Patents Assigned to SANDOZ
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Patent number: 4003885Abstract: Compounds of the formula ##STR1## in which X signifies hydrogen, halogen or --SO.sub.3 M,M signifies hydrogen or a non-chromophoric cation, andK.sub.1 and K.sub.2, which are the same or different, each signifies a coupling component which has at least one free amino, enolic hydroxy or phenolic hydroxy group,And mixtures thereof, are useful as anionic dyes for natural and regenerated cellulose, natural and synthetic polyamides, polyurethanes, basically modified polyolefins, paper and, particularly, leather. The dyes are well-soluble in water, resistant to acid, have relatively low substantivity on leather, produce level dyeings and have no hardening effect on chrome-tanned leather and exhibit good fastness to light and wet treatments on paper. Also disclosed are compounds of the formula ##STR2## wherein M and X are as defined above, which are useful as intermediates.Type: GrantFiled: July 2, 1974Date of Patent: January 18, 1977Assignee: Sandoz Ltd.Inventors: Claude Vogel, Heinz Wicki
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Patent number: 4004011Abstract: This invention provides new compounds of formula I, ##STR1## wherein R is 3-pyridyl or 3-pyridyl mono- or polysubstituted BY LOWER ALKYL, LOWER ALKOXY, LOWER ALKYLTHIO, PHENOXY, HALOGEN, HYDROXY, OR THE GROUP ##STR2## wherein each of R.sub.1 and R.sub.2 is, independently, hydrogen or lower alkyl,Useful as prolactin secretion inhibitors for the treatment of galactorrhea.Type: GrantFiled: April 9, 1975Date of Patent: January 18, 1977Assignee: Sandoz Ltd.Inventors: Hartmut Hauth, Hans Tscherter
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Patent number: 4003377Abstract: An improved patient ventilator for providing a mode of operation wherein mandatory breaths are supplied to a patient intermittently, and wherein those mandatory breaths are synchronized with the patient's normal breathing cycle. An adjustable timer provides an output signal for controlling the duration between mandatory breaths, and a delay circuit prevents the output signal from the timer from initiating the mandatory breath for a predetermined delay period to permit the patient to initiate that breath himself. The intermittent mandatory breaths are made "mandatory" by closing off an exhalation valve while a fixed quantity or pressure level of oxygen is supplied to the patient.Type: GrantFiled: August 21, 1975Date of Patent: January 18, 1977Assignee: Sandoz, Inc.Inventor: William R. Dahl
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Patent number: 4003889Abstract: Disclosed are compounds of formula I, ##STR1## in which either R.sub.1, R.sub.2 and R.sub.3, which may be the same or different, each signifies a hydrogen atom, a chlorine or fluorine atom, an alkyl radical of 1 to 4 carbon atoms, an alkoxy radical of 1 to 4 carbon atoms, a cyano group, a group --SO.sub.3 M, an unsubstituted phenyl radical or a phenyl radical substituted by up to 2 substituents selected from chlorine, fluorine, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms and the group --SO.sub.3 M, with the proviso that only one of R.sub.1, R.sub.2 and R.sub.3 signifies an unsubstituted or substituted phenyl radical,Or two ofR.sub.1, r.sub.2 and R.sub.3 together form a methylenedioxy group, the other of R.sub.1, R.sub.2 and R.sub.3 having one of the above significances,R.sub.4 signifies a hydrogen atom, a chlorine or fluorine atom, an alkyl radical of 1 to 4 carbon atoms or an alkoxy radical of 1 to 4 carbon atoms,R.sub.Type: GrantFiled: June 17, 1974Date of Patent: January 18, 1977Assignee: Sandoz Ltd.Inventors: Ivan Joseph Bolton, Alec Victor Mercer, Fritz Fleck
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Patent number: 4004009Abstract: The compounds are aryl-pyridazinone derivatives, e.g., 1-methyl-5-(2'-fluoro-5'-trifluoromethylphenyl)-1H-pyrazolo [4,3-c]pyridazin-6(5H)-one. They are useful as antihypertensives and are prepared by treating a hydrazinopyridazinone with a dialkylamino dialkyl-acetal.Type: GrantFiled: July 31, 1975Date of Patent: January 18, 1977Assignee: Sandoz, Inc.Inventor: Paul L. Anderson
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Patent number: 4002751Abstract: Substituted 5-hydrazinopyridazin-3(2H)-ones, e.g., 4-chloro-2-(3-trifluoromethylphenyl)-5-(1-methylhydrazino)-pyridazin-3(2H) -one or 4-chloro-2-(2-fluoro-5-trifluoromethylphenyl)-5-(1-methylhydrazino)-pyrida zin-3(2H)-one, are prepared by treating halogenated pyridazin-3-(2H)-ones with hydrazine and substituted hydrazines and are useful as central nervous system depressants and sleep inducers.Type: GrantFiled: May 2, 1975Date of Patent: January 11, 1977Assignee: Sandoz, Inc.Inventor: Jerome Linder
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Patent number: 4002785Abstract: The present invention concerns a method of producing non-woven fabrics by impregnating a non-woven fibrous web with a binding agent dispersion characterized by the use of a compound of the formula: ##STR1## wherein R is a substituted or unsubstituted aliphatic hydrocarbon substituent,R.sub.1, r.sub.2 and R.sub.3 are each hydrogen, alkyl or polyalkoxy substituentsn is an integer andZ is zero or an integer in free base, acid addition salt or quaternary ammonium salt form, to prevent migration of the binding agent.Type: GrantFiled: August 22, 1975Date of Patent: January 11, 1977Assignee: Sandoz Ltd.Inventors: Marcel Grossmann, Richard Hochreuter
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Patent number: 4001285Abstract: The invention provides novel compounds of formula ##STR1## in which R signifies a hydrocarbon radical of 5 to 22 carbon atoms, which may be substituted,R.sub.1 and R.sub.2, which may be the same or different, each signifies a hydrogen atom or a lower alkyl radical which may be substituted, provided that at least one of R.sub.2 and R.sub.1 or the R.sub.1 's signifies hydroxyalkyl or carboxyalkyl, in which the alkyl radical contains 1 to 4 carbon atoms, or a radical of formula --CH.sub.2 SO.sub.3.sup.- M.sup.+, --CH.sub.2 --CH.sub.2 --O).sub.p H, --CH.sub.2 --CH(CH.sub.3)O).sub.p H, --CH.sub.2 --CH.sub.2 --CN or --CH.sub.2 --CH.sub.2 CONH.sub.2,p signifies 1 to 10,X signifies --CONH--, ##STR2## --O-- or --S--, m signifies 0 to 6,n or the n's, which may be the same or different when m is greater than 1, each signifies from 1 to 8,a signifies 0 or 1 andM.sup.+ signifies hydrogen, an ammonium cation or an equivalent of a metal cation, and quaternary ammonium derivatives thereof, useful as textile finishing agents.Type: GrantFiled: February 3, 1975Date of Patent: January 4, 1977Assignee: Sandoz Ltd.Inventor: Richard Hochreuter
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Patent number: 4001206Abstract: Disclosed are compounds of the formula ##STR1## in which R, R.sub.1 and R.sub.4, which may be the same or different, each signify a hydrogen atom, an alkyl radical of 1 to 6 carbon atoms or an alkoxy radical of 1 to 6 carbon atoms,R.sub.2 signifies an alkyl radical of 1 to 6 carbon atoms,R.sub.3 signifies a hydrogen atom or an alkyl radical of 1 to 6 carbon atoms,n signifies 0 or 1,m signifies 0 or 1, andp signifies 0 to 3With the proviso that the compounds contain at least one sulphonic acid group; their water soluble salts, process for the production thereof, compositions containing same and a process for dyeing paper therewith.The dyes are highly substantive to paper and produces dyeings that exhibit good fastness to light, water, milk, fruit juices and alcohol but that are bleachable by oxidation or reduction.Type: GrantFiled: February 11, 1972Date of Patent: January 4, 1977Assignee: Sandoz Ltd.Inventor: Georg Schoefberger
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Patent number: 4000258Abstract: Stable suspensions of Bacillus thuringiensis insecticide in a liquid selected from the group consisting of (a) alcohols having at least about 7 carbon atoms; (b) polyethylene glycols having a molecular weight of at least about 300; (c) polypropylene glycols having a molecular weight of at least about 180; (d) polyethylenepropylene glycols having a molecular weight of at least about 250; (e) ethoxylated alcohols having a molecular weight greater than about 120; and (f) propoxylated alcohols having a molecular weight greater than about 120.Type: GrantFiled: January 19, 1972Date of Patent: December 28, 1976Assignee: Sandoz, Inc.Inventors: Tsuong R. Shieh, Martin H. Rogoff
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Patent number: 4000139Abstract: The invention concerns a novel process for the production of a compound of formula I, ##STR1## wherein R.sub.1 is the cyano group, or -COX, wherein X is the amino group or an -O-(lower)alkyl radical, andR.sub.2 to R.sub.5 are substituents inert to internal cyclization conditions,Comprising subjecting a compound of formula II, ##STR2## wherein the variables R.sub.1 to R.sub.5 are as defined above, and R.sub.6 is a radical capable of leaving under the reaction conditions, to an intramolecular condensation in the presence of a base, the compounds of formula I being useful intermediates in the preparation of ergot alkaloids.Type: GrantFiled: July 2, 1974Date of Patent: December 28, 1976Assignee: Sandoz Ltd.Inventors: Peter Stutz, Paul Stadler
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Patent number: 4000307Abstract: Alkanoyl isoindolinylmethyl alkylphenones of the formula, ##STR1## e.g. 4'-(5-pivaloyl-2-isoindolinylmethyl)-pivalophenone, are prepared by reacting a 3',4'-bis(bromomethyl)alkylphenone with a 4'-(aminomethyl)alkylphenone-(2,2-dimethyl-1,3-propanediyl)cyclic ketal and hydrolyzing the ketal formed, and are useful as hypolipidemic agents.Type: GrantFiled: November 19, 1975Date of Patent: December 28, 1976Assignee: Sandoz, Inc.Inventor: Jeffrey Nadelson
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Patent number: 4000158Abstract: Disclosed are phthalocyanine dyes of formula ##STR1## IN WHICH Me signifies copper or nickelPc signifies a phthalocyanine radical,The R.sub.1 's, independently, signify a linear, branched or cyclic aliphatic radical, unsubstituted or substituted by chlorine, bromine, alkoxy, cyano, alkylcarbonyl, alkoxycarbonyl, benzoyl, alkylcarbonyloxy, alkoxycarbonyloxy or benzoyloxy,The R.sub.2 's, independently, signify a phenyl radical, unsubstituted or substituted by a chlorine or bromine atom or a nitro or cyano group or by up to two substituents selected from methyl, methoxy and ethoxy groups,m signifies 1 or 2, andn signifies 2 or 3,The sum n + m being 3 or 4And mixtures thereof, their production and use particularly in the dyeing of paper and plastics and in the production of surface coating media such as inks and lacquers.Type: GrantFiled: January 24, 1974Date of Patent: December 28, 1976Assignee: Sandoz Ltd.Inventor: Hans von Tobel
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Patent number: 3998835Abstract: This invention provides new compounds of formula I, ##STR1## wherein X is sulphur or oxygen,R is alkyl of 3 to 7 carbon atoms or cycloalkyl of 3 to 7 carbon atoms, cycloalkyl of 3 to 7 carbon atoms monosubstituted by alkyl of 1 to 4 carbon atoms, .alpha.-dialkylpropinyl of 5 to 9 carbon atoms or .alpha.-dialkyl-allyl of 5 to 9 carbon atoms, hydroxyalkyl of 2 to 7 carbon atoms or phenoxyalkyl of 8 to 11 carbon atoms, the oxygen atom of the last two radicals being separated by at least two carbon atoms from the nitrogen atom to which R is bound,R.sub.1 isI. hydrogen or alkyl of 1 to 4 carbon atoms in the 2,3,6 or 7 position, orIi. chlorine or bromine, in the 2, 3 or 7 position,Iii. nitro or --NHA wherein A is alkanoyl of 1 to 4 carbon atoms, in the 2, 3 or 7 position, orIv. fluorine, cyano or COOB, wherein B is alkyl of 1 to 4 carbon atoms, in the 2 or 3 position, andR.sub.2 isI. hydrogen or alkyl of 1 to 4 carbon atoms in the 2, 3, 6 or 7 position,Ii. chlorine or bromine, in the 2, 3 or 7 position, orIii.Type: GrantFiled: August 20, 1975Date of Patent: December 21, 1976Assignee: Sandoz Ltd.Inventors: Fran Troxler, Erik Wiskott
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Patent number: 3998850Abstract: Substituted -4'-aminoacetyl alkanoylphenones, e.g., 4'-(4-methyl-1-piperazinylacetyl)pivalophenone, are prepared by treating corresponding 4'-(haloacetyl)alkanoylphenones with substituted amines, and are useful as hypolipidemic agents.Type: GrantFiled: January 8, 1975Date of Patent: December 21, 1976Assignee: Sandoz, Inc.Inventors: William J. Houlihan, Jeffrey Nadelson
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Patent number: 3998803Abstract: Dyes of the formula ##STR1## wherein R.sub.1 is hydrogen or cyano,R.sub.2 is alkyl, aryl or heterocyclyl, or a substituted derivative there f,R.sub.20 is hydrocarbyl, heterocyclyl or amino, or a substituted derivative thereof preferably containing a protonizable nitrogen atom, andD is aromatic carbocyclyl or heterocyclyl, or a substituted derivative thereof, with the proviso that it is free of cationic groups,With the proviso that the molecule contains at least one protonizable nitrogen atom. These dyes are eminently suitable for the dyeing and printing of textiles which consist of or contain fibers of polyacrylonitrile or copolymers of acrylonitrile. They are suitable for dyeing polyesters and polyamides modified to contain acid groups as well as leather and paper. The dyes have high tinctorial strengths and give level dyeings exhibiting good fastness to light and wet treatments. The dyes are produced by diazotizing an amine of the formula D-NH.sub.Type: GrantFiled: June 17, 1974Date of Patent: December 21, 1976Assignee: Fidelity Union Trust Company, Executive Trustee Under the Sandoz TrustInventors: Hermann Burkhard, Roland Entschel, Willy Steinemann
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Patent number: 3997664Abstract: The compounds are steroidal 17-propadienyl carbinols and derivatives thereof. The compounds have estrogenic/progestational activity.Type: GrantFiled: March 24, 1975Date of Patent: December 14, 1976Assignee: Sandoz, Inc.Inventors: Eugene E. Galantay, Dietmar A. Habeck
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Patent number: 3997593Abstract: This invention provides a new process for the preparation of a compound of formula I, ##STR1## wherein R' is alkyl or cycloalkyl, andR is an organic radical which is inert under the reaction conditions,By oxidizing a compound of formula II, ##STR2## wherein R and R' are as defined above, with nitric acid.Type: GrantFiled: June 5, 1975Date of Patent: December 14, 1976Assignee: Sandoz Ltd.Inventors: Paul Stadler, Gernot Wersin
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Patent number: 3997520Abstract: This invention relates to monoazo compounds of the formula I, ##STR1## in which R.sub.1 signifies a hydrogen atom, an alkyl radical or an unsubstituted or substituted phenyl radical,Each of R.sub.2 and R.sub.3 signifies a hydrogen atom, a cycloalkyl radical, an alkenyl radical or an unsubstituted or substituted alkyl radical, with the proviso that when one of R.sub.2 and R.sub.3 signifies a hydrogen atom, the other has a significance other than hydrogen,R.sub.4 signifies an .alpha.- or .beta.-chloro- or bromoethyl radical,R.sub.5 signifies a hydrogen atom or a methoxy or ethoxy radical, andX signifies a group of the formula --CO--or --CO--O--.These compounds are useful as disperse dyes, particularly for the exhaust dyeing, pad dyeing and printing of synthetic and semi-synthetic hydrophobic materials such as linear and aromatic polyesters, cellulose acetates and polyamides.Type: GrantFiled: July 11, 1974Date of Patent: December 14, 1976Assignee: Sandoz Ltd.Inventor: Ruedi Altermatt
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Patent number: 3997555Abstract: CNS depressants of the formula: ##SPC1##Wherein R.sup.o is hydroxyalkyl of 1 to 5 carbon atoms and R is hydrogen, halo, alkyl, alkoxy or trifluoromethyl.Type: GrantFiled: December 23, 1974Date of Patent: December 14, 1976Assignee: Sandoz, Inc.Inventor: Goetz E. Hardtmann