises the step of applying an electrolyte to the substrate prior to or after application of said aqueous paste, said paste being free from added electrolyte.
    Type: Grant
    Filed: September 20, 1976
    Date of Patent: January 1, 1980
    Assignee: Sandoz Ltd.
    Inventors: Paul Koltai, Georg Robert
  • N-9,10-dihydrolysergyl-m-aminobenzoic acid amide derivative
    Patent number: 4180581
    Abstract: The present invention provides compounds of formula I, ##STR1## wherein X is hydrogen, chlorine or bromine andY is hydrogen or bromine, with the proviso that when X is chlorine Y is hydrogen,Z is carbonyl or sulphonyl,R.sub.1 is alkyl of 1 to 4 carbon atoms, andeither (i)R.sub.2 is hydrogen or alkyl of 1 to 5 carbon atoms, andR.sub.3 is hydrogen, alkyl of 1 to 5 carbon atoms, or phenyl,or (ii)R.sub.2 together with R.sub.3 is a radical of formula ##STR2## wherein R.sub.4, R.sub.5, R.sub.6 and R.sub.7 are, independently, hydrogen or alkyl of 1 to 4 carbon atoms,or (iii)R.sub.2 together with R.sub.4 is a radical of formula--(CH.sub.2).sub.2 --A--(CH.sub.2).sub.2 --wherein A is a bond, oxygen, sulphur or NR.sub.8 wherein R.sub.8 is hydrogen, alkyl of 1 to 4 carbon atoms, phenyl or alkoxyphenyl,useful as venotonising agents.
    Type: Grant
    Filed: January 26, 1978
    Date of Patent: December 25, 1979
    Assignee: Sandoz Ltd.
    Inventor: Paul Stadler
  • Dibenz[c,f]imidazo [1,2-a] [1]azepin-9-ols
    Patent number: 4180671
    Abstract: Dibenz[c,f]imidazo [1,2-a] [1]azepin-9-ols of the general formula ##STR1## where R.sub.1 represents H or mono or di-chloro or fluoro, andR.sub.2 represents H, chloro, fluoro, alkyl of 1-3 carbon atoms, e.g., methyl, ethyl or isopropyl, alkoxy of 1-3 carbon atoms, e.g., methoxy or ethoxy, or trifluoromethyl,prepared by borohydride hydrogenation of the corresponding 9-ones are useful as anti-convulsant agents.
    Type: Grant
    Filed: May 22, 1978
    Date of Patent: December 25, 1979
    Assignee: Sandoz, Inc.
    Inventor: William J. Houlihan
  • Substituted hydroxy pyridones
    Patent number: 4179566
    Abstract: Substituted hydroxy pyridones, e.g., 3-(1-iminopropyl)-4-hydroxy-6-phenyl-1-methyl-2(1H)-pyridone, are prepared by reducing corresponding isoxazolo[4,5-c]pyridin-4(5H)-ones and are useful as minor tranquilizers, sleep inducers and neuroleptics.
    Type: Grant
    Filed: July 17, 1978
    Date of Patent: December 18, 1979
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Para-phenyl stilbene derivatives
    Patent number: 4179578
    Abstract: Stilbene derivatives having at least one further phenyl substituent in the para-position to a benzene ring in the stilbene are optical brighteners particularly suitable for incorporation on spinning masses.
    Type: Grant
    Filed: April 14, 1977
    Date of Patent: December 18, 1979
    Assignee: Sandoz Ltd.
    Inventors: Fritz Fleck, Hans Kittl, Salvatore Valenti
  • (4-Hydroxy-4-piperidyl)-alkanoic acid amides
    Patent number: 4178377
    Abstract: The present invention concerns novel compounds of formula I, ##STR1## wherein R.sub.1 is phenethyl, phenethyl monosubstituted in the phenyl ring by fluorine, chlorine, bromine, lower alkyl or lower alkoxy, butyrophenone or butyrophenone monosubstituted in the phenyl ring by fluorine, chlorine, bromine, lower alkyl or lower alkoxy,R.sub.2 is an OR.sub.5 group,wherein R.sub.5 is lower alkyl, lower alkenyl, phenyl or phenyl monosubstituted by fluorine, chlorine, bromine, lower alkyl or lower alkoxy,or an ##STR2## group, wherein independently each of R.sub.6 and R.sub.7 is hydrogen, lower alkyl or cycloalkylalkyl, cycloalkyl, phenyl, phenyl monosubstituted by fluorine, chlorine, bromine, lower alkyl or lower alkoxy, lower phenylalkyl or lower phenylalkyl monosubstituted in the phenyl ring by fluorine, chlorine, bromine, lower alkyl or lower alkoxy, orwherein R.sub.6 and R.sub.
    Type: Grant
    Filed: August 19, 1977
    Date of Patent: December 11, 1979
    Assignee: Sandoz Ltd.
    Inventors: Erwin Rissi, Anton Ebnother
  • 6-(Substituted phenyl)-4,5-dihydro-pyridazin-3(2H)-ones
    Patent number: 4177273
    Abstract: The present invention provides new pyridazinones of the formula ##STR1## where R is alkyl;R.sub.1 and R.sub.2 are halo, alkyl, alkoxy, amino; nitro or trifluoromethyl;R.sub.3 is hydrogen, hydroxy, or acyloxy;R.sub.4 is hydrogen or alkyl; andR.sub.5 is hydroxy or acyl;which are useful as central nervous system depressants.
    Type: Grant
    Filed: June 14, 1978
    Date of Patent: December 4, 1979
    Assignee: Sandoz, Inc.
    Inventor: Gregory B. Bennett
  • 4-Phenyl isoquinolines
    Patent number: 4175191
    Abstract: 3-Substituted-4-aryl isoquinolines, e.g. 3-tertiary butyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline, prepared from corresponding isoquinoline intermediates, are useful as anti-diabetic agents.
    Type: Grant
    Filed: November 17, 1977
    Date of Patent: November 20, 1979
    Assignee: Sandoz, Inc.
    Inventors: William J. Houlihan, Jeffrey Nadelson
  • .alpha.-Alkyl-p-phenoxy benzyl alcohols, compositions and treating lipidemia
    Patent number: 4175138
    Abstract: Hypolipidemic agents of the formula: ##STR1## wherein X is C.dbd.O or CHOH,R.degree. is branched lower alkyl,R is hydrogen, alkyl, or halo,n is 1 or 2, andR' and R" are hydrogen, halo, alkyl or alkoxy, e.g., 4-phenoxy pivalophenone.
    Type: Grant
    Filed: January 30, 1978
    Date of Patent: November 20, 1979
    Assignee: Sandoz, Inc.
    Inventor: Faizulla G. Kathawala
  • Substituted 3,1-benzazasilines
    Patent number: 4175091
    Abstract: Compounds of the following structure ##STR1## where R.sub.1 represents H or alkyl having 1-5 carbon atoms,R.sub.2, R.sub.3, R.sub.4 and R.sub.5 each, independently represents H or alkyl having 1-2 carbon atomsR.sub.6 represents H, alkyl having 1-5 carbon atoms, halo, alkoxy having 1-5 carbon atoms or ##STR2## where R.sub.8 and R.sub.9 each, independently, represent alkyl having 1-2 carbon atoms, andR.sub.7 represents alkyl having 1-5 carbon atoms,e.g., 1-(p-chlorophenyl)-1,4-dihydro-.beta.,.beta.,1-trimethyl-3,1-benzazasiline -3(2H)-ethanol, are prepared from corresponding oxazolo benzazasilanes by reduction with borohydride, and are useful as sleep inducers.
    Type: Grant
    Filed: February 27, 1978
    Date of Patent: November 20, 1979
    Assignee: Sandoz, Inc.
    Inventor: Sandor Barcza
  • Antibiotic S 31794/F-1
    Patent number: 4173629
    Abstract: This invention provides S 31794/F-1 which is a useful anti-mycotic for combatting Candida albicans infections.
    Type: Grant
    Filed: June 28, 1978
    Date of Patent: November 6, 1979
    Assignee: Sandoz Ltd.
    Inventors: Michael M. Dreyfuss, Hans Tscherter
  • Preparation of quinazolin-2(1H)-ones
    Patent number: 4171441
    Abstract: Quinazoline-2(1H)-ones are prepared by dehydrogenating a 5,6,7,8-tetrahydro-2(1H)-quinazolinone with sulfur in the presence of a metal oxide, hydroxide or halide.
    Type: Grant
    Filed: July 21, 1978
    Date of Patent: October 16, 1979
    Assignee: Sandoz, Inc.
    Inventor: Joseph A. Smith
  • Hydro-4-phenyl-benz[f]isoindoline compounds
    Patent number: 4171369
    Abstract: The present invention concerns novel hydro-4-phenyl-benz[f]isoindoline derivatives, of the formula ##STR1## wherein R is hydrogen or substituted or unsubstituted alkyl,R.sub.1 and R.sub.2 are hydrogen, halogen or alkyl, and eitherX and Y are hydrogen, orX and Y together are an additional bond,Useful as analgesics and antidepressants.
    Type: Grant
    Filed: March 17, 1975
    Date of Patent: October 16, 1979
    Assignee: Sandoz Ltd.
    Inventors: Roland Achini, Wolfgang Oppolzer, Emil Pfenninger
  • Thiocyanomethyl substituted anthraquinone disperse dyes
    Patent number: 4170600
    Abstract: The present invention relates to disperse dyestuffs of the anthraquinone series which contain at least one group of formula --Y--CH.sub.2 (SCN) where Y is a mono- or binuclear aryl group, which dyestuffs are useful for dyeing or printing textile substrates consisting of or comprising synthetic or semi-synthetic, hydrophobic high molecular weight organic materials.
    Type: Grant
    Filed: May 30, 1978
    Date of Patent: October 9, 1979
    Assignee: Sandoz Ltd.
    Inventor: Werner Baumann
  • Substituted hydroxy pyridones
    Patent number: 4170705
    Abstract: Substituted hydroxy pyridones, e.g., 3-(.alpha.-N-methyliminobenzyl)-4-hydroxy-6-phenyl-1-methyl-2(1H)-pyridone , are prepared by reacting a corresponding substituted hydroxy pyridone carbonyl with an alkyl amine, and are useful as minor tranquilizers, sleep inducers, muscle relaxants, and neuroleptics.
    Type: Grant
    Filed: July 17, 1978
    Date of Patent: October 9, 1979
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Process for the preparation of 1,3,3-trimethyl-2-oxabicyclo[2,2,2]octan-6-ones
    Patent number: 4170599
    Abstract: 1,3,3-Trimethyl-2-oxabicyclo[2,2,2]octan-6-ones are prepared by first epoxidizing .alpha.-terpineol with a peracid and thereafter oxidizing the resulting product with an appropriate oxidizing agent.
    Type: Grant
    Filed: June 19, 1978
    Date of Patent: October 9, 1979
    Assignee: Sandoz, Inc.
    Inventor: Gregory B. Bennett